Organ-on-Chip Centre Twente | MESA+ Institute

The Organ-on-Chip Centre Twente (OoCCT) is a centre of expertise supported by the MESA+ Institute and the TechMed Centre of the University of Twente. OoCCT brings together researchers interested in Organ-on-Chip to share their knowledge. The affiliated scientists, across all faculties, are encouraged to share their vision on the topic of Organs-on-Chips, discuss the latest developments in the field, explore practical collaborations and participate in writing research proposals. Equally important, OoCCT aims to provide services to researchers and companies outside of the University of Twente and give them access to the technology developed here in order to accelerate innovation and real-world application of Organs-on-Chips.

COVID-19 in miniaturized heart models

Researchers of Applied Stem Cell Technologies, Ncardia, LUMC, and River Biomedics will collaborate to apply miniaturized heart models in COVID-19 research. Human pluripotent stem cell derived heart models will be used for a rapid evaluation of important COVID-19 therapies and for development of SARS-CoV-2 disease models to investigate how infection affects the heart.

Translational Organ-on-Chip Platform

Much like all computer equipment interfaces through a Universal Serial Bus (USB), biologist should be able to use chips from different vendors to obtain an OoC model that specifically answers their questions of interest.

The Translational Organ-on-Chip Platform (TOP) is a platform to provide infrastructure for automated microfluidic chip control, open for academic and commercial chip developers

Mini Organs-on-Chips

Despite decades of research, there are still no drugs for many diseases. And the drugs that are available may only be effective in some patients or cause unwanted side-effects. Organ-on-Chip technology with human cells is a promising approach to address these problems.

In this booklet, researchers describe the challenges they face in developing these models and what is needed to implement them in practice.

hDMT lustrum booklet presented

The fifth annual hDMT Consortium meeting was held on November 12, 2021. Janny van den Eijnden-van Raaij, managing director of hDMT, presented the lustrum booklet of hDMT, called ‘Vital network on Organ-on-Chip’, which describes what hDMT is, what has been achieved during the past 5 years and where hDMT will go.

Organs-on-Chips

At the University of Twente, we develop Organs-on-Chips to investigate the safety of health products and to understand the mechanisms of disease. We believe Organs-on-Chips will find widespread use in biomedical science and will progressively reduce the need for animal models as the mainstay in efficacy and toxicity testing. Connected to the Dutch Organ-on-Chip consortium “human Organ and Disease Model Technologies” (hDMT) and actively involved in the Netherlands Organ-on-Chip Initiative (NOCI), the Organ-on-Chip Center Twente is an important Dutch Organ-on-Chip partner in many projects. In addition, the University of Twente was involved in founding the European Organ-on-Chip Society (EUROoCS) to bring together Organ-on-Chip researchers internationally.

Expertise

Researchers at the University of Twente are international leaders in key technological fields for Organ-on-Chip development, such as materials science, biofabrication, sensing, imaging, stem cell technology and tissue engineering. As a result, we play a leading role worldwide in the development of innovative Organs-on-Chips. By working with our strong network of biomedical, clinical and industrial partners, we apply our Organs-on-Chips in the development of personalized treatments for patients in many disease areas.

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