Reseacrchers of the nanobiophysics group show a proof-of-priciple method to quantify a biomarker for parkinson's in complex fluids.
Amyloid fibrils of the protein α-synuclein (αS) have recently been identified as a biomarker for Parkinson’s disease. To detect if fibrils are present or not (yes/no), seed amplification assays have been developed. We performed a proof of principle study in which we quantified the number αS fibrils present in fibril spiked model solutions. We show that quantification is possible down to the single fibril level even in compositionally complex fluids like blood serum.
You can read the full artilce here: Quantitative Seed Amplification Assay: A Proof-of-Principle Study in ACS Physical Chemistry B