Jan R. Buitenweg: Nociceptive and Somatosensory Processing

Contrary to acute pain, the causes and maintaining factors of chronic pain are poorly understood. Once acute pain has become chronic, in only one out of four patients therapy results in a pain reduction of more than 50%.

Clinical research indicates that maladaptive mechanisms in the brain and spinal cord contribute to persistence of many chronic pain syndroms. However, these central mechanisms cannot be observed and modulated sufficiently for successful and reliable clinical diagnosis, prevention or treatment of chronic pain.

The major objective of this principal investigator track is the development of psychophysical and neurophysiological techniques enabling clinical assessment and treatment of chronic pain syndroms.

Present projects focus on two general challenges of the chronic pain problem:


Development of methods for controlled stimulation and recording of activity in pain related neural pathways, revealing or inducing functional changes of nociceptive subsystems.


Development of mathematical models for explaining and predicting experimental and clinical results, based on principles of neurostimulation, neurocomputational methods.


Jan R. Buitenweg

Robert-Jan Doll

Ed Droog

Meyke Roosink

Vishy Sankarasubramanian

Victor Sluiter

Peter Steenbergen

Peter Veltink

Marcel Weusthof


EEMCS Eprints

Jan R. Buitenweg: Nociceptive and Somatosensory Processing

NociTRACK: Point of Care Pain Management through Hyperalgesia Monitoring

This project includes four next steps important for successful application and availability of the NociTRACK system for improved pain management and prevention of chronic pain after surgery ... read more

NeuroSIPE: PaINSIGHT - CLosed loop identification of the nociceptive system

The PaINSIGHT project, which is funded by the STW Perspective Programme NeuroSIPE, is a collaboration between the BSS and AAMP groups of the University of Twente and the University Medical Centre St. Radboud. The project focuses on parameter identification of the nociceptive system for improved monitoring of chronic pain development. ... read more