This section gives an overview of all the Organ-on-Chip publications in which our members were involved. A number of highlights can be found in the top of this section. The full list, ordered by publication year, can be found below.
2023
Heinrich, M. A., Heinrich, L., Ankone, M. J. K., Vergauwen, B., & Prakash, J. (2023). Endotoxin contamination alters macrophage-cancer cell interaction and therapeutic efficacy in pre-clinical 3D in vitro models. Biomaterials Advances, 144, [213220]. https://doi.org/10.1016/j.bioadv.2022.213220
2022
Kolkman, R. W., Segerink, L., & Huskens, J. (2022). Selective Enrichment of Hypermethylated DNA by a Multivalent Binding Platform. Advanced materials interfaces, 9(35), [2201557]. https://doi.org/10.1002/admi.202201557
Hu, M., Frega, M., Tolner, E. A., van den Maagdenberg, A. M. J. M., Frimat, J. P., & le Feber, J. (2022). MEA-ToolBox: an Open Source Toolbox for Standardized Analysis of Multi-Electrode Array Data. Neuroinformatics, 20(4), 1077-1092. https://doi.org/10.1007/s12021-022-09591-6
de Graaf, M. N. S., Vivas, A., van der Meer, A. D., Mummery, C. L., & Orlova, V. V. (2022). Pressure-Driven Perfusion System to Control, Multiplex and Recirculate Cell Culture Medium for Organs-on-Chips. Micromachines, 13(8), [1359]. https://doi.org/10.3390/mi13081359
Vivas, A., IJspeert, C., Pan, J. Y., Vermeul, K., van den Berg, A., Passier, R., Keller, S. S., & van der Meer, A. D. (2022). Generation and Culture of Cardiac Microtissues in a Microfluidic Chip with a Reversible Open Top Enables Electrical Pacing, Dynamic Drug Dosing and Endothelial Cell Co-Culture. Advanced Materials Technologies, 7(7), [2101355]. https://doi.org/10.1002/admt.202101355
Post, J. N., Loerakker, S., Merks, R. M. H., & Carlier, A. (2022). Implementing Computational Modeling in Tissue Engineering: Where Disciplines Meet. Tissue Engineering - Part A, 28(11-12), 542-554. https://doi.org/10.1089/ten.tea.2021.0215
Baptista, D., Moreira Teixeira, L., Barata, D., Tahmasebi Birgani, Z., King, J., Van Riet, S., Pasman, T., Poot, A. A., Stamatialis, D., Rottier, R. J., Hiemstra, P. S., Carlier, A., Van Blitterswijk, C., Habibović, P., Giselbrecht, S., & Truckenmüller, R. (2022). 3D Lung-on-Chip Model Based on Biomimetically Microcurved Culture Membranes. ACS Biomaterials Science and Engineering, 8(6), 2684-2699. https://doi.org/10.1021/acsbiomaterials.1c01463
Bossink, E. G. B. M., Vollertsen, A. R., Loessberg-Zahl, J. T., van der Meer, A. D., Segerink, L. I., & Odijk, M. (2022). Systematic characterization of cleanroom-free fabricated macrovalves, demonstrating pumps and mixers for automated fluid handling tuned for organ-on-chip applications. Microsystems & nanoengineering, 8, [54]. https://doi.org/10.1038/s41378-022-00378-y
Buentello, D. C., Koch, L. S., Trujillo-De Santiago, G., Alvarez, M. M., & Broersen, K. (2022). Use of standard U-bottom and V-bottom well plates to generate neuroepithelial embryoid bodies. PLoS ONE, 17(5 May), [e0262062]. https://doi.org/10.1371/journal.pone.0262062
Paggi, C. A., Hendriks, J., Karperien, M., & Gac, S. L. (2022). Emulating the chondrocyte microenvironment using multi-directional mechanical stimulation in a cartilage-on-chip. Lab on a chip, 22(9), 1815-1828. https://doi.org/10.1039/D1LC01069G
Komen, J., van Neerven, S., Bossink, E. G. B. M., de Groot, N., Nijman, L., van den Berg, A., Vermeulen, L., & van der Meer, A. (2022). The Effect of Dynamic, In Vivo-like Oxaliplatin on HCT116 Spheroids in a Cancer-on-Chip Model Is Representative of the Response in Xenografts. Micromachines, 13(5), [739]. https://doi.org/10.3390/mi13050739
Vivas, A., Mikhal, J., Ong, G. M., Eigenbrodt, A., van der Meer, A. D., Aquarius, R., Geurts, B. J., & Boogaarts, H. D. (2022). Aneurysm-on-a-Chip: Setting Flow Parameters for Microfluidic Endothelial Cultures Based on Computational Fluid Dynamics Modeling of Intracranial Aneurysms. Brain Sciences, 12(5), [603]. https://doi.org/10.3390/brainsci12050603
Rivera-Arbeláez, J. M., Cofiño-Fabres, C., Schwach, V., Boonen, T., ten Den, S. A., Vermeul, K., van den Berg, A., Segerink, L. I., Ribeiro, M. C., & Passier, R. (2022). Contractility analysis of human engineered 3D heart tissues by an automatic tracking technique using a standalone application. PLoS ONE, 17, [e0266834]. https://doi.org/10.1371/journal.pone.0266834
Paggi, C. A., Moreira Teixeira, L., le Gac, S., & Karperien, M. (2022). Joint-on-chip platforms: entering a new era of in vitro models for arthritis. Nature reviews rheumatology, 18, 217-231. https://doi.org/10.1038/s41584-021-00736-6
Vivas, A., van den Berg, A., Passier, R., Odijk, M., & van der Meer, A. D. (2022). Fluidic circuit board with modular sensor and valves enables stand-alone, tubeless microfluidic flow control in organs-on-chips. Lab on a chip, 22(6), 1231-1243. https://doi.org/10.1039/d1lc00999k
Ribeiro, M. C., Rivera-Arbelaez, J. M., Cofino-Fabres, C., Schwach, V., Slaats, R. H., ten Den, S. A., Vermeul, K., van den Berg, A., Perez-Pomares, J. M., Segerink, L. I., Guadix, J. A., & Passier, R. (2022). A New Versatile Platform for Assessment of Improved Cardiac Performance in Human-Engineered Heart Tissues. Journal of Personalized Medicine, 12(2), [214]. https://doi.org/10.3390/jpm12020214
Palacio-Castaneda, V., Velthuijs, N., Le Gac, S., & Verdurmen, W. P. R. (2022). Oxygen control: the often overlooked but essential piece to create better in vitro systems. Lab on a chip, 22, 1068-1092. https://doi.org/10.1039/d1lc00603g
Borges, A. C., Broersen, K., Leandro, P., & Fernandes, T. G. (2022). Engineering Organoids for in vitro Modeling of Phenylketonuria. Frontiers in Molecular Neuroscience, 14, [787242]. https://doi.org/10.3389/fnmol.2021.787242
Conceição, F., Sousa, D. M., Loessberg-Zahl, J., Vollertsen, A. R., Neto, E., Søe, K., Paredes, J., Leferink, A., & Lamghari, M. (2022). A metastasis-on-a-chip approach to explore the sympathetic modulation of breast cancer bone metastasis. Materials Today Bio, 13, [100219]. https://doi.org/10.1016/j.mtbio.2022.100219
Calejo, I., Heinrich, M. A., Zambito, G., Mezzanotte, L., Prakash, J., & Teixeira, L. M. (2022). Advancing Tumor Microenvironment Research by Combining Organs-on-Chips and Biosensors. In Microfluidics and Biosensors in Cancer Research: Applications in Cancer Modeling and Theranostics (pp. 171-203). (Advances in Experimental Medicine and Biology; Vol. 1379). Springer Gabler. https://doi.org/10.1007/978-3-031-04039-9_7
Ahmed, H. M. M. A. M., & Moreira Teixeira, L. S. (2022). New Endeavors of (Micro)Tissue Engineering: Cells Tissues Organs on-Chip and Communication Thereof. Cells tissues organs, 211(6). https://doi.org/10.1159/000516356
2021
Bossink, E. G. B. M., Segerink, L., & Odijk, M. (2021). Organ-on-Chip Technology for Aerobic Intestinal Host - Anaerobic Microbiota Research. Organs-on-a-Chip, 4, [100013]. https://doi.org/10.1016/j.ooc.2021.100013
Paloschi, V., Sabater-Lleal, M., Middelkamp, H. H. T., De sa Vivas, A. G., Johansson, S., van der Meer, A., Tenje, M., & Maegdefessel, L. (2021). Organ-on-a-chip technology: a novel approach to investigate cardiovascular diseases. Cardiovascular Research, 117(14), 2742-2754. https://doi.org/10.1093/cvr/cvab088
Moreira Teixeira Leijten, L. S., & Mezzanotte, L. (2021). New bioimaging avenues for organs-on-chips by integration of bioluminescence. View, 2(6), [20200177]. https://doi.org/10.1002/VIW.20200177
Cuartas-Vélez, C., Veenstra, C., Kruitwagen, S., Petersen, W., & Bosschaart, N. (2021). Optical density based quantification of total haemoglobin concentrations with spectroscopic optical coherence tomography. Scientific reports, 11(1), [8680]. https://doi.org/10.1038/s41598-021-88063-4
Muzzi, L., Di Lisa, D., Arnaldi, P., Aprile, D., Pastorino, L., Martinoia, S., & Frega, M. (2021). Rapid generation of functional engineered 3D human neuronal assemblies: Network dynamics evaluated by micro-electrodes arrays. Journal of neural engineering, 18(6), [066030]. https://doi.org/10.1088/1741-2552/ac3e02
Popa, E. O., Hilten, M. V., Oosterkamp, E., & Bogaardt, M-J. (2021). The use of digital twins in healthcare: socio-ethical benefits and socio-ethical risks. Life sciences, society and policy, 17, [6]. https://doi.org/10.1186/s40504-021-00113-x
Zakharova, M., Tibbe, M. P., Koch, L. S., Le-The, H., Leferink, A. M., van den Berg, A., van der Meer, A. D., Broersen, K., & Segerink, L. I. (2021). Transwell-Integrated 2 µm Thick Transparent Polydimethylsiloxane Membranes with Controlled Pore Sizes and Distribution to Model the Blood-Brain Barrier. Advanced Materials Technologies, 6(12), [2100138]. https://doi.org/10.1002/admt.202100138
Schneider, S., Bubeck, M., Rogal, J., Weener, H. J., Rojas, C., Weiss, M., Heymann, M., van der Meer, A. D., & Loskill, P. (2021). Peristaltic on-chip pump for tunable media circulation and whole blood perfusion in PDMS-free organ-on-chip and Organ-Disc systems. Lab on a chip, 21(20), 3963-3978. https://doi.org/10.1039/d1lc00494h
Kamperman, T., Henke, S., Crispim, J. F., Willemen, N. G. A., Dijkstra, P. J., Lee, W., Offerhaus, H. L., Neubauer, M., Smink, A. M., de Vos, P., de Haan, B. J., Karperien, M., Shin, S. R., & Leijten, J. (2021). Tethering Cells via Enzymatic Oxidative Crosslinking Enables Mechanotransduction in Non-Cell-Adhesive Materials. Advanced materials, 33(42), [2102660]. https://doi.org/10.1002/adma.202102660
Vollertsen, A. R., Vivas, A., van Meer, B., van den Berg, A., Odijk, M., & van der Meer, A. D. (2021). Facilitating implementation of organs-on-chips by open platform technology. Biomicrofluidics, 15(5), [051301]. https://doi.org/10.1063/5.0063428
Arik, Y. B., De Sa Vivas, A., Laarveld, D., Van Laar, N., Gemser, J., Visscher, T., Van Den Berg, A., Passier, R., & Van Der Meer, A. D. (2021). Collagen i Based Enzymatically Degradable Membranes for Organ-on-a-Chip Barrier Models. ACS Biomaterials Science and Engineering, 7(7), 2998-3005. https://doi.org/10.1021/acsbiomaterials.0c00297
Heinrich, M. A., Mostafa, A. M. R. H., Morton, J. P., Hawinkels, L. J. A. C., & Prakash, J. (2021). Translating complexity and heterogeneity of pancreatic tumor: 3D in vitro to in vivo models. Advanced drug delivery reviews, 174, 265-293. https://doi.org/10.1016/j.addr.2021.04.018
Vollertsen, A. R., Den, S. A. T., Schwach, V., van den Berg, A., Passier, R., van der Meer, A. D., & Odijk, M. (2021). Highly parallelized human embryonic stem cell differentiation to cardiac mesoderm in nanoliter chambers on a microfluidic chip. Biomedical microdevices, 23(2), [30]. https://doi.org/10.1007/s10544-021-00556-1
Tanumihardja, E., Paradelo Rodríguez, A., Loessberg-Zahl, J. T., Mei, B., Olthuis, W., & van den Berg, A. (2021). On-chip electrocatalytic NO sensing using ruthenium oxide nanorods. Sensors and Actuators, B: Chemical, 334, [129631]. https://doi.org/10.1016/j.snb.2021.129631
Low, L. A., Mummery, C., Berridge, B. R., Austin, C. P., & Tagle, D. A. (2021). Organs-on-chips: into the next decade. Nature Reviews Drug Discovery, 20(5), 345-361. https://doi.org/10.1038/s41573-020-0079-3
Komen, J., van Neerven, S. M., van den Berg, A., Vermeulen, L., & van der Meer, A. D. (2021). Mimicking and surpassing the xenograft model with cancer-on-chip technology. EBioMedicine, 66, [103303]. https://doi.org/10.1016/j.ebiom.2021.103303
Rodrigues, J., Heinrich, M. A., Teixeira, L. M., & Prakash, J. (2021). 3D In Vitro Model (R)evolution: Unveiling Tumor–Stroma Interactions. Trends in cancer, 7(3), 249-264. https://doi.org/10.1016/j.trecan.2020.10.009
Middelkamp, H. H. T., Verboven, A. H. A., De sa Vivas, A. G., Schoenmaker, C., Klein Gunnewiek, T. M., Passier, R., Albers, C. A., 't Hoen, P. A. C., Nadif Kasri, N., & van der Meer, A. D. (2021). Cell type-specific changes in transcriptomic profiles of endothelial cells, iPSC-derived neurons and astrocytes cultured on microfluidic chips. Scientific reports, 11(1), [2281]. https://doi.org/10.1038/s41598-021-81933-x
Mercuri, M., & Fernandez Rivas, D. (2021). Challenges and opportunities for small volumes delivery into the skin. Biomicrofluidics, 15(1), [011301]. https://doi.org/10.1063/5.0030163
Baptista, D., Teixeira, L. M., Birgani, Z. T., van Riet, S., Pasman, T., Poot, A., Stamatialis, D., Rottier, R. J., Hiemstra, P. S., Habibović, P., van Blitterswijk, C., Giselbrecht, S., & Truckenmüller, R. (2021). 3D alveolar in vitro model based on epithelialized biomimetically curved culture membranes. Biomaterials, 266, [120436]. https://doi.org/10.1016/j.biomaterials.2020.120436
2020
Stein, J. M., Mummery, C. L., & Bellin, M. (2020). Engineered models of the human heart: directions and challenges. Stem cell reports. https://doi.org/10.1016/j.stemcr.2020.11.013
Bossink, E. G. B. M., Slob, J. V. M., Wasserberg, D., Segerink, L., & Odijk, M. (2020). Versatile fabrication and integration method of optical oxygen sensors in organ-on-chips. In 2020 IEEE sensors (IEEE SENSORS; Vol. 2020). IEEE. https://doi.org/10.1109/SENSORS47125.2020.9278735
Arik, Y. B., Buijsman, W., Loessberg-Zahl, J. T., Cuartas Velez, C. A., Veenstra, C., Logtenberg, S., Grobbink, A. M., Bergveld, P., Gagliardi, G., den Hollander, A. I., Bosschaart, N., van den Berg, A., Passier, R., & van der Meer, A. (2020). Microfluidic organ-on-a-chip model of the outer blood–retinal barrier with clinically relevant readouts for tissue permeability and vascular structure. Lab on a chip, 21(2), 272-283. https://doi.org/10.1039/d0lc00639d
Loessberg-Zahl, J. T., Beumer, J., van den Berg, A., Eijkel, J. C. T., & van der Meer, A. D. (2020). Patterning Biological Gels for 3D Cell Culture inside Microfluidic Devices by Local Surface Modification through Laminar Flow Patterning. Micromachines, 11(12), [1112]. https://doi.org/10.3390/mi11121112
Rodrigues, J., Heinrich, M. A., Teixeira, L. M., & Prakash, J. (Accepted/In press). 3D In Vitro Model (R)evolution: Unveiling Tumor–Stroma Interactions. Trends in cancer. https://doi.org/10.1016/j.trecan.2020.10.009
Quan, Y., Sun, M., Tan, Z., Eijkel, J. C. T., Van Den Berg, A., Van Der Meer, A., & Xie, Y. (2020). Organ-on-a-chip: The next generation platform for risk assessment of radiobiology. RSC advances, 10(65), 39521-39530. https://doi.org/10.1039/d0ra05173j
Punt, A., Bouwmeester, H., Blaauboer, B. J., Coecke, S., Hakkert, B., Hendriks, D. F. G., Jennings, P., Kramer, N. I., Neuhoff, S., Masereeuw, R., Paini, A., Peijnenburg, A. A. C. M., Rooseboom, M., Shuler, M. L., Sorrell, I., Spee, B., Strikwold, M., Van der Meer, A. D., Van der Zande, M., ... Heringa, M. B. (2020). New approach methodologies (NAMs) for human-relevant biokinetics predictions: Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment. ALTEX, 37(4), 607-622. https://doi.org/10.14573/altex.2003242
Dostanić, M., Windt, L. M., Stein, J. M., Van Meer, B. J., Bellin, M., Orlova, V., Mastrangeli, M., Mummery, C. L., & Sarro, P. M. (2020). A Miniaturized EHT Platform for Accurate Measurements of Tissue Contractile Properties. Journal of microelectromechanical systems, 29(5), 881-887. [9152964]. https://doi.org/10.1109/JMEMS.2020.3011196
Bossink, E. G. B. M., Zakharova, M., Odijk, M., & Segerink, L. (2020). Measuring barrier function in a gut-on-chip. In μTAS 2020: The 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 943-944)
Morsink, M. A. J., Willemen, N. G. A., Leijten, J., Bansal, R., & Shin, S. R. (2020). Immune organs and immune cells on a chip: An overview of biomedical applications. Micromachines, 11(9), [849]. https://doi.org/10.3390/MI11090849
Komen, J., Westerbeek, E. Y., Kolkman, R. W., Roesthuis, J., Lievens, C., van den Berg, A., & van der Meer, A. D. (2020). Controlled pharmacokinetic anti-cancer drug concentration profiles lead to growth inhibition of colorectal cancer cells in a microfluidic device. Lab on a chip, 20(17), 3167-3178. https://doi.org/10.1039/d0lc00419g
Zakharova, M., Palma do Carmo, M. A., van der Helm, M. W., Le-The, H., de Graaf, M. N. S., Orlova, V., van den Berg, A., van der Meer, A. D., Broersen, K., & Segerink, L. I. (2020). Multiplexed blood-brain barrier organ-on-chip. Lab on a chip, 20(17), 3132-3143. https://doi.org/10.1039/d0lc00399a
Paggi, C. A., Venzac, B., Karperien, M., Leijten, J., & le Gac, S. (2020). Monolithic microfluidic platform for exerting gradients of compression on cell-laden hydrogels, and application to a model of the articular cartilage. Sensors and actuators. B: Chemical, 315, [127917]. https://doi.org/10.1016/j.snb.2020.127917
Schroën, K., de Ruiter, J., & Berton-Carabin, C. C. (2020). Microtechnological Tools to Achieve Sustainable Food Processes, Products, and Ingredients. Food Engineering Reviews, 12(2), 101-120. https://doi.org/10.1007/s12393-020-09212-5
Sacchi, M., Bansal, R., & Rouwkema, J. (2020). Bioengineered 3D Models to Recapitulate Tissue Fibrosis. Trends in biotechnology, 38(6), 623-636. https://doi.org/10.1016/j.tibtech.2019.12.010
Schwach, V., Slaats, R. H., & Passier, R. (2020). Human Pluripotent Stem Cell-Derived Cardiomyocytes for Assessment of Anticancer Drug-Induced Cardiotoxicity. Frontiers in Cardiovascular Medicine, 7, 1-12. [50]. https://doi.org/10.3389/fcvm.2020.00050
Chou, D. B., Frismantas, V., Milton, Y., David, R., Pop-Damkov, P., Ferguson, D., MacDonald, A., Vargel Bölükbaşı, Ö., Joyce, C. E., Moreira Teixeira, L. S., Rech, A., Jiang, A., Calamari, E., Jalili-Firoozinezhad, S., Furlong, B. A., O’Sullivan, L. R., Ng, C. F., Choe, Y., Marquez, S., ... Ingber, D. E. (2020). On-chip recapitulation of clinical bone marrow toxicities and patient-specific pathophysiology. Nature Biomedical Engineering, 4(4), 394-406. https://doi.org/10.1038/s41551-019-0495-z
de Almeida Monteiro Melo Ferraz, M., Nagashima, J. B., Venzac, B., Le Gac, S., & Songsasen, N. (2020). A dog oviduct-on-a-chip model of serous tubal intraepithelial carcinoma. Scientific reports, 10(1), [1575]. https://doi.org/10.1038/s41598-020-58507-4
Ferraz, M., Nagashima, J. B., Venzac, B., le Gac, S., & Songsasen, N. (2020). 3D printed mold leachates in PDMS microfluidic devices. Scientific reports, 10(1), [994]. https://doi.org/10.1038/s41598-020-57816-y
Sharma, S., Venzac, B., Burgers, T., le Gac, S., & Schlatt, S. (2020). Microfluidics in male reproduction: Is ex vivo culture of primate testis tissue a future strategy for assisted reproductive technologies or toxicology research? Molecular Human Reproduction, 26(3), 179-192. https://doi.org/10.1093/molehr/gaaa006
Low, L. A., Mummery, C., Berridge, B. R., Austin, C. P., & Tagle, D. A. (Accepted/In press). Organs-on-chips: into the next decade. Nature Reviews Drug Discovery. https://doi.org/10.1038/s41573-020-0079-3
2019
Das, P., Van Der Meer, A. D., Vivas, A., Arik, Y. B., Remigy, J. C., Lahitte, J. F., ... Bacchin, P. (2019). Tunable Microstructured Membranes in Organs-on-Chips to Monitor Transendothelial Hydraulic Resistance. Tissue Engineering - Part A, 25(23-24), 1635-1645. https://doi.org/10.1089/ten.tea.2019.0021
Albers, H. J., Passier, R., van den Berg, A., & van der Meer, A. D. (2019). Automated analysis of platelet aggregation on cultured endothelium in a microfluidic chip perfused with human whole blood. Micromachines, 10(11), [781]. https://doi.org/10.3390/mi10110781
Bossink, E. G. B. M., Vollertsen, A. R., Segerink, L. I., & Odijk, M. (2019). Macro valve and peristaltic pump with cleanroom-free fabrication for multiplexed organ-on-chip applications. In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (23 ed., pp. 1664-1665). Basel, Switzerland: Chemical and Biological Micro Systems Society.
Vollertsen, A., Bossink, E., de Boer, D., Spalink, J., Passier, R., van den Berg, A., ... Odijk, M. (2019). Standardized, modular microfluidic building blocks for automated cell culturing systems. In P. Diettrich, E. Delamarche, & A. Hierlemann (Eds.), 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (23 ed., pp. 86-87). Basel, Switzerland: Chemical and Biological Micro Systems Society.
Piluso, S., Li, Y., Abinzano, F., Levato, R., Moreira Teixeira, L., Karperien, M., ... Malda, J. (2019). Mimicking the Articular Joint with In Vitro Models. Trends in biotechnology, 37(10), 1063-1077. https://doi.org/10.1016/j.tibtech.2019.03.003
Ng, P., Belgur, C., Barthakur, S., van der Meer, A. D., Hamilton, G. A., & Barrile, R. (2019). Organs-on-Chips: a new paradigm for safety assessment of drug-induced thrombosis. Current Opinion in Toxicology, 17, 1-8. https://doi.org/10.1016/j.cotox.2019.08.004
Franzen, N., van Harten, W. H., Retèl, V. P., Loskill, P., van den Eijnden-van Raaij, J., & IJzerman, M. (2019). Impact of organ-on-a-chip technology on pharmaceutical R&D costs. Drug discovery today, 24(9), 1720-1724. https://doi.org/10.1016/j.drudis.2019.06.003
Schwach, V., & Passier, R. (2019). Native cardiac environment and its impact on engineering cardiac tissue. Biomaterials Science, 7(9), 3566-3580. https://doi.org/10.1039/c8bm01348a
De Graaf, M. N. S., Cochrane, A., van den Hil, F. E., Buijsman, W., van der Meer, A., van den Berg, A., ... Orlova, V. V. (2019). Scalable microphysiological system to model three-dimensional blood vessels. APL Bioengineering, 3(2), [026105]. https://doi.org/10.1063/1.5090986
Cochrane, A., Albers, H. J., Passier, R., Mummery, C. L., van den Berg, A., Orlova, V. V., & van der Meer, A. (2019). Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology. Advanced drug delivery reviews, 140, 68-77. https://doi.org/10.1016/j.addr.2018.06.007
van der Helm, M. W., Henry, O. Y. F., Bein, A., Hamkins-Indik, T., Cronce, M. J., Leineweber, W. D., ... Segerink, L. I. (2019). Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy. Lab on a chip, 19(3), 452-463. https://doi.org/10.1039/c8lc00129d
Van Den Berg, A., Mummery, C. L., Passier, R., & Van der Meer, A. D. (2019). Personalised organs-on-chips: functional testing for precision medicine. Lab on a chip, 19(2), 198-205. https://doi.org/10.1039/c8lc00827b
2018
Tanumihardja, E., Olthuis, W., & van den Berg, A. (2018). Ruthenium Oxide pH Sensing for Organs-On-Chip Studies. In Proceedings of Eurosensors 2018 (13 ed., Vol. 2, pp. 1-4). [2130709] (Proceedings (MDPI)). Basel, Switzerland: Multidisciplinary Digital Publishing Institute. https://doi.org/10.3390/proceedings2130709
Barrile, R., van der Meer, A. D., Park, H., Fraser, J. P., Simic, D., Teng, F., ... Otieno, M. A. (2018). Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems. Clinical pharmacology & therapeutics, 104(6), 1240-1248. https://doi.org/10.1002/cpt.1054
Stamatialis, D. (2018). Book Presentation Biomedical Membranes and (Bio) Artificial Organs. Artificial organs, 42(11), 1104-1105. https://doi.org/10.1111/aor.13377
Bossink, E. G. B. M., Henry, O. Y. F., Benz, M. A., Segerink, L., Ingber, D. E., & Odijk, M. (2018). A miniaturized clark oxygen sensor for organ-on-chip devices. In F-G. Tseng, & G-B. Lee (Eds.), MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Science (pp. 889-892). The Chemical and Biological Microsystems Society.
Albers, H. J., da Silva Simão, J. P., Middelkamp, H. H. T., Mummery, C. L., Passier, R., van den Berg, A., ... van der Meer, A. D. (2018). Human induced pluripotent stem cell-derived endothelial cells in thrombosis-on-a-chip devices. In F-G. Tseng, & G-B. Lee (Eds.), MicroTas 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 2392-2393). The Chemical and Biological Microsystems Society.
Ribas, J., Pawlikowsk, J., & Rouwkema, J. (2018). Microphysiological systems: analysis of the current status, challenges and commercial future. Microphysiological systems, 2, [10]. https://doi.org/10.21037/mps.2018.10.01
Dekker, S., Buesink, W., Blom, M., Alessio, M., Verplanck, N., Hihoud, M., ... Odijk, M. (2018). Standardized and modular microfluidic platform for fast Lab on Chip system development. Sensors and actuators. B: Chemical, 272, 468-478. https://doi.org/10.1016/j.snb.2018.04.005
Quirós-Solano, W. F., Gaio, N., Stassen, O. M. J. A., Arik, Y. B., Silvestri, C., Van Engeland, N. C. A., ... Sarro, P. M. (2018). Microfabricated tuneable and transferable porous PDMS membranes for Organs-on-Chips. Scientific reports, 8(1), [13524]. https://doi.org/10.1038/s41598-018-31912-6
Tanumihardja, E., Olthuis, W., & van den Berg, A. (2018). Ruthenium oxide nanorods as potentiometric ph sensor for organs-on-chip purposes. Sensors (Switzerland), 18(9), [2901]. https://doi.org/10.3390/s18092901
Pamies, D., Bal-Price, A., Chesne, C., Coecke, S., Dinnyes, A., Eskes, C., ... Daneshian, M. (2018). Advanced Good Cell Culture Practice for Human Primary, Stem Cell-Derived and Organoid Models as well as Microphysiological Systems. Alternatives to Animal Experimentation, 35(3), 353-378. https://doi.org/10.14573/altex.1710081
Arık, Y. B., van der Helm, M. W., Odijk, M., Segerink, L. I., Passier, R., van den Berg, A., & van der Meer, A. D. (2018). Barriers-on-chips: Measurement of barrier function of tissues in organs-on-chips. Biomicrofluidics, 12(4), [042218]. https://doi.org/10.1063/1.5023041
Pasman, T., Grijpma, D. W., Stamatialis, D., & Poot, A. A. (2018). Flat and microstructured polymeric membranes in organs-on-chips. Journal of the Royal Society. Interface, 15(144), 1-15. [20180351]. https://doi.org/10.1098/rsif.2018.0351
Xie, S., Gardeniers, J. G. E., & Luttge, R. (2018). Nanoscale membrane actuator for in vitro mechano-stimuli responsive studies of neuronal cell networks on chip. Journal of micromechanics and microengineering, 28(8), [085011]. https://doi.org/10.1088/1361-6439/aabf7e
Quiros-Solano, W. F., Gaio, N., Silvestri, C., Arik, Y. B., Stassen, O. M. J. A., Van Der Meer, A. D., ... Sarro, P. M. (2018). A novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly. In 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018 (Vol. 2018-January, pp. 318-321). (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2018-January). IEEE. https://doi.org/10.1109/MEMSYS.2018.8346550
Devalla, H. D., & Passier, R. (2018). Cardiac differentiation of pluripotent stem cells and implications for modeling the heart in health and disease. Science Translational Medicine, 10(435), [eaah5457]. https://doi.org/10.1126/scitranslmed.aah5457
Rocca, M., Fragasso, A., Liu, W., Heinrich, M. A., & Zhang, Y. S. (2018). Embedded Multimaterial Extrusion Bioprinting. SLAS Technology, 23(2), 154-163. https://doi.org/10.1177/2472630317742071
Tibbe, M. P., Leferink, A. M., van den Berg, A., Eijkel, J. C. T., & Segerink, L. (2018). Microfluidic Gel Patterning Method by Use of a Temporary Membrane for Organ-On-Chip Applications. Advanced Materials Technologies, 3(3), [1700200]. https://doi.org/10.1002/admt.201700200
Beekers, I., van Rooij, T., Verweij, M. D., Versluis, M., de Jong, N., Trietsch, S. J., & Kooiman, K. (2018). Acoustic Characterization of a Vessel-on-a-Chip Microfluidic System for Ultrasound-Mediated Drug Delivery. IEEE transactions on ultrasonics, ferroelectrics and frequency control, 65(4), 570-581. https://doi.org/10.1109/TUFFC.2018.2803137
Jain, A., Barrile, R., van der Meer, A. D., Mammoto, A., Mammoto, T., De Ceunynck, K., ... Ingber, D. E. (2018). Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics. Clinical pharmacology & therapeutics, 103(2), 332-340. https://doi.org/10.1002/cpt.742
de Almeida Monteiro Melo Ferraz, M., Henning, H. H. W., Ferreira da Costa, P., Malda, J., le Gac, S., Bray, F., ... Gadella, B. M. (2018). Potential Health and Environmental Risks of Three-Dimensional Engineered Polymers. Environmental science & technology letters, 5(2), 80-85. https://doi.org/10.1021/acs.estlett.7b00495
Seo, J., Shin, J. Y., Leijten, J., Jeon, O., Camci-Unal, G., Dikina, A. D., ... Khademhosseini, A. (2018). High-throughput approaches for screening and analysis of cell behaviors. Biomaterials, 153, 85-101. https://doi.org/10.1016/j.biomaterials.2017.06.022
Tibbe, M. P., van der Meer, A. D., van den Berg, A., Stamatialis, D., & Segerink, L. (2018). Membranes for Organs-on-Chips. In D. Stamatialis (Ed.), Biomedical Membranes and (Bio)Artificial Organs (pp. 295-321). World Scientific. https://doi.org/10.1142/9789813223974_0011
2017
Gümüscü, B., Albers, H. J., Van Den Berg, A., Eijkel, J. C. T., & Van Der Meer, A. D. (2017). Compartmentalized 3D Tissue Culture Arrays under Controlled Microfluidic Delivery. Scientific reports, 7, [3381]. https://doi.org/10.1038/s41598-017-01944-5
van der Helm, M., Henry, O., Hamkins-Indik, T., Cronce, M., Leineweber, W., Odijk, M., ... Segerink, L. (2017). Electrical simulations and experimental results of 4-electrode AC transepithelial electrical resistance measurements in gut-on-a-chip. In A. Lee, & D. DeVoe (Eds.), 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1114-1115). (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS); Vol. 2017). Chemical and Biological Microstystems Society.
Gümüscü, B., Albers, H. J., van den Berg, A., Eijkel, J., & van der Meer, A. D. (2017). A gut-on-a-chip study: Enabling on-demand manipulation of the outer cell microenvironment in a multicompartmental 3D culture array. In A. Lee, & D. DeVoe (Eds.), 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1013). (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS); Vol. 2017). The Chemical and Biological Microsystems Society.
Loessberg-Zahl, J., Makkinga, D., van der Meer, A., Eijkel, J., & van den Berg, A. (2017). Configurable gel geometry via flow patterning for angiogenisis assays. In A. Lee, & D. D. (Eds.), 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1074-). (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS); Vol. 2017). The Chemical and Biological Microsystems Society.
Le-The, H., Palma do Carmo, M. A., van der Helm, M. W., Bomer, J. G., Segerink, L. I., van den Berg, A., & Eijkel, J. C. T. (2017). Large-area fabrication of sub-μm PDMS through hole membranes. In A. Lee, & D. DeVoe (Eds.), 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 375-376). (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS); Vol. 2017). The Chemical and Biological Microsystems Society.
Van der Meer, A. (2017). Organs-on-chips for vascular function. Toxicology Letters, 280(1), S29. https://doi.org/10.1016/j.toxlet.2017.07.069
Le Gac, S. (2017). Microfluidic technology: new opportunities to develop physiologically relevant in vitro models integrated microfluidic platform for the in vitro pre-implantation culture of individual mammalian embryos and their in situ characterization. In 47th European Solid-State Device Research Conference (ESSDERC 2017) (pp. 260-263). Piscataway, NJ: IEEE. https://doi.org/10.1109/ESSDERC.2017.8066641
Van Den Berg, A. (2017). LABS, cells and organs on chip: Technologies and biomedical applications. In TRANSDUCERS 2017 - 19th International Conference on Solid-State Sensors, Actuators and Microsystems (pp. 6-9). [7993974] IEEE. https://doi.org/10.1109/TRANSDUCERS.2017.7993974
Ribas, J., Zhang, Y. S., Pitrez, P. R., Leijten, J. C. H., Miscuglio, M., Rouwkema, J., ... Khademhosseini, A. (2017). Biomechanical Strain Exacerbates Inflammation on a Progeria-on-a-Chip Model. Small, 13(15), [1603737]. https://doi.org/10.1002/smll.201603737
Zolfagharian, A., Kouzani, A. Z., Khoo, S. Y., Gibson, I., & Kaynak, A. (2017). 3D printed hydrogel soft actuators. In Proceedings of the 2016 IEEE Region 10 Conference, TENCON 2016 (pp. 2272-2277). [7848433] IEEE. https://doi.org/10.1109/TENCON.2016.7848433
Van der Helm, M. W., Odijk, M., Frimat, J-P., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A., & Segerink, L. I. (2017). Fabrication and validation of an organ-on-chip system with integrated electrodes to directly quantify transendothelial electrical resistance. Journal of visualized experiments, 127, [e56334]. https://doi.org/10.3791/56334
Costa, P. F., Albers, H. J., Linssen, J. E. A., Middelkamp, H. H. T., van der Hout, L., Passier, R., ... van der Meer, A. D. (2017). Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data. Lab on a chip, 17(16), 2785-2792. https://doi.org/10.1039/c7lc00202e
Van Meer, B. J., de Vries, H., Firth, K. S. A., van Weerd, J., Tertoolen, L. G. J., Karperien, H. B. J., ... Mummery, C. L. (2017). Small molecule absorption by PDMS in the context of drug response bioassays. Biochemical and biophysical research communications, 482(2), 323-328. https://doi.org/10.1016/j.bbrc.2016.11.062
2016
Abbas, Y., Zhu, X., de Boer, H. L., Tanvir, N. B., Olthuis, W., & van den Berg, A. (2016). Potentiometric measurement with a Kelvin probe: Contactless measurement of chloride ions in aqueous electrolyte. Sensors and actuators. B: Chemical, 236, 1126-1132. https://doi.org/10.1016/j.snb.2016.06.150
Sinha, R., le Gac, S., Verdonschot, N. J. J., van den Berg, A., Koopman, H. F. J. M., & Rouwkema, J. (2016). Effects of varying degrees of surface strain anisotropies on endothelial cells. In 10th World Biomaterials Congress (pp. -). Montreal, Canada: Frontiers Media S.A.. https://doi.org/10.3389/conf.FBIOE.2016.01.01637
Passier, R., Orlova, V. V., & Mummery, C. (2016). Complex Tissue and Disease Modeling using hiPSCs. Cell stem cell, 18(3), 309-321. https://doi.org/10.1016/j.stem.2016.02.011
Middelkamp, H. H. T., van der Meer, A. D., Hummel, J. M., Stamatialis, D., Mummery, C. L., Passier, P. C. J. J., & IJzerman, M. J. (2016). Organs-on-Chips in Drug Development: The Importance of Involving Stakeholders in Early Health Technology Assessment. Applied in vitro toxicology, 2(2), 74-81. https://doi.org/10.1089/aivt.2015.0029
Picollet-D'hahan, N., Dolega, M. E., Liguori, L., Marquette, C., le Gac, S., Gidrol, X., & Martin, D. K. (2016). A 3D Toolbox to Enhance Physiological Relevance of Human Tissue Models. Trends in biotechnology, 34(9), 757-769. https://doi.org/10.1016/j.tibtech.2016.06.012
Ribas, J., Sadeghi, H., Manbachi, A., Leijten, J. C. H., Brinegar, K., Zhang, Y. S., ... Khademhosseini, A. (2016). Cardiovascular Organ-on-a-Chip Platforms for Drug Discovery and Development. Applied in vitro toxicology, 2(2), 82-96. https://doi.org/10.1089/aivt.2016.0002
Van der Helm, M. W., Odijk, M., Frimat, J-P., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A., & Segerink, L. I. (2016). Direct quantification of transendothelial electrical resistance in organs-on-chips. Biosensors and bioelectronics, 85, 924-929. https://doi.org/10.1016/j.bios.2016.06.014
van der Helm, M. W., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A., & Segerink, L. I. (2016). Microfluidic organ-on-chip technology for blood-brain barrier research. Tissue barriers, 4(1), e1142493-. [e1142493]. https://doi.org/10.1080/21688370.2016.1142493
Rouwkema, J., & Khademhosseini, A. (2016). Vascularization and Angiogenesis in Tissue Engineering: Beyond Creating Static Networks. Trends in biotechnology, 34(9), 733-745. https://doi.org/10.1016/j.tibtech.2016.03.002
Karperien, H. B. J. (2016). Weefselregeneratie en tissue-engineering. In B. Roelen, W. Hoekstra, B. Defize, & A. van de Graaf (Eds.), Stamcellen: wetenschap, werkelijkheid en fictie (pp. 31-35). (Cahier biowetenschappen en maatschappij; No. 35.2). Stichting BWM.
2015
van der Helm, M. W., Odijk, M., Frimat, J-P., Eijkel, J. C. T., van den Berg, A., & Segerink, L. I. (2015). Simple and stable transendothelial electrical resistance measurement in organs-on-chips. In The 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences (uTAS 2015) (pp. 771-773). (Proceedings International Conference on Miniaturized Systems for Chemistry and Life Sciences, μTAS). Chemical and Biological Micro Systems Society.
Braakhuis, H. M., Kloet, S. K., Kezic, S., Kuper, F., Park, M. V. D. Z., le Gac, S., ... Bouwmeester, H. (2015). Progress and future of in vitro models to study translocation of nanoparticles. Archives of toxicology, 89(9), 1469-1495. https://doi.org/10.1007/s00204-015-1518-5
Chen, S., van den Berg, A., & Carlen, E. (2015). Sensitivity and detection limit analysis of silicon nanowire bio(chemical) sensors. Sensors and actuators. B: Chemical, 209, 486-489. https://doi.org/10.1016/j.snb.2014.12.007
Benam, K. H., Dauth, S., Hassell, B., Herland, A., Jain, A., Jang, K. J., ... Ingber, D. E. (2015). Engineered in vitro disease models. Annual Review of Pathology: Mechanisms of Disease, 10, 195-262. https://doi.org/10.1146/annurev-pathol-012414-040418
van der Meer, A. D., Wolbers, F., & Vermes, I. (2015). Blood-brain barrier (BBB): an overview of the research of the blood-brain barrier using microfluidic devices. In A. van den Berg, L. Segerink, & L. I. Segerink (Eds.), Microfluidics for medical applications (pp. 40-53). (RSC Nanoscience & Nanotechnology; No. 36). Cambridge: Royal Society of Chemistry. https://doi.org/10.1039/9781849737593-00040
Odijk, M., van der Meer, A. D., Levner, D., Kim, H. J., van der Helm, M. W., Segerink, L. I., ... van den Berg, A. (2015). Measuring direct current trans-epithelial electrical resistance in organ-on-a-chip microsystems. Lab on a chip, 15(3), 745-752. https://doi.org/10.1039/c4lc01219d
Segerink, L., & van den Berg, A. (2015). Preface book Microfluidics for medical applications. In A. van den Berg, & L. Segerink (Eds.), Microfluidics for medical applications (pp. vii-ix). (RSC Nanoscience & Nanotechnology; No. 36). Cambridge, UK: Royal Society of Chemistry. https://doi.org/10.1039/9781849737593-FP007
2014
Moroni, L., Schrooten, J., Truckenmüller, R., Rouwkema, J., Sohier, J., & van Blitterswijk, C. (2014). Tissue Engineering: An Introduction. In C. A. van Blitterswijk, & J. de Boer (Eds.), Tissue Engineering (2 ed., pp. 1–21). Academic Press. https://doi.org/10.1016/B978-0-12-420145-3.00001-8
2013
van der Meer, A. D., Orlova, V. V., tem Dijke, P., van den Berg, A., & Mummery, C. L. (2013). Three-dimensional co-cultures of human endothelial cells and embryonic stem cell-derived pericytes inside a microfluidic device. Lab on a chip, 13(18), 3562-3568. https://doi.org/10.1039/c3lc50435b
Harink, B., le Gac, S., Truckenmüller, R. K., van Blitterswijk, C., & Habibovic, P. (2013). Regeneration-on-a-chip? The perspectives on use of microfluidics in regenerative medicine. Lab on a chip, 13(18), 3512-3528. https://doi.org/10.1039/C3LC50293G
2012
van der Meer, A. D., & van den Berg, A. (2012). Organs-on-chips: breaking the in vitro impasse. Integrative biology, 4(5), 461-470. https://doi.org/10.1039/c2ib00176d