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Session 1A: Cancer: Diagnosis, treatment and rehabilitation

Chairs: Khalid Daoudi (BMPI) & Marjan Hummel (HTSR)


Cancer diagnostics in urine: Nanopil 2.0 – Rik Rurup (BIOS)

A novel method for non-invasive bladder cancer diagnostics in urine will be discussed.

Keywords: Early diagnostics, Cancer, Epigenetics


Lowering the detection limit of circulating tumor cells - Guus van Dalum (MCBP)

The presence of circulating tumor cells(CTC) in peripheral blood from cancer patients is associated with poor prognosis. Using current techniques these CTC are found in a fraction of all patients diagnosed with metastatic cancer. At MCBP several approaches to lower this detection limit are investigated.

Keywords: Diagnostic's, Cancer, Liquid biopsy


Differential Magnetometry – selective sensing of magnetic nanoparticles for intra-operative applications - Sebastiaan Waanders (NIM)

Conventional techniques for intra-operative detection of for lymph nodes in breast cancer are limited by logistical difficulties (radioactive tracers) or bad SNR in the case of AC magnetometry. We developed a magnetic alternative (DiffMag) that offers the selectivity of radioactive methods with the inherent safety of magnetic tracers.

Keywords: Nonlinear magnetometry, Breast cancer, Intra-operative tools


Assessing clinical value of PET/CT and MRI-DWI using multi-criteria decision analysis -

Henk Broekhuizen (HTSR)

To succeed in the market, medical innovations must show added clinical value. Multi-criteria decision analysis can facilitate this assessment and highlight critical areas of uncertainty. We present the research protocol for an assessment of added value of PET/CT and MRI-DWI for monitoring of treatment response in non-small cell lung cancer.

Keywords: early HTA, MCDA, uncertainty analysis, lung cancer


Co-creation of an ICT-supported cancer rehabilitation program for lung cancer survivors - Josien Timmerman (BSS)

The use of ICT can improve post-surgery care for cancer survivors treated with lung resection. However, implementation of ICT applications is challenging, often hampered by non-acceptance of the developed service by its end-users. A promising approach is to involve the end-users early and continuously during the developmental process through a user-centered design approach.

Keywords: telerehabilitation, lung cancer, user-centered design

Session 1B: Movement of machine and man

Chairs: Yan Zhao (BSS) & Aart van Apeldoorn (DBE)


Ultrasound-guided control of a robotically-actuated catheter for cardiac interventions - Guus Vrooijink (BME)

The clinician often has limited and non-intuitive control over the tip of the instrument in minimally invasive surgery. We integrate a robotically-actuated delivery sheath (RADS) to potentially assist the clinician. We use 2D ultrasound images to steer the RADS in closed-loop in order to compensate for beating heart motions.


Neural Network Dynamics in Parkinson's Disease - Bettina Schwab (AA)

Why do Parkinson's disease patients suffer from motor symptoms? By describing neural networks as dynamical systems, our research targets the basic mechanisms underlying abnormal activity in the basal ganglia - which is thought to be responsible for stiffness and slowing of movement.

Keywords: computational modeling, neurons, gap junctions


The Movement Diagnostic System - Frauke Luft (BSS)

Diagnosis for Essential Tremor, Parkinson’s disease and limb dystonia frequently fails, especially in early disease stages. Closed-loop system identification allows assessing the brain nuclei, using fMRI. We develop a Movement Diagnostic System to accurately locate specific CNS pathological changes by differentiating between normal and abnormal brain activations.

Keywords: Movement disorders, fMRI, EEG


Balance control strategies in perturbed human walking - Mark Vlutters (BME)

The development of a balance assisting exoskeleton requires an understanding of balance control in healthy humans. Simple models have been extensively used to mimic balance control during human walking. Here, we explore to what extend a simple model can explain balance recovery actions observed in humans after a force perturbation during walking.

Keywords: Walking, Balance, Fall prevention


Ways to accelerate Anterior Cruciate Ligament repair - Corina Ghebes (DBE)

The ACL represents one of the major ligaments in the human knee. After injury, ACL healing is frequently insufficient to restore functionality and thus surgical reconstruction is performed. Describing the cells of the native tissue as well as looking into new cell sources we aim to contribute to the acceleration of ACL repair.

Keywords: Anterior cruciate ligament (ACL), tissue regeneration, stem cells