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Student Projects in Organs-on-Chips

The design, development and application of organs-on-chips is a multi-disciplinary process. This means that students with a wide range of skills are needed to tackle the various engineering challenges. Whether you are a student with a background in biomedical engineering, chemical technology, applied physics, electrical engineering, technical medicine or even health sciences, there will likely be a project for you in the field of organs-on-chips.

Multiple departments in the MIRA Institute offer projects for students who want to work on organ-on-chip technology. Projects are available for Bachelor’s students (both B.Sc. and BAS) and Master’s students. Here you’ll find descriptions of typical projects, accompanied by the type of practical skills you would acquire. The descriptions also list contact details of the people that can discuss concrete options with you.

If you are unsure about what type of project to pursue, or if you have any other general questions, feel free to contact Andries van der Meer.

Projects

Organs-on-Chips and Vascular Disease Dr. Andries van der Meer develops organs-on-chips to study vascular disease. His projects have a strong focus on cell biology and the application of stem cell technology, 3D biofabrication and microfluidic technology. Measuring the Blood-Brain Barrier Using a Chip Dr. Loes Segerink works on sensor technology for organs-on-chips. The focus of her research is on the engineering of a physiologically relevant blood-brain barrier-on-chip, which enables measurement of both electrical resistance and permeability, and which facilitates mechanical and biochemical modulation of the barrier. Lung-on-a-Chip Dr. André Poot and Prof. Dimitrios Stamatialis prepare a lung-on-a-chip for the development of novel strategies for lung regeneration as well as the engineering of bioartificial lung tissue. In this project, lung alveolar epithelial cells and microvascular endothelial cells will be cultured on either side of a curved, flexible and elastic membrane in a microfluidic chip. Kidney-on-a-Chip Dr. André Poot and Prof. Dimitrios Stamatialis develop a kidney-on-a-chip for toxicity studies and tissue engineering applications. In this project, kidney epithelial cells and vascular endothelial cells will be cultured on either side of a flat membrane in a microfluidic chip. Subsequently, the flat membrane will be changed for a hollow fiber membrane. Baby Blood-Brain Barrier on Chip Dr. Nienke Bosschaart works on non-invasive alternatives for blood sampling in pre-term babies. In this project, she collaborates with dr. Loes Segerink and dr. Andries van der Meer to develop a microfluidic chip to mimic the distribution of bilirubin in the blood and the brain of newborns.