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PhD position in Computational Systems Biology

Job description

We offer a PhD position in Systems Biology at the University of Twente (UT). The successful applicant will join the Applied Analysis (AA) group at the Department of Applied Mathematics at the Faculty of Electrical Engineering, Mathematics and Computer Science. A strong collaboration with the Developmental BioEngineering (DBE) group is part of the position.

About the project:
Tissue engineering strategies have so far failed to succesfully make articular cartilage. The NWO project SCI-MAP explores the variability of cell differentiation using a systems biology approach. We work with biologists and tissue engineers to advance the use of induced pluripotent stem cells (iPSCs) in the clinical setting of joint diseases by determining and understanding key modifiable factors that direct and maintain stem cell differentiation into chondrogenic lineages.

Computational models have the potential to transform experimental biology by describing and understanding observations and ultimately to predict cell behavior. You will work at the interface of applied mathematics and biology developing new models incorporating data from the consortium. Through simulations and numerical bifurcation analysis you will assist with the design of new biological experiments. The PhD project will be carried out under the supervision of Dr. Janine Post (DBE) and Dr. Hil Meijer (AA).

Your profile

We look for a highly motivated, enthusiastic researcher who is driven by curiosity and:

  • Has, or will shortly acquire, a master’s degree in Mathematics, Biomedical Engineering, Systems Biology or a related field;
  • Has experience with mathematical modeling and/or numerical bifurcation analysis;
  • Has a strong interest in systems biology, or is willing to acquire such knowledge;
  • Experience in analysis of big data (transcriptomics, proteomics) and chondrogenesis/cartilage will be considered a benefit;
  • Is proficient in programming to solve complex problems with data and numerics;
  • Is a team player with good communication skills;
  • Is proficient in English, both spoken and written.

Our offer

The terms of employment are in accordance with the Dutch Collective Labour Agreement for Universities (CAO) and include:

  • A fulltime PhD position for four years, with a qualifier in the first year;
  • Full status as an employee at the UT, including pension and health care benefits;
  • The salary will range from € 2.395 (1st year) to € 3.061,- (4th year) per month, plus a holiday allowance of 8% and a year-end bonus of 8.3%;
  • A solid pension scheme;
  • Excellent facilities for professional and personal development.

Information and application

Are you interested to be part of our team? Please send your application before 16-8-2021, and include:

  • A motivation letter explaining your interest and qualifications for this position;
  • A detailed CV (resume) and add a publication list when applicable;
  • A transcript of B.Sc. and M.Sc. education;
  • We may request a TOEFL or IELTS score to verify sufficient skills in English.

An online assessment could be part of the application procedure.

For inquiries about this position and our offer, you can contact Dr. Hil Meijer (h.g.e.meijer@utwente.nl) or Dr. Janine Post (j.n.post@utwente.nl).

About the department

Department of Applied Mathematics
The faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS) uses mathematics, electronics and computer technology to contribute to the development of Information and Communication Technology (ICT). With ICT present in almost every device and product we use nowadays, we embrace our role as contributors to a broad range of societal activities and as pioneers of tomorrow's digital society. As part of a people-first tech university that aims to shape society, individuals and connections, our faculty works together intensively with industrial partners and researchers in the Netherlands and abroad and conducts extensive research for external commissioning parties and funders. Our research has a high profile both in the Netherlands and internationally. It has been accommodated in three multidisciplinary UT research institutes: Mesa+ Institute, TechMed Centre and Digital Society Institute.
Specifically, the Applied Analysis group focusses on the combination of models, machine learning and uncertainty quantification to advance methods for and understanding of clinical data. 

Department of Developmental BioEngineering
The department of Developmental BioEngineering is a research group with a highly international character. The main goal of this group is to investigate novel and challenging technologies and science in the field of Regenerative Medicine, which can be used for tissue repair. Research focuses on i) Fundamental aspects of joint and cartilage homeostasis, ii) Cell therapy for treatment of joint disorders, and iii) Injectable, in situ gelating extracellular matrices for soft tissue repair.

About the organization

The faculty of Electrical Engineering, Mathematics and Computer Science (EEMCS) uses mathematics, electronics and computer technology to contribute to the development of Information and Communication Technology (ICT). With ICT present in almost every device and product we use nowadays, we embrace our role as contributors to a broad range of societal activities and as pioneers of tomorrow's digital society. As part of a people-first tech university that aims to shape society, individuals and connections, our faculty works together intensively with industrial partners and researchers in the Netherlands and abroad, and conducts extensive research for external commissioning parties and funders. Our research has a high profile both in the Netherlands and internationally. It has been accommodated in three multidisciplinary UT research institutes: Mesa+ Institute, TechMed Centre and Digital Society Institute.

University of Twente (UT)

University of Twente (UT) has entered the new decade with an ambitious, new vision, mission and strategy. As ‘the ultimate people-first university of technology' we are rapidly expanding on our High Tech Human Touch philosophy and the unique role it affords us in society. Everything we do is aimed at maximum impact on people, society and connections through the sustainable utilisation of science and technology. We want to contribute to the development of a fair, digital and sustainable society through our open, inclusive and entrepreneurial attitude. This attitude permeates everything we do and is present in every one of UT's departments and faculties. Building on our rich legacy in merging technical and social sciences, we focus on five distinguishing research domains: Improving healthcare by personalised technologies; Creating intelligent manufacturing systems; Shaping our world with smart materials; Engineering our digital society; and Engineering for a resilient world.

As an employer, University of Twente offers jobs that matter. We equip you as a staff member to shape new opportunities both for yourself and for our society. With us, you will be part of a leading tech university that is changing our world for the better. We offer an open, inclusive and entrepreneurial climate, in which we encourage you to make healthy choices, for example, with our flexible, customisable conditions.

PhD position in Computational Systems Biology
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