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Program

Session 2A

Chairs: Rik Rurup (BIOS) and Bram Zoetebier (DBE)

13.30-13.45

Spectroscopic optical coherence tomography for absorption quantification in the blue wavelength region - Colin Veenstra (BMPI)

Spectroscopic optical coherence tomography (sOCT) allows for quantitative and localized measurements of optical absorption within a single blood vessel. sOCT has the potential for noninvasive quantification of clinically important chromophore concentrations in blood. We developed an sOCT system that operates around the blue edge of the visible spectrum for quantification of both bilirubin and hemoglobin concentrations. First measurements on whole blood show an agreement between estimated and expected total chromophore concentrations within 10%.

13.45-14.00

Hemodynamic comparison of stent configurations used for aortoiliac occlusive disease - Erik Groot Jebbink (PoF)

Aortoiliac occlusive disease can become incapacitating if left untreated. Several endovascular options exist (i.e. stent placement), however, it is unknown to what extent different options influence blood flow and in turn longterm outcome. This study focused on hemodynamic comparison of the most frequently used stent configurations to aid stent choice in the clinical setting.

Keywords: stents, hemodynamics, aortic bifurcation

14.00-14.15

Technology in Heart Surgery – Follow your Heart, Use your Head – Frank Halfwerk (BME)

Sacred cows in heart surgery are slowly adjusted with technological advancements and enable us to predict surgical outcome instead of “trial and error”. We showcase our research in fluid dynamics for bypass surgery, repair of ascending aorta using decellularised arteries and a minimal invasive approach to repair the mitral valve.

Keywords: Cardio-thoracic Surgery, Biomechanical Engineering, Thoraxcentrum Twente

14.15-14.30

Analysis of brain activity in comatose patients after cardiac arrest - Barry Ruijter (CNPH)

Yearly, 5000 patients are admitted comatose to Intensive Care Units in The Netherlands after cardiopulmonary resuscitation. Only half of them eventually regain consciousness. We use electroencephalography (EEG) to assist in outcome prediction and treatment optimization. Besides, we study potential pathophysiological mechanisms with computational models relating EEG abnormalities to synaptic dynamics.

Keywords: postanoxic encephalopathy, quantitative electroencephalography, neural mean field model

14.30-14.45

Fathoming Frailty and Neurodegenerative Disease – David Lyreskog (PHIL)

The concept of ‘frailty’ is frequently used in development of assistive and therapeutical technologies for the elderly. Although often helpful, it does not distinguish patients with neurodegenerative diseases. To this end, I re(de)fine the concept of frailty so that it can complement current concepts in practice, and facilitate the development and assessment of medical technologies aimed at helping aging populations.

Keywords: Frailty, Aging, Neurodegenerative Disease

Session 2B

Chairs: Joost van Kordelaar (BME) and Guillaume Lajoinie (PoF)

13.30-13.45

Enzyme-mediated changes in amyloid plaque deposition

- Federica Cioffi (NBP)

Aggregated amyloid-beta (Aβ) peptide has been reported to play a crucial role in the development of Alzheimer’s disease (AD). We used an in vitro model containing Aβ plaques to screen for degrading activity of known Aβ proteases. These proteolytic enzymes are able to remove amyloid plaques from mice brain vibrosections.

Keywords: Alzheimer’s disease, Amyloid-beta, proteases

13.45-14.00

3D Printing of Melt Processable Polymeric Materials for Use in

Tissue Engineering Scaffolds – Aysun Guney (BST)

3D printing enables the manufacturing of designed porous structures that have highly controlled geometries. However, the number of biodegradable polymeric materials available remains very limited. This research is focused on design and fabrication of new materials as porous tissue engineering scaffolds. Triblock copolymers of poly(trimethylene carbonate) and poly(ε-caprolactone) were synthesized and evaluated for use in 3D printing.

Keywords: 3D printing, thermoplastic elastomers, tissue engineering scaffolds

14.00-14.15

WNT blows your SOX off – Kannan Govindaraj (DBE)

Transcription factors are DNA binding proteins that regulate the transcription of a set of genes. SOX9 is the master transcription factor for cartilage development and plays a key role in osteoarthritis pathophysiology. Here we use Fluorescence Recovery After Photobleaching (FRAP) to study the activity of SOX9.

Keywords: FRAP, Transcription factors, Osteoarthritis

14.15-14.30

Visual cues via smart glasses to reduce freezing of gait in Parkinson’s Disease - Sabine Janssen (BSS)

Some people with Parkinson’s Disease suffer from ‘freezing of gait’: episodes of feeling ‘glued to the floor’. External rhythmic cues, such as bars on the floor, can alleviate freezing of gait but are difficult to apply in daily living. We investigate whether augmented visual cues delivered via smart glasses reduce freezing of gait.

Keywords: Parkinson’s Disease; Smart glasses; cueing

14.30-14.45

Practice makes perfect if you interact with a partner? – Niek Beckers (BME)

Humans have an astonishing ability to smoothly coordinate their movements, for instance when carrying a table together or teaching infants how to walk, by exerting forces onto each other. Does practicing a motor task together with a partner improve your ability to learn a motor skill?

Keywords: Human motor control and learning; physical human-human interaction