Examples of University of Twente research projects related to Kidney Health.
- Artificial Placenta
we aim to develop a physiological artificial placenta (ArtPlac) for life-support, using the natural placenta as a blueprint. ArtPlac will provide a less invasive, lifesaving, and infant- and family-centred developmental care.
We believe combining extracorporeal lung and kidney support in a single device could offer a safer alternative for treating patients with end-stage lung disease with or without restricted kidney function.
- NXTGEN High-tech project 'Art Organs'
In the NXTGEN High-tech project 'Art Organs', the UT works together with eleven companies, two knowledge institutions and the Kidney Foundation on the development of better dialysis techniques.
- Development of a new generation of dialysis membranes
This project funded by BASF (Ludwigshafen) will investigate the development of new membranes based on poly(aryl ether sulfone polymers) (tradename Ultrason®) combined with new polymer additives and solvents to mitigate current membrane problems.
- NODIAL - development of NOvel membrane DIALyzers for portable / artificial kidney devices
In this project, two laboratory-scale hollow fibre dialyzers will be developed for out-to-inside filtration, consisting of a single-layer membrane and a double- layer mixed-matrix membrane.
- M3 Nephron - Mixed Matrix Membranes for home dialysis
‘Mixed Matrix Membranes for home dialysis’ introduces a new type of filter to simultaneously remove toxins from people living with a kidney diseases’ blood and endotoxins from the therapy’s dialysate solution, for healthier people and greener therapy
- Innovative Bioengineered Membranes for Improved Treatment of Kidney Failure
This project aims to develop new membrane concepts for achieving high removal of uremic toxins combined with low water consumption. Specific focus will be on regeneration of dialysis fluid to be re-used, including efficient urea removal.
- Strategic Collaboration with RadboudUMC
The group of Biomaterials Science and Technology (BST) of the Faculty of Science and Technology at the TechMed centre has signed a formal academic collaboration agreement with the departments of Nephrology and Physiology at Radboudumc.
- Cost Action for Big Data in Nephrology (PerMediK)
The scientific aim of PerMediK is to support the development of a path towards personalized medicine in chronic kidney disease (CKD), based on multidimensional -omics data (Big Data).
- Diabetes and Lifestyle Cohort Twente (DIALECT) (clinical database and biobank)
DIALECT is an observational prospective cohort study performed in the Ziekenhuis Groep Twente (ZGT, Almelo) which investigates the effect of lifestyle and medication use on outcomes in patients with type 2 diabetes.
- International consortium for clinical trials in chronic kidney disease and diabetes
In this consortium, the effect of promising new therapies for chronic kidney disease is evaluated in clinical trials with smart design.
AKI-PATROL is a Dutch Kidney Foundation funded consortium of three participating hospitals in the Netherlands that aims to improve the quality of care regarding acute kidney injury (AKI) in hospitalized patients.
- Arthritis Research & Collaboration Hub (ARCH) study group
A national consortium that performs studies in the field of systemic auto-immune diseases.
- Optimising Access Surgery in Senior Haemodialysis Patients (OASIS)
A national multicentre study that aims to investigate the best strategy for vascular access creation in elderly haemodialysis patients.
- Micro-RENALization: Realization of a 3D tubular kidney-on-a-chip platform mimicking renal micro-physiology
The complementarity between UTwente and RadboudUMC enable working towards a complete 3D glomerulus-on-a-chip and tubule(s)-on-a-chip units. We will develop a glomerular filtration unit using a hollow fibre glomerulus-on-a-chip setup.
- Total-Body PET/CT Applications in Cardio-Kidney Diseases
The whole-body coverage enables simultaneous assessment of multiple organs and the large vascular structures of the body, opening new opportunities for imaging systemic mechanisms, disorders, or treatments.
- Understanding Liver Treatment to Improve Microsphere Optimal distribution (Ultimo)
In this project we want to learn what these parameters are and set-up a planning system that can calculate the most optimal treatment approach resulting in an optimal patient outcome by more efficacy and less side effects.
- Optical Coherence Tomography and High-Fidelity Flow Simulations for improved Stent Planning in Femoropopliteal Disease
Catheter-mounted optical coherence tomography (OCT) is a laser-based interference technique that, in one or several pullbacks, can produce a 3D-geometry of the vessel wall with micrometer resolution.
- Improving Electrochemical Regeneration of Dialysate for a Wearable Kidney and Development of a Micro Total Analysis Platform for Home Measurements
First aim: to make electro-Second aim: development of a micro-total-analysis platform for home blood and dialysate measurements to monitor treatment quality by the WAK.
- Microtechnology for an implantable artificial kidney
Through cutting-edge nanotechnology and microfluidics, we seek to engineer this compact artificial membrane filtration unit that will serve as a foundation for future IAK modules and transform the health and quality of life of ESKD patients.
- Green nephrology: Improving water efficiency during dialysis
We are looking into more efficient use of water during haemodialysis, by developing more efficient water treatment modules to reduce the amount of tap water and reuse part of the spent dialysate.
- Shared decision making with the use of quantitative value elicitation techniques
Dr. van Til’s current research is focused on supporting shared decision making with the use of quantitative value elicitation techniques. She aims to increase patient and public involvement organizational and societal decision making in health care
- Advanced organ bioengineering and therapeutics
The lab is carrying out dynamic inter-disciplinary research in the field of peptide therapeutics, cell-specific targeted delivery and nanomedicine for the indications in the field of fibrotic diseases and (immuno)-oncology.
- Translational Liver Research
Focus: understanding the underlying disease mechanisms and cellular crosstalk, identification of new therapeutic and diagnostic targets, non-invasive detection methods and single-cell analysis, designing of novel cell‐specific (nano)therapeutics
- Using microscale physics combined with deep-learning for super-resolution ultrasound imaging
Focus: Lab-on-a-chip Microfluidics, ultrasound therapy with microbubbles, ultrasound imaging, high-Speed imaging, ultrafast plane-wave ultrasound imaging, ultrasound super-resolution from raw ultrasound data using deep learning
- Molecular Kidney Physiology
His research interests include the regulation of Ca2+ and Mg2+ transport in epithelia with a specific focus on the molecular regulation of epithelial Ca2+ and Mg2+ channels (TRPV5&6, TRPM6&7), members of transient receptor potential (TRP) channels.
- Robotics and Mechatronics Group
Focus: imaging techniques in cancer, image-guided interventions and robotics, implementing and performing oncological interventions with special focus on MR-guided interventions, like MR-guided cryosurgery, focal laser ablation, ultrassound surgery.
- Clinical Translation of Advanced Technologies for Diagnosis and Treatment of Vascular Disorders
Clinical Translation of Advanced Technologies for Diagnosis and Treatment of Vascular Disorders.