In this Perspective article, the concept of an open platform for organs-on-chips is defined from a technical perspective. Moreover, we discuss the importance of involving different stakeholders in the development, manufacturing, and application of such an open platform. Published in Biomicrofluidics.
We use a modular platform to automatically control parallelized cell culturing chips. Moreover, we also use the same platform for liquid dosing into the chips. Published in Microsystems & Nanoengineering.
In this research paper, we use a Fluidic Circuit Board to connect commercial reservoirs, flow sensors and valves to an in-house developed Heart-on-Chip. The integrated system is then used for long-term dynamic cell culture. Published in Lab on a Chip.
The concept of TOP as an organ-on-chip open technology platform has been described in a number of our publications. In addition, we have published multiple studies in which TOP is used to implement a fit-for-purpose organ-on-chip model.
- De Graaf, et al. Multiplexed fluidic circuit board for controlled perfusion of 3D blood vessels-on-a-chip. Lab on a Chip, 2023
- De Graaf, et al. Pressure-Driven Perfusion System to Control, Multiplex and Recirculate Cell Culture Medium for Organs-on-Chips. Micromachines, 2022
- Vivas, et al. - Fluidic Circuit Board with Modular Sensor and Valves Enables Stand-Alone, Tubeless Microfluidic Flow Control in Organs-on-Chips, Lab on a Chip, 2022
- Vollertsen, et al. - Modular operation of microfluidic chips for highly parallelized cell culture and liquid dosing via a fluidic circuit board. Microsystems & Nanoengineering, 2020
- Vollertsen, et al. - Facilitating implementation of organs-on-chips by open platform technology. Biomicrofluidics, 2021