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Program

Session 1A

Chairs: Heidi Muijzer-Witteveen (BME) and Oresti Banos (BSS)

11.15-11.30

Circulating Tumor Cells a Real Time Liquid Biopsy – Kiki Andree (MCBP)

Circulating tumor cells (CTC) are cancer cells that detach from their primary site, migrate through the body and form secondary tumors. We aim to identify, isolate and characterize a sufficient number of CTC in metastatic cancer patients to represent a real-time liquid biopsy by increasing the blood volume analyzed.

Keywords: circulating tumor cells, liquid biopsy, large blood volumes

11.30-11.45

An in vitro vascularization approach in micro-object-based bottom-up tissue and tumor engineering strategies – Anne Leferink (BIOS)

Micro-objects were introduced as cell-culture substrates to obtain dense aggregates without compromising cells’ viability. Cellular distribution and aggregation behavior showed to be tailorable by varying object’s geometry and density. HUVECs in co-cultures with hMSCs showed some degree of self-alignment which could be considered an early indication of vascularization of multicellular micro-tissues.

Keywords: Microfabrication, bottom-up tissue engineering, in vitro vascularization.

11.45-12.00

Targeted microRNA delivery to modulate the pancreatic tumor stroma – Jonas Schnittert (BST)

Pancreatic cancer’s progression is largely supported by cancer associated fibroblasts (CAFs) as main part of its tumor microenvironment. During disease progression, quiescent stellate cells (PSCs) differentiate into cancer associated fibroblasts (CAFs). We have developed a delivery system, which specifically delivers therapeutic miRNAs to PSCs and prevents their differentiation into CAFs.

Keywords: Cancer associated fibroblasts, microRNA, targeted delivery

12.00-12.15

MRI-compatible robots for breast biopsy –Vincent Groenhuis (RaM)

MRI-compatible robots driven by innovative pneumatic linear stepper motors have been developed using 3D printing and laser-cutting techniques. These prototypes can manipulate a biopsy needle inside the bore under MRI guidance for breast biopsies. This way, MRI-guided interventions can be performed more accurate and efficient than with conventional manually-operated methods.

Keywords: MRI, biopsy, pneumatics

12.15-12.30

Improving Health Care by Understanding Stakeholder Preferences - Marieke Weernink (HTSR)

Stakeholder preferences are increasingly being considered important because they can inform the development of new health care innovations, the evaluation of current health care services, and decisions on reimbursement and access of new drugs and devices to the market. In this presentation the use and importance of collecting stakeholder values will be discussed and exemplified.

Keywords: Stakeholder preferences, Health Technology Assessment, Technology development

 

Session 1B

Chairs: Jeroen Leijten (DBE) and Markus Beck (MCBP)

11.15-11.30

In-air Microfluidics – Tom Kamperman (DBE)

In-air microfluidics is a novel chip-free technology that connects the fields of additive manufacturing and microfluidics. It uniquely (1) omits all wall-induced disadvantages (e.g. limited throughput) of traditional chip-based microfluidics, (2) solves the printability / shape-fidelity paradox of 3D printing, and (3) enables one-step printing of (bio)materials with intrinsic hierarchy.

Keywords: chip-free; microfluidics; additive manufacturing

11.30-11.45

Tumor Stroma-containing 3D Spheroid Arrays: A Tool to Study Nanomedicine - Dwi Priwitaningrum (BST)

Solid tumors possess an abundant stroma, mostly composed of cancer-associated fibroblasts and extracellular matrix. In cancer, tumor stroma hinders nanoparticle penetration. We developed in vitro 3D-culture model to mimic in vivo tumor stroma. We used this model to investigate the penetration of nanoparticles in a stroma rich tumors.

Keywords: 3D-in vitro, tumor stroma, nanoparticle penetration

11.45-12.00

Microrobotic Grippers for Minimally Invasive Surgery – Federico Ongaro (BME)

The use of small, maneuverable, untethered and reconfigurable robots could provide numerous advantages in minimally invasive surgeries and micromanipulation tasks. This presentation will discuss the potential of dexterous and untethered magnetic micro-grippers as alternatives or complements to conventional tethered micromanipulation devices.

Keywords: Micro-robotics, closed-loop control, minimally invasive surgery

12.00-12.15

The effect of metabolic alkalosis on the ventilatory response in healthy subjects – Eline Mos-Oppersma (BSS)

12.15-12.30

How to show the value of your diagnostic innovation to clinicians and decision makers in healthcare – Michelle Kip (HTSR)

New diagnostic tests can influence quality of care and health outcomes in numerous ways. Insight in the value of diagnostic information is crucial to optimize development and implementation. Health technology assessment can determine if a new test could potentially improve health outcomes at acceptable costs. This is demonstrated using a case study on point-of-care troponin testing.

Keywords: Value of diagnostic information, health technology assessment, point-of-care troponin