Knee Arthroplasty

Optimized function through customized total knee arthroplasty


Total knee arthroplasty (TKA) is a surgical intervention, which involves replacing the diseased articular surfaces of the knee joint with artificial components. In the intraoperative procedure, the surgeons apply a standardized strategy in terms of prostheses and operation guidelines, disregarding the large variations that are present in the patient-specific anatomical features and gait patterns. As a consequence, one in five patients remains unsatisfied with the surgical outcomes, reporting persistent pain and functional limitations during activities of daily living.


The goal of this project is to provide an optimal preoperative plan, combining musculoskeletal modeling of the lower-extremity with advanced medical imaging and accurate surgical execution, customized to individual patient’s characteristics and needs. Our methodology aims to improve the quality and efficiency of care for patients undergoing TKA, ensuring life-long vital functioning.

Contact N.J.J. Verdonschot (Nico)
Professor Implant Biomechanics P. Tzanetis (Periklis)
Postdoctoral Researcher