arshdeep_sidhu

Trained as a biologist and a chemist in her bachelors, Arshdeep gained perspective in molecular biology during her Masters course (2007). Then she joined the Biomolecular NMR Lab at National Institute of Immunology, New Delhi as a research scholar, investigating protein-protein interaction in signalling proteins by solution NMR and other biophysical techniques. In March 2012, she joined NBP group as a PhD student, she is currently involved in developing methodology to functionalize α-synuclein fibrils into conductive and photonic wires.

Contact Info:

Arshdeep Sidhu

Nanobiophysics

University of Twente

Institute for Nanotechnology MESA+

Zuidhirst ZH166

Drienerlolaan 5

7522 NB Enschede, The Netherlands

Phone no. +31-(0)53-489-3466

Email: a.sidhu@utwente.nl

Topic: Self-assembled amyloid nanostructures as scaffolds for creating photonic and electronic assemblies.

The human alpha-synuclein protein self-assembles to form ~10 nm diameter amyloid fibrils that are chemically and mechanically extremely stable. These properties, together with the possibility to site-specifically functionalize the protein, make amyloid an attractive biomaterial for use in the fabrication of nanophotonic and nanoelectronic devices. In contrast to chemical polymer synthesis, amyloid formation is a spontaneous process not requiring addition of catalysts. We will create nanophotonic wires by binding specific fluorophores or nanocrystals (quantum dots) to genetically cysteine modified protein molecules constituting the fibrils. Similarly, for use in nanoelectronic devices conductive nanowires will be constructed by attaching nanogold particles to the fibrils.