This section gives an overview of all the Organ-on-Chip publications in which our members were involved. A number of highlights can be found in the top of this section. The full list, ordered by publication year, can be found below.


Monolithic microfluidic platform for exerting gradients of compression on cell-laden hydrogels, and application to a model of the articular cartilage

Carlo Alberto Paggi, Bastien Venzac, Marcel Karperien, Jeroen Leijten, Séverine Le Gac. Sensors and actuators. B: Chemical 2020

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Organs-on-chips: breaking the in vitro impasse

Andries van der Meer, Albert van den Berg. Integrative biology 2012

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Personalised organs-on-chips: functional testing for precision medicine

Albert van den Berg, Christine Mummery, Robert Passier, Andries van der Meer. Lab on a Chip 2019

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Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data

Pedro Costa, Hugo Albers, John Linssen, Heleen Middelkamp, Linda van der Hout, Robert Passier, Albert van den Berg, Jos Malda and Andries van der Meer. Lab on a Chip 2017

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2021

Komen, J., van Neerven, S. M., van den Berg, A., Vermeulen, L., & van der Meer, A. D. (2021). Mimicking and surpassing the xenograft model with cancer-on-chip technology. EBioMedicine, 66, [103303]. https://doi.org/10.1016/j.ebiom.2021.103303

Paloschi, V., Sabater-Lleal, M., Middelkamp, H. H. T., De sa Vivas, A. G., Johansson, S., van der Meer, A., Tenje, M., & Maegdefessel, L. (2021). Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases. Cardiovascular Research. https://doi.org/10.1093/cvr/cvab088

Tanumihardja, E., Paradelo Rodríguez, A., Loessberg-Zahl, J. T., Mei, B., Olthuis, W., & van den Berg, A. (2021). On-chip electrocatalytic NO sensing using ruthenium oxide nanorods. Sensors and Actuators, B: Chemical, 334, [129631]. https://doi.org/10.1016/j.snb.2021.129631

Middelkamp, H. H. T., Verboven, A. H. A., De sa Vivas, A. G., Schoenmaker, C., Klein Gunnewiek, T. M., Passier, R., Albers, C. A., 't Hoen, P. A. C., Nadif Kasri, N., & van der Meer, A. D. (2021). Cell type-specific changes in transcriptomic profiles of endothelial cells, iPSC-derived neurons and astrocytes cultured on microfluidic chips. Scientific reports, 11(1), [2281]. https://doi.org/10.1038/s41598-021-81933-x

Mercuri, M., & Fernandez Rivas, D. (2021). Challenges and opportunities for small volumes delivery into the skin. Biomicrofluidics, 15(1), [011301]. https://doi.org/10.1063/5.0030163

Baptista, D., Teixeira, L. M., Birgani, Z. T., van Riet, S., Pasman, T., Poot, A., Stamatialis, D., Rottier, R. J., Hiemstra, P. S., Habibović, P., van Blitterswijk, C., Giselbrecht, S., & Truckenmüller, R. (2021). 3D alveolar in vitro model based on epithelialized biomimetically curved culture membranes. Biomaterials, 266, [120436]. https://doi.org/10.1016/j.biomaterials.2020.120436

2020

Bossink, E. G. B. M., Slob, J. V. M., Wasserberg, D., Segerink, L., & Odijk, M. (2020). Versatile fabrication and integration method of optical oxygen sensors in organ-on-chips. In 2020 IEEE sensors (IEEE SENSORS; Vol. 2020). IEEE. https://doi.org/10.1109/SENSORS47125.2020.9278735

Arik, Y. B., Buijsman, W., Loessberg-Zahl, J. T., Cuartas Velez, C. A., Veenstra, C., Logtenberg, S., Grobbink, A. M., Bergveld, P., Gagliardi, G., den Hollander, A. I., Bosschaart, N., van den Berg, A., Passier, R., & van der Meer, A. (2020). Microfluidic organ-on-a-chip model of the outer blood–retinal barrier with clinically relevant readouts for tissue permeability and vascular structure. Lab on a chip, 21(2), 272-283. https://doi.org/10.1039/d0lc00639d

Loessberg-Zahl, J. T., Beumer, J., van den Berg, A., Eijkel, J. C. T., & van der Meer, A. D. (2020). Patterning Biological Gels for 3D Cell Culture inside Microfluidic Devices by Local Surface Modification through Laminar Flow Patterning. Micromachines, 11(12), [1112]. https://doi.org/10.3390/mi11121112

Rodrigues, J., Heinrich, M. A., Teixeira, L. M., & Prakash, J. (Accepted/In press). 3D In Vitro Model (R)evolution: Unveiling Tumor–Stroma Interactions. Trends in cancer. https://doi.org/10.1016/j.trecan.2020.10.009

Quan, Y., Sun, M., Tan, Z., Eijkel, J. C. T., Van Den Berg, A., Van Der Meer, A., & Xie, Y. (2020). Organ-on-a-chip: The next generation platform for risk assessment of radiobiology. RSC advances, 10(65), 39521-39530. https://doi.org/10.1039/d0ra05173j

Punt, A., Bouwmeester, H., Blaauboer, B. J., Coecke, S., Hakkert, B., Hendriks, D. F. G., Jennings, P., Kramer, N. I., Neuhoff, S., Masereeuw, R., Paini, A., Peijnenburg, A. A. C. M., Rooseboom, M., Shuler, M. L., Sorrell, I., Spee, B., Strikwold, M., Van der Meer, A. D., Van der Zande, M., ... Heringa, M. B. (2020). New approach methodologies (NAMs) for human-relevant biokinetics predictions: Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment. ALTEX, 37(4), 607-622. https://doi.org/10.14573/altex.2003242

Dostanić, M., Windt, L. M., Stein, J. M., Van Meer, B. J., Bellin, M., Orlova, V., Mastrangeli, M., Mummery, C. L., & Sarro, P. M. (2020). A Miniaturized EHT Platform for Accurate Measurements of Tissue Contractile Properties. Journal of microelectromechanical systems, 29(5), 881-887. [9152964]. https://doi.org/10.1109/JMEMS.2020.3011196

Bossink, E. G. B. M., Zakharova, M., Odijk, M., & Segerink, L. (2020). Measuring barrier function in a gut-on-chip. In μTAS 2020: The 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 943-944)

Morsink, M. A. J., Willemen, N. G. A., Leijten, J., Bansal, R., & Shin, S. R. (2020). Immune organs and immune cells on a chip: An overview of biomedical applications. Micromachines, 11(9), [849]. https://doi.org/10.3390/MI11090849

Komen, J., Westerbeek, E. Y., Kolkman, R. W., Roesthuis, J., Lievens, C., van den Berg, A., & van der Meer, A. D. (2020). Controlled pharmacokinetic anti-cancer drug concentration profiles lead to growth inhibition of colorectal cancer cells in a microfluidic device. Lab on a chip, 20(17), 3167-3178. https://doi.org/10.1039/d0lc00419g

Zakharova, M., Palma do Carmo, M. A., van der Helm, M. W., Le-The, H., de Graaf, M. N. S., Orlova, V., van den Berg, A., van der Meer, A. D., Broersen, K., & Segerink, L. I. (2020). Multiplexed blood-brain barrier organ-on-chip. Lab on a chip, 20(17), 3132-3143. https://doi.org/10.1039/d0lc00399a

Paggi, C. A., Venzac, B., Karperien, M., Leijten, J., & le Gac, S. (2020). Monolithic microfluidic platform for exerting gradients of compression on cell-laden hydrogels, and application to a model of the articular cartilage. Sensors and actuators. B: Chemical, 315, [127917]. https://doi.org/10.1016/j.snb.2020.127917

Schroën, K., de Ruiter, J., & Berton-Carabin, C. C. (2020). Microtechnological Tools to Achieve Sustainable Food Processes, Products, and Ingredients. Food Engineering Reviews, 12(2), 101-120. https://doi.org/10.1007/s12393-020-09212-5

Sacchi, M., Bansal, R., & Rouwkema, J. (2020). Bioengineered 3D Models to Recapitulate Tissue Fibrosis. Trends in biotechnology, 38(6), 623-636. https://doi.org/10.1016/j.tibtech.2019.12.010

Schwach, V., Slaats, R. H., & Passier, R. (2020). Human Pluripotent Stem Cell-Derived Cardiomyocytes for Assessment of Anticancer Drug-Induced Cardiotoxicity. Frontiers in Cardiovascular Medicine, 7, 1-12. [50]. https://doi.org/10.3389/fcvm.2020.00050

Chou, D. B., Frismantas, V., Milton, Y., David, R., Pop-Damkov, P., Ferguson, D., MacDonald, A., Vargel Bölükbaşı, Ö., Joyce, C. E., Moreira Teixeira, L. S., Rech, A., Jiang, A., Calamari, E., Jalili-Firoozinezhad, S., Furlong, B. A., O’Sullivan, L. R., Ng, C. F., Choe, Y., Marquez, S., ... Ingber, D. E. (2020). On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology. Nature Biomedical Engineering, 4(4), 394-406. https://doi.org/10.1038/s41551-019-0495-z

de Almeida Monteiro Melo Ferraz, M., Nagashima, J. B., Venzac, B., Le Gac, S., & Songsasen, N. (2020). A dog oviduct-on-a-chip model of serous tubal intraepithelial carcinoma. Scientific reports, 10(1), [1575]. https://doi.org/10.1038/s41598-020-58507-4

Ferraz, M., Nagashima, J. B., Venzac, B., le Gac, S., & Songsasen, N. (2020). 3D printed mold leachates in PDMS microfluidic devices. Scientific reports, 10(1), [994]. https://doi.org/10.1038/s41598-020-57816-y

Sharma, S., Venzac, B., Burgers, T., le Gac, S., & Schlatt, S. (2020). Microfluidics in male reproduction: Is ex vivo culture of primate testis tissue a future strategy for assisted reproductive technologies or toxicology research? Molecular Human Reproduction, 26(3), 179-192. https://doi.org/10.1093/molehr/gaaa006

Low, L. A., Mummery, C., Berridge, B. R., Austin, C. P., & Tagle, D. A. (Accepted/In press). Organs-on-chips: into the next decade. Nature Reviews Drug Discovery. https://doi.org/10.1038/s41573-020-0079-3

2019

Das, P., Van Der Meer, A. D., Vivas, A., Arik, Y. B., Remigy, J. C., Lahitte, J. F., ... Bacchin, P. (2019). Tunable Microstructured Membranes in Organs-on-Chips to Monitor Transendothelial Hydraulic Resistance. Tissue Engineering - Part A, 25(23-24), 1635-1645. https://doi.org/10.1089/ten.tea.2019.0021

Albers, H. J., Passier, R., van den Berg, A., & van der Meer, A. D. (2019). Automated analysis of platelet aggregation on cultured endothelium in a microfluidic chip perfused with human whole blood. Micromachines, 10(11), [781]. https://doi.org/10.3390/mi10110781

Bossink, E. G. B. M., Vollertsen, A. R., Segerink, L. I., & Odijk, M. (2019). Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (23 ed., pp. 1664-1665). Basel, Switzerland: Chemical and Biological Micro Systems Society.

Vollertsen, A., Bossink, E., de Boer, D., Spalink, J., Passier, R., van den Berg, A., ... Odijk, M. (2019). Standardized, modular microfluidic building blocks for automated cell culturing systems. In P. Diettrich, E. Delamarche, & A. Hierlemann (Eds.), 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (23 ed., pp. 86-87). Basel, Switzerland: Chemical and Biological Micro Systems Society.

Piluso, S., Li, Y., Abinzano, F., Levato, R., Moreira Teixeira, L., Karperien, M., ... Malda, J. (2019). Mimicking the Articular Joint with In Vitro Models. Trends in biotechnology, 37(10), 1063-1077. https://doi.org/10.1016/j.tibtech.2019.03.003

Ng, P., Belgur, C., Barthakur, S., van der Meer, A. D., Hamilton, G. A., & Barrile, R. (2019). Organs-on-Chips: a new paradigm for safety assessment of drug-induced thrombosis. Current Opinion in Toxicology, 17, 1-8. https://doi.org/10.1016/j.cotox.2019.08.004

Franzen, N., van Harten, W. H., Retèl, V. P., Loskill, P., van den Eijnden-van Raaij, J., & IJzerman, M. (2019). Impact of organ-on-a-chip technology on pharmaceutical R&D costs. Drug discovery today, 24(9), 1720-1724. https://doi.org/10.1016/j.drudis.2019.06.003

Schwach, V., & Passier, R. (2019). Native cardiac environment and its impact on engineering cardiac tissue. Biomaterials Science, 7(9), 3566-3580. https://doi.org/10.1039/c8bm01348a

De Graaf, M. N. S., Cochrane, A., van den Hil, F. E., Buijsman, W., van der Meer, A., van den Berg, A., ... Orlova, V. V. (2019). Scalable microphysiological system to model three-dimensional blood vessels. APL Bioengineering, 3(2), [026105]. https://doi.org/10.1063/1.5090986

Cochrane, A., Albers, H. J., Passier, R., Mummery, C. L., van den Berg, A., Orlova, V. V., & van der Meer, A. (2019). Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology. Advanced drug delivery reviews, 140, 68-77. https://doi.org/10.1016/j.addr.2018.06.007

van der Helm, M. W., Henry, O. Y. F., Bein, A., Hamkins-Indik, T., Cronce, M. J., Leineweber, W. D., ... Segerink, L. I. (2019). Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy. Lab on a chip, 19(3), 452-463. https://doi.org/10.1039/c8lc00129d

Van Den Berg, A., Mummery, C. L., Passier, R., & Van der Meer, A. D. (2019). Personalised organs-on-chips: functional testing for precision medicine. Lab on a chip, 19(2), 198-205. https://doi.org/10.1039/c8lc00827b

2018

Tanumihardja, E., Olthuis, W., & van den Berg, A. (2018). Ruthenium Oxide pH Sensing for Organs-On-Chip Studies. In Proceedings of Eurosensors 2018 (13 ed., Vol. 2, pp. 1-4). [2130709] (Proceedings (MDPI)). Basel, Switzerland: Multidisciplinary Digital Publishing Institute. https://doi.org/10.3390/proceedings2130709

Barrile, R., van der Meer, A. D., Park, H., Fraser, J. P., Simic, D., Teng, F., ... Otieno, M. A. (2018). Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems. Clinical pharmacology & therapeutics, 104(6), 1240-1248. https://doi.org/10.1002/cpt.1054

Stamatialis, D. (2018). Book Presentation Biomedical Membranes and (Bio) Artificial Organs. Artificial organs, 42(11), 1104-1105. https://doi.org/10.1111/aor.13377

Bossink, E. G. B. M., Henry, O. Y. F., Benz, M. A., Segerink, L., Ingber, D. E., & Odijk, M. (2018). A miniaturized clark oxygen sensor for organ-on-chip devices. In F-G. Tseng, & G-B. Lee (Eds.), MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Science (pp. 889-892). The Chemical and Biological Microsystems Society.

Albers, H. J., da Silva Simão, J. P., Middelkamp, H. H. T., Mummery, C. L., Passier, R., van den Berg, A., ... van der Meer, A. D. (2018). Human induced pluripotent stem cell-derived endothelial cells in thrombosis-on-a-chip devices. In F-G. Tseng, & G-B. Lee (Eds.), MicroTas 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 2392-2393). The Chemical and Biological Microsystems Society.

Ribas, J., Pawlikowsk, J., & Rouwkema, J. (2018). Microphysiological systems: analysis of the current status, challenges and commercial future. Microphysiological systems, 2, [10]. https://doi.org/10.21037/mps.2018.10.01

Dekker, S., Buesink, W., Blom, M., Alessio, M., Verplanck, N., Hihoud, M., ... Odijk, M. (2018). Standardized and modular microfluidic platform for fast Lab on Chip system development. Sensors and actuators. B: Chemical, 272, 468-478. https://doi.org/10.1016/j.snb.2018.04.005

Quirós-Solano, W. F., Gaio, N., Stassen, O. M. J. A., Arik, Y. B., Silvestri, C., Van Engeland, N. C. A., ... Sarro, P. M. (2018). Microfabricated tuneable and transferable porous PDMS membranes for Organs-on-Chips. Scientific reports, 8(1), [13524]. https://doi.org/10.1038/s41598-018-31912-6

Tanumihardja, E., Olthuis, W., & van den Berg, A. (2018). Ruthenium oxide nanorods as potentiometric ph sensor for organs-on-chip purposes. Sensors (Switzerland), 18(9), [2901]. https://doi.org/10.3390/s18092901

Pamies, D., Bal-Price, A., Chesne, C., Coecke, S., Dinnyes, A., Eskes, C., ... Daneshian, M. (2018). Advanced Good Cell Culture Practice for Human Primary, Stem Cell-Derived and Organoid Models as well as Microphysiological Systems. Alternatives to Animal Experimentation, 35(3), 353-378. https://doi.org/10.14573/altex.1710081

Arık, Y. B., van der Helm, M. W., Odijk, M., Segerink, L. I., Passier, R., van den Berg, A., & van der Meer, A. D. (2018). Barriers-on-chips: Measurement of barrier function of tissues in organs-on-chips. Biomicrofluidics, 12(4), [042218]. https://doi.org/10.1063/1.5023041

Pasman, T., Grijpma, D. W., Stamatialis, D., & Poot, A. A. (2018). Flat and microstructured polymeric membranes in organs-on-chips. Journal of the Royal Society. Interface, 15(144), 1-15. [20180351]. https://doi.org/10.1098/rsif.2018.0351

Xie, S., Gardeniers, J. G. E., & Luttge, R. (2018). Nanoscale membrane actuator for in vitro mechano-stimuli responsive studies of neuronal cell networks on chip. Journal of micromechanics and microengineering, 28(8), [085011]. https://doi.org/10.1088/1361-6439/aabf7e

Quiros-Solano, W. F., Gaio, N., Silvestri, C., Arik, Y. B., Stassen, O. M. J. A., Van Der Meer, A. D., ... Sarro, P. M. (2018). A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly. In 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018 (Vol. 2018-January, pp. 318-321). (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2018-January). IEEE. https://doi.org/10.1109/MEMSYS.2018.8346550

Devalla, H. D., & Passier, R. (2018). Cardiac differentiation of pluripotent stem cells and implications for modeling the heart in health and disease. Science Translational Medicine, 10(435), [eaah5457]. https://doi.org/10.1126/scitranslmed.aah5457

Rocca, M., Fragasso, A., Liu, W., Heinrich, M. A., & Zhang, Y. S. (2018). Embedded Multimaterial Extrusion Bioprinting. SLAS Technology, 23(2), 154-163. https://doi.org/10.1177/2472630317742071

Tibbe, M. P., Leferink, A. M., van den Berg, A., Eijkel, J. C. T., & Segerink, L. (2018). Microfluidic Gel Patterning Method by Use of a Temporary Membrane for Organ-On-Chip Applications. Advanced Materials Technologies, 3(3), [1700200]. https://doi.org/10.1002/admt.201700200

Beekers, I., van Rooij, T., Verweij, M. D., Versluis, M., de Jong, N., Trietsch, S. J., & Kooiman, K. (2018). Acoustic Characterization of a Vessel-on-a-Chip Microfluidic System for Ultrasound-Mediated Drug Delivery. IEEE transactions on ultrasonics, ferroelectrics and frequency control, 65(4), 570-581. https://doi.org/10.1109/TUFFC.2018.2803137

Jain, A., Barrile, R., van der Meer, A. D., Mammoto, A., Mammoto, T., De Ceunynck, K., ... Ingber, D. E. (2018). Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics. Clinical pharmacology & therapeutics, 103(2), 332-340. https://doi.org/10.1002/cpt.742

de Almeida Monteiro Melo Ferraz, M., Henning, H. H. W., Ferreira da Costa, P., Malda, J., le Gac, S., Bray, F., ... Gadella, B. M. (2018). Potential Health and Environmental Risks of Three-Dimensional Engineered Polymers. Environmental science & technology letters, 5(2), 80-85. https://doi.org/10.1021/acs.estlett.7b00495

Seo, J., Shin, J. Y., Leijten, J., Jeon, O., Camci-Unal, G., Dikina, A. D., ... Khademhosseini, A. (2018). High-throughput approaches for screening and analysis of cell behaviors. Biomaterials, 153, 85-101. https://doi.org/10.1016/j.biomaterials.2017.06.022

Tibbe, M. P., van der Meer, A. D., van den Berg, A., Stamatialis, D., & Segerink, L. (2018). Membranes for Organs-on-Chips. In D. Stamatialis (Ed.), Biomedical Membranes and (Bio)Artificial Organs (pp. 295-321). World Scientific. https://doi.org/10.1142/9789813223974_0011

2017

Gümüscü, B., Albers, H. J., Van Den Berg, A., Eijkel, J. C. T., & Van Der Meer, A. D. (2017). Compartmentalized 3D Tissue Culture Arrays under Controlled Microfluidic Delivery. Scientific reports, 7, [3381]. https://doi.org/10.1038/s41598-017-01944-5

van der Helm, M., Henry, O., Hamkins-Indik, T., Cronce, M., Leineweber, W., Odijk, M., ... Segerink, L. (2017). Electrical simulations and experimental results of 4-electrode AC transepithelial electrical resistance measurements in gut-on-a-chip. In A. Lee, & D. DeVoe (Eds.), 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1114-1115). (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS); Vol. 2017). Chemical and Biological Microstystems Society.

Gümüscü, B., Albers, H. J., van den Berg, A., Eijkel, J., & van der Meer, A. D. (2017). A gut-on-a-chip study: Enabling on-demand manipulation of the outer cell microenvironment in a multicompartmental 3D culture array. In A. Lee, & D. DeVoe (Eds.), 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1013). (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS); Vol. 2017). The Chemical and Biological Microsystems Society.

Loessberg-Zahl, J., Makkinga, D., van der Meer, A., Eijkel, J., & van den Berg, A. (2017). Configurable gel geometry via flow patterning for angiogenisis assays. In A. Lee, & D. D. (Eds.), 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1074-). (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS); Vol. 2017). The Chemical and Biological Microsystems Society.

Le-The, H., Palma do Carmo, M. A., van der Helm, M. W., Bomer, J. G., Segerink, L. I., van den Berg, A., & Eijkel, J. C. T. (2017). Large-area fabrication of sub-μm PDMS through hole membranes. In A. Lee, & D. DeVoe (Eds.), 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 375-376). (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS); Vol. 2017). The Chemical and Biological Microsystems Society.

Van der Meer, A. (2017). Organs-on-chips for vascular function. Toxicology Letters, 280(1), S29. https://doi.org/10.1016/j.toxlet.2017.07.069

Le Gac, S. (2017). Microfluidic technology: new opportunities to develop physiologically relevant in vitro models integrated microfluidic platform for the in vitro pre-implantation culture of individual mammalian embryos and their in situ characterization. In 47th European Solid-State Device Research Conference (ESSDERC 2017) (pp. 260-263). Piscataway, NJ: IEEE. https://doi.org/10.1109/ESSDERC.2017.8066641

Van Den Berg, A. (2017). LABS, cells and organs on chip: Technologies and biomedical applications. In TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems (pp. 6-9). [7993974] IEEE. https://doi.org/10.1109/TRANSDUCERS.2017.7993974

Ribas, J., Zhang, Y. S., Pitrez, P. R., Leijten, J. C. H., Miscuglio, M., Rouwkema, J., ... Khademhosseini, A. (2017). Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model. Small, 13(15), [1603737]. https://doi.org/10.1002/smll.201603737

Zolfagharian, A., Kouzani, A. Z., Khoo, S. Y., Gibson, I., & Kaynak, A. (2017). 3D printed hydrogel soft actuators. In Proceedings of the 2016 IEEE Region 10 Conference, TENCON 2016 (pp. 2272-2277). [7848433] IEEE. https://doi.org/10.1109/TENCON.2016.7848433

Van der Helm, M. W., Odijk, M., Frimat, J-P., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A., & Segerink, L. I. (2017). Fabrication and validation of an organ-on-chip system with integrated electrodes to directly quantify transendothelial electrical resistance. Journal of visualized experiments, 127, [e56334]. https://doi.org/10.3791/56334

Costa, P. F., Albers, H. J., Linssen, J. E. A., Middelkamp, H. H. T., van der Hout, L., Passier, R., ... van der Meer, A. D. (2017). Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data. Lab on a chip, 17(16), 2785-2792. https://doi.org/10.1039/c7lc00202e

Van Meer, B. J., de Vries, H., Firth, K. S. A., van Weerd, J., Tertoolen, L. G. J., Karperien, H. B. J., ... Mummery, C. L. (2017). Small molecule absorption by PDMS in the context of drug response bioassays. Biochemical and biophysical research communications, 482(2), 323-328. https://doi.org/10.1016/j.bbrc.2016.11.062

2016

Abbas, Y., Zhu, X., de Boer, H. L., Tanvir, N. B., Olthuis, W., & van den Berg, A. (2016). Potentiometric measurement with a Kelvin probe: Contactless measurement of chloride ions in aqueous electrolyte. Sensors and actuators. B: Chemical, 236, 1126-1132. https://doi.org/10.1016/j.snb.2016.06.150

Sinha, R., le Gac, S., Verdonschot, N. J. J., van den Berg, A., Koopman, H. F. J. M., & Rouwkema, J. (2016). Effects of varying degrees of surface strain anisotropies on endothelial cells. In 10th World Biomaterials Congress (pp. -). Montreal, Canada: Frontiers Media S.A.. https://doi.org/10.3389/conf.FBIOE.2016.01.01637

Passier, R., Orlova, V. V., & Mummery, C. (2016). Complex Tissue and Disease Modeling using hiPSCs. Cell stem cell, 18(3), 309-321. https://doi.org/10.1016/j.stem.2016.02.011

Middelkamp, H. H. T., van der Meer, A. D., Hummel, J. M., Stamatialis, D., Mummery, C. L., Passier, P. C. J. J., & IJzerman, M. J. (2016). Organs-on-Chips in Drug Development: The Importance of Involving Stakeholders in Early Health Technology Assessment. Applied in vitro toxicology, 2(2), 74-81. https://doi.org/10.1089/aivt.2015.0029

Picollet-D'hahan, N., Dolega, M. E., Liguori, L., Marquette, C., le Gac, S., Gidrol, X., & Martin, D. K. (2016). A 3D Toolbox to Enhance Physiological Relevance of Human Tissue Models. Trends in biotechnology, 34(9), 757-769. https://doi.org/10.1016/j.tibtech.2016.06.012

Ribas, J., Sadeghi, H., Manbachi, A., Leijten, J. C. H., Brinegar, K., Zhang, Y. S., ... Khademhosseini, A. (2016). Cardiovascular Organ-on-a-Chip Platforms for Drug Discovery and Development. Applied in vitro toxicology, 2(2), 82-96. https://doi.org/10.1089/aivt.2016.0002

Van der Helm, M. W., Odijk, M., Frimat, J-P., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A., & Segerink, L. I. (2016). Direct quantification of transendothelial electrical resistance in organs-on-chips. Biosensors and bioelectronics, 85, 924-929. https://doi.org/10.1016/j.bios.2016.06.014

van der Helm, M. W., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A., & Segerink, L. I. (2016). Microfluidic organ-on-chip technology for blood-brain barrier research. Tissue barriers, 4(1), e1142493-. [e1142493]. https://doi.org/10.1080/21688370.2016.1142493

Rouwkema, J., & Khademhosseini, A. (2016). Vascularization and Angiogenesis in Tissue Engineering: Beyond Creating Static Networks. Trends in biotechnology, 34(9), 733-745. https://doi.org/10.1016/j.tibtech.2016.03.002

Karperien, H. B. J. (2016). Weefselregeneratie en tissue-engineering. In B. Roelen, W. Hoekstra, B. Defize, & A. van de Graaf (Eds.), Stamcellen: wetenschap, werkelijkheid en fictie (pp. 31-35). (Cahier biowetenschappen en maatschappij; No. 35.2). Stichting BWM.

2015

van der Helm, M. W., Odijk, M., Frimat, J-P., Eijkel, J. C. T., van den Berg, A., & Segerink, L. I. (2015). Simple and stable transendothelial electrical resistance measurement in organs-on-chips. In The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2015) (pp. 771-773). (Proceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS). Chemical and Biological Micro Systems Society.

Braakhuis, H. M., Kloet, S. K., Kezic, S., Kuper, F., Park, M. V. D. Z., le Gac, S., ... Bouwmeester, H. (2015). Progress and future of in vitro models to study translocation of nanoparticles. Archives of toxicology, 89(9), 1469-1495. https://doi.org/10.1007/s00204-015-1518-5

Chen, S., van den Berg, A., & Carlen, E. (2015). Sensitivity and detection limit analysis of silicon nanowire bio(chemical) sensors. Sensors and actuators. B: Chemical, 209, 486-489. https://doi.org/10.1016/j.snb.2014.12.007

Benam, K. H., Dauth, S., Hassell, B., Herland, A., Jain, A., Jang, K. J., ... Ingber, D. E. (2015). Engineered in vitro disease models. Annual Review of Pathology: Mechanisms of Disease, 10, 195-262. https://doi.org/10.1146/annurev-pathol-012414-040418

van der Meer, A. D., Wolbers, F., & Vermes, I. (2015). Blood-brain barrier (BBB): an overview of the research of the blood-brain barrier using microfluidic devices. In A. van den Berg, L. Segerink, & L. I. Segerink (Eds.), Microfluidics for medical applications (pp. 40-53). (RSC Nanoscience & Nanotechnology; No. 36). Cambridge: Royal Society of Chemistry. https://doi.org/10.1039/9781849737593-00040

Odijk, M., van der Meer, A. D., Levner, D., Kim, H. J., van der Helm, M. W., Segerink, L. I., ... van den Berg, A. (2015). Measuring direct current trans-epithelial electrical resistance in organ-on-a-chip microsystems. Lab on a chip, 15(3), 745-752. https://doi.org/10.1039/c4lc01219d

Segerink, L., & van den Berg, A. (2015). Preface book Microfluidics for medical applications. In A. van den Berg, & L. Segerink (Eds.), Microfluidics for medical applications (pp. vii-ix). (RSC Nanoscience & Nanotechnology; No. 36). Cambridge, UK: Royal Society of Chemistry. https://doi.org/10.1039/9781849737593-FP007

2014

Moroni, L., Schrooten, J., Truckenmüller, R., Rouwkema, J., Sohier, J., & van Blitterswijk, C. (2014). Tissue Engineering: An Introduction. In C. A. van Blitterswijk, & J. de Boer (Eds.), Tissue Engineering (2 ed., pp. 1–21). Academic Press. https://doi.org/10.1016/B978-0-12-420145-3.00001-8

2013

van der Meer, A. D., Orlova, V. V., tem Dijke, P., van den Berg, A., & Mummery, C. L. (2013). Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device. Lab on a chip, 13(18), 3562-3568. https://doi.org/10.1039/c3lc50435b

Harink, B., le Gac, S., Truckenmüller, R. K., van Blitterswijk, C., & Habibovic, P. (2013). Regeneration-on-a-chip? The perspectives on use of microfluidics in regenerative medicine. Lab on a chip, 13(18), 3512-3528. https://doi.org/10.1039/C3LC50293G

2012

van der Meer, A. D., & van den Berg, A. (2012). Organs-on-chips: breaking the in vitro impasse. Integrative biology, 4(5), 461-470. https://doi.org/10.1039/c2ib00176d