On July 1st Prof. Simon Corrie is visiting Jurriaan Huskens, Department of Molecules and Materials.
You are invited to attend his lecture.
The title of his lecture and abstract:
Re-thinking biochemical sensors:
imaging approaches to monitoring biomolecules in situ
A/Professor Simon Corrie - Engineering | Monash University
Department of Chemical and Biological Engineering, Monash University, Melbourne, Australia
Abstract:
Continuous glucose monitoring is a technology that demonstrates the transformational impact of bioanalytical devices in human health.
There are currently a range of devices on the market relying on either enzymatic activity or binder affinity as the sensing mechanism, and either electrochemical or optical detection modalities.
However, this success is yet to be replicated for other critical analytes, due to a combination of biofouling and the lack of suitable bioreceptors with the stability/function profile of glucose oxidase. In our team, we design biosensors comprised of engineered nanomaterials (e.g. organosilicas, polymers) and/or proteins (e.g. antibody fragments, enzymes), designed for continuous monitoring of critical analytes in situ via imaging modalities (including fluorescence, ultrasound, and photoacoustic approaches).
We reason that designing these devices for in situ biosensing could lead to new implantable biosensors with spatio-temporal resolution. Designing devices to this high standard could also lead to solutions that address related unmet needs in diverse areas, including biochemical monitoring of engineered tissues and simplification of point-of-care biosensors.
This presentation will describe our approaches to develop a) nanoparticle-based sensors for spatio-temporal monitoring of pH and oxygen, and b) antibody fragments that produce unique fluorescent signals upon selective protein binding.
Bio: Simon Corrie completed his undergraduate degree in Chemical Engineering and PhD in Physical Chemistry at the University of Queensland, before undertaking postdoctoral studies at the HPV Research Laboratory at the University of Washington in Seattle, USA.
After returning to Australia he developed microneedle arrays for wearable immunoassays at the Australian Institute for Bioengineering and Nanotechnology, after which he joined the Chemical and Biological Engineering Department at Monash University in 2016 to establish the Nanosensor Engineering Lab.
His research interests lie in developing nanomaterials and proteins for applications in bio-sensing, bio-assays and (recently) bio-catalysis, with applications including biomedical diagnostics, environmental monitoring, and green chemistry.