Harrie Weinans studied Mechanical Engineering (Biomedical Technology) at the University of Twente and received his PhD from the Radboud University Nijmegen in 1991 on a topic related to orthopedic implant fixation and bone regeneration. In 1994 and 1995 he was postdoc at Rush Medical Center, Chicago, USA. In general his research involves the physical and mechanical aspects of musculoskeletal tissues in relation to degeneration and repair. Ever since, his work focused on orthopedics with a specific interest in bone and cartilage, in particular the role of mechanical loading, activity and (over) weight in relation to bone growth and adaptation and cartilage degeneration. In animal models detailed pre-clinical imaging methods have been developed by his group that enable to investigate the interaction between overloading, cartilage breakdown, mechanical cartilage properties and aspects related to joint homeostasis and the cellular process that are involved. A major goal of his research is not only to investigate the degenerative processes of the joint, but to find methods that can counterbalance this degeneration or even induce appropriate regeneration after the tissue is already diminished. Harrie Weinans was professor of Mechanobiology at the Erasmus Medical Center from 2004 until 2013 and currently works at the UMC Utrecht and the TUDelft, where he is professor of Tissue Biomechanics and Implants. He has been the Principal Investigator of many research grants and consortia. Since 2015 he coordinates the APPROACH consortium, an IMI/EU funded project that concerns the development of better guidelines for differentially diagnosing the right patient for the right treatment in osteoarthritis.