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Medical Cell BioPhysics (MCBP)
Medical Cell BioPhysics (MCBP)
UTFacultiesTNWResearchDept BISMCBPScientific Output

MCBP Scientific Output

The publications of our group members are listed below. For older publications, please use the publications archive (2009 and older).

Jump to: 2024 | 2023 | 2022 | 2021 | 2020 | 2019 | 2018 | 2017 | 2016 | 2015 | 2014 | 2013 | 2012 | 2011 | 2010 | 2009 | 2008 | 2007 | 2006 | 2005 | 2004 | 2003 | 2002 | 2001 | 2000 | 1999 | 1998 | 1997 | 1996 | 1995 | 1994 | 1993 | 1992 | 1991 | 1990 | 1989 | 1988 | 1987 | 1986 | 1985 | 1984

2024

A nanowell platform to identify, sort and expand high antibody-producing cells (2024)Scientific reports, 14(1). Article 9457. Abali, F., Schasfoort, R., Nijland, S., Wittenberns, J., Tibbe, A. G. J., den Hartog, M., Boon, L. & Terstappen, L. W. M. M.https://doi.org/10.1038/s41598-024-60054-1Diagnostic Accuracy of Raman Spectroscopy Integrated With Polarized Light Microscopy for Calcium Pyrophosphate–Associated Arthritis (2024)Arthritis care & research, 76(9), 1333-1341. Niessink, T., Janssen, M., Giesen, T., Efdé, M. N., Comarniceanu, A. C., Otto, C. & Jansen, T. L.https://doi.org/10.1002/acr.25350Novel therapeutic strategies for the treatment of liver diseases (2024)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Geervliet, E. K.https://doi.org/10.3990/1.9789036561372High-Resolution Raman Imaging of >300 Patient-Derived Cells from Nine Different Leukemia Subtypes: A Global Clustering Approach (2024)Analytical chemistry, 96(23), 9468–9477. Vanna, R., Masella, A., Bazzarelli, M., Ronchi, P., Lenferink, A., Tresoldi, C., Morasso, C., Bedoni, M., Cerullo, G., Polli, D., Ciceri, F., De Poli, G., Bregonzio, M. & Otto, C.https://doi.org/10.1021/acs.analchem.4c00787PERFECTRA: A pragmatic, multicentre, real-life study comparing treat-to-target strategies with baricitinib versus TNF inhibitors in patients with active rheumatoid arthritis after failure on csDMARDs (2024)RMD Open, 10(2). Article e004291. van de Laar, C. J., Oude Voshaar, M. A. H., ten Klooster, P., Tedjo, D. I., Bos, R., Jansen, T., Willemze, A., Versteeg, G. A., Goekoop-Ruiterman, Y. P. M., Kroot, E.-J. & van de Laar, M.https://doi.org/10.1136/rmdopen-2024-004291Supplementary data to "High-Resolution Raman Imaging of >300 Patient-Derived Cells from Nine Different Leukemia Subtypes: A Global Clustering Approach" (2024)[Dataset Types › Dataset]. Zenodo. Vanna, R., Masella, A., Manuela, B., Lenferink, A., Morasso, C., Cerullo, G., Polli, D., Bregonzio, M. & Otto, C.https://doi.org/10.5281/zenodo.11195903Raman spectroscopic analysis of joint capsule calcification of the fingers (2024)Clinical rheumatology, 43, 1783-1784. Jansen, T. L., Janssen, M., Otto, C., Vosters, J. L. G. & Niessink, T.https://doi.org/10.1007/s10067-024-06941-4Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients (2024)Molecular oncology. Booijink, R., Terstappen, L. W. M. M., Dathathri, E., Isebia, K., Kraan, J., Martens, J. & Bansal, R.https://doi.org/10.1002/1878-0261.13653Identification of extracellular vesicles from their Raman spectra via self-supervised learning (2024)Scientific reports, 14(1). Article 6791 (E-pub ahead of print/First online). Jensen, M. N., Guerreiro, E. M., Enciso-Martinez, A., Kruglik, S. G., Otto, C., Snir, O., Ricaud, B. & Hellesø, O. G.https://doi.org/10.1038/s41598-024-56788-7Fatigue-Related Changes of Daily Function: Most Promising Measures for the Digital Age (2024)Digital Biomarkers, 8(1), 30-39 (E-pub ahead of print/First online). Maetzler, W., Guedes, L. C., Emmert, K. N., Kudelka, J., Hildesheim, H. L., Paulides, E., Connolly, H., Davies, K., Dilda, V., Ahmaniemi, T., Avedano, L., Bouça-Machado, R., Chambers, M., Chatterjee, M., Gallagher, P., Graeber, J., Maetzler, C., Kaduszkiewicz, H., Kennedy, N., … consortium, o. b. o. t. I.-F. p.https://doi.org/10.1159/000536568Treat to Target in gout yields superior outcomes compared to Treat to Avoid Symptoms approach (results from Gout TrEatment Strategy (GO TEST) OVERTURE trial) (2024)Gout, Urate, and Crystal Deposition Disease (Accepted/In press). Moses, A., Oude Voshaar, M. A. H., Jansen, T. L. T. A. & van de Laar, M. A. F. J.A magnetic microneedle to isolate single immunomagnetically labeled cells (2024)Lab on a chip, 24(3), 460-466. Stevens, M., Harder, P. & Terstappen, L. W. M. M.https://doi.org/10.1039/d3lc00920cThe Prevalence of Titanium Dioxide Particles in Synovial Fluid Samples Drops after European Union Ban (2024)Gout, Urate, and Crystal Deposition Disease, 2(1), 45-51. Niessink, T., Janssen, M., Jansen, T. L. & Otto, C.https://doi.org/10.3390/gucdd2010004Training an automated circulating tumor cell classifier when the true classification is uncertain (2024)PNAS Nexus, 3(2). Nanou, A., Stoecklein, N. H., Doerr, D., Driemel, C., Terstappen, L. W. M. M., Coumans, F. A. W. & Furmanski, P.https://doi.org/10.1093/pnasnexus/pgae048The Material World of 3D-Bioprinted and Microfluidic-Chip Models of Human Liver Fibrosis (2024)Advanced materials, 36(2). Article 2307673. Carvalho, A. M., Bansal, R., Barrias, C. C. & Sarmento, B.https://doi.org/10.1002/adma.202307673

2023

Flow-based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product (2023)Molecular oncology (E-pub ahead of print/First online). Stevens, M., Mentink, A., Coumans, F. A. W., Dathathri, E., Isebia, K. T., Kraan, J., de Wit, R., Martens, J. W. M. & Terstappen, L. W. M. M.https://doi.org/10.1002/1878-0261.13565Improving circulating tumor cell detection from diagnostic leukapheresis material: Getting the most out of it (2023)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Stevens, M.https://doi.org/10.3990/1.9789036559096Measuring antigen expression of cancer cell lines and circulating tumour cells (2023)Scientific reports, 13(1). Article 6051. Mentink, A., Isebia, K. T., Kraan, J., Terstappen, L. W. M. M. & Stevens, M.https://doi.org/10.1038/s41598-023-33179-yTest characteristics of Raman spectroscopy integrated with polarized light microscopy for the diagnosis of acute gouty arthritis (2023)Joint bone spine, 90(6). Article 105611. Niessink, T., Giesen, T., Efdé, M., Comarniceanu, A., Janssen, M., Otto, C. & Jansen, T. L.https://doi.org/10.1016/j.jbspin.2023.105611Hepatocyte survival and proliferation by fibroblast growth factor 7 attenuates liver inflammation, and fibrogenesis during acute liver injury via paracrine mechanisms (2023)Biomedicine and Pharmacotherapy, 167. Article 115612. Geervliet, E., Terstappen, L. W. M. M. & Bansal, R.https://doi.org/10.1016/j.biopha.2023.115612Improved enrichment of circulating tumor cells from diagnostic leukapheresis product (2023)Cytometry. Part A, 103(11), 881-888. Stevens, M., Mentink, A., Nanou, A., Coumans, F. A. W., Isebia, K. T., Kraan, J., Hamberg, P., Martens, J. W. M. & Terstappen, L. W. M. M.https://doi.org/10.1002/cyto.a.24779Physical association of low density lipoprotein particles and extracellular vesicles unveiled by single particle analysis (2023)Journal of Extracellular Vesicles, 12(11). Article 12376. Lozano-Andrés, E., Enciso-Martinez, A., Gijsbers, A., Ridolfi, A., Van Niel, G., Libregts, S. F. W. M., Pinheiro, C., van Herwijnen, M. J. C., Hendrix, A., Brucale, M., Valle, F., Peters, P. J., Otto, C., Arkesteijn, G. J. A. & Wauben, M. H. M.https://doi.org/10.1002/jev2.12376The 2023 ACR/EULAR Classification Criteria for Calcium Pyrophosphate Deposition Disease (2023)Annals of the rheumatic diseases, 82(10), 1248-1257. Abhishek, A., Tedeschi, S. K., Pascart, T., Latourte, A., Dalbeth, N., Neogi, T., Fuller, A., Rosenthal, A., Becce, F., Bardin, T., Ea, H. K., Filippou, G., FitzGerald, J., Iagnocco, A. M., Lioté, F., McCarthy, G. M., Ramonda, R., Richette, P., Sivera, F., … Choi, H. K.https://doi.org/10.1136/ard-2023-224575The 2023 ACR/EULAR Classification Criteria for Calcium Pyrophosphate Deposition Disease (2023)Arthritis & rheumatology, 75(10), 1703-1713. Abhishek, A., Tedeschi, S. K., Pascart, T., Latourte, A., Dalbeth, N., Neogi, T., Fuller, A., Rosenthal, A., Becce, F., Bardin, T., Ea, H. K., Filippou, G., FitzGerald, J., Iagnocco, A. M., Lioté, F., McCarthy, G. M., Ramonda, R., Richette, P., Sivera, F., … Choi, H. K.https://doi.org/10.1002/art.42619Data underlying the publication: Test characteristics of Raman spectroscopy integrated with polarized light microscopy for the diagnosis of acute gouty arthritis (2023)[Dataset Types › Dataset]. 4TU.Centre for Research Data. Niessink, T.https://doi.org/10.4121/465546d9-7a8f-4c11-8934-c00e48c44aa9Clinical image: synovitis of the metacarpophalangeal joints (2023)Annals of the rheumatic diseases, 82, 992-993. Weele, L. v. d., Niessink, T., Maas, M., Griot, P. D., Janssen, M., Otto, C., Jansen, T. L., Tas, S. W. & Vries, N. d.https://doi.org/10.1136/ard-2022-223290Development of a standard set of PROs and generic PROMs for Dutch medical specialist care: Recommendations from the Outcome-Based Healthcare Program Working Group Generic PROMs (2023)Quality of life research, 32(6), 1595-1605. Oude Voshaar, M., Terwee, C. B., Haverman, L., van der Kolk, B., Harkes, M., van Woerden, C. S., van Breda, F., Breukink, S., de Hoop, I., Vermeulen, H., de Graaf, E., Hazelet, J., van Leiden, B., Stienen, J., Hoekstra, M., Bart, H., van Bommel, H., Determann, D., Verburg, M., … Beurskens, A. J.https://doi.org/10.1007/s11136-022-03328-3Hepatic Stellate Cell Targeting Using Peptide-Modified Biologicals (2023)In Hepatic Stellate Cells: Methods and Protocols (pp. 269-284) (Methods in Molecular Biology; Vol. 2669). Humana Press. Bansal, R. & Poelstra, K.https://doi.org/10.1007/978-1-0716-3207-9_17Gradient method for accurate affinity determinations (2023)Analytical biochemistry, 667. Article 115085. Schasfoort, R. B. M.https://doi.org/10.1016/j.ab.2023.115085Data from Comparing Circulating Tumor Cell Counts with Dynamic Tumor Size Changes as Predictor of Overall Survival: A Quantitative Modeling Framework (2023)[Non-textual form › Web publication/site]. Netterberg, I., Karlsson, M. O., Terstappen, L. W. M. M., Koopman, M., Punt, C. J. A. & Friberg, L. E.https://doi.org/10.1158/1078-0432.c.6529016Calcium carbonates are novel positive birefringent crystals in synovial fluid (2023)Clinical rheumatology, 42, 635-636. Niessink, T., Otto, C., Janssen, M. & Jansen, T. L.https://doi.org/10.1007/s10067-022-06441-3In Vivo Detection of Circulating Cancer-Associated Fibroblasts in Breast Tumor Mouse Xenograft: Impact of Tumor Stroma and Chemotherapy (2023)Cancers, 15(4). Article 1127. Lu, T., Oomens, L., Terstappen, L. W. M. M. & Prakash, J.https://doi.org/10.3390/cancers15041127Circulating Tumor Cells (CTC) and Tumor-Derived Extracellular Vesicles (tdEV) (2023)In Current Cancer Research (pp. 113-136) (Current Cancer Research; Vol. Part F1235). Springer Nature. Nanou, A., Beekman, P., Enciso Martinez, A. & Terstappen, L. W. M. M.https://doi.org/10.1007/978-3-031-22903-9_6Raman hyperspectral imaging detects novel and combinations of crystals in synovial fluids of patients with a swollen joint (2023)Journal of raman spectroscopy, 54(1), 47-53. Niessink, T., Kuipers, C., Jong, B. Z. d., Lenferink, A. T. M., Janssen, M., Jansen, T. L. & Otto, C.https://doi.org/10.1002/jrs.6452Real-life results of urate-driven pharmacotherapy with three urate lowering drugs in gout: allopurinol, febuxostat and benzbromarone (2023)Exploration of Musculoskeletal Diseases, 1, 97–105. Hotea, I., Giesen, T., Comarniceanu, A., Efde, M., van Osch, F., Janssen, M. & Jansen, T. L.https://doi.org/10.37349/emd.2023.00014Single Cell Secretome Analyses of Hepatic Stellate Cells: Aiming for Single Cell Phenomics (2023)In Hepatic Stellate Cells: Methods and Protocols (pp. 257-268) (Methods in Molecular Biology; Vol. 2669). Humana Press. Booijink, R., Terstappen, L. & Bansal, R.https://doi.org/10.1007/978-1-0716-3207-9_16Tumor-Derived Extracellular Vesicles as Complementary Prognostic Factors to Circulating Tumor Cells in Metastatic Breast Cancer (2023)JCO Precision Oncology, 7. Article e2200372. Nanou, A., Miao, J., Coumans, F. A. W., Dolce, E. M., Darga, E., Barlow, W., Smerage, J. B., Paoletti, C., Godwin, A. K., Pusztai, L., Sharma, P., Thompson, A., Hortobagyi, G. N., Terstappen, L. W. M. M. & Hayes, D. F.https://doi.org/10.1200/PO.22.00372

2022

Kinetic characterization of SPR-based biomarker assays enables quality control, calibration free measurements and robust optimization for clinical application (2022)Analytical biochemistry, 658. Article 114918. Hendriks, J., Schasfoort, R. B. M., Huskens, J., Saris, D. B. F. & Karperien, M.https://doi.org/10.1016/j.ab.2022.114918Characterizing Circulating Tumor Cells and Tumor-Derived Extracellular Vesicles in Metastatic Castration-Naive and Castration-Resistant Prostate Cancer Patients (2022)Cancers, 14(18). Article 4404. Isebia, K. T., Dathathri, E., Verschoor, N., Nanou, A., de Jong, A. C., Coumans, F. A. W., Terstappen, L. W. M. M., Kraan, J., Martens, J. W. M., Bansal, R. & Lolkema, M. P.https://doi.org/10.3390/cancers14184404A type IV Autotaxin inhibitor ameliorates acute liver injury and nonalcoholic steatohepatitis (2022)EMBO molecular medicine, 14(9). Article e16333. Booijink, R., Salgado-Polo, F., Jamieson, C., Perrakis, A. & Bansal, R.https://doi.org/10.15252/emmm.202216333Physical association of low density lipoprotein particles and extracellular vesicles unveiled by single particle analysis (2022)[Working paper › Preprint]. bioRxiv. Lozano-Andrés, E., Enciso-Martinez, A., Gijsbers, A., Libregts, S. F. W. M., Pinheiro, C., Niel, G. V., Hendrix, A., Peters, P. J., Otto, C., Arkesteijn, G. J. A. & Wauben, M. H. M.https://doi.org/10.1101/2022.08.31.5060223D Culture Modeling of Metastatic Breast Cancer Cells in Additive Manufactured Scaffolds (2022)ACS applied materials & interfaces, 14(24), 28389-28402. Nanou, A., Lorenzo-Moldero, I., Gazouleas, K. D., Cortese, B. & Moroni, L.https://doi.org/10.1021/acsami.2c07492StarDist Image Segmentation Improves Circulating Tumor Cell Detection (2022)Cancers, 14(12). Article 2916. Stevens, M., Nanou, A., Terstappen, L. W. M. M., Driemel, C., Stoecklein, N. H. & Coumans, F. A. W.https://doi.org/10.3390/cancers14122916Clinical Images: Detection of titanium dioxide particles by Raman spectroscopy in synovial fluid from a swollen ankle (2022)Arthritis & rheumatology, 74(6), 1069-1069. Niessink, T., Ringoot, J., Janssen, M., Otto, C. & Jansen, T. L. T. A.https://doi.org/10.1002/art.42078Extracellular Vesicles: A New Source of Biomarkers in Pediatric Solid Tumors? A Systematic Review (2022)Frontiers in oncology, 12. Article 887210. Lak, N. S. M., van der Kooi, E. J., Enciso-Martinez, A., Lozano-Andrés, E., Otto, C., Wauben, M. H. M. & Tytgat, G. A. M.https://doi.org/10.3389/fonc.2022.887210Liquid Biopsy Based Circulating Biomarkers in Metastatic Prostate Cancer (2022)Frontiers in oncology, 12. Article 863472. Dathathri, E., Isebia, K. T., Abali, F., Lolkema, M. P., Martens, J. W. M., Terstappen, L. W. M. M. & Bansal, R.https://doi.org/10.3389/fonc.2022.863472A type IV Autotaxin inhibitor ameliorates acute liver injury and non-alcoholic steatohepatitis in mice (2022)[Working paper › Preprint]. bioRxiv. Booijink, R., Salgado-Polo, F., Jamieson, C., Perrakis, A. & Bansal, R.https://doi.org/10.1101/2022.05.19.492626One-Step Fabrication of Porous Membrane-Based Scaffolds by Air-Water Interfacial Phase Separation: Opportunities for Engineered Tissues (2022)Membranes, 12(5). Article 453. Allijn, I., du Preez, N., Tasior, M., Bansal, R. & Stamatialis, D.https://doi.org/10.3390/membranes12050453High Titers of Low Affinity Antibodies in COVID-19 Patients Are Associated With Disease Severity (2022)Frontiers in Immunology, 13. Article 867716. Hendriks, J., Schasfoort, R., Koerselman, M., Dannenberg, M., Cornet, A. D., Beishuizen, A., van der Palen, J., Krabbe, J., Mulder, A. H. L. & Karperien, M.https://doi.org/10.3389/fimmu.2022.867716Karyotype diversification in colorectal cancer (2022)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Bollen, Y.https://doi.org/10.3990/1.9789036553506Surface Plasmon Resonance Imaging (SPRi) and Photonic Integrated Circuits (PIC) for COVID-19 Severity Monitoring (2022)COVID, 2(3), 389-397. Steglich, P. & Schasfoort, R. B. M.https://doi.org/10.3390/covid2030027Lipoxygenases in chronic liver diseases: current insights and future perspectives (2022)Trends in pharmacological sciences, 43(3), 188-205. Heinrich, L., Booijink, R. S., Khurana, A. & Bansal, R.https://doi.org/10.1016/j.tips.2021.12.001Src kinase as a potential therapeutic target in non-alcoholic and alcoholic steatohepatitis (2022)Clinical and translational discovery, 2(1). Article e18. Kurniawan, D. W., Booijink, R. S., Jajoriya, A. K., Dhawan, G., Mishra, D., Oosterhuis, D., Argemi, J., Storm, G., Olinga, P., Bataller, R., Mohanty, S. K., Mishra, D. P., Prakash, J. & Bansal, R.https://doi.org/10.1002/ctd2.18Leukapheresis increases circulating tumour cell yield in non-small cell lung cancer, counts related to tumour response and survival (2022)British journal of cancer, 126, 409-418. Tamminga, M., Andree, K. C., van den Bos, H., Hiltermann, T. J. N., Mentink, A., Spierings, D. C. J., Lansdorp, P., Timens, W., Schuuring, E., Terstappen, L. W. M. M. & Groen, H. J. M.https://doi.org/10.1038/s41416-021-01634-0Efficient and error-free fluorescent gene tagging in human organoids without double-strand DNA cleavage (2022)PLoS Biology, 20(1), 1-16. Article e3001527. Bollen, Y., Hageman, J. H., van Leenen, P., Derks, L. L. M., Ponsioen, B., Buissant des Amorie, J. R., Verlaan-Klink, I., van den Bos, M., Terstappen, L. W. M. M., van Boxtel, R. & Snippert, H. J. G.https://doi.org/10.1371/journal.pbio.3001527MicroRNA in the Tumor Stroma: Diagnostic and Therapeutic Implications (2022)In The Tumor Stroma: Biology and Therapeutics. Jenny Stanford Publishing. Lu, T., Terstappen, L. W. M. M. & Prakash, J.https://doi.org/10.1201/9781003224921-8

2021

Fast and non-invasive Raman imaging of material distributions at interfaces (2021)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Nair, S.https://doi.org/10.3990/1.9789036553124Measurement of the drug sensitivity of single prostate cancer cells (2021)Cancers, 13(23). Article 6083. Abali, F., Baghi, N., Mout, L., Broekmaat, J. J., Tibbe, A. G. J. & Terstappen, L. W. M. M.https://doi.org/10.3390/cancers13236083The presence of an ECM capsule around liver tumor models blocks the penetration of (Nano)-Drugs (2021)In Proceedings of the 25th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2021 (pp. 637-638). Zuchowska, A., Bansal, R. & le Gac, S.Dynamic changes of circulating tumor DNA predict clinical outcome in patients with advanced non-small-cell lung cancer treated with immune checkpoint inhibitors (2021)JCO Precision Oncology, 5, 1540-1553. Weber, S., van der Leest, P., Donker, H. C., Schlange, T., Timens, W., Tamminga, M., Hasenleithner, S. O., Graf, R., Moser, T., Spiegl, B., Yaspo, M. L., Terstappen, L. W. M. M., Sidorenkov, G., Hiltermann, T. J., Speicher, M. R., Schuuring, E., Heitzer, E. & Groen, H. J. M.https://doi.org/10.1200/PO.21.00182A review of oxidative stress products and related genes in early alzheimer's disease (2021)Journal of Alzheimer's Disease, 83(3), 977-1001. Cioffi, F., Adam, R. H. I., Bansal, R. & Broersen, K.https://doi.org/10.3233/JAD-210497Ultrasensitive Detection and in Situ Imaging of Analytes on Graphene Oxide Analogues Using Enhanced Raman Spectroscopy (2021)Analytical chemistry, 93(38), 12966-12972. Nair, S., Gao, J., Otto, C., Duits, M. H. G. & Mugele, F.https://doi.org/10.1021/acs.analchem.1c02581High Mobility Group Box 1 Release by Cholangiocytes Governs Biliary Atresia Pathogenesis and Correlates With Increases in Afflicted Infants (2021)Hepatology, 74(2), 864-878. Mohanty, S. K., Donnelly, B., Temple, H., Ortiz-Perez, A., Mowery, S., Lobeck, I., Dupree, P., Poling, H. M., McNeal, M., Mourya, R., Jenkins, T., Bansal, R., Bezerra, J. & Tiao, G.https://doi.org/10.1002/hep.31745Reconstructing single-cell karyotype alterations in colorectal cancer identifies punctuated and gradual diversification patterns (2021)Nature genetics, 53(8), 1187-1195. Bollen, Y., Stelloo, E., van Leenen, P., van den Bos, M., Ponsioen, B., Lu, B., van Roosmalen, M. J., Bolhaqueiro, A. C. F., Kimberley, C., Mossner, M., Cross, W. C. H., Besselink, N. J. M., van der Roest, B., Boymans, S., Oost, K. C., de Vries, S. G., Rehmann, H., Cuppen, E., Lens, S. M. A., … Snippert, H. J. G.https://doi.org/10.1038/s41588-021-00891-2Nanotechnology platforms for detection and analysis of clinically relevant biological nanoparticles (2021)[Thesis › PhD Thesis - Research external, graduation external]. Wageningen University. 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Mostafa, A. M. R. H., Bansal, R. & Prakash, J.https://doi.org/10.1039/9781788015783-00307Algorithm-improved high speed and non-invasive confocal Raman imaging of two-dimensional materials (2020)National Science Review, 7(3), 620-628. Nair, S., Gao, J., Yao, Q., Duits, M. H. G., Otto, C. & Mugele, F.https://doi.org/10.1093/nsr/nwz177Innate Immunity and Pathogenesis of Biliary Atresia (2020)Frontiers in Immunology, 11. Article 329. Ortiz-Perez, A., Donnelly, B., Temple, H., Tiao, G., Bansal, R. & Mohanty, S. K.https://doi.org/10.3389/fimmu.2020.00329Label-free identification and chemical characterisation of single extracellular vesicles and lipoproteins by synchronous Rayleigh and Raman scattering (2020)Journal of Extracellular Vesicles, 9(1). Article 1730134. Enciso-Martinez, A., Van Der Pol, E., Hau, C. M., Nieuwland, R., Van Leeuwen, T. G., Terstappen, L. W. M. M. & Otto, C.https://doi.org/10.1080/20013078.2020.1730134Electrochemical Detection of Tumor-Derived Extracellular Vesicles on Nanointerdigitated Electrodes (2020)Nano letters, 20(2), 820-828. Mathew, D. G., Beekman, P., Lemay, S. G., Zuilhof, H., le Gac, S. & van der Wiel, W. G.https://doi.org/10.1021/acs.nanolett.9b02741Deep learning of circulating tumour cells (2020)Nature Machine Intelligence, 2(2), 124-133. Zeune, L. L., Boink, Y. E., van Dalum, G., Nanou, A., de Wit, S., Andree, K. C., Swennenhuis, J. F., van Gils, S. A., Terstappen, L. W. M. M. & Brune, C.https://doi.org/10.1038/s42256-020-0153-xClassifying Raman Spectra of Extracellular Vesicles based on Convolutional Neural Networks for Prostate Cancer Detection (2020)Journal of raman spectroscopy, 51(2), 293-300. Lee, W., Lenferink, A. T. M., Otto, C. & Offerhaus, H. L.https://doi.org/10.1002/jrs.5770Synchronized Rayleigh and Raman scattering for the characterization of single optically trapped extracellular vesicles (2020)Nanomedicine : nanotechnology, biology and medicine, 24. Article 102109. Enciso-Martinez, A., van der Pol, E., Lenferink, A. T. M., Terstappen, L. W. M. M., van Leeuwen, T. G. & Otto, C.https://doi.org/10.1016/j.nano.2019.102109Silver Nanocubes Coated in Ceria: Core/Shell Size Effects on Light-Induced Charge Transfer (2020)ACS applied materials & interfaces, 12(1), 1905-1912. O'Neill, D. B., Prezgot, D., Ianoul, A., Otto, C., Mul, G. & Huijser, A.https://doi.org/10.1021/acsami.9b18393FGF2 engineered SPIONs attenuate tumor stroma and potentiate the effect of chemotherapy in 3D heterospheroidal model of pancreatic tumor (2020)Nanotheranostics, 4(1), 26-39. Mardhian, D. F., Vrynas, A., Storm, G., Bansal, R. & Prakash, J.https://doi.org/10.7150/ntno.38092Modelling the tumor micro-environment in hepatocellular carcinoma using multi-cellular spheroids (2020)In Proceedings of MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 937-938) (MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences). The Chemical and Biological Microsystems Society. Ortiz-Perez, A., Zuchowska, A., Blondé, J. B., Bansal, R. & Le Gac, S.Multi-modal analysis of tumor-derived extracellular vesicles immunocaptured from plasma (2020)In MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 404-405) (MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences). The Chemical and Biological Microsystems Society. Beekman, P., Enciso-Martinez, A., Piontek, M., Terstappen, L., Roos, W., Otto, C. & Le Gac, S.Organosilicon interaction with biological membranes (2020)In MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1035-1036). The Chemical and Biological Microsystems Society. Beekman, P., Enciso-Martinez, A., Pujari, S., Zuilhof, H., Terstappen, L., Otto, C. & Le Gac, S.Why are 3D-printed molds inhibiting PDMS curing? (2020)In MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 282-283). The Chemical and Biological Microsystems Society. Venzac, B., Deng, S., Mahmoud, Z., Lenferink, A., Bray, F., Otto, C., Rolando, C. & Le Gac, S.

2019

Therapeutic Targeting of Hepatic Macrophages for the Treatment of Liver Diseases (2019)Frontiers in Immunology, 10. Article 2852. van der Heide, D., Weiskirchen, R. & Bansal, R.https://doi.org/10.3389/fimmu.2019.02852Circulating tumor cells in lung cancer are prognostic and predictive for worse tumor response in both targeted- and chemotherapy (2019)Translational Lung Cancer Research, 8(6), 854-861. Tamminga, M., de Wit, S., Schuuring, E., Timens, W., Terstappen, L. W. M. M., Hiltermann, T. J. N. & Groen, H. J. M.https://doi.org/10.21037/tlcr.2019.11.06Refractive index to evaluate staining specificity of extracellular vesicles by flow cytometry (2019)Journal of Extracellular Vesicles, 8(1). Article 1643671. de Rond, L., Libregts, S. F. W. M., Rikkert, L. G., Hau, C. M., van der Pol, E., Nieuwland, R., van Leeuwen, T. G. & Coumans, F. A. W.https://doi.org/10.1080/20013078.2019.1643671Response to letter to the editor (2019)Journal of Extracellular Vesicles, 8(1). Article 1648997. Rikkert, L. G., Nieuwland, R., Terstappen, L. W. M. M. & Coumans, F. A. W.https://doi.org/10.1080/20013078.2019.1648997Diagnostic Leukapheresis Increases Circulating Tumor Cell Yield in Non-Small Cell Lung Cancer Patients, Which Correspond with Response and Survival (2019)Cell Reports Medicine (E-pub ahead of print/First online). Tamminga, M., Andree, K. C., van den Bos, H., Mentink-Leusink, A., Spierings, D. C. J., Lansdorp, P. M., Timens, W., Schuuring, E., Terstappen, L. W. M. M. & Groen, H. J. M.https://doi.org/10.2139/ssrn.3490278Algorithm improved high speed and non-invasive confocal Raman imaging of two-dimensional materials (2019)[Contribution to conference › Poster] MESA+ Meeting 2019. Nair, S., Duits, M., Mugele, F., Otto, C., Gao, J. & Yao, Q.Circulating Tumor Cells a Real-Time Liquid Biopsy (2019)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Andree, K. C.https://doi.org/10.3990/1.9789036548182Leukocyte-Derived Extracellular Vesicles in Blood with and without EpCAM Enrichment (2019)Cells, 8(8). Article 937. Nanou, A., Zeune, L. L. & Terstappen, L. W. M. M.https://doi.org/10.3390/cells8080937Immuno-capture of extracellular vesicles for individual multi-modal characterization using AFM, SEM and Raman spectroscopy (2019)Lab on a chip, 19(15), 2526-2536. Beekman, P., Enciso-Martinez, A., Rho, H. S., Pujari, S. P., Lenferink, A., Zuilhof, H., Terstappen, L. W. M. M., Otto, C. & Le Gac, S.https://doi.org/10.1039/c9lc00081jEPAC-lung: pooled analysis of circulating tumour cells in advanced non-small cell lung cancer (2019)European journal of cancer, 117, 60-68. Lindsay, C. R., Blackhall, F. H., Carmel, A., Fernandez-Gutierrez, F., Gazzaniga, P., Groen, H. J. M., Hiltermann, T. J. N., Krebs, M. G., Loges, S., López-López, R., Muinelo-Romay, L., Pantel, K., Priest, L., Riethdorf, S., Rossi, E., Terstappen, L., Wikman, H., Soria, J. C., Farace, F., … Michiels, S.https://doi.org/10.1016/j.ejca.2019.04.019Circulating tumor cells in advanced non-small cell lung cancer patients are associated with worse tumor response to checkpoint inhibitors (2019)Journal for ImmunoTherapy of Cancer, 7(1). Article 173. Tamminga, M., De Wit, S., Hiltermann, T. J. N., Timens, W., Schuuring, E., Terstappen, L. W. M. M. & Groen, H. J. M.https://doi.org/10.1186/s40425-019-0649-2Combined microfluidics–confocal Raman microscopy platform for studying enhanced oil recovery mechanisms (2019)Journal of raman spectroscopy, 50(7), 996-1007. Gao, J., Nair, S., Duits, M. H. G., Otto, C. & Mugele, F.https://doi.org/10.1002/jrs.5601Tumor-derived extracellular vesicles in blood of metastatic breast, colorectal, prostate, and non-small cell lung cancer patients associate with worse survival (2019)Cancer research, 79(13_Supplement). Article 4464. Nanou, A., Zeune, L. L., de Wit, S., Miller, M. C., Punt, C. J. A., Groen, H. J. M., Hayes, D. F., de Bono, J. S. & Terstappen, L. W. M. M.https://doi.org/10.1158/1538-7445.am2019-4464Single tube liquid biopsy for advanced non-small cell lung cancer (2019)International journal of cancer, 144(12), 3127-3137. de Wit, S., Rossi, E., Weber, S., Tamminga, M., Manicone, M., Swennenhuis, J. F., Groothuis-Oudshoorn, C. G. M., Vidotto, R., Facchinetti, A., Zeune, L. L., Schuuring, E., Zamarchi, R., Hiltermann, T. J. N., Speicher, M. R., Heitzer, E., Terstappen, L. W. M. M. & Groen, H. J. M.https://doi.org/10.1002/ijc.32056Multiplex label free characterization of cancer cell lines using surface plasmon resonance imaging (2019)Biosensors, 9(2). Article 70. Stojanović, I., Ruivo, C. F., Van Der Velden, T. J. G., Schasfoort, R. B. M. & Terstappen, L. W. M. M.https://doi.org/10.3390/bios9020070Real-world data on discordance between estrogen, progesterone, and HER2 receptor expression on diagnostic tumor biopsy versus tumor resection material (2019)Breast cancer research and treatment, 175(2), 451-458. Berghuis, A. M. S., van Deurzen, C. H. M., Koffijberg, H., Terstappen, L. W. M. M., Sleijfer, S. & IJzerman, M. J.https://doi.org/10.1007/s10549-019-05141-yA microwell array platform to print and measure biomolecules produced by single cells (2019)Lab on a chip, 19(10), 1850-1859. Abali, F., Broekmaat, J. J., Tibbe, A. G. J., Schasfoort, R. B. M., Zeune, L. L. & Terstappen, L. W. M. M.https://doi.org/10.1039/C9LC00100JEPAC-Lung: Pooled analysis of circulating tumor cells in advanced non-small cell lung cancer (2019)Annals of oncology, 30(Supplement 2), ii7-ii7. Lindsay, C. R., Blackhall, F. H., Carmel, A., Gazzaniga, P., Groen, H. J. M., Krebs, M. G., Muinelo-Romay, L., Pantel, K., Rossi, E., Terstappen, L., Wikman, H., Soria, J.-C., Farace, F. F., Renehan, A., Dive, C., Besse, B. & Michiels, S.https://doi.org/10.1093/annonc/mdz073Understanding the Giant Gap between Single-Pore- and Membrane-Based Nanofluidic Osmotic Power Generators (2019)Small, 15(11). Article 1804279. Gao, J., Liu, X., Jiang, Y., Ding, L., Jiang, L. & Guo, W.https://doi.org/10.1002/smll.201804279Tumor cell capture from blood by flowing across antibody-coated surfaces (2019)Lab on a chip, 19(6), 1006-1012. Andree, K. C., Mentink, A., Nguyen, A. T., Goldsteen, P., van Dalum, G., Broekmaat, J. J., van Rijn, C. J. M. & Terstappen, L. W. M. M.https://doi.org/10.1039/C8LC01158CAutomated CTC Classification, Enumeration and Pheno Typing: Where Math meets Biology (2019)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Zeune, L. L.https://doi.org/10.3990/1.9789036547130Self-Seeding Microwells to Isolate and Assess the Viability of Single Circulating Tumor Cells (2019)International journal of molecular sciences, 20(3). Article 477. Andree, K., Abali, F., Oomens, L., Passanha, F., Broekmaat, J., Kraan, J., Mendelaar, P., Sleijfer, S. & Terstappen, L.https://doi.org/10.3390/ijms20030477Microfluidics and Raman imaging as a platform to study low salinity enhanced oil recovery (2019)[Contribution to conference › Poster] Physics@Veldhoven 2019. Nair, S., Otto, C., Duits, M. & Mugele, F.Quality of Extracellular Vesicle Images by Transmission Electron Microscopy is Operator and Protocol dependent (2019)Journal of Extracellular Vesicles, 8(1). Article 1555419. Rikkert, L. G., Nieuwland, R., Terstappen, L. W. M. M. & Coumans, F. A. W.https://doi.org/10.1080/20013078.2018.15554193D model of liver cancer in vitro as a tool to evaluate nanomedicines (2019)[Contribution to conference › Paper] NanoBioTech-Montreux 2019. Ortiz Perez, A., Blondé, J.-B. G. M., Bansal, R. & le Gac, S.Large expert-curated database for benchmarking document similarity detection in biomedical literature search (2019)Database : the journal of biological databases and curation, 2019, 1-67. Brown, P., Zhou, Y., Tan, A. C., El-Esawi, M. A., Liehr, T., Blanck, O., Gladue, D. P., Almeida, G. M. F., Cernava, T., Sorzano, C. O., Yeung, A. W. K., Engel, M. S., Chandrasekaran, A. R., Muth, T., Staege, M. S., Daulatabad, S. V., Widera, D., Zhang, J., Meule, A., … Nguyen, T. T. H.https://doi.org/10.1093/database/baz085On-line impedimetric monitoring of single cell electrical lysis in a microfluidic device (2019)[Contribution to conference › Poster] 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019. Sukas, S., van den Berg, A., Terstappen, L. & le Gac, S.PDMS curing inhibition by 3D-printed templates. Why? And how to avoid it (2019)[Contribution to conference › Poster] NanoBioTech-Montreux 2019. Venzac, B., le Gac, S., Otto, C. & Lenferink, A. T. M.PDMS curing inhibition by 3D-printed templates. Why? And how to avoid it (2019)[Contribution to conference › Poster] 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019. Venzac, B., le Gac, S., Yang, S., Lenferink, A. T. M. & Otto, C.

2018

Centrifugation affects the purity of liquid biopsy-based tumor biomarkers (2018)Cytometry. Part A, 93(12), 1207-1212. Rikkert, L. G., van der Pol, E., van Leeuwen, T. G., Nieuwland, R. & Coumans, F. A. W.https://doi.org/10.1002/cyto.a.23641CTC Technologies and Tools (2018)Cytometry. Part A, 93(12), 1197-1201. Coumans, F., van Dalum, G. & Terstappen, L. W. M. M.https://doi.org/10.1002/cyto.a.23684Protein-Protein Interactions in Human Disease, Part A. Advances in Protein Chemistry and Structural Biology, Volume 110. Edited by Rossen Donev. Academic Press. Amsterdam (The Netherlands) and New York: Elsevier. $171.00. xi + 275 p.; ill.; no index. ISBN: 978-0-12-814344-5. 2018 (2018)Quarterly Review of Biology, 93(4), 385. Schasfoort, R. B. M.https://doi.org/10.1086/700819Single-Cell Analyses of Prostate Cancer Liquid Biopsies Acquired by Apheresis (2018)Clinical cancer research, 24(22), 5635-5644. Lambros, M. B., Seed, G., Sumanasuriya, S., Gil, V., Crespo, M., Fontes, M., Chandler, R., Mehra, N., Fowler, G., Ebbs, B., Flohr, P., Miranda, S., Yuan, W., Mackay, A., Ferreira, A., Pereira, R., Bertan, C., Figueiredo, I., Riisnaes, R., … De Bono, J. S.https://doi.org/10.1158/1078-0432.CCR-18-0862Toward a real liquid biopsy in metastatic breast and prostate cancer: Diagnostic LeukApheresis increases CTC yields in a European prospective multicenter study (CTCTrap) (2018)International journal of cancer, 143(10), 2584-2591. Andree, K. C., Mentink, A., Zeune, L. L., Terstappen, L. W. M. M., Stoecklein, N. H., Neves, R. P., Driemel, C., Lampignano, R., Yang, L., Neubauer, H., Fehm, T., Fischer, J. C., Rossi, E., Manicone, M., Basso, U., Marson, P., Zamarchi, R., Loriot, Y., Lapierre, V., … de Bono, J. S.https://doi.org/10.1002/ijc.31752VyCAP's puncher technology for single cell identification, isolation, and analysis (2018)Cytometry. Part A, 93A(12), 1255-1259. Stevens, M., Oomens, L., Broekmaat, J. J., Weersink, J., Abali, F., Swennenhuis, J. F. & Tibbe, A. G. J.https://doi.org/10.1002/cyto.a.23631A microfluidic droplet serial dilutor with enhanced mixing (2018)[Contribution to conference › Poster] 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018. Rho, H. S., Yang, Y., Terstappen, L. W. M. M., Habibovic, P. & le Gac, S.A microfluidic droplet serial dilutor with enhanced mixing (2018)In MicroTas 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1114-1115). The Chemical and Biological Microsystems Society. Rho, H. S., Yang, Y., Terstappen, L. W. M. M., Habibović, P. & le Gac, S.Immunocapturing of extracellular vesicles on stainless steel for multi-modal individual characterization with correlative light, electron and probe microscopy (2018)[Contribution to conference › Poster] 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2018. Beekman, P., Enciso Martinez, A., Terstappen, L. W. M. M., Otto, C. & le Gac, S.Immunocapturing of extracellular vesicles on stainless steel for multi-modal individual characterization with correlative light, electron and probe microscopy (2018)In MicroTas 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 2402-2403). The Chemical and Biological Microsystems Society. Beekman, P., Enciso Martinez, A., Terstappen, L., Otto, C. & le Gac, S.EpCAMhigh and EpCAMlow circulating tumour cells in metastatic prostate and breast cancer patients (2018)Oncotarget, 9(86), 35705-35716. Mutter, S., Manicone, M., Rossi, E., Lampignano, R., Berghuis, A. M. S., Andree, K. C., IJzerman, M. J. & Terstappen, L. W. M. M.https://doi.org/10.18632/oncotarget.26298Scanning Electron Microscopy of Circulating Tumor Cells and tumor-derived Extracellular Vesicles (2018)Cancers, 10(11). Article 416. Nanou, A., Crespo, M., Flohr, P., de Bono, J. S. & Terstappen, L. W. M. M.https://doi.org/10.3390/cancers10110416Trends in SPR Cytometry: Advances in Label-Free Detection of Cell Parameters (2018)Biosensors, 8(4). Article 102. Schasfoort, R. B. M., Abali, F., Stojanovic, I., Vidarsson, G. & Terstappen, L.https://doi.org/10.3390/bios8040102A Microfluidic platform combined with Confocal Raman Imaging to study Enhanced Oil Recovery (2018)[Contribution to conference › Poster] Liquids@Interfaces 2018. Nair, S., Gao, J., Duits, M. H. G., Otto, C. & Mugele, F. G.All-printed cell counting chambers with on-chip sample preparation for point-of-care CD4 counting (2018)Biosensors & bioelectronics, 117, 659-668. Wasserberg, D., Zhang, X., Breukers, C., Connell, B. J., Baeten, E., van den Blink, D., Solà Benet, È., Bloem, A. C., Nijhuis, M., Wensing, A. M. J., Terstappen, L. W. M. M. & Beck, M.https://doi.org/10.1016/j.bios.2018.07.002Classification of cells in CTC enriched samples by advanced image analysis (2018)Cancers, 10(10). Article 377. Mutter-de Wit, S., Zeune, L. L., Hiltermann, T. J. N., Groen, H. J. M., van Dalum, G. & Terstappen, L. W. M. M.https://doi.org/10.3390/cancers10100377Label-Free Prostate Cancer Detection by Characterization of Extracellular Vesicles Using Raman Spectroscopy (2018)Analytical chemistry, 90(19), 11290-11296. Lee, W., Nanou, A., Rikkert, L., Coumans, F. A. W., Otto, C., Terstappen, L. W. M. M. & Offerhaus, H. L.https://doi.org/10.1021/acs.analchem.8b01831How to Agree on a CTC: Evaluating the Consensus in Circulating Tumor Cell Scoring (2018)Cytometry. Part A, 93(12), 1202-1206. Zeune, L. L., de Wit, S., Berghuis, A. M. S., IJzerman, M. J., Terstappen, L. W. M. M. & Brune, C.https://doi.org/10.1002/cyto.a.23576SEM-Raman image cytometry of cells (2018)Analyst, 143(18), 4495-4502. Enciso-Martinez, A., Timmermans, F. J., Nanou, A., Terstappen, L. W. M. M. & Otto, C.https://doi.org/10.1039/c8an00955dHealth economic impact of liquid biopsies in cancer management (2018)Expert review of pharmacoeconomics & outcomes research, 18(6), 593-599. IJzerman, M. J., Berghuis, A. M. S., de Bono, J. S. & Terstappen, L. W. M. M.https://doi.org/10.1080/14737167.2018.1505505How to create state-of-the-art genetic model systems: strategies for optimal CRISPR-mediated genome editing (2018)Nucleic acids research, 46(13), 6435-6454. Bollen, Y., Post, J., Koo, B.-K. & Snippert, H. J. G.https://doi.org/10.1093/nar/gky571Deep learning to identify circulating tumor cells by ACCEPT (2018)[Contribution to conference › Abstract] 11th International Symposium on Minimal Residual Cancer. Zeune, L. L., van Dalum, G., Nanou, A., Mutter-de Wit, S., Andree, K. C., Swennenhuis, J. F., Terstappen, L. W. M. M. & Brune, C.https://doi.org/10.1007/s10585-018-9911-0Circulating tumour cell increase as a biomarker of disease progression in metastatic castration-resistant prostate cancer patients with low baseline CTC counts (2018)Annals of oncology, 29(7), 1554-1560. Lorente, D., Olmos, D., Mateo, J., Dolling, D., Bianchini, D., Seed, G., Flohr, P., Crespo, M., Figueiredo, I., Miranda, S., Scher, H. I., Terstappen, L. W. M. M. & de Bono, J. S.https://doi.org/10.1093/annonc/mdy172Circulating Tumor Cells and Beyond (2018)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Mutter-de Wit, S.https://doi.org/10.3990/1.9789036545662Nanoparticle Enhancement Cascade for Sensitive Multiplex Measurements of Biomarkers in Complex Fluids with Surface Plasmon Resonance Imaging (2018)Analytical chemistry, 90(11), 6563-6571. Hendriks, J., Stojanovic, I., Schasfoort, R. B. M., Saris, D. B. F. & Karperien, M.https://doi.org/10.1021/acs.analchem.8b00260Consensus Statement on Circulating Biomarkers for Advanced Prostate Cancer (2018)European urology oncology, 1(2), 151-159. Sumanasuriya, S., Omlin, A., Armstrong, A., Attard, G., Chi, K. N., Bevan, C. L., Shibakawa, A., IJzerman, M. J., De Laere, B., Lolkema, M., Lorente, D., Luo, J., Mehra, N., Olmos, D., Scher, H., Soule, H., Stoecklein, N. H., Terstappen, L. W. M. M., Waugh, D. & de Bono, J. S.https://doi.org/10.1016/j.euo.2018.02.009Characterization of Extracellular Vesicles using Raman Spectroscope for Label-free Cancer Detection (2018)[Contribution to conference › Poster] International Society for Extracellular Vesicles Annual Meeting 2018. Lee, W., Nanou, A., Rikkert, L., Coumans, F. A. W., Otto, C., Terstappen, L. W. M. M. & Offerhaus, H. L.http://www.isev2018.orgClassification of cell populations in CTC enriched samples by advanced image analysis (2018)[Contribution to conference › Poster] 109th AACR Annual Meeting 2018. de Wit, S., Zeune, L. L., Brune, C., van Dalum, G., Hiltermann, T. J. N., Groen, H. J. M. & Terstappen, L. W. M. M.Evidence on the cost of breast cancer drugs is required for rational decision making (2018)Ecancermedicalscience, 12. Article 825. Berghuis, A. M. S., Koffijberg, H., Terstappen, L. W. M. M., Sleijfer, S. & IJzerman, M. J.https://doi.org/10.3332/ecancer.2018.825Circulating tumor cells, tumor-derived extracellular vesicles and plasma cytokeratins in castration-resistant prostate cancer patients (2018)Oncotarget, 9(27), 19283-19293. Nanou, A., Coumans, F. A. W., Dalum, G. v., Zeune, L. L., Dolling, D., Onstenk, W., Crespo, M., Fontes, M. S., Rescigno, P., Fowler, G., Flohr, P., Brune, C., Sleijfer, S., de Bono, J. S. & Terstappen, L. W. M. M.https://doi.org/10.18632/oncotarget.25019SCLC (2018)[Dataset Types › Dataset]. MCBP. Breukers, C.Interrogating Metastatic Prostate Cancer Treatment Switch Decisions: A Multi-institutional Survey (2018)European urology focus, 4(2), 235-244. Lorente, D., Ravi, P., Mehra, N., Pezaro, C., Omlin, A., Gilman, A., Miranda, M., Rescigno, P., Kolinsky, M., Porta, N., Bianchini, D., Tunariu, N., Perez, R., Mateo, J., Payne, H., Terstappen, L. W. M. M., IJzerman, M. J., Hall, E. & de Bono, J.https://doi.org/10.1016/j.euf.2016.09.005In vitro antimicrobial susceptibility testing methods: agar dilution to 3D tissue-engineered models (2018)European journal of clinical microbiology & infectious diseases, 37(2), 187-208. Schumacher, A., Vranken, T., Malhotra, A., Arts, J. J. C. & Habibovic, P.https://doi.org/10.1007/s10096-017-3089-2Parallel probing of drug uptake of single cancer cells on a microfluidic device (2018)Electrophoresis, 39(3), 548-556. Yang, Y. S., le Gac, S., Terstappen, L. & Rho, H. S.https://doi.org/10.1002/elps.201700351Device and Method for the Continuous Trapping of Circulating Tumor Cells (2018)[Patent › Patent]. Bromhead Johnson. Stevens, M., Nijsink, F. T., van Dalum, G., Tibbe, A. G. J., Broekmaat, J. J. & Terstappen, L. W. M. M.https://patents.google.com/patent/WO2018189401A1/enLeukocyte depletion using ferrofluids to enrich circulating tumor cells from diagnostic leukapheresis (2018)[Contribution to conference › Poster] 11th International Symposium on Minimal Residual Cancer (Unpublished). Mentink-Leusink, A.Modalities for image- and molecular-guided cancer surgery (2018)British journal of surgery, 105(2), e69-e83. Stammes, M. A., Bugby, S. L., Porta, T., Pierzchalski, K., Devling, T., Otto, C., Dijkstra, J., Vahrmeijer, A. L., de Geus-Oei, L. F. & Mieog, J. S. D.https://doi.org/10.1002/bjs.10789Spermine induced reversible collapse of deoxyribonucleic acid-bridged nanoparticle-based assemblies (2018)Nano research, 11(1), 383-396. Göeken, K. L., Schasfoort, R. B. M., Subramaniam, V. & Gill, R.https://doi.org/10.1007/s12274-017-1641-0

2017

Hyperspectral Raman imaging of neuritic plaques and neurofibrillary tangles in brain tissue from Alzheimer's disease patients (2017)Scientific reports, 7(1). Article 15603. Michael, R., Lenferink, A., Vrensen, G. F. J. M., Gelpi, E., Barraquer, R. I. & Otto, C.https://doi.org/10.1038/s41598-017-16002-3Characterization of Extracellular Vesicles using Raman Spectroscope for Label-free Prostate Cancer Detection (2017)[Contribution to conference › Poster] NLSEV kickoff meeting 2017. Lee, W., Nanou, A., Rikkert, L. G., Enciso Martinez, A., Coumans, F. A. W., Otto, C., Terstappen, L. W. M. M. & Offerhaus, H. L.Non-traditional whispering gallery modes inside microspheres visualized with Fourier analysis (2017)Optics express, 25(23), 28946-28956. Chang, L., Timmermans, F. & Otto, C.https://doi.org/10.1364/OE.25.028946Quantifying HER-2 expression on Circulating Tumor Cells by ACCEPT (2017)PLoS ONE, 12(10). Article e0186562. Zeune, L. L., van Dalum, G., Decraene, C., Proudhon, C., Fehm, T., Neubauer, H., Rack, B., Alunni-fabbroni, M., Terstappen, L. W. M. M., van Gils, S. A. & Brune, C.https://doi.org/10.1371/journal.pone.0186562Evaluating the consensus in circulating tumor cell scoring (2017)[Contribution to conference › Poster] 3rd Advances in Circulating Tumor Cells 2017. Zeune, L. L., Mutter-de Wit, S., van Dalum, G., Andree, K. C., Swennenhuis, J. F., Mentink-Leusink, A., Terstappen, L. W. M. M., Nanou, A. & Enciso Martinez, A.Single tube liquid biopsy for NSCLC, in Advances in Circulating Tumour Cells (2017)[Contribution to conference › Poster] 3rd Advances in Circulating Tumor Cells 2017. Mutter-de Wit, S.Microfluidic capturing of circulating tumor cells (CTC) from blood samples using Smart Sieves (2017)[Contribution to conference › Poster] Annual Dutch Meeting on Molecular and Cellular Biophysics, Dutch Biophysics 2017. Beekman, P.Rapid screening of IgG quality attributes – effects on Fc receptor binding (2017)FEBS Open Bio, 7(10), 1557-1574. Geuijen, K. P. M., Oppers-Tiemissen, C., Egging, D. F., Simons, P. J., Boon, L., Schasfoort, R. B. M. & Eppink, M. H. M.https://doi.org/10.1002/2211-5463.12283Surface plasmon resonance is an analytically sensitive method for antigen profiling of extracellular vesicles (2017)Clinical chemistry, 63(10), 1633-1641. Gool, E. L., Stojanovic, I., Schasfoort, R. B. M., Sturk, A., van Leeuwen, T. G., Nieuwland, R., Terstappen, L. W. M. M. & Coumans, F. A. W.https://doi.org/10.1373/clinchem.2016.271049Integrated Raman and electron microscopy: correlative chemical specificity and nanoscale resolution (2017)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Timmermans, F. J.https://doi.org/10.3990/1.9789462337190The cost of expensive breast cancer drugs (2017)[Contribution to conference › Poster] ESMO 2017 Congress. Berghuis, A. M. S., Koffijberg, H., Terstappen, L. W. M. M., Sleijfer, S. & IJzerman, M. J.Estimating The Drug Treatment Cost of Breast Cancer (2017)Value in health, 20(9), A430-A431. Berghuis, A. M. S., Koffijberg, H., Terstappen, L. W. M. M., Sleijfer, S. & IJzerman, M. J.https://doi.org/10.1016/j.jval.2017.08.189Rapid Buffer and Ligand Screening for Affinity Chromatography by Multiplexed Surface Plasmon Resonance Imaging (2017)Biotechnology journal, 12(9). Article 1700154. Geuijen, K. P. M., van Wijk-Basten, D. E. J. W., Egging, D. F., Schasfoort, R. B. M. & Eppink, M. H.https://doi.org/10.1002/biot.201700154Isolation of single cells for protein therapeutics using microwell selection and Surface Plasmon Resonance imaging (2017)Analytical biochemistry, 531, 45-47. Abali, F., Stevens, M., Tibbe, A. G. J., Terstappen, L. W. M. M., van der Velde, P. N. & Schasfoort, R. B. M.https://doi.org/10.1016/j.ab.2017.05.021Distinguishing septic from normal donors by detection of sPLA2-IIA from human plasma using a microsieve-based immunoassay (2017)Journal of immunological methods, 447, 86-91. Zweitzig, D. R., Tibbe, A. G., Kopnitsky, M. J., Cichonski, K. & Terstappen, L. W. M. M.https://doi.org/10.1016/j.jim.2017.04.007Automated identification of circulating tumor cells by image analysis (2017)[Contribution to conference › Abstract]. Zeune, L. L., Dalum, G. V., Bidard, F.-C., Pierga, J.-Y., Fehm, T., Neubauer, H., Rack, B., Alunni-fabbroni, M., Crespo, M., de Bono, J., Terstappen, L. W. M. M. & Brune, C.https://doi.org/10.1158/1538-7445.AM2017-1733Combining contrast invariant L1 data fidelities with nonlinear spectral image decomposition (2017)In Scale Space and Variational Methods in Computer Vision - 6th International Conference, SSVM 2017, Proceedings (pp. 80-93) (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); Vol. 10302 LNCS). Springer. Zeune, L., van Gils, S. A., Terstappen, L. & Brune, C.https://doi.org/10.1007/978-3-319-58771-4_7A new highly sensitive method for multiplex measurements of biomarkers in synovial fluid aspirates (2017)Osteoarthritis and cartilage, 25(Supplement 1), S99-S99. Article 129. Hendriks, J., Stojanovic, I., Saris, D. B. & Karperien, M.https://doi.org/10.1016/j.joca.2017.02.159EpCAM+ and EpCAM– circulating tumor cells in metastatic cancer patients: a multicenter study (2017)[Contribution to conference › Poster] American Association for Cancer Research, Washington DC, USA, April 1-5 2017. Mutter-de Wit, S.Liquid biopsy in advanced NSCLC: EpCAM+ and EpCAM– circulating tumor cells, tumor derived extracellular vesicles and cell-free circulating tumor DNA. (2017)[Contribution to conference › Poster] American Association for Cancer Research, Washington DC, USA, April 1-5 2017. Mutter-de Wit, S.Observation of whispering gallery modes through electron beam-induced deposition (2017)Optics letters, 42(7), 1337-1340. Timmermans, F. J., Chang, L., Van Wolferen, H. A. G. M., Lenferink, A. T. M. & Otto, C.https://doi.org/10.1364/OL.42.001337DNA Detection by Flow Cytometry using PNA‐Modified Metal–Organic Framework Particles (2017)Chemistry : a European journal, 23(17), 4180-4186. Mejia-Ariza, R., Rosselli, J., Breukers, C., Manicardi, A., Terstappen, L., Corradini, R. & Huskens, J.https://doi.org/10.1002/chem.201605803On-chip sample preparations for point-of-care cellular analysis of blood (2017)In Point-of-Care Diagnostics - New Progresses and Perspectives (pp. 115-139). IAPC. Zhang, X., Terstappen, L. W. M. M. & Beck, M.https://doi.org/10.5599/obp.11.4Detecting blood-based biomarkers in metastatic breast cancer: A systematic review of their current status and clinical utility (2017)International journal of molecular sciences, 18(2). Article 363. Berghuis, A. M. S., Koffijberg, H., Prakash, J., Terstappen, L. W. M. M. & IJzerman, M. J.https://doi.org/10.3390/ijms18020363Multiscale Segmentation via Bregman Distances and Nonlinear Spectral Analysis (2017)SIAM journal on imaging sciences, 10(1), 111-146. Zeune, L., van Dalum, G., Terstappen, L. W. M. M., van Gils, S. A. & Brune, C.https://doi.org/10.1137/16M1074503Hands-free cytometry of whole blood: controlled antibody release from hydrogels for on-chip cell staining (2017)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Zhang, X.https://doi.org/10.3990/1.9789036542746In vivo imaging of antileukemic drug asparaginase reveals a rapid macrophage-mediated clearance from the bone marrow (2017)The Journal of nuclear medicine, 58(2), 214-220. Van Der Meer, L. T., Terry, S. Y. A., Van Ingen Schenau, D. S., Andree, K. C., Franssen, G. M., Roeleveld, D. M., Metselaar, J. M., Reinheckel, T., Hoogerbrugge, P. M., Boerman, O. C. & van Leeuwen, F. N.https://doi.org/10.2967/jnumed.116.177741Characterization of Extracellular Vesicles using Raman Spectroscopy (2017)[Contribution to conference › Poster] Physics@Veldhoven 2017. Lee, W., Nanou, A., Terstappen, L. W. M. M., Rho, H. S., le Gac, S. & Offerhaus, H. L.Unmasking circulating tumor cells (2017)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Swennenhuis, J. F.https://doi.org/10.3990/1.9789036542685Adaptive Classification of Arbitrary Activities Through Hidden Markov Modeling with Automated Optimal Initialization (2017)In Wearable Robotics: Challenges and Trends: Proceedings of the 2nd International Symposium on Wearable Robotics, WeRob2016, October 18-21, 2016, Segovia, Spain (pp. 367-371) (Biosystems & Biorobotics; Vol. 16). Springer. Baten, C. T. M., Tromper, T. & Zeune, L. L.https://doi.org/10.1007/978-3-319-46532-6_60Automated Identification of Circulating Tumor Cells by Image Analysis (2017)[Contribution to conference › Poster] 108th AACR Annual Meeting 2017. Zeune, L. L.https://doi.org/10.1158/1538-7445.AM2017-1733Gas sensing performance at room temperature of nanogap interdigitated electrodes for detection of acetone at low concentration (2017)RSC advances, 7(79), 50279-50286. Minh, Q. N., Tong, H. D., Kuijk, A., van de Bent, F., Beekman, P. & van Rijn, C. J. M.https://doi.org/10.1039/c7ra09441hLeukocyte depletion using ferrofluids to enrich circulating tumor cells (2017)[Contribution to conference › Poster] 3rd Advances in Circulating Tumor Cells 2017 (Unpublished). Mentink-Leusink, A.Searching for Standards: Multicenter Ring Trials to Evaluate Technologies for the Enrichment of Circulating Tumor Cells (2017)Journal of thoracic oncology, 12(1), S1096. Article P2.06-039. Bender, S., Luetke-Eversloh, M., Neves, R., Stoecklein, N., Terstappen, L., Baggiani, B., Krahn, T., Pantel, K. & Schlange, T.https://doi.org/10.1016/j.jtho.2016.11.1532Targeting protein-loaded CB[8]-mediated supramolecular nanocarriers to cells (2017)RSC advances, 7(86), 54341-54346. Cavatorta, E., Voskuhl, J., Wasserberg, D., Brinkmann, J., Huskens, J. & Jonkheijm, P.https://doi.org/10.1039/c7ra10980f

2016

Challenges for CTC-based. liquid biopsies: a focus on the low CTC frequency and diagnostic leukapheresis (DLA) as potential solution. (2016)Expert review of molecular diagnostics, 16(2), 147-164. Stoecklein, N. H., Fischer, J. C., Niederacher, D. & Terstappen, L. W. M. M.https://doi.org/10.1586/14737159.2016.1123095Decline in Circulating Tumor Cell Count and treatment outcome in advanced prostate cancer (2016)European urology, 70(6), 985-992. Lorente, D., Olmos, D., Mateo, J., Bianchini, D., Seed, G., Fleisher, M., Danila, D. C., Flohr, P., Crespo, M., Figueiredo, I., Miranda, S., Beaten, K., Molina, A., Kheoh, T., McCormack, R., Terstappen, L. W. M. M., Scher, H. I. & de Bono, J. S.https://doi.org/10.1016/j.eururo.2016.05.023Cancer-ID: Isolation and characterization of tumor-derived extracellular vesicles (2016)[Contribution to conference › Poster] MIRA Day 2016. Nanou, A., Enciso Martinez, A., Beekman, P., Lee, W., Rho, H. S., le Gac, S., van Rijn, C. J. M., Offerhaus, H. L., Otto, C. & Terstappen, L. W. M. M.SPRi cytometry: sensitively sensing the sensitive side of cells (2016)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Stojanovic, I.https://doi.org/10.3990/1.6047415Correlative SEM SERS for quantitative analysis of dimer nanoparticles. (2016)Analyst, 141(23), 6455-6462. Timmermans, F. J., Lenferink, A. T. M., van Wolferen, H. A. G. M. & Otto, C.https://doi.org/10.1039/C6AN01648KLow-cost point-of-care diagnostics using printed cell counting chambers (2016)[Contribution to conference › Paper] 20th International Conference on Miniaturized Systems for Chemistry and LifeSciences, µTAS 2016. van Dalum, J., Wasserberg, D., Zhang, X., Breukers, C., Terstappen, L. W. M. M. & Beck, M.Identification and characterization of cells and extracellular vesicles (EVs) by SEM-Raman (2016)[Contribution to conference › Poster] Annual Dutch Meeting on Molecular and Cellular Biophysics, Dutch Biophysics 2016. Enciso Martinez, A., Terstappen, L. W. M. M. & Otto, C.Characterization of low affinity Fcγ receptor biotinylation under controlled reaction conditions by mass spectrometry and ligand binding analysis (2016)Protein science, 25(10), 1841-1852. Geuijen, K. P. M., Egging, D. F., Bartels, S., Schouten, J., Schasfoort, R. B. & Eppink, M. H.https://doi.org/10.1002/pro.2994Calcium Carbonate Nucleation Investigated in a Double Pulse Experiment (2016)Crystal growth & design, 16(9), 4839-4845. Liszka, B. M., Wagterveld, R. M., Witkamp, G.-J. & Otto, C.https://doi.org/10.1021/acs.cgd.6b00058Feasibility of a simple microsieve-based immunoassay platform (2016)Journal of immunological methods, 437, 21-27. Zweitzig, D. R., Tibbe, A. G. J., Nguyen, A. T., van Rijn, C. J. M., Kopnitsky, M. J., Cichonski, K. & Terstappen, L. W. M. M.https://doi.org/10.1016/j.jim.2016.07.002IMI's CANCER-ID: Status of liquid biopsy standardization (2016)Cancer research, 76(14, supplement), 1826. Article Abstract 1826. Pantel, K., Terstappen, L. W. M. M., Baggiani, B., Krahn, T. & Schlange, T.https://doi.org/10.1158/1538-7445.AM2016-1826Standardization of technologies for CTC, ctDNA and miRNA enrichment, isolation and analysis for liquid biopsies during the first year of IMI's CANCER-ID (2016)Cancer research, 76. Article Abstract 513. Schlange, T., Stoecklein, N., Neves, R. P., Pleier, S., Bender, S., Brychta, N., Luetke-Eversloh, M. V., Andree, K., Terstappen, L., Krahn, T. & Krahn, T.https://doi.org/10.1158/1538-7445.AM2016-513Cancer Stem Cells, Epithelial to Mesenchymal Markers, and Circulating Tumor Cells in Small Cell Lung Cancer (2016)Clinical lung cancer, 17(6), 535-542. Pore, M. M., Meijer, C., de Bock, G. H., Boersma-van Ek, W., Terstappen, L. W. M. M., Groen, H. J. M., Timens, W., Kruyt, F. A. E. & Hiltermann, T. J. N.https://doi.org/10.1016/j.cllc.2016.05.015Growth Rate and Morphology of a Single Calcium Carbonate Crystal on Polysulfone Film Measured with Time Lapse Raman Micro Spectroscopy (2016)Journal of analytical & bioanalytical techniques, 7(4), 321-. Article 321. Liszka, B., Lenferink, A. T. M. & Otto, C.https://doi.org/10.4172/2155-9872.1000321Circulating tumor cell (CTC) rise and outcome in patients with metastatic castration-resistant prostate cancer (mCRPC) with low baseline CTC counts. (2016)Journal of clinical oncology, 34(15), 5042-5042. Lorente, D., Olmos, D., Mateo, J., Zafeiriou, Z., Rescigno, P., Bianchini, D., Mehra, N., Molina, A., Kheoh, T., Baeten, K., Mccormack, R. T., Terstappen, L. W. M. M., Scher, H. I. & de Bono, J. S.http://ascopubs.org/doi/abs/10.1200/JCO.2016.34.15_suppl.5042Capture of Tumor Cells on Anti-EpCAM-Functionalized Poly(acrylic acid)-Coated Surfaces (2016)ACS applied materials & interfaces, 8(23), 14349-14356. Andree, K. C., Barradas, A. M. C., Nguyen, A. T., Mentink-Leusink, A., Stojanović, I., Baggerman, J., van Dalum, J., van Rijn, C. J. M. & Terstappen, L. W. M. M.https://doi.org/10.1021/acsami.6b01241Pooled Analysis of the Prognostic Relevance of Circulating Tumor Cells in Primary Breast Cancer (2016)Clinical cancer research, 22(10), 2583-2593. Janni, W. J., Rack, B., Terstappen, L. W. M. M., Pierga, J. Y., Taran, F. A., Fehm, T., Hall, C., De Groot, M. R., Bidard, F. C., Friedl, T. W. P., Fasching, P. A., Brucker, S. Y., Pantel, K. & Lucci, A.https://doi.org/10.1158/1078-0432.CCR-15-1603New technology to investigate crystallization on polymer surfaces (2016)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Liszka, B.https://doi.org/10.3990/1.9789036541169Isolation of circulating tumor cells from diagnostic leukapheresis. (2016)[Contribution to conference › Poster] EMTRAIN PhD Workshop Bayer. Andree, K. C., Mentink-Leusink, A., Scholz, M., Kirchner, R., Neves, R. P., Driemel, C., Lampignano, R., Neubauer, H., Niederacher, D., Fischer, J. C., Stoecklein, N. H. & Terstappen, L. W. M. M.Vibrational phase microscipy (2016)In Coherent Raman Scattering Microscopy (pp. 277-290). CRC Press/Balkema. Jurna, M., Otto, C. & Offerhaus, H. L.The isolation of CTC from diagnostic leukapheresis. (2016)[Contribution to conference › Poster] 107th AACR Annual Meeting 2016. Andree, K. C., Mentink-Leusink, A., Scholz, M., Krichner, R., Terstappen, L. W. M. M., Rui, R. P., Driemel, C., Lampignano, R., Neubauer, H., Niederacher, D., Fehm, T., Wolfram, H. J., Fischer, J. C. & Stoecklein, N. H.Standardization of technologies for CTC, ctDNA and miRNA enrichment, isolation and analysis for liquid biopsies during the first year of IMI’s CANCER-ID. (2016)[Contribution to conference › Poster] 107th AACR Annual Meeting 2016. Schlange, T., Stoecklein, N. H., Neves, R. P., Pleier, S., Bender, S., Brychta, N., Luetke-Eversloh, M. V., Andree, K. C., Terstappen, L. W. M. M. & Krahn, T.Integration of correlative Raman microscopy in a dualbeam FIB SEM (2016)Journal of raman spectroscopy, 47(8), 956-962. Timmermans, F. J., Liszka, B., Lenferink, A. T. M., van Wolferen, H. A. G. M. & Otto, C.https://doi.org/10.1002/jrs.4931Single cancer cell analysis on a chip (2016)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Yang, Y. S.https://doi.org/10.3990/1.9789036540919Modeling single cell antibody excretion on a biosensor (2016)Analytical biochemistry, 504, 1-3. Stojanović, I., Baumgartner, W., van der Velden, T. J. G., Terstappen, L. W. M. M. & Schasfoort, R. B. M.https://doi.org/10.1016/j.ab.2016.03.018Interpolation method for accurate affinity ranking of arrayed ligand analyte interactions (2016)Analytical biochemistry, 500, 21-23. Schasfoort, R. B. M., Andree, K., van der Velde, N., van der Kooi, A., Stojanović, I. & Terstappen, L. W. M. M.https://doi.org/10.1016/j.ab.2016.01.023Detection of apoptosis in cancer cell lines using Surface Plasmon Resonance imaging (2016)Sensing and bio-sensing research, 7, 48-54. Stojanović, I., van Hal, Y., van der Velden, T. J. G., Schasfoort, R. B. M. & Terstappen, L. W. M. M.https://doi.org/10.1016/j.sbsr.2016.01.002Challenges in circulating tumor cell detection by the CellSearch system (2016)Molecular oncology, 10(3), 395-407. Andree, K. C., van Dalum, G. & Terstappen, L. W. M. M.https://doi.org/10.1016/j.molonc.2015.12.002Controlled antibody release from gelatin for on-chip sample preparation (2016)Analyst, 141(10), 3068-3076. Zhang, X., Wasserberg, D., Breukers, C., Terstappen, L. W. M. M. & Beck, M.https://doi.org/10.1039/C5AN02090EImproving the CellSearch® system (2016)Expert review of molecular diagnostics, 16(12), 1291-1305. Swennenhuis, J. F., van Dalum, G., Zeune, L. L. & Terstappen, L. W. M. M.https://doi.org/10.1080/14737159.2016.1255144Programmable V-type Valve for Cell and Particle Manipulation in Microfluidic Devices (2016)Lab on a chip, 16(2), 305-311. Rho, H. S., Yang, Y. S., Hanke, A. T., Ottens, M., Terstappen, L. W. M. M. & Gardeniers, H.https://doi.org/10.1039/C5LC01206FProtein profiles in cortical and nuclear regions of aged human donor lenses: A confocal Raman microspectroscopic and imaging study (2016)Experimental eye research, 145, 100-109. Vrensen, G. F. J. M., Otto, C., Lenferink, A., Liszka, B., Montenegro, G. A., Barraquer, R. I. & Michael, R.https://doi.org/10.1016/j.exer.2015.11.009Redox-active host-guest supramolecular assemblies of peptides and proteins at surfaces (2016)European polymer journal, 83, 380-389. Brinkmann, J., Wasserberg, D. & Jonkheijm, P.https://doi.org/10.1016/j.eurpolymj.2016.03.029Scaffolding of cystine-stabilized miniproteins (2016)ChemistrySelect, 1(5), 1039-1046. Sankaran, S., Stojanovic, I., Barendregt, A., Heck, A. J. R., Schasfoort, R. B. M. & Jonkheijm, P.https://doi.org/10.1002/slct.201600323Simple and affordable method for immunophenotyping using a microfluidic chip sample preparation with image cytometry (2016)[Patent › Patent] (Submitted). Beck, M. & Terstappen, L. W. M. M.Temperature switch cytometry–releasing antibody on demand from inkjet-printed gelatin for on-chip immunostaining (2016)ACS applied materials & interfaces, 8(41), 27539-27545. Zhang, X., Wasserberg, D., Breukers, C., Terstappen, L. W. M. M. & Beck, M.https://doi.org/10.1021/acsami.6b09206

2015

Raman-Opto-Fluidics for high resolution cell imaging (2015)[Contribution to conference › Poster] Focus on Microscopy, FOM 2015. Liszka, B. M., Rho, H. S., Yang, Y. S., Lenferink, A. T. M., Terstappen, L. W. M. M. & Otto, C.Microfluidic device for whole genome amplification of single cancer cells isolated from whole blood (2015)[Contribution to conference › Poster] 19th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2015. Yang, Y. S., Rho, H. S., Stevens, M., Tibbe, A. G. J., Gardeniers, J. G. E. & Terstappen, L. W. M. M.Microfluidic device for DNA amplification of single cancer cells isolated from whole blood by self-seeding microwells (2015)Lab on a chip, 15(22), 4331-4337. Yang, Y., Rho, H. S., Stevens, M., Tibbe, A. G. J., Gardeniers, H. & Terstappen, L. W. M. M.https://doi.org/10.1039/C5LC00816FLabel-Free Glycoprofiling with Multiplex Surface Plasmon Resonance: A Tool to Quantify Sialylation of Erythropoietin (2015)Analytical chemistry, 87(16), 8115-8122. Geuijen, K. P. M., Halim, L. A., Schellekens, H., Schasfoort, R. B., Wijffels, R. H. & Eppink, M. H.https://doi.org/10.1021/acs.analchem.5b00870Thermal annealing using ultra-short laser pulses to improve the electrical properties of Al:ZnO thin films (2015)Acta materialia, 98, 327-335. Article 12296. Scorticati, D., Illiberi, A., Bor, T. C., Eijt, S. W. H., Schut, H., Römer, G. R. B. E., Klein Gunnewiek, M., Lenferink, A. T. M., Kniknie, B. J., Mary-Joy, R., Dorenkamper, M. S., de Lange, D. F., Otto, C., Borsa, D., Soppe, W. J. & Huis In 't Veld, A. J.https://doi.org/10.1016/j.actamat.2015.07.047EpCAM+ and EpCAM- circulating tumor cells in metastatic lung cancer (2015)[Contribution to conference › Poster] 106th AACR Annual Meeting 2015. de Wit, S., van Dalum, G., Lenferink, A. T. M., Tibbe, A. G. J., Hiltermann, J. T. N., Groen, H. J. M., van Rijn, C. J. M. & Terstappen, L. W. M. M.https://doi.org/10.1158/1538-7445.AM2015-377Raman microscopy for cellular investigations - From single cell imaging to drug carrier uptake visualization (2015)Advanced drug delivery reviews, 89, 71-90. Kann, B., Offerhaus, H. L., Windbergs, M. & Otto, C.https://doi.org/10.1016/j.addr.2015.02.006“Reagent Release from Hydrogel Coated Cell Counting Chambers for On-chip Sample Preparation” 30th Congress of the International Society for Advancement of Cytometry (2015)[Contribution to conference › Poster]. Zhang, X., Wasserberg, D., Terstappen, L. W. M. M. & Beck, M.Multiscale Segmentation of Tumor Cells Using Bregman Distances (2015)[Contribution to conference › Poster] NDNS+ Workshop 2015. Zeune, L. L., Brune, C., van Gils, S. A., van Dalum, G. & Terstappen, L. W. M. M.Identifying Circulating Tumor Cells (CTCs) by Image Analysis (2015)[Contribution to conference › Poster] MIRA Event 'Top Technology for Patients' 2015. Zeune, L. L., Brune, C., van Gils, S. A., van Dalum, G. & Terstappen, L. W. M. M.Platinum(II) as bifunctional linker in antibody-drug conjugate formation: Coupling of a 4-nitrobenzo-2-oxa-1,3-diazole fluorophore to trastuzumab as a model (2015)ChemMedChem, 10(5), 797-803. Waalboer, D. C. J., Muns, J. A., Sijbrandi, N. J., Schasfoort, R. B. M., Haselberg, R., Somsen, G. W., Houthoff, H. J. & Van Dongen, G. A. M. S.https://doi.org/10.1002/cmdc.201402496Microfluidic devices for the interrogation of single circulating tumor cells (2015)[Contribution to conference › Poster] 106th AACR Annual Meeting 2015. Yang, Y. S., Rho, H. S., Swennenhuis, J. F., Stevens, M., Tibbe, A. G. J., le Gac, S., Gardeniers, H. & Terstappen, L. W. M. M.https://doi.org/10.1158/1538-7445.AM2015-367Microfluidic devices for the interrogation of single circulating tumor cells (2015)[Contribution to conference › Abstract] 106th AACR Annual Meeting 2015. Yang, Y. S., Rho, H. S., Swennenhuis, J. F., Stevens, M., Tibbe, A. G. J., le Gac, S., Gardeniers, J. G. E. & Terstappen, L. W. M. M.https://doi.org/10.1158/1538-7445.AM2015-367Single cell isolation and DNA analysis from circulating tumor cells using a self sorting nanowell plate (2015)[Contribution to conference › Poster] 106th AACR Annual Meeting 2015. Swennenhuis, J. F., Tibbe, A. G. J., Stevens, M., Stoecklein, N. H., Neves, R., Tong, H. D., van Rijn, C. J. M. & Terstappen, L. W. M. M.https://doi.org/10.1158/1538-7445.AM2015-1606Androgen receptor expression in circulating tumour cells from castration-resistant prostate cancer patients treated with novel endocrine agents (2015)British journal of cancer, 112(7), 1166-1174. Crespo, M., van Dalum, G., Ferraldeschi, R., Zafeiriou, Z., Sideris, S., Lorente, D., Bianchini, D., Rodrigues, D. N., Riisnaes, R., Miranda, S., Figueiredo, I., Flohr, P., Nowakowska, K., de Bono, J. S., Terstappen, L. W. M. M. & Attard, G.https://doi.org/10.1038/bjc.2015.63C-reactive protein enhances IgG-mediated phagocyte responses and thrombocytopenia (2015)Blood, 125(11), 1793-1802. Kapur, R., Heitink-Pollé, K. M. J., Porcelijn, L., Bentlage, A. E. H., Bruin, M. C. A., Visser, R., Roos, D., Schasfoort, R. B. M., De Haas, M., Van Der Schoot, C. E. & Vidarsson, G.https://doi.org/10.1182/blood-2014-05-579110Label free monitoring of antibody production from individual hybridoma cells by surface plasmon resonance imaging. (2015)[Contribution to conference › Poster] De label free technologies conference van Elsevier. Stojanovic, I.Label-free imaging and identification of typical cells of acute myeloid leukaemia and myelodysplastic syndrome by Raman microspectroscopy (2015)Analyst, 140(4), 1054-1064. Vanna, R., Ronchi, P., Lenferink, A. T. M., Tresoldi, C., Morasso, C., Mehn, D., Bedoni, M., Picciolini, S., Terstappen, L. W. M. M., Ciceri, F., Otto, C. & Gramatica, F.https://doi.org/10.1039/c4an02127dThe role and definition of cancer cells in blood (2015)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. van Dalum, G.https://doi.org/10.3990/1.9789036538312A microfluidic chip for high resolution Raman imaging of biological cells (2015)RSC advances, 5(61), 49350-49355. Liszka, B., Rho, H. S., Yang, Y. S., Lenferink, A. T. M., Terstappen, L. W. M. M. & Otto, C.https://doi.org/10.1039/c5ra05185aCCR 20th Anniversary Commentary: Paving the Way for Circulating Tumor Cells (2015)Clinical cancer research, 21(13), 2883-2885. Allard, W. J. & Terstappen, L. W. M. M.https://doi.org/10.1158/1078-0432.CCR-14-2559Chapter 9: Isolation and characterization of circulating tumor cells (2015)In Microfluidics for medical applications (pp. 191-212) (Nanoscience and nanotechnology). Royal Society of Chemistry. Yang, Y. S. & Terstappen, L. W. M. M.https://doi.org/10.1039/9781849737593-00191Circulating tumor cells before and during follow-up after breast cancer surgery. (2015)International journal of oncology, 46(1), 407-413. van Dalum, G., van der Stam, G. J., Tibbe, A. G. J., Franken, B., Mastboom, W. J. B., Vermes, I., de Groot, M. R. & Terstappen, L. W. M. M.https://doi.org/10.3892/ijo.2014.2694Circulating Tumour Cells: A key to cancer detection, drug. (2015)[Other contribution › Other contribution]. NVVI dutch society for immunology. Terstappen, L. W. M. M.Contributed Review: Review of integrated correlative light and electron microscopy (2015)Review of scientific instruments, 86(1). Article 011501. Timmermans, F. J. & Otto, C.https://doi.org/10.1063/1.4905434Detection and Characterization of Circulating Tumor Cells by the CellSearch Approach (2015)In Whole Genome Amplification: Methods and Protocols (pp. 263-278) (Methods in Molecular Biology; Vol. 1347). Humana Press. Coumans, F. & Terstappen, L.https://doi.org/10.1007/978-1-4939-2990-0_18Hybrid imaging of fluorescently labeled cancer drugs and label-free four-wave mixing microscopy of cancer cells and tissues (2015)[Contribution to conference › Poster] FOM DutchBiophysics 2015. Krabbendam, R., Pool, M., Offerhaus, H. L., Herek, J. L. & Otto, C.Hybrid imaging of fluorescently labeled cancer drugs and label-free four-wave mixing microscopy of cancer cells and tissues (2015)Journal of biomedical optics, 20(8). Article 086006. Krabbendam, R., Pool, M., de Vries, L. G., Offerhaus, H. L., Herek, J. L. & Otto, C.https://doi.org/10.1117/1.jbo.20.8.086006Importance of circulating tumor cells in newly diagnosed colorectal cancer (2015)International journal of oncology, 46(3), 1361-1368. van Dalum, G., Stam, G.-J., Scholten, L. F. A., Mastboom, W. J. B., Vermes, I., Tibbe, A. G. J., de Groot, M. R. & Terstappen, L. W. M. M.https://doi.org/10.3892/ijo.2015.2824Methods and means for detecting cells using surface plasmon resonance (2015)[Patent › Patent] (Submitted). Vidarsson, G. & Schasfoort, R. B. M.MicroTrio. (2015)[Other contribution › Other contribution]. UT Niews. 03|2015.. Timmermans, F. J.Quantification of antibody production of individual hybridoma cells by Surface Plasmon Resonance imaging (2015)Analytical biochemistry, 485, 112-118. Stojanovic, I., van der Velden, T. J. G., Mulder, H. W., Schasfoort, R. B. M. & Terstappen, L. W. M. M.https://doi.org/10.1016/j.ab.2015.06.018Raman micro-spectroscopy for quantitative thickness measurement of nanometer thin polymer films (2015)Journal of raman spectroscopy, 46(12), 1230-1234. Liszka, B., Lenferink, A. T. M., Witkamp, G.-J. & Otto, C.https://doi.org/10.1002/jrs.4749Sample Preparation Methods Following CellSearch Approach Compatible of Single-Cell Whole-Genome Amplification: An Overview (2015)In Whole Genome Amplification: Methods and Protocols (pp. 57-67) (Methods in Molecular Biology). Springer. Swennenhuis, J. F. & Terstappen, L. W. M. M.https://doi.org/10.1007/978-1-4939-2990-0_4Self-seeding microwell chip for the isolation and characterization of single cells (2015)Lab on a chip, 15(14), 3039-3046. Swennenhuis, J. F., Tibbe, A. G. J., Stevens, M., Katika, M., van Dalum, J., Tong, H. D., van Rijn, C. J. M. & Terstappen, L. W. M. M.https://doi.org/10.1039/C5LC00304KThe detection of EpCAM+ and EpCAM– circulating tumor cells (2015)Scientific reports, 5. Article 12270. de Wit, S., van Dalum, G., Lenferink, A. T. M., Tibbe, A. G. J., Hiltermann, T. J. N., Groen, H. J. M., van Rijn, C. J. M. & Terstappen, L. W. M. M.https://doi.org/10.1038/srep12270

2014

Kinetics of Antibody Release from Gelatine layers for On-Chip Sample Preparation (2014)[Contribution to conference › Abstract] 4th European Conference on Microfluidics. Zhang, X., Wasserberg, D., Terstappen, L. W. M. M. & Beck, M.Kinetics of Antibody Release from Gelatine layers for On-Chip Sample Preparation (2014)[Contribution to conference › Poster] 4th European Conference on Microfluidics. Zhang, X., Wasserberg, D., Terstappen, L. W. M. M. & Beck, M.Chemically-specific dual/differential CARS micro-spectroscopy of saturated and unsaturated lipid droplets (2014)Journal of biophotonics, 7(1-2), 68-76. Di Napoli, C., Masia, F., Pope, I., Otto, C., Langbein, W. & Borri, P.https://doi.org/10.1002/jbio.201200197Integrated Raman microscope with FIB-SEM (2014)[Contribution to conference › Poster] IOP Photonic Devices Symposium 2014. Timmermans, F. J., Lenferink, A. T. M., van Wolferen, H. A. G. M. & Otto, C.Single cell in a WGA cup: Open-well whole genome amplification device (2014)[Contribution to conference › Poster] NanoBioTech Montreux 2014. Yang, Y. S., Rho, H. S., Stevens, M., Tibbe, A. G. J., Gardeniers, J. G. E. & Terstappen, L. W. M. M.Single cell in a WGA cup: Open-well whole genome amplification device (2014)[Contribution to conference › Poster] NanoCity 2014. Yang, Y. S., Rho, H. S., Stevens, M., Tibbe, A. G. J., Gardeniers, J. G. E. & Terstappen, L. W. M. M.EpCAM negative circulating tumor cells in metastatic lung cancer enriched by filtration (2014)[Contribution to conference › Poster] 2nd Advances in Circulating Tumor Cells, ACTC 2014. de Wit, S., van Dalum, G., Lenferink, A. T. M., Tibbe, A. G. J., van Rijn, C. J. M., Hiltermann, T. J. N., Groen, H. J. M. & Terstappen, L. W. M. M.Parallel single cancer cell whole genome amplification using button-valve assisted mixing in nanoliter chambers (2014)PLoS ONE, 9(9), -. Article e107958. Yang, Y. S., Swennenhuis, J. F., Rho, H. S., le Gac, S. & Terstappen, L. W. M. M.https://doi.org/10.1371/journal.pone.0107958Raman-Opto-Fluidic for in situ crystal growth imaging resolution imaging (2014)[Contribution to conference › Poster] 15th International Conference on the Crystallization of Biological Macromolecules. Liszka, B. M., Lenferink, A. T. M., Yang, Y. S., Rho, H. S., Witkamp, G.-J., Terstappen, L. W. M. M. & Otto, C.Raman-Opto-Fluidic for in situ high resolution imaging (2014)[Contribution to conference › Poster] Annual Dutch Meeting on Molecular and Cellular Biophysics, Dutch Biophysics 2014. Liszka, B.Raman-Opto-Fluidic for in situ high resolution imaging (2014)[Contribution to conference › Poster] XXIV International Conference on Raman Spectroscopy, ICORS 2014. Liszka, B. M., Lenferink, A. T. M., Yang, Y. S., Rho, H. S., Witkamp, G.-J., Terstappen, L. W. M. M. & Otto, C.Raman microspectroscopy enables the identification of different cell subpopulations in Acute Leukemia patients (2014)[Contribution to conference › Poster] GISR 2014. Vanna, R., Ronchi, P., Lenferink, A. T. M., Tresoldi, C., Terstappen, L. W. M. M., Otto, C., Mehn, D., Bedoni, M., Ciceri, F. & Gramatica, F.Spectral unmixing of heterodyne CARS microscopy in the complex plane (2014)[Contribution to conference › Abstract] Focus on Microscopy, FOM 2014. Garbacik, E. T., Korterik, J. P., Otto, C., Zare, A., Herek, J. L. & Offerhaus, H. L.Circulating tumor cells in metastatic lung cancer enriched by EpCAM expression and physical characteristics (2014)[Contribution to conference › Poster] 105th AACR Annual Meeting 2014. de Wit, S., van Dalum, G., van Dalum, J., Lenferink, A., Tibbe, A., van Rijn, C., Hiltermann, J., Groen, H. & Terstappen, L.https://doi.org/10.1158/1538-7445.AM2014-4825A simple and affordable method for immunophenotyping using a microfluidic chip sample preparation with image cytometry (2014)[Patent › Patent]. Beck, M. & Terstappen , L. W. M. M.Raman spectroscopy for the assessment of acute myeloid leukemia: a proof of concept study (2014)In Biomedical Vibrational Spectroscopy VI: Advances in Research and Industry (pp. 89390F/1-89390F/10) (Proceedings of SPIE; Vol. 8939). SPIE. Vanna, R., Tresoldi, C., Lenferink, A. T. M., Ronchi, P., Morasso, C., Mehn, D., Bedoni, M., Pignatari, C., Terstappen, L. W. M. M., Ciceri, F., Otto, C. & Gramatica, F.https://doi.org/10.1117/12.2039186Leon Terstappen on Circulating Tumor Cells: Biology and Technology (2014)[Other contribution › Other contribution]. MDPI. Terstappen, L. W. M. M.A novel side electrode configuration integrated in fused silica microsystems for synchronous optical and electrical spectroscopy (2014)Lab on a chip, 14(11), 1821-1825. Sukas, S., Schreuder, F., de Wagenaar, B., Swennenhuis, J. F., van den Berg, A., Terstappen, L. W. M. M. & le Gac, S.https://doi.org/10.1039/c3lc51433aAbsence of amyloid-beta in lenses of Alzheimer patients: A confocal Raman microspectroscopic study (2014)Experimental eye research, 119, 44-53. Michael, R., Otto, C., Lenferink, A. T. M., Gelpi, E., Montenegro, G. A., Rosandic, J., Tresssera, F., Barraquer, R. I. & Vrensen, G. F. J. M.https://doi.org/10.1016/j.exer.2013.11.016Circulating Tumor Cell: Trapping Devices (2014)In Biofunctional Surface Engineering (pp. 268-290). Pan Stanford Publishing. Coumans, F. A. W., Ligthart, S., Swennenhuis, J. F. & Terstappen, L. W. M. M.Detection of Circulating Tumor Cells (2014)Scientifica, 2014(819362), -. Article 819362. Mutter-de Wit, S., van Dalum, G. & Terstappen, L. W. M. M.https://doi.org/10.1155/2014/819362Dynamics of oligo(phenylene-ethynylene) self-assembled monolayers on Au(111) (2014)Chemical physics letters, 614, 45-48. Wu, H., Sotthewes, K., Méndez-Ardoy, A., Kudernac, T., Huskens, J., Lenferink, A., Otto, C., Schön, P. M., Vancso, G. J. & Zandvliet, H. J. W.https://doi.org/10.1016/j.cplett.2014.09.007Epi-detection of vibrational phase contrast coherent anti-Stokes Raman scattering (2014)Optics letters, 39(20), 5814-5817. Garbacik, E. T., Korterik, J. P., Otto, C., Herek, J. L. & Offerhaus, H. L.https://doi.org/10.1364/OL.39.005814High-throughput and multiplexed regeneration buffer scouting for affinity-based interactions (2014)Analytical biochemistry, 454, 38-40. Geuijen, K. P. M., Schasfoort, R. B. M., Wijffels, R. H. & Eppink, M. H. M.https://doi.org/10.1016/j.ab.2014.03.011Importance of circulating tumor cells in newly diagnosed colorectal cancer (2014)[Contribution to conference › Poster] 105th AACR Annual Meeting 2014. van Dalum, G., de Groot, M. R., Stam, G.-J., Scholten, L. F. A., Mastboom, W. J. B., Vermes, I. & Terstappen, L. W. M. M.https://doi.org/10.1158/1538-7445.AM2014-3064Integrated Correlative Raman micro-spectroscopy with FIB-SEM (2014)[Contribution to conference › Poster] Physics@FOM Veldhoven 2014. Timmermans, F. J., Lenferink, A. T. M. & Otto, C.Integrated Raman microscope with FIB-SEM (2014)[Contribution to conference › Poster] International Microscopy Congress 2014. Timmermans, F. J., Lenferink, A. T. M., van Wolferen, H. A. G. M. & Otto, C.International study on inter-reader variability for circulating tumor cells in breast cancer (2014)Breast cancer research, 16(2). Article R43. Ignatiadis, M., Riethdorf, S., Bidard, F.-C., Vaucher, I., Khazour, M., Rothe, F., Metallo, J., Rouas, G., Payne, R. E., Coombes, R. C., Teufel, I., Andergassen, U., Apostolaki, S., Politaki, E., Mavroudis, D., Bessi, S., Pestrin, M., di Leo, A., Campion, M., … Pantel, K.https://doi.org/10.1186/bcr3647Oxidative stabilization of mixed mayonnaises made with linseed oil and saturated medium-chain triglyceride oil (2014)Food chemistry, 152, 378-385. Raudsepp, P., Brüggemann, D. A., Lenferink, A. T. M., Otto, C. & Andersen, M. L.https://doi.org/10.1016/j.foodchem.2013.11.141The size of surface microstructures as an osteogenic factor in calcium phosphate ceramics (2014)Acta biomaterialia, 10(7), 3254-3263. Zhang, J., Luo, X., Barbieri, D., Barradas, A. M. C., de Bruijn, J. D., van Blitterswijk, C. & Yuan, H.https://doi.org/10.1016/j.actbio.2014.03.021

2013

High content imaging in the screening of biomaterial-induced MSC behavior (2013)Biomaterials, 34(5), 1498-1505. Unadkat, H. V., Groen, N., Doorn, J., Fischer, B., Barradas, A. M. C., Hulsman, M., van de Peppel, J., Moroni, L., van Leeuwen, J. P., Reinders, M. J. T., van Blitterswijk, C. A. & de Boer, J.https://doi.org/10.1016/j.biomaterials.2012.10.035Real Time Selection and Monitoring of Therapy for Cancer Patients. (2013)[Contribution to conference › Poster] NanoNextNL NanoMedicine Day: Royal Academy of Sciences (KNAW):. Yang, Y. S.Integrated Correlative Raman Micro-Spectroscopy with FIB-SEM (2013)[Contribution to conference › Poster] NVvM Materials Science Meeting 2013 at Utrecht University. Timmermans, F. J.Integrated Raman micro-spectroscopy with FIB-SEM (2013)[Contribution to conference › Poster] NVvM materials science meeting. Timmermans, F. J., Lenferink, A. T. M. & Otto, C.It’s all about the epitope (2013)[Contribution to conference › Poster] European Antibody Congress 2013. Schasfoort, R. B. M.Ranking the affinity (2013)[Contribution to conference › Poster] European Antibody Congress 2013. Schasfoort, R. B. M.Imaging of immunomagnetically enriched rare cells. (2013)[Patent › Patent] (Submitted). Scholtens, T. M., Greve, J., Tibbe, A. G. J., Terstappen, L. W. M. M. & Schreuder, F.Label-Free Detection of Insulin and Glucagon within Human Islets of Langerhans Using Raman Spectroscopy (2013)PLoS ONE, 8(10), e78148-e78148. Hilderink, J., Otto, C., Slump, C. H., Lenferink, A. T. M., Engelse, M. A., van Blitterswijk, C., de Koning, E. J. P., Karperien, H. B. J. & van Apeldoorn, A. A.https://doi.org/10.1371/journal.pone.0078148Applications of fluorescence and nonlinear optics for molecular imaging of cancer drugs (2013)[Contribution to conference › Poster] 37th Annual meeting NNV AMO Lunteren 2013. Krabbendam, R., Garbacik, E. T., Otto, C., de Vries, E. L., Offerhaus, H. L. & Herek, J. L.Tuning the kondo effect in thin Au films by depositing a thin layer of Au on molecular spin-dopants (2013)Nanotechnology, 24(37), 375204. Ataç, D., Gang, T., Yilmaz, M. D., Bose, S., Lenferink, A. T. M., Otto, C., de Jong, M. P., Huskens, J. & van der Wiel, W. G.https://doi.org/10.1088/0957-4484/24/37/375204coherent anti-Stokes Raman scattering (CARS) imaging for pharmaceutics (2013)[Contribution to conference › Poster] MESA+ Meeting 2013. Krabbendam, R., Fussell, A. L., Garbacik, E. T., Otto, C., Offerhaus, H. L. & Herek, J. L.Optical and electrical properties of SnO2 thin films after ultra-short pulsed laser annealing (2013)In Laser material processing for solar energy devices II (pp. 1-12) (Proceedings of SPIE). SPIE. Scorticati, D., Illiberi, A., Römer, G. R. B. E., Bor, T., Ogieglo, W., Klein Gunnewiek, M., Lenferink, A., Otto, C., Skolski, J. Z. P., Grob, F., de Lange, D. F. & Huis in 't Veld, A. J.https://doi.org/10.1117/12.2023635Pneumatic microfluidics for in-situ detection of mineralization by Micro-Raman Spectroscopy (2013)[Contribution to conference › Poster] 15th European Conference on the Spectroscopy Biological Molecules, ECSBM 2013. Liszka, B., Lenferink, A. T. M., Yang, Y. S., Rho, H. S., Witkamp, G. J., Terstappen, L. & Otto, C.Mouse models for osteoinduction and heterotopic ossification (2013)[Patent › Patent] (In preparation). Barradas, A. M. C. & de Boer, J.Circulating Tumor Cells Count and Morphological Features in Breast, Colorectal and Prostate Cancer (2013)PLoS ONE, 8(6). Article e67148. Ligthart, S. T., Coumans, F. A. W., Bidard, F. C., Simkens, L. H. J., Punt, C. J. A., De Groot, M. R., Attard, G., de Bono, J. S., Pierga, J.-Y. & Terstappen, L. W. M. M.https://doi.org/10.1371/journal.pone.0067148Label-free cell profiling (2013)[Contribution to conference › Poster] 23rd Regional Congress of the International Society of Blood Transfusion (ISBT). Schasfoort, R. B. M., Bentlage, A. E. H., Stojanovic, I., van der Kooi, A., van der Schoot, E., Terstappen, L. W. M. M. & Vidarsson, G.Molecular mechanisms of biomaterial-driven osteogenic differentiation in human mesenchymal stromal cells (2013)Integrative biology, 5(7), 920-931. Barradas, A. M. C., Monticone, V., Hulsman, M., Danoux, C., Fernandes, H. A. M., Tahmasebi Birgani, Z., Barrere-de Groot, F. Y., Yuan, H., Reinders, M. J. T., Habibovic, P., van Blitterswijk, C. & de Boer, J.https://doi.org/10.1039/C3IB40027AA simple and affordable method for immuophenotyping using a microfluidic chip sample preparation with image cytometry (2013)[Patent › Patent]. Beck, M. & Terstappen, L. W. M. M.Unbiased quantitative assessment of Her-2 expression of circulating tumor cells in patients with metastatic and non-metastatic breast cancer (2013)Annals of oncology, 24(5), 1231-1238. Ligthart, S. T., Bidard, F.-C., Decraene, C., Bachelot, T., Delaloge, S., Brain, E., Campone, M., Viens, P., Pierga, J.-Y. & Terstappen, L. W. M. M.https://doi.org/10.1093/annonc/mds625Analysis of cell surface antigens by Surface Plasmon Resonance imaging (2013)Biosensors & bioelectronics, 52, 36-43. Stojanovic, I., Schasfoort, R. B. M. & Terstappen, L. W. M. M.https://doi.org/10.1016/j.bios.2013.08.027CTCTrap: the European route to a liquid biopsy for all cancer patients (2013)[Contribution to conference › Poster] XXII Porto Cancer Meeting. Barradas, A. M. C., Mutter-de Wit, S., Swennenhuis, J. F. & Terstappen, L. W. M. M.https://www.utwente.nl/en/tnw/mcbp/documentation/Posters/#fsviewer-242344-cancer-meeting-porto-2013-joost-swennenhuisDetection of cancer before distant metastasis (2013)[Contribution to conference › Poster] 104th AACR Annual Meeting 2013. Coumans, F. A. W., Siesling, S. & Terstappen, L. W. M. M.Detection of EpCAM negative circulating tumor cells in CellSearch waste (2013)Cancer research, 73(8_supplement). Article 1459. van Dalum, G., Lenferink, A. T. M. & Terstappen, L. W. M. M.https://doi.org/10.1158/1538-7445.AM2013-1459Hyperspectral coherent anti-Stokes Raman scattering microscopy for in situ analysis of solid-state crystal polymorphs (2013)In Proceedings of Multiphoton Microscopy in the Biomedical Sciences XIII (pp. -) (Proceedings of SPIE; Vol. 8588). SPIE. Garbacik, E. T., Fussell, A. L., Gures, S., Korterik, J. P., Otto, C., Herek, J. L. & Offerhaus, H. L.https://doi.org/10.1117/12.2004522Early mineral deposition from aqueous system at surface (2013)[Contribution to conference › Poster] Physics@FOM Veldhoven 2013. Liszka, B. M., Lenferink, A. T. M., Witkamp, G.-J., Terstappen, L. W. M. M. & Otto, C.Combining technologies to create bioactive hybrid scaffolds for bone tissue engineering (2013)Biomatter, 3(2), 1-13. Article e23705. Nandakumar, A., Barradas, A. M. C., de Boer, J., Moroni, L., van Blitterswijk, C. & Habibovic, P.https://doi.org/10.4161/biom.23705Detection of cancer before distant metastasis (2013)BMC cancer, 13(1). Article 283. Coumans, F. A. W., Siesling, S. & Terstappen, L. W. M. M.https://doi.org/10.1186/1471-2407-13-283Effect of Metal–Liquid Interface Composition on the Adsorption of a Cyanine Dye onto Gold Nanoparticles (2013)Langmuir, 29(4), 1139-1147. Guerrini, L., Jurasekova, Z., del Puerto, E., Hartsuiker, L., Domingo, C., Garcia-Ramos, J. V., Otto, C. & Sanchez-Cortes, S.https://doi.org/10.1021/la304617tEfficiency of whole genome amplification of single circulating tumor cells enriched by CellSearch and sorted by FACS (2013)Genome medicine, 5(11), 1-11. Article 106. Swennenhuis, J. F., Reumers, J., Thys, K., Aerssens, J. & Terstappen, L. W. M. M.https://doi.org/10.1186/gm510Filter characteristics influencing circulating tumor cell enrichment from whole blood. (2013)PLoS ONE, 8(4). Article e61770. Coumans, F. A. W., van Dalum, G., Beck, M. & Terstappen, L.https://doi.org/10.1371/journal.pone.0061770Filtration Parameters Influencing Circulating Tumor Cell Enrichment from Whole Blood (2013)PLoS ONE, 8(4). Article e61774. Coumans, F. A. W., van Dalum, G., Beck, M. & Terstappen, L. W. M. M.https://doi.org/10.1371/journal.pone.0061774In planta imaging of Δ9-tetrahydrocannabinolic acid in Cannabis sativa L. with hyperspectral coherent anti-Stokes Raman scattering microscopy (2013)Journal of biomedical optics, 18(4), 046009-1-046009-5. Article 046009. Garbacik, E. T., Korai, R. P., Frater, E. H., Korterik, J. P., Otto, C. & Offerhaus, H. L.https://doi.org/10.1117/1.JBO.18.4.046009Isolation and characterization of circulating tumor cells. Microfluidics for medicine or medical applications. (2013)In Royal Society of Chemistry in the serie Nanoscience and nanotechnology (pp. -). Yang, Y. S. & Terstappen, L. W. M. M.Label-free cell profiling (2013)Analytical biochemistry, 439(1), 4-6. Schasfoort, R. B. M., Bentlage, A. E. H., Stojanovic, I., van der Kooi, A., van der Schoot, E., Terstappen, L. W. M. M. & Vidarsson, G.https://doi.org/10.1016/j.ab.2013.04.001Label-free Raman monitoring of extracellular matrix formation in three-dimensional polymeric scaffolds (2013)Journal of the Royal Society. Interface, 10(86), -. Article 20130464. Kunstar, A., Leferink, A. M., Okagbare, P. I., Morris, M. D., Roessler, B. J., Otto, C., Karperien, H. B. J., van Blitterswijk, C., Moroni, L. & van Apeldoorn, A. A.https://doi.org/10.1098/​rsif.2013.0464Localization precision for asymmetric single-molecule images in superresolution localization microscopy (2013)Biophysical journal, 104(2, suppl. 1), 667a-. Zhu, X., Otto, C. & Zhang, D.https://doi.org/10.1016/j.bpj.2012.11.3683Monitoring Apoptosis and BCL-2 on Circulating Tumor Cells (CTC) in Patients with Metastatic Breast Cancer (2013)Molecular oncology, 7(3), 680-692. Smerage, J. B., Budd, G. T., Doyle, G. V., Brown, M., Paoletti, C., Muniz, M., Miller, M. C., Repollet, M. I., Chianese, D. A., Connelly, M. C., Terstappen, L. W. M. M. & Hayes, D. F.https://doi.org/10.1016/j.molonc.2013.02.013The expected health economic value of using circulating tumor cells to personalize cancer treatment (2013)Value in health, 16(7), A424-A424. Article PCN180. Schreuder, K., Hummel, J. M., Terstappen, L. W. M. M. & IJzerman, M. J.https://doi.org/10.1016/j.jval.2013.08.579Towards the biological understanding of CTC: capture technolgies, definitions and potential to create metastasis (2013)Cancers, 5(4), 1619-1642. Barradas, A. M. C. & Terstappen, L. W. M. M.https://doi.org/10.3390/cancers5041619

2012

Analysis of circulating tumor cells, fragments, and debris (2012)[Patent › Patent]. Rao, G. C., Larson, C., Repollet, M., Rutner, H., Terstappen, L. W. M. M., O' Hara, S. M. & Gross, S.https://patents.google.com/patent/US8329422B2/enConstruction of repeat-free Fluorescence In situ Hybridization probes (2012)Nucleic acids research, 40(3), -. Article e20. Swennenhuis, J. F., Foulk, B., Coumans, F. A. W. & Terstappen, L. W. M. M.https://doi.org/10.1093/nar/gkr1123Catching metastasizing cells in the act (2012)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Coumans, F. A. W.https://doi.org/10.3990/1.9789036534444Applications of hyperspectral CARS microscopy (2012)[Contribution to conference › Poster] 36th NNV AMO Annual Meeting Lunteren 2012. Garbacik, E. T., Fussell, A. L., Korai, R. P., Korterik, J. P., Otto, C., Herek, J. L. & Offerhaus, H. L.Automated classification and enhanced characterization of circulating tumor cells by image cytometry (2012)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Scholtens, T. M.https://doi.org/10.3990/1.9789036534215Feasibility of genetic aberrations analysis in the Circulating Tumor Cells (CTCs) (2012)[Contribution to conference › Paper] ESMO 2012 Congress. Antonello, J., Rossi, E., Basso, U., Facchinetti, A., Zagonel, V., Swennenhuis, J. F., Terstappen, L. W. M. M., Amadori, A. & Zamarchi, R.Single-cell whole genome amplification of Circulating Tumor Cells (CTC) isolated with the CellSearch system. (2012)[Contribution to conference › Poster] 1st Advances in Circulating Tumor Cells, ACTC 2012 . Swennenhuis, J. F., Reumers, J., Aerssens, J., Thys, K. & Terstappen, L. W. M. M.Challenges in the enumeration and phenotyping of CTC (2012)Clinical cancer research, 18, 5711-5718. Coumans, F. A. W., Ligthart, S., Uhr, J. & Terstappen, L. W. M. M.https://doi.org/10.1158/1078-0432.CCR-12-1585Chemically selective imaging using CARS (2012)[Contribution to conference › Poster] MESA+ Meeting 2012. van Rhijn, A. C. W., Garbacik, E. T., Fussell, A. L., Jafar Pour, A., Jurna, M., Timmermans, F. J., Korai, R. P., Korterik, J. P., Otto, C., Offerhaus, H. L. & Herek, J. L.Applications of hyperspectral CARS microscopy (2012)[Contribution to conference › Poster] 11th European Conference on Nonlinear Optical Spectroscopy, ECONOS 2012. Garbacik, E. T., Fussell, A. L., Korai, R. P., Korterik, J. P., Otto, C., Herek, J. L. & Offerhaus, H. L.Filtration requirements for circulating tumor cell enrichment and detection (2012)[Contribution to conference › Poster] XXVII Congress of the International Society for Advancement of Cytometry, CYTO 2012. van Dalum, G., Coumans, F. A. W., Beck, M. & Terstappen, L. W. M. M.Circulating tumor cells in small-cell lung cancer: a predictive and prognostic factor (2012)Annals of oncology, 23(11), 2937-2942. Hiltermann, T. J. N., Pore, M. M., van den Berg, A., Timens, W., Boezen, H. M., Liesker, J. J. W., Schouwink, J. H., Wijnands, W. J. A., Kerner, G. S. M. A., Kruyt, F. A. E., Tissing, H., Tibbe, A. G. J., Terstappen, L. W. M. M. & Groen, H. J. M.https://doi.org/10.1093/annonc/mds138Methods and algorithms for cell enumeration in a low-cost cytometer (2012)[Patent › Patent] (Submitted). Coumans, F. A. W., Greve, J., Modica, F. P., Terstappen, L. W. M. M., Tibbe, A. G. J. & Verrant, J. A.Redefining circulating tumor cells by image processing (2012)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Ligthart, S.https://doi.org/10.3990/1.9789036533645Development and applications of nonlinear optical spectroscopy: 10th ECONOS/30th ECW meeting in Enschede, the Netherlands (2012)Journal of raman spectroscopy, 43(5), 593-594. Offerhaus, H. L., Radi, P. & Otto, C.https://doi.org/10.1002/jrs.4108All patients with metastatic breast, colorectal and prostate carcinoma have circulating tumor cells (2012)[Contribution to conference › Poster] 103rd AACR Annual Meeting 2012. Coumans, F. A. W., Ligthart, S. & Terstappen, L. W. M. M.https://doi.org/10.1158/1538-7445.AM2012-2391Key factors for filtration of tumor cells from whole blood (2012)[Contribution to conference › Poster] 103rd AACR Annual Meeting 2012. van Dalum, G., Coumans, F. A. W., Beck, M. & Terstappen, L. W. M. M.Unbiased quantitative assessment of Her-2 expression of circulating tumor cells in patients with metastatic and non metastatic breast cancer (2012)[Contribution to conference › Paper] 103rd AACR Annual Meeting 2012. Pierga, J.-Y., Ligthart, S., Bidard, F.-C., Decraene, C., Bachelot, T., Delaloge, S., Brain, E., Campone, M., Viens, P. & Terstappen, L. W. M. M.https://doi.org/10.1158/1538-7445.AM2012-2368Flat-top illumination profile in an epifluorescence microscope by dual microlens arrays (2012)Cytometry. Part A, 81A(4), 324-331. Coumans, F. A. W., van der Pol, E. & Terstappen, L. W. M. M.https://doi.org/10.1002/cyto.a.22029Background-free nonlinear microspectroscopy with vibrational molecular interferometry (2012)In Multiphoton Microscopy in the Biomedical Sciences XII: 22–24 January 2012, San Francisco, California, United States. Article 822605 (Proceedings of SPIE; Vol. 8226). SPIE. Garbacik, E. T., Korterik, J. P., Otto, C., Mukamel, S., Herek, J. L. & Offerhaus, H. L.https://doi.org/10.1117/12.908158Method and apparatus for imaging target components in a biological sample using permanent magnets (2012)[Patent › Patent] (Submitted). Tibbe, A. G. J. & Terstappen, L. W. M. M.Circulating tumor cells as a possible prognostic tool in newly diagnosed non-metastatic colorectal cancer? (2012)Journal of clinical oncology, 30(4_suppl.), 395-395. Scholten, L., Terstappen, L. W. M. M., van der Palen, J., Mastboom, W., Tibbe, A., Vermes, I. & de Groot, M.https://doi.org/10.1200/jco.2012.30.4_suppl.395Circulating tumor cells as a possible prognostic tool in newly diagnosed non-metastatic colorectal cancer? (2012)[Contribution to conference › Paper] 2012 ASCO Gastrointestinal Cancers Symposium. Scholten, L. F. A., Terstappen, L. W. M. M., van der Palen, J., Mastboom, W., Tibbe, A., Vermes, I. & de Groot, M.Automated Identification of Circulating Tumor Cells by Image Cytometry (2012)Cytometry. Part A, 81A(2), 138-148. Scholtens, T. M., Schreuder, F., Ligthart, S., Swennenhuis, J. F., Greve, J. & Terstappen, L. W. M. M.https://doi.org/10.1002/cyto.a.22002Circulating tumor cells, disease recurrence and survival in newly diagnosed breast cancer (2012)Breast cancer research, 14(5), 1-8. Article R133. Franken, B., De Groot, M. R., Mastboom, W. J. B., Vermes, I., van der Palen, J. A. M., Tibbe, A. G. J. & Terstappen, L. W. M. M.https://doi.org/10.1186/bcr3333Directed Supramolecular Surface Assembly of SNAP-tag Fusion Proteins (2012)Chemistry : a European journal, 18(22), 6788-6794. Uhlenheuer, D. A., Wasserberg, D., Haase, C., Nguyen, H. D., Schenkel, J. H., Huskens, J., Ravoo, B. J., Jonkheijm, P. & Brunsveld, L.https://doi.org/10.1002/chem.201200238FISH probe counting in circulating tumor cells (2012)In Cytokeratins - tools in oncology (pp. 119-134). InTech. Ligthart, S., Swennenhuis, J. F., Greve, J. & Terstappen, L. W. M. M.https://doi.org/10.5772/34457Immunomagnetic separation technologies (2012)In Minimal Residual Disease and Circulating Tumor Cells in Breast Cancer (pp. 43-58) (Recent Results in Cancer Research). Hoeppener, A. E. L. M., Swennenhuis, J. F. & Terstappen, L. W. M. M.https://doi.org/10.1007/978-3-642-28160-0_4Interpretation of changes in Circulating Tumor Cell counts (2012)Translational oncology, 5(6), 486-491. Coumans, F. A. W., Ligthart, S. & Terstappen, L.http://www.transonc.com/abstract.php?msid=340Metastasis and circulating tumor cells (2012)Electronic Journal of the International Federation of Clinical Chemistry and Laboratory Medicine, 23(3), 1-11. van Dalum, G., Holland, L. & Terstappen, L. W. M. M.http://www.ifcc.org/media/209935/eJIFCC%20n%203_2012_07%20Van%20Dalum.pdfMethod for estimating the single molecular affinity (2012)Analytical biochemistry, 421(2), 794-796. Schasfoort, R. B. M., de Lau, W., van der Kooi, A., Clevers, H. & Engbers, G. H. M.https://doi.org/10.1016/j.ab.2011.12.011On-chip sample preparation by controlled release of antibodies for simple CD4 counting (2012)Lab on a chip, 12, 167-173. Beck, M., Brockhuis, S., van der Velde, N., Breukers, C., Greve, J. & Terstappen, L. W. M. M.https://doi.org/10.1039/C1LC20565JOptimized filtration conditions for circulating tumor cells (2012)[Contribution to conference › Poster]. van Dalum, G., Coumans, F. A. W., Beck, M. & Terstappen, L. W. M. M.Orientationally Controlled Immobilization of Visible Fluorescent Proteins (2012)[Contribution to conference › Poster] Supramolecular Chemistry 2012 - Zing Conference. Wasserberg, D.Patterning perylenes on surfaces using thiol-ene chemistry (2012)Journal of materials chemistry, 22, 16606-16610. Wasserberg, D., Steentjes, T., Stopel, M. H. W., Huskens, J., Blum, C., Subramaniam, V. & Jonkheijm, P.https://doi.org/10.1039/c2jm32610hRaman and Fluorescence Spectral Imaging of Live Breast Cancer Cells Incubated with PEGylated Gold Nanorods (2012)Applied spectroscopy, 66(1), 66-74. Hartsuiker, L., Petersen, W., Rayavarapu, R. G., Lenferink, A. T. M., Poot, A. A., Terstappen, L. W. M. M., van Leeuwen, T., Manohar, S. & Otto, C.https://doi.org/10.1366/11-06373Rapid identification of heterogeneous mixture components with hyperspectral coherent anti-Stokes Raman scattering imaging (2012)Journal of raman spectroscopy, 43(5), 651-655. Garbacik, E. T., Herek, J. L., Otto, C. & Offerhaus, H. L.https://doi.org/10.1002/jrs.4064Recognizing different tissues in human fetal femur cartilage by label-free Raman microspectroscopy (2012)Journal of biomedical optics, 17(11), -. Article 116012. Kunstar, A., Leijten, J. C. H., van Leuveren, S., Hilderink, J., Otto, C., van Blitterswijk, C., Karperien, H. B. J. & van Apeldoorn, A. A.https://doi.org/10.1117/1.JBO.17.11.116012Replacement of Retinyl Esters by Polyunsaturated Triacylglycerol Species in Lipid Droplets of Hepatic Stellate Cells during Activation (2012)PLoS ONE, 7(4), -. Article e34945. Testerink, N., Ajat, M. A., Houweling, M., Brouwers, J. F., Pully, V. V., van Manen, H. J., Otto, C., Helms, J. B. & Vaandrager, A. B.https://doi.org/10.1371/journal.pone.0034945Self-attaching and cell-attracting in-situ forming dextran-tyramine conjugates hydrogels for arthroscopic cartilage repair (2012)Biomaterials, 33(11), 3164-3174. Moreira Teixeira, L., Bijl, S., Pully, V. V., Otto, C., Jin, R., Feijen, J., van Blitterswijk, C., Dijkstra, P. J. & Karperien, H. B. J.https://doi.org/10.1016/j.biomaterials.2012.01.001Vibrational Phase Microscopy (2012)In Coherent Raman Scattering Microscopy (pp. 277-). CRC Press (Taylor & Francis). Jurna, M., Otto, C. & Offerhaus, H. L.

2011

Microspectroscopic Characterisation of Gold Nanorods for Cancer Cell Detection (2011)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Hartsuiker, L.https://doi.org/10.3990/1.9789036532402ANALYZERS WITH TIME VARIATION BASED ON COLOR-CODED SPATIAL MODULATION (2011)[Patent › Patent]. Martini, J., Kiesel, P., Huck, M., Bern, M., Johnson Noble, M., Bassler, M., Beck, M. & Bern Marshall, W.Vibrational molecular interferometry (2011)[Contribution to conference › Poster] ICAVS6. Garbacik, E. T., Korterik, J. P., Otto, C., Herek, J. L. & Offerhaus, H. L.Non-invasive quality control for ISLET transplantation using Raman spectroscopy (2011)Histology and histopathology, 26(Suppl. 1), 308-308. Hilderink, J., de Koning, E. J. P., Engelse, M. A., Otto, C., van Blitterswijk, C. A., van Apeldoorn, A. A. & Karperien, M.Simple and affordable method for immunophenotyping using a microfluidic chip sample preparation with image cytometry. (2011)[Patent › Patent] (In preparation). Beck, M. & Terstappen, L. W. M. M.Raman and fluorescence emission of gold nanorods in live breast cancer cells (2011)[Contribution to conference › Poster] Focus on Microscopy, FOM 2011. Hartsuiker, L., Petersen, W., Lenferink, A., Manohar, S., van Leeuwen, T. G., Terstappen, L. W. M. M. & Otto, C.Characterization of individual gold nano particles for bio-medical applications (2011)[Contribution to conference › Poster] Focus on Microscopy, FOM 2011. Lenferink, A. T. M., Hartsuiker, L., Petersen, W., Manohar, S. & Otto, C.Monitoring dynamic processes in complex space with vibrational phase contrast CARS (2011)[Contribution to conference › Poster] presented with integrated video at NWO Chemistry. Garbacik, E. T., Jurna, M., Korterik, J. P., Otto, C., Herek, J. L. & Offerhaus, H. L.method for assessing disease states by profile analysis of isolated circulating endothelial cells (2011)[Patent › Patent] (Submitted). Connelly, M. C., Doyle, G. V., Rao, G. C. & Terstappen, L. W. M. M.Microsieve Filter and Methods for use in Optical Analysis (2011)[Patent › Patent] (In preparation). Tibbe, A. G. J., van Rijn, C. J. M. & Terstappen, L. W. M. M.Monitoring dynamic processes in complex space with vibrational phase contrast CARS (2011)[Contribution to conference › Poster] Physics@FOM Veldhoven 2011. Garbacik, E. T., Jurna, M., Korterik, J. P., Otto, C., Herek, J. L. & Offerhaus, H. L.Analysis of Circulating Tumor Cells, Fragments, and Debris (2011)[Patent › Patent]. Rao, G. C., Larson, C., Repollet, M., Rutner, H., Terstappen, L. W. M. M., O' Hara, S. M. & Gross, S.https://patents.google.com/patent/US7863012B2/enAcoustic carrier transport in InP-based structures (2011)Chinese journal of physics, 49(1: Special issue), 520-526. Beck, M., Yang, G., Santos, P. V. & Nötzel, R.http://psroc.org/cjp/download.php?type=paper&vol=49&num=1&page=520Background-Free Nonlinear Microspectroscopy with Vibrational Molecular Interferometry (2011)Physical review letters, 107(25). Article 253902. Garbacik, E. T., Korterik, J. P., Otto, C., Mukamel, S., Herek, J. L. & Offerhaus, H. L.https://doi.org/10.1103/PhysRevLett.107.253902CellTracks TDI: an Image Cytometer for Cell Characterization. (2011)Cytometry. Part A, 79, 203-213. Scholtens, T. M., Schreuder, F., Ligthart, S., Swennenhuis, J. F., Tibbe, A. G. J., Greve, J. & Terstappen, L. W. M. M.Circulating Cancer Cells and their Clinical Applications. (2011)Clinical chemistry, 57(11), 1478-1484. Diamandis, E. P., Pantel, K., Scher, H. I., Terstappen, L. W. M. M. & Lianidou, E.https://doi.org/10.1373/clinchem.2011.166678Circulating Melanoma Cells and Survival in Metastatic Melanoma (2011)International journal of oncology, 38(3), 755-760. Rao, C., Bui, T., Connelly, M., Doyle, G. V., Karydis, I., Middleton, M. R., Clack, G., Malone, M., Coumans, F. A. W. & Terstappen, L. W. M. M.Circulating Tumor Cell isolation and diagnostics: towards routine clinical use (2011)Cancer research, 71(18), 5955-5960. van der Stolpe, A., Pantel, K., Sleijfer, S., Terstappen, L. W. M. M. & den Toonder, J. M. J.https://doi.org/10.1158/0008-5472.CAN-11-1254External quality assurance of circulating tumor cell enumeration using the CellSearch(®) system: a feasibility study (2011)Cytometry. Part B : Clinical cytometry, 80B(2), 112-118. Kraan, J., Sleijfer, S., Strijbos, M. H., Ingatiadis, M., Peeters, D., Pierga, J. Y., Farace, F., Rietdorf, S., Fehm, T., Zorzino, L., Tibbe, A. G. J., Maestro, M., Gisbert-Criado, R., Denton, G., de Bono, J. S., Dive, C., Foekens, J. A. & Gratema, J. W.https://doi.org/10.1002/cyto.b.20573Gold nanoparticles for tumour detection and treatment (2011)In Clinical and Biomedical Spectroscopy and Imaging II. Article 80871O (Proceedings of SPIE; Vol. 8087). SPIE. Hartsuiker, L., Petersen, W., Jose, J., van Es, P., Lenferink, A. T. M., Poot, A. A., Terstappen, L. W. M. M., van Leeuwen, T., Manohar, S. & Otto, C.https://doi.org/10.1117/12.889131Identification of autoantibody profiles by monitoring autoantibody biomarkers in rheumatoid arthritis with microarray surface plasmon resonance imaging (2011)Arthritis & rheumatism, 63(S10), S685-S686. Article 1747. van Beers, J. J. B. C., Segbers-Lokate, A. M. C., Vree-Egberts, W., Schasfoort, R. B. M. & Pruijn, G. J. M.https://acrabstracts.org/meetings-archive/Lgr5 homologues associate with Wnt receptors and mediate R-spondin signalling (2011)Nature, 476(7360), 293-297. de Lau, W., Barker, N., Low, T. Y., Koo, B.-K., Li, V. S. W., Teunissen, H., Kujala, P., Haegebarth, A., Peters, P. J. M., van de Wetering, M., Stange, D. E., Es, J. E., Guardavaccaro, D., Schasfoort, R. B. M., Mohri, Y., Nishimori, K., Mohammed, S., Heck, A. J. R. & Clevers, H.https://doi.org/10.1038/nature10337Monitoring CD4 in Whole Blood with an Opto-fluidic Detector Based on Spatially Modulated Fluorescence Emission (2011)Cytometry. Part A, 79A(4), 317-324. Kiesel, P. & Beck, M.https://doi.org/10.1002/cyto.a.21042Monomer adsorption of indocyanine green to gold nanoparticles (2011)Nanoscale, 3(10), 4247-4253. Guerrini, L., Hartsuiker, L., Manohar, S. & Otto, C.https://doi.org/10.1039/C1NR10551EQuantitative detection of gold nanoparticles on individual, unstained cancer cells by Scanning Electron Microscopy (2011)Journal of microscopy, 244(2), 187-193. Hartsuiker, L., van Es, P., Petersen, W., van Leeuwen, T. G., Terstappen, L. W. M. M. & Otto, C.https://doi.org/10.1111/j.1365-2818.2011.03528.xQuantum Dots are key for Raman/fluorescence Combo (2011)BioOptics World, 4(6), -. Otto, C. & van Manen, H. J.Raman microspectroscopy: A non-invasive analysis tool for monitoring of collagen-containing extracellular matrix formation in a medium-throughput culture system (2011)Tissue engineering. Part C: Methods, 17(7), 737-744. Kunstar, A., Otto, C., Karperien, H. B. J., van Blitterswijk, C. & van Apeldoorn, A. A.https://doi.org/10.1089/ten.tec.2010.0574Single-Molecule DNA Force Spectroscopy to Probe Interactions with the Tri-Peptide Lys-Trp-Lys (2011)ChemPhysChem, 12(14), 2545-2548. Murade, C. U., Subramaniam, V., Otto, C. & Bennink, M. L.https://doi.org/10.1002/cphc.201100561Strategies for patterning biomolecules with dip-pen nanolithography (2011)Small, 7(8), 989-1002. Wu, C. C., Reinhoudt, D., Otto, C., Subramaniam, V. & Velders, A.https://doi.org/10.1002/smll.201190026The feasibility of Cryo In-SEM Raman microspectroscopy (2011)Journal of microscopy, 244(2), 122-128. Hazekamp, J., Reed, M. G., Howard, C. V., van Apeldoorn, A. A. & Otto, C.https://doi.org/10.1111/j.1365-2818.2011.03515Time Lapse Raman Imaging of Single Live Lymphocytes (2011)Journal of raman spectroscopy, 42(2), 167-173. Pully, V. V., Lenferink, A. T. M. & Otto, C.https://doi.org/10.1002/jrs.2683Unbiased and automated identification of a circulating tumour cell definition that associates with overall survival (2011)PLoS ONE, 6(11), e27419-. Ligthart, S., Coumans, F. A. W., Attard, G., Mukick Cassidy, A., de Bono, J. S. & Terstappen, L. W. M. M.https://doi.org/10.1371/journal.pone.0027419

2010

High-density periodic arrays of subwavelength nanopyramids for surface enhanced Raman scattering (2010)In XXII International Conference on Raman Spectroscopy, ICORS 2010 (pp. 960-961) (AIP conference proceedings; Vol. 1267). American Institute of Physics. Jin, M., Pully, V., Otto, C., Van Den Berg, A. & Carlen, E. T.https://doi.org/10.1063/1.3482914Vibrational phase contrast CARS imaging (2010)In XXII International Conference on Raman Spectroscopy, ICORS 2010 (pp. 90-91). Offerhaus, H. L., Jurna, M., Korterik, J. P. & Otto, C.https://doi.org/10.1063/1.3482884Detecteren en karakteriseren van kankercellen in bloed (2010)[Contribution to conference › Paper] Health Valley. Terstappen, L. W. M. M.Method and apparatus from imaging target components in a biological sample using permanent magnets (2010)[Patent › Patent] (Submitted). Tibbe, A. G. J. & Terstappen, L. W. M. M.CTC classification with the Cellsearch system (2010)[Other contribution › Other contribution]. Terstappen, L. W. M. M.Spatially modulated emission' advances point-of-care diagnostics (2010)Laser Focus World, 46(10), 47-50. Kiesel, P., Martini, J., Beck, M., Huck, M., Bern, M. & Johnson, N.https://www.laserfocusworld.com/articles/2010/11/optofluidics-spatially-modulated-emission-advances-point-of-care-diagnostics.htmlIntegrated Microspectrometer for Biological Applications (2010)[Contribution to conference › Poster] 34th Annual Meeting NNV AMO Lunteren 2010. Stephenson, A. J., Garbacik, E. T., Jurna, M., Korterik, J. P., Herek, J. L., Otto, C. & Offerhaus, H. L.Hybrid imaging of gold nanorods on breast cancer cells (2010)[Contribution to conference › Poster] Annual Dutch meeting on Molecular and Cellular Biophysics 2010. Hartsuiker, L., van Es, P., Petersen, W., Manohar, S., van Leeuwen, T., van Apeldoorn, A. A., Poot, A. A., Terstappen, L. W. M. M. & Otto, C.A lab-on-a-chip system integrated with subwavelength periodic patterned metal surfaces for sers-based molecular identification biosensing (2010)In Proceedings of the 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010 (pp. 1250-1252) (International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]; Vol. 2010). The Chemical and Biological Microsystems Society. Jin, M., Shui, L., Otto, C., van den Berg, A. & Carlen, E.Integrated electrokinetic Lab-on-a-chip based biosensor- a tool for drug screening applications (2010)In 14th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2010 (pp. 581-583) (International Conference on Miniaterized Systems for Chemistry and Life Sciences : [proceedings]; Vol. 2010). The Chemical and Biological Microsystems Society. Krishnamoorthy, G., Carlen, E. T., Schasfoort, R. B. M. & van den Berg, A.A Method For Assessing Disease States By Profile Analysis of Isolated Circulating Endothelial Cells (2010)[Patent › Patent] (Submitted). Connelly, M. C., Doyle, G. V., Rao, G. C. & Terstappen, L. W. M. M.Broadband Raman Response of Gold Nanorods With And Without Cancer Cells (2010)[Contribution to conference › Poster] XXII International Conference on Raman Spectroscopy, ICORS 2010. Hartsuiker, L., Petersen, W., Rayavarapu, R. G., Manohar, S., van Leeuwen, T., Terstappen, L. W. M. M. & Otto, C.Dynamic process measurements in the complex plane with vibrational phase contrast CARS (2010)[Contribution to conference › Poster] XXII International Conference on Raman Spectroscopy, ICORS 2010. Garbacik, E. T., Jurna, M., Korterik, J. P., Herek, J. L., Otto, C. & Offerhaus, H. L.Dynamic process measurements in the complex plane with vibrational phase contrast CARS (2010)[Contribution to conference › Poster] Microscopy and Microanalysis 2010. Garbacik, E. T., Jurna, M., Korterik, J. P., Herek, J. L., Otto, C. & Offerhaus, H. L.Methods and Algorithms for cell enumeration in low-cost cytometer (2010)[Patent › Patent] (Submitted). Coumans, F. A. W., Greve, J., Modica, F. P., Terstappen, L. W. M. M., Tibbe, A. G. J. & Verrant, J. A.http://www.freepatentsonline.com/7764821.htmlSurface plasmon resonance imaging based multiplex biosensor: Integration of biomolecular screening, detection and kinetics estimation. (2010)Sensors and Actuators B: Chemical, 148(2), 511-521. Krishnamoorthy, G., Carlen, E., van den Berg, A. & Schasfoort, R. B. M.https://doi.org/10.1016/j.snb.2010.04.015Causing Relative Motion (2010)[Patent › Patent]. Kiesel, P., Beck, M., Bassler, M. & Johnson Noble, M.Obtaining Sensing Results and/or Data in Response to Object Detection (2010)[Patent › Patent]. Kiesel, P., Beck, M., Martini, J., Bassler, M. & Johnson Noble, M.Obtaining Sensing Results Indicating Time Variation (2010)[Patent › Patent]. Kiesel, P., Martini, J., Bassler, M., Beck, M. & Johnson Noble, M.Circulating endothelial cells (CECs) as marker for vascular effects of cisplatin-based chemotherapy for testicular cancer (TC) (2010)[Contribution to conference › Paper] 46th Annual Meeting of the American Society of Clinical Oncology (ASCO) 2010. Altena, R., de Haas, E. C., Tibbe, A. G. J., Smit, A. J., Connelly, M. C., Terstappen, L. W. M. M., Meijer, C., Boezen, H., de Vries, E. & Gietema, J. A.Circulating tumor cells (CTC) in small cell lung cancer (SCLC): a promising prognostic facto (2010)[Contribution to conference › Paper] 46th Annual Meeting of the American Society of Clinical Oncology (ASCO) 2010. Hiltermann, T. N. J., Liesker, J. J. W., Schouwink, J. H., Kaajan, J. P. G., Boezen, H. M., Tissing, H., Tibbe, A. G. J., Terstappen, L. W. M. M. & Groen, H. J. M.Electrokinetic Lab-on-a-BioChip for Multi-ligand/Multi-analyte Biosensing (2010)Analytical chemistry, 82(10), 4145-4150. Article 10.1021/ac1003163. Krishnamoorthy, G., Carlen, E., de Boer, H. L., van den Berg, A. & Schasfoort, R. B. M.https://doi.org/10.1021/ac1003163CARS Application: Medical Imaging and Spectroscopy (2010)[Contribution to conference › Poster] Colloquium Optical Sciences 2010. Nahidi Azar, L., Garbacik, E. T., Jurna, M., Otto, C., Herek, J. L. & Offerhaus, H. L.Simple and affordable CD4 counting enabled by on-chip sample preparation and image cytometry” Parallel Session 2-6: Cytometry Technology II: Low Cost Technologies for Point of Care (2010)[Contribution to conference › Paper] XXV Congress of the International Society for Advancement of Cytometry, CYTO 2010. Beck, M.CARS visualized in the complex plane (2010)[Contribution to conference › Poster] microCARS Workshop Applications of CARS/Non-Linear Microscopy 2010. Jurna, M., Garbacik, E. T., Korterik, J. P., Herek, J. L., Otto, C. & Offerhaus, H. L.Automatic classification of EpCAM+, Cytokeratin+ objects versus survival in castration resistant prostate cancer (2010)[Contribution to conference › Poster] 101st AACR Annual Meeting 2010. Ligthart, S. T., Coumans, F. A. W., Attard, G., de Bono, J. S. & Terstappen, L. W. M. M.https://doi.org/10.1158/1538-7445.AM10-1730Development of automatic FISH probe counting in CTC (2010)[Contribution to conference › Poster] 101st AACR Annual Meeting 2010. Ligthart, S. T., Swennenhuis, J. F., Greve, J. & Terstappen, L. W. M. M.https://doi.org/10.1158/1538-7445.AM10-3760Optimizing islet transplantation for type 1 diabetes (2010)[Contribution to conference › Poster] MIRA Event 'Top Technology for patients' 2010. Buitinga, M., Hilderink, J., Trückenmuller, R., Otto, C., van Blitterswijk, C., Post, J. N., van Apeldoorn, A. A. & Karperien, H. B. J.Raman spectroscopy and imaging of gold nanoparticles with cells (2010)[Contribution to conference › Poster] MIRA Event 'Top Technology for patients' 2010. Hartsuiker, L., Rayavarapu, R. G., Petersen, W., van Leeuwen, T., Terstappen, L. W. M. M., Manohar, S. & Otto, C.Long-Range Energy Propagation in Nanometer Arrays of Light Harvesting Antenna Complexes (2010)Nano letters, 10(4), 1450-1457. Escalante Marun, M., Lenferink, A. T. M., Zhao, Y., Tas, N. R., Huskens, J., Hunter, C. N., Subramaniam, V. & Otto, C.https://doi.org/10.1021/nl1003569FLOW SCHEMES FOR ENHANCED LIGHT-TARGET INTERACTION IN FLUIDIC CHANNELS (2010)[Patent › Patent]. Beck, M., Kiesel, P., Bassler, M. & Burgel, T.Microbioreactors for raman microscopy of stromal cell differentiation (2010)Analytical chemistry, 82(5), 1844-1850. Vishnu, V. P., Lenferink, A., Van Manen, H. J., Subramaniam, V., Van Blitterswijk, C. A. & Otto, C.https://doi.org/10.1021/ac902515cMagnetic separation apparatus and methods (2010)[Patent › Patent] (Submitted). Tibbe, A. G. J., Terstappen, L. W. M. M. & Scholtens, T. M.Vibrational Phase Contrast CARS microscopy (2010)[Contribution to conference › Poster] Physics@FOM Veldhoven 2010. Jurna, M., Garbacik, E. T., Korterik, J. P., Otto, C., Herek, J. L. & Offerhaus, H. L.A comparison of breast cancer tumor cells with varying expression of the Her2/neu receptor by Raman microspectroscopic imaging (2010)Analyst, 135(12), 3220-3226. Hartsuiker, L., Zeijen, N. J. L., Terstappen, L. W. M. M. & Otto, C.https://doi.org/10.1039/C0AN00524JA FRET-FLIM Study Reveals the Interaction between ALCAM and Actin as a Potential Regulator of ALCAM Binding Activity (2010)Biophysical journal, 98(3, Suppl. 1), 748a. Tudor, C., Esseling-Ozdoba, A., Figdor, C., Kanger, J. S. & Subramaniam, V.https://doi.org/10.1016/j.bpj.2009.12.4102All circulating EpCAM+CK+CD45- objects predict overall survival in castration-resistant prostate cancer (2010)Annals of oncology, 21(9), 1851-1857. Coumans, F. A. W., Coumans, F. A. W., Doggen, C. J. M., Attard, G., de Bono, J. S. & Terstappen, L. W. M. M.https://doi.org/10.1093/annonc/mdq030Circulating Endothelial Cells, Circulating Tumour Cells, Tissue Factor, Endothelin-1 and Overall Survival In Prostate Cancer Patients Treated With Docetaxel (2010)European journal of cancer, 46, 2027-2035. Strijbos, M. H., Gratama, J. W., Schmitz, P. I. M., Rao, C., Onstenk, W., Doyle, G. V., Miller, M. C., de Wit, R., Terstappen, L. W. M. M. & Sleijfer, S.https://doi.org/10.1016/j.ejca.2010.03.030Circulating tumour cells early predict progression-free and overall survival in advanced colorectal cancer patients treated with chemotherapy and targeted agents (2010)Annals of oncology, 21, 1006-2012. Tol, J., Miller, M. C., Tibbe, A. G. J., Cats, A., Creemers, G. J. M., Vos, A. H., Nagtegaal, I. D., Terstappen, L. W. M. M. & Punt, C. J. A.Clinical Evaluation of a Simple Image Cytometer for CD4 Enumeration on HIV Infected Patients (2010)Cytometry. Part B : Clinical cytometry, 78B(1), 31-36. Li, X., Li, X., Breukers, C., Ymeti, A., Pattanapanyasat, K., Sukapirom, K., Terstappen, L. W. M. M. & Greve, J.https://doi.org/10.1002/cyto.b.20488Electrokinetic label-free screening chip: a marriage of multiplexing and high throughput analysis using surface plasmon resonance imaging (2010)Lab on a chip, 10(8), 986-990. Article 10.1039/c000705f. Krishnamoorthy, G., Carlen, E., Bomer, J. G., Wijnperle, D., de Boer, H. L., van den Berg, A. & Schasfoort, R. B. M.https://doi.org/10.1039/c000705fForce spectroscopy and fluorescence microscopy of dsDNA-YOYO-1 complexes: implications for the structure of dsDNA in the overstretching region (2010)Nucleic acids research, 38, 3423-3431. Murade, C. U., Subramaniam, V., Otto, C. & Bennink, M. L.Heterodyne Interferometric Polarization Coherent anti-Stokes Raman scattering (HIP-CARS) (2010)Journal of raman spectroscopy, 41(12), 1678-1681. Orsel, K., Garbacik, E. T., Jurna, M., Korterik, J. P., Otto, C., Herek, J. L. & Offerhaus, H. L.https://doi.org/10.1002/jrs.2621Heterodyne interferometric polarization-sensitive coherent anti-Stokes Raman scattering (HIP-CARS) spectroscopy (2010)In Proceedings of the NATO Advanced Study Institute on Biophotonics: Spectroscopy, Imaging, Sensing, and Manipulation (pp. 387-388). Garbacik, E. T., Jurna, M., Otto, C., Herek, J. L. & Offerhaus, H. L.High-density periodic arrays of self-aligned subwavelength nanopyramids for surface-enhanced Raman spectroscopy (2010)The Journal of physical chemistry C, 114(50), 21953-21959. Jin, M., Pully, V. V., Otto, C., van den Berg, A. & Carlen, E.https://doi.org/10.1021/jp106245aHigh-resolution narrowband CARS spectroscopy in the spectral fingerprint region (2010)Journal of raman spectroscopy, 40(9), 1229-1233. Chimento, P. F., Jurna, M., Bouwmans, H. S. P., Garbacik, E. T., Hartsuiker, L., Otto, C., Herek, J. L. & Offerhaus, H. L.https://doi.org/10.1002/jrs.2267Hybrid Raman-Fluorescence Microscopy on Single Cells using Quantum Dots (2010)In Methods in Molecular Imaging (pp. -). Springer. van Manen, H. W. J. & Otto, C.Hybrid Rayleigh, Raman and TPE fluorescence spectral confocal microscopy of living cells (2010)Journal of raman spectroscopy, 41(6), 599-608. Pully, V. V., Lenferink, A. T. M. & Otto, C.https://doi.org/10.1002/jrs.2501In vitro toxicity studies of polymer-coated gold nanorods (2010)Nanotechnology, 21(14), 145101-. Rayavarapu, R. G., Petersen, W., Hartsuiker, L., Chin, P., Janssen, H., van Leeuwen, F. W. B., Otto, C., Manohar, S. & van Leeuwen, T.https://doi.org/10.1088/0957-4484/21/14/145101Mapping of citrullinated fibrinogen B-cell epitopes in rheumatoid arthritis by imaging surface plasmon resonance (2010)Arthritis research & therapy, 12(6), -. Article R219. van Beers, J. J. B. C., Raijmakers, R., Alexander, L.-E., Stammen-Vogelzangs, J., Lokate, A. M. C., Heck, A. J. R., Schasfoort, R. B. M. & Pruijn, G. J. M.https://doi.org/10.1186/ar3205Membrane invaginations in Rhodobacter Sphaeroides is initiated at curved regions of the cytoplasmic membrane, then forms budded and fully detached spherical Vesicles. (2010)Molecular microbiology, 76(4), 833-847. Tucker, J. D., Siebert, C. A., Escalante Marun, M., Adams, P. G., Olsen, J. D., Otto, C., Stokes, D. L. & Hunter, C. N.https://doi.org/10.1111/j.1365-2958.2010.07153.xMicrobioreactors for Raman of Stromal Cell Differentiation (2010)Analytical chemistry, 82, 1844-1850. Pully, V. V., Lenferink, A. T. M., Subramaniam, V., van Blitterswijk, C. & Otto, C.Optical and non-optical methods for detection and characterization of microparticles and exosomes (2010)Journal of thrombosis and haemostasis, 8(12), 2596-2607. van der Pol, E., Hoekstra, A. G., Sturk, A., Otto, C., van Leeuwen, T. G. & Nieuwland, R.https://doi.org/10.1111/j.1538-7836.2010.04074.xProtein immobilization on Ni(II) Ion patterns prepared by microcontact printing and dip-pen nanolithography (2010)ACS nano, 4, 1083-1091. Wu, C. C., Reinhoudt, D., Otto, C., Velders, A. & Subramaniam, V.Raman-Fluorescence hybrid microspectroscopy of cell nuclei (2010)Vibrational spectroscopy, 53, 12-18. Pully, V. V., Lenferink, A. T. M. & Otto, C.Significance of Circulating Tumor Cells detected by the CellSearch System in Patients with Metastatic Breast Colorectal and Prostate Cancer (2010)Journal of oncology, 2010, 1-8. Article 617421. Miller, M. C., Doyle, G. V. & Terstappen, L. W. M. M.https://doi.org/10.1155/2010/617421Significant and Sustained Antitumor Activity in Post-Docetaxel, Castration-Resistant Prostate Cancer With the CYP17 Inhibitor Abiraterone Acetate (2010)Journal of clinical oncology, 28(9), 1489-1495. Reid, A. H. M., Attard, G., Danila, D. C., Oommen, N. B., Olmos, D., Fong, P. C., Molife, L. R., Hunt, J., Messiou, C., Parker, C., Dearnaley, D., Swennenhuis, J. F., Terstappen, L. W. M. M., Lee, G., Kheoh, T., Molina, A., Ryan, C. J., Small, E., Scher, H. I. & de Bono, J. S.https://doi.org/10.1200/JCO.2009.24.6819Thermosensitive hydrogel-containing polymersomes for controlled drug delivery (2010)Journal of controlled release, 146(3), 400-408. Lee, J. S., Zhou, W., Meng, F., Zhang, D., Otto, C. & Feijen, J.https://doi.org/10.1016/j.corel.2010.06.002Vibrational phase contrast CARS microscopy for quantitative analysis (2010)In Multiphoton Microscopy in the Biomedical Sciences X. Article 75690F (Proceedings of SPIE; Vol. 7569). SPIE. Jurna, M., Garbacik, E. T., Korterik, J. P., Otto, C., Herek, J. L. & Offerhaus, H. L.https://doi.org/10.1117/12.840178Visualizing Resonances in the Complex Plane with Vibrational Phase Contrast Coherent Anti-Stokes Raman Scattering (CARS) (2010)Analytical chemistry, 82(18), 7656-7659. Jurna, M., Garbacik, E. T., Korterik, J. P., Herek, J. L., Otto, C. & Offerhaus, H. L.https://doi.org/10.1021/ac101453s

2009

Raman spectroscopic characterization of pancreatic islets for transplantation in type 1 diabetes patients (2009)[Contribution to conference › Poster] 18th NBTE Annual Meeting 2009. Hilderink, J., de Koning, E. J. P., Engelse, M. A., Otto, C., van Blitterswijk, C., van Apeldoorn, A. A. & Karperien, H. B. J.Producing Filters With Combined Transmission and/or Reflection Functions (2009)[Patent › Patent]. Bassler, M., Kiesel, P., Beck, M., Hegyi, A., Buergel, T. & Johnson Noble, M.Producing Time Variation In Emanating Light (2009)[Patent › Patent]. Kiesel, P., Beck, M., Bassler, M. & Johnson Noble, M.Transmitting/Reflecting Emanating Light With Time Variation (2009)[Patent › Patent]. Bassler, M., Beck, M., Kiesel, P., Hegyi, A., Buergel, T. & Johnson Noble, M.Obtaining sensing results and/or data in response to object detection (2009)[Patent › Patent]. Kiesel, P., Beck, M., Martini, J., Bassler, M., Johnson, N. M., Hegyi, A. & Buergel, T.CARS Techniques for Medical Imaging and Spectroscopy (2009)[Contribution to conference › Poster] Joint workshop for Imaging Guided Targeted Drug Delivery. Garbacik, E. T., Jurna, M., Korterik, J. P., Herek, J. L., Otto, C. & Offerhaus, H. L.Integrated Electrokinetic Sample Focusing and Surface Plasmon Resonance Imaging System for Measuring Biomolecular Interactions (2009)Analytical chemistry, 81(5), 1957-1963. Article 10.1021/ac802668z. Krishnamoorthy, G., Carlen, E., Kohlheyer, D., Schasfoort, R. B. M. & van den Berg, A.https://doi.org/10.1021/ac802668zCD4 and CD8 Enumeration for HIV Monitoring in Resource-Constrained Settings (2009)Cytometry. Part B : Clinical cytometry, 76B, 118-126. Li, X., Breukers, C., Ymeti, A., Lunter, B., Terstappen, L. W. M. M. & Greve, J.Characterization of Circulating Tumor Cells by Fluorescence In-Situ Hybridization (2009)Cytometry. Part A, 75A(6), 520-527. Swennenhuis, J. F., Tibbe, A. G. J., Levink, R., Terstappen, L. W. M. M. & Sipkema, R. C. J.https://doi.org/10.1002/cyto.a.20718Characterization of ERG, AR and PTEN gene status in circulating tumor cells from patients with castration-resistant prostate cancer (2009)Cancer research, 69(7), 2912-2918. Attard, G., Swennenhuis, J. F., Olmos, D., Reid, A. H. M., Vickers, E., A'Hern, R., Levink, R., Coumans, F., Moreira, J., Riisnaes, R., Oommen, N. B., Hawche, G., Jameson, C., Thompson, E., Sipkema, R., Carden, C. P., Parker, C., Dearnaley, D., Kaye, S. B., … De Bono, J. S.https://doi.org/10.1158/0008-5472.CAN-08-3667Cholesterol esters are detected by Raman microspectroscopy in HeLa cells (2009)Journal of raman spectroscopy, 40(2), 117-118. van Manen, H. J. & Otto, C.https://doi.org/10.1002/jrs.2168Circulating Tumor Cells (CTC) as intermediate end points in castration-resistant prostate cancer (CRPC): a single-centre experience (2009)Annals of oncology, 20, 27-37. Olmos, D., Arkenau, H. T., Ang, J. E., Ledaki, I., Attard, G., Carden, C. P., Reid, A. H. M., Hem, R. A., Fong, P. C., Oomen, N. B., Molife, R., Dearnaley, D., Parker, C., Terstappen, L. W. M. M. & de Bono, J. S.Circulating tumour cells during laparoscopic and open surgery for primary colonic cancer in portal and peripheral blood (2009)European journal of surgical oncology, 35(9), 942-950. Wind, J., Tuynman, J. B., Tibbe, A. G. J., Swennenhuis, J. F., Richel, D. J., van Berge Henegouwen, M. I. & Bemelman, W. A.https://doi.org/10.1016/j.ejso.2008.12.003Circulating tumour cells early predict progression-free and overall survivalin advanced colorectal cancer patients treated with chemotherapy and targeted agents (2009)Annals of oncology, 463-. Tol, J., Miller, M. C., Tibbe, A. G. J., Cats, A., Creemers, G. J. M., Vos, A. H., Nagtegaal, I. D., Terstappen, L. W. M. M. & Punt, C. J. A.Coherent anti-stokes raman scattering microscopy to monitor drug dissolution in different oral pharmaceutical tablets (2009)Journal of innovative optical health sciences, 2(1), 37-43. Jurna, M., Windbergs, M., Strachan, C. J., Hartsuiker, L., Otto, C., Kleinebudde, P., Herek, J. L. & Offerhaus, H. L.https://doi.org/10.1142/S1793545809000322Commentary the molecular characterization of 19 breast cancer cell lines by Sieuwerts et al. (2009)Journal of the National Cancer Institute, 101, 895-. Connelly, M. C., Wang, Y., Doyle, G. V., Terstappen, L. W. M. M. & McCormack, R.Designing porosity and topography of poly(1,3-trimethylene carbonate) scaffolds (2009)Acta biomaterialia, 5(9), 3281-3294. Papenburg, B. J., Schüller-Ravoo, S., Bolhuis-Versteeg, L. A. M., Hartsuiker, L., Grijpma, D. W., Feijen, J., Wessling, M. & Stamatialis, D.https://doi.org/10.1016/j.actbio.2009.05.017Prognostic Significance of Circulating Tumor Cells in Patients with Metastatic Colorectal Cancer (2009)Annals of oncology, 20, 1223-1229. Cohen, S. J., Punt, C. J. A., Iannotti, N., Saidman, B. H., Sabbath, K. D., Gabrail, N. Y., Picus, J., Morse, M., Mitchell, E., Miller, M. C., Doyle, G. V., Tissing, H., Terstappen, L. W. M. M. & Meropol, N. J.Re: Anti-epithelial cell adhesion molecule antibodies and the detection of circulating normal-like breast tumor cells (2009)Journal of the National Cancer Institute, 101(12), 895. Connelly, M., Wang, Y., Doyle, G. V., Terstappen, L. & McCormack, R.https://doi.org/10.1093/jnci/djp117Safety, Pharmacokinetics, and Pharmacodynamics of the Insulin-Like Growth Factor Type 1 Receptor Inhibitor Figitumumab (CP-751, 871) in Combination with Paclitaxel and Carboplatin (2009)Journal of thoracic oncology, 4(11), 1397-1403. Karp, D. D., Pollak, M. N., Cohen, R. B., Eisenberg, P. D., Haluska, P., Yin, D., Lipton, A., Demers, L., Leitzel, K., Hixon, M. L., Terstappen, L. W. M. M., Garland, L., Paz-Ares, L. G., Cardenal, F. & Gualberto, A.https://doi.org/10.1097/JTO.0b013e3181ba2f1dSingle injection microarray-based biosensor kinetics (2009)Analytical methods, 1(3), 162-169. Krishnamoorthy, G., Carlen, E., Beusink, J. B., Schasfoort, R. B. M. & van den Berg, A.https://doi.org/10.1039/b9ay00176jThe intensity of the 1602 cm-1 band in human cells is related to mitochondrial activity (2009)Journal of raman spectroscopy, 40(5), 473-475. Pully, V. V. & Otto, C.https://doi.org/10.1002/jrs.2269

2008

Device and method for modulating light (2008)[Patent › Patent]. Beck, M., Santos, P. V. & Morais De Lima, M. J.https://patents.google.com/patent/EP1990677B1/enOn-chip electrokinetic sample focusing for microarray-based biomolecular interaction assays (2008)In 12th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 311-313) (microTAS; Vol. 2). The Chemical and Biological Microsystems Society. Krishnamoorthy, G., Carlen, E., Kohlheyer, D., Schasfoort, R. B. M. & van den Berg, A.Nanometer arrays of functional light harvesting antenna complexes by nanoimprint lithography and host--guest interactions (2008)Journal of the American Chemical Society, 130(28), 8892-8893. Escalante Marun, M., Zhao, Y., Ludden, M. J. W., Vermeij, R. J., Olsen, J. D., Berenschot, J. W., Hunter, C. N., Huskens, J., Subramaniam, V. & Otto, C.https://doi.org/10.1021/ja802843mA microfluidic device for array patterning by perpendicular electrokinetic focusing (2008)Microfluidics and nanofluidics, 4(6), 557-564. Kohlheyer, D., Unnikrishnan, S., Besselink, G. A. J., Schlautmann, S. & Schasfoort, R. B. M.https://doi.org/10.1007/s10404-007-0217-9Bubble-Free Operation of a Microfluidic Free-Flow Electrophoresis Chip with Integrated Pt Electrodes (2008)Analytical chemistry, 80(11), 4111-4118. Kohlheyer, D., Eijkel, J. C. T., Schlautmann, S., van den Berg, A. & Schasfoort, R. B. M.https://doi.org/10.1021/ac800275cBackground free CARS imaging by phase sensitive heterodyne CARS (2008)Optics express, 16(20), 15863-15869. Jurna, M., Korterik, J. P., Otto, C., Herek, J. L. & Offerhaus, H. L.https://doi.org/10.1364/OE.16.015863Directed assembly of functional light harvesting antenna complexes onto chemically patterned surfaces (2008)Nanotechnology, 19(2). Article 025101. Escalante Marun, M., Maury, P., Bruinink, C. M., van der Werf, K., Olsen, J. D., Timney, J. A., Huskens, J., Hunter, C. N., Subramaniam, V. & Otto, C.https://doi.org/10.1088/0957-4484/19/02/025101Electrokinetic sorting and collection of fractions for preparative capillary electrophoresis on a chip (2008)Lab on a chip, 8(5), 801-809. Zalewski, D. R., Schlautmann, S., Schasfoort, R. B. M. & Gardeniers, J. G. E.https://doi.org/10.1039/b717785bFabrication and Visualization of Metal-Ion Patterns on Glass by Dip-Pen Nanolithography (2008)ChemPhysChem, 9(12), 1680-1687. Basabe Desmonts, L., Wu, C.-C., van der Werf, K., Péter, M., Bennink, M. L., Otto, C., Velders, A. H., Reinhoudt, D., Subramaniam, V. & Crego Calama, M.https://doi.org/10.1002/cphc.200700853Miniaturizing free-flow electrophoresis - A critical review (2008)Electrophoresis, 29(69160R/5), 977-993. Kohlheyer, D., Eijkel, J. C. T., van den Berg, A. & Schasfoort, R. B. M.https://doi.org/10.1002/elps.200700725Noninvasive imaging of protein metabolic labeling in single human cells using stable isotopes and Raman microscopy (2008)Analytical chemistry, 80(24), 9576-9582. van Manen, H. J., Lenferink, A. T. M. & Otto, C.https://doi.org/10.1021/ac801841yQuantitative Fluorescence Correlation Spectroscopy reveals a 1000-fold increase in lifetime of protein functionality (2008)Biophysical journal, 95(7), 3439-3446. Zhang, D., Lans, H., Vermeulen, W., Lenferink, A. T. M. & Otto, C.https://doi.org/10.1529/biophysj.108.133215Refractive index sensing of green fluorescent proteins in living cells using fluorescence lifetime imaging microscopy (2008)Biophysical journal, 94(8), L67-L69. van Manen, H. J., Verkuijlen, P., Wittendorp, P., Subramaniam, V., van den Berg, T. K., Roos, D. & Otto, C.https://doi.org/10.1529/biophysj.107.127837Shot noise limited heterodyne detection of CARS signals (2008)[Contribution to conference › Paper] SPIE San Jose. Jurna, M., Búttner, E., Korterik, J. P., Otto, C., Rimke, I. & Offerhaus, H. L.

2007

Microfluidic high-resolution free-flow isoelectric focusing (2007)Analytical chemistry, 79(21), 8190-8198. Kohlheyer, D., Eijkel, J. C. T., Schlautmann, S., van den Berg, A. & Schasfoort, R. B. M.https://doi.org/10.1021/ac071419BBiomolecular Interaction Monitoring of Autoantibodies by Scanning Surface Plasmon Resonance Microarray Imaging (2007)Journal of the American Chemical Society, 129(7/45), 14013-14018. Article 10.1021/ja075103x. Lokate, A. M. C., Beusink, J. B., Besselink, G. A. J., Pruijn, G. J. M. & Schasfoort, R. B. M.https://doi.org/10.1021/ja075103xDevices and methods to image objects (2007)[Patent › Patent]. Tibbe, A. G. J., Greve, J., Terstappen, L. W. M. M. & de Grooth, B. G.Combined Lab-on-a-Chip and microarray approach for biomolecular interaction sensing using surface plasmon resonance imaging (2007)In Eleventh International Conference on Miniaturized Systems for Chemistry and Life Sciences - The proceedings of microTAS 2007 Conference (pp. 676-678) (Micro Total Analysis Systems; Vol. 1). The Chemical and Biological Microsystems Society. Krishnamoorthy, G., Beusink, J. B., Carlen, E., Schlautmann, S., de Boer, H. L., van den Berg, A. & Schasfoort, R. B. M.Proteomics-on-a-chip for Biomarker discovery (2007)In Eleventh International Conference on Miniaturized Systems for Chemistry and Life Sciences - The proceedings of microTAS 2007 Conference (pp. 1243-1245) (Micro Total Analysis Systems; Vol. 2). The Chemical and Biological Microsystems Society. Schasfoort, R. B. M., Kohlheyer, D., Schlautmann, S., Eijkel, J. C. T. & van den Berg, A.Kijken Denken Doen (Look Think Do) (2007)[Book/Report › Inaugural speech]. University of Twente. Terstappen, L. W. M. M.Angle-scanning SPR imaging for detection of biomolecular interactions on microarrays (2007)Biosensors & bioelectronics, 23(Paper P-NS/6), 839-844. Beusink, J. B., Lokate, A. M. C., Besselink, G. A. J., Pruijn, G. J. M. & Schasfoort, R. B. M.https://doi.org/10.1016/j.bios.2007.08.025An image cytometer for resource-poor settings to monitor disease progression in HIV infection (2007)Cytometry. Part A, A(3), 132-142. Ymeti, A., Li, X., Lunter, B., Breukers, C., Tibbe, A. G. J., Terstappen, L. W. M. M. & Greve, J.https://doi.org/10.1002/cyto.a.20375CD4+T Lymphocytes enumeration by an easy-to-use single platform image cytometer for HIV monitoring in resource-constrained settings (2007)Cytometry. Part B : Clinical cytometry, 72B(5), 397-407. Li, X., Ymeti, A., Lunter, B., Breukers, C., Tibbe, A. G. J., Terstappen, L. W. M. M. & Greve, J.https://doi.org/10.1002/cyto.b.20165Directed formation of micro- and nanoscale patterns of functional light-harvesting LH2 complexes (2007)Journal of the American Chemical Society, 129(47), 14625-14631. Reynolds, N. P., Janusz, S., Escalante Marun, M., Escalante-Marun, M., Timney, J., Ducker, R. E., Olsen, J. D., Otto, C., Subramaniam, V., Leggett, G. J. & Hunter, C. N.https://doi.org/10.1021/ja073658mHybrid confocal Raman fluorescence microscopy on single cells using semiconductor quantum dots (2007)Nano letters, 7(6), 1631-1636. van Manen, H. J. & Otto, C.https://doi.org/10.1021/nl0705945Intracellular degradation of microspheres based on cross-linked dextran hydrogels or amphiphilic block copolymers: a comparative raman microscopy study. (2007)International journal of nanomedicine, 2(2), 241-252. van Manen, H. J., van Apeldoorn, A. A., Verrijk, R., van Blitterswijk, C. & Otto, C.https://doi.org/10.2147/IJN.SProtein shape and crowding drive domain formation and curvature in biological membranes (2007)Biophysical journal, 94(2), -. Frese, R. N., Pamies, J. C., Olsen, J. D., Bahatyrova, S., van der Weij-de Wit, C. D., Aartsma, T. J., Otto, C., Hunter, C. N., Frenkel, D. & van Grondelle, R.https://doi.org/10.1529/biophysj.107.116913Shot noise limited heterodyne detection of CARS signals (2007)Optics express, 15(23), 15207-15213. Jurna, M., Korterik, J. P., Otto, C. & Offerhaus, H. L.https://doi.org/10.1364/OE.15.015207

2006

Free flow zone electrophoresis and isoelectric focusing using a microfabricated glass device with ion permeable membranes (2006)Lab on a chip, 6, 374-380. Kohlheyer, D., Besselink, G. A. J., Schlautmann, S. & Schasfoort, R. B. M.https://doi.org/10.1039/B514731JNoncritical phase-matched lithium triborate optical parametric oscillator for high resolution coherent anti-stokes Raman scattering spectroscopy and microscopy (2006)Applied physics letters, 89(25), 251116/1-6. Jurna, M., Korterik, J. P., Offerhaus, H. L. & Otto, C.https://doi.org/10.1063/1.2420773Single-Cell Optical Imaging of the Phagocyte NADPH Oxidase (2006)Antioxidants & redox signaling, 8(9-10), 1509-1522. van Manen, H. J., Van Bruggen, R., Roos, D. & Otto, C.https://doi.org/10.1089/ars.2006.8.1509Ultracompact Optical Sensors based on high index-contrast Photonic Structures (2006)In Optical Chemical Sensors (pp. 281-295). Article 10.1007/1-4020-4611-1 (NATO Science Series, Series II: Mathematics, Physics and Chemistry; Vol. 224). Springer. Driessen, A., Hoekstra, H., Hopman, W. C. L., Kelderman, H., Lambeck, P., van Lith, J., Klunder, D. J. W., de Ridder, R. M., Krioukov, E. & Otto, C.https://doi.org/10.1007/1-4020-4611-1

2005

Two-photon fluorescence excitation using an integrated optical microcavity: a promising tool for biosensing of natural chromophores (2005)Talanta, 65(5), 1086-1090. Article 10.1016/j.talanta.2004.02.048. Krioukov, E., Klunder, D. J. W., Driessen, A., Greve, J. & Otto, C.https://doi.org/10.1016/j.talanta.2004.02.048Combined AFM and confocal fluorescence microscope for applications in bio-nanotechnology (2005)Journal of microscopy, 217(1), 109-116. Kassies, R., van der Werf, K., Lenferink, A. T. M., Hunter, C. N., Olsen, J. D., Subramaniam, V. & Otto, C.https://doi.org/10.1111/j.0022-2720.2005.01428.xElectroosmotically controllable multi-flow microreactor (2005)Microfluidics and nanofluidics, 1(3), 242-248. Kohlheyer, D., Besselink, G. A. J., Lammertink, R. G. H., Schlautmann, S., Unnikrishnan, S. & Schasfoort, R. B. M.https://doi.org/10.1007/s10404-004-0031-6Parallel high-resolution confocal Raman SEM analysis of inorganic and organic bone matrix constituents (2005)Journal of the Royal Society. Interface, 2(2), 1-7. van Apeldoorn, A. A., Aksenov, Y., Stigter, M., Hofland, I., de Bruijn, J. D., Koerten, H. K., Otto, C., Greve, J. & van Blitterswijk, C.https://doi.org/10.1098/​rsif.2004.0018

2004

Microresonators as building blocks for VLSI Photonics (2004)In Microresonators as building blocks for VLSI photonics: International School of Quantum Electronics, 39th Course (pp. 01-18) (AIP Conference Proceedings; Vol. 709). American Institute of Physics. Driessen, A., Geuzebroek, D. H., Hoekstra, H., Kelderman, H., Klein, E. J., Klunder, D. J. W., Roeloffzen, C. G. H., Tan, F. S., Krioukov, E., Otto, C., Gersen, H., van Hulst, N. F. & Kuipers, L.https://doi.org/10.1063/1.1764011Development of a Multichannel Integrated Young Interferometer Immunosensor (2004)[Thesis › PhD Thesis - Research UT, graduation UT]. Twente University Press (TUP). Ymeti, A.Easy Count, A Simple Cell Enumeration System (2004)Cytometry, 59A(1), 86-86. Tibbe, A. G. J., Li, X., van der Kooi, A., Koutroulis, M., Gohel, D., Droog, E., Greve, J. & Terstappen, L. W. M. M.https://doi.org/10.1002/cyto.a.20045.absElectroosmotic guiding of sample flows in a laminar flow chamber (2004)Electrophoresis, 25(21-22), 3705-3711. Besselink, G. A. J., Vulto, P., Lammertink, R. G. H., Schlautmann, S., van den Berg, A., Olthuis, W., Engbers, G. H. M. & Schasfoort, R. B. M.https://doi.org/10.1002/elps.200406033Intracellular Chemical Imaging of Heme-Containing Enzymes Involved in Innate Immunity Using Resonance Raman Microscopy (2004)The Journal of physical chemistry B, 108(48), 18762-18771. van Manen, H. J., Kraan, Y. M., Roos, D. & Otto, C.https://doi.org/10.1021/jp046955bRaman Imaging of PLGA Microsphere Degradation Inside Macrophages (2004)Journal of the American Chemical Society, 126, 13226-13227. van Apeldoorn, A. A., van Manen, H. J., Bezemer, J. M., de Bruijn, J. D., van Blitterswijk, C. & Otto, C.https://doi.org/10.1021/ja0459936Signal amplification on planar and gel-type sensor surfaces in surface plasmon resonance-based detection of prostate-specific antigen (2004)Analytical biochemistry, 333(1), 165-173. Besselink, G. A. J., Kooyman, R. P. H., van Os, P. J. H. J., Engbers, G. H. M. & Schasfoort, R. B. M.https://doi.org/10.1016/j.ab.2004.05.009The native architecture of a photosynthetic membrane (2004)Nature, 430(7003), 1058-1062. Bahatyrova, S., Frese, R. N., Siebert, C. A., Olsen, J. D., van der Werf, K., van Grondelle, R., Niederman, R. A., Bulough, P. A., Otto, C. & Hunter, C. N.https://doi.org/10.1038/nature02823Time Delay Integration, A Fast and Simple Imaging Method in CellTracks (2004)Cytometry. Part A, 59A(1), 155-155. Schreuder, F., Greve, J., Tibbe, A. G. J. & Terstappen, L. W. M. M.https://doi.org/10.1002/cyto.a.20044.abs

2003

Combined Raman and continuous-wave-excited two-photon fluorescence cell imaging (2003)Optics letters, 28(21), 2073-2075. Uzunbajakava, N. & Otto, C.https://doi.org/10.1364/OL.28.002073Modification of ISFETs with a monolayer of latex beads for specific detection of proteins (2003)Biosensors & bioelectronics, 18(9), 1109-1114. Besselink, G. A. J., Schasfoort, R. B. M. & Bergveld, P.https://doi.org/10.1016/S0956-5663(02)00243-9Nonresonant Confocal Raman Imaging of DNA and Protein Distribution in Apoptotic Cells (2003)Biophysical journal, 84(6), 3968-3981. Uzunbajakava, N., Lenferink, A. T. M., Kraan, Y. M., Volokhina, E., Vrensen, G., Greve, J. & Otto, C.https://doi.org/10.1016/S0006-3495(03)75124-8Nonresonant Raman Imaging of Protein Distribution in Single Human Cells (2003)Biopolymers, 72(1), 1-9. Uzunbajakava, N., Lenferink, A. T. M., Kraan, Y. M., Willekens, B., Vrensen, G., Greve, J. & Otto, C.https://doi.org/10.1002/bip.10246Performance of integrated optical microcavities for refractive index and fluorescence sensing (2003)Sensors and actuators, B90(1-3), 58-67. Krioukov, E., Greve, J. & Otto, C.https://doi.org/10.1016/S0925-4005(03)00022-4

2002

CellTracks cell analysis system for rare cell detection (2002)In Clinical Diagnostic Systems: Technologies and Instrumentation (pp. 20-28) (Proceedings of SPIE; Vol. 4625). SPIE. Kagan, M. T., Trainer, M. N., Bendele, T., Rao, C., Horton, A., Tibbe, A. G. J., Greve, J. & Terstappen, L. W. M. M.https://doi.org/10.1117/12.469792Cell Analysis System Based on Compact Disk Technology (2002)Cytometry, 47(3), 173-182. Tibbe, A. G. J., de Grooth, B. G., Greve, J., Rao, C., Dolan, G. J. & Terstappen, L. W. M. M.https://doi.org/10.1002/cyto.10061Imaging technique implemented in CellTracks system (2002)Cytometry, 47(4), 248-255. Tibbe, A. G. J., de Grooth, B. G., Greve, J., Dolan, G. J. & Terstappen, L. W. M. M.https://doi.org/10.1002/cyto.10085Integrated optical microcavities for enhanced evanescent-wave spectroscopy (2002)Optics letters, 27(17), 1504-1506. Krioukov, E., Klunder, D. J. W., Driessen, A., Greve, J. & Otto, C.https://doi.org/10.1364/OL.27.001504Magnetic Field Design for Selecting and Aligning Immunomagnetic Labeled Cells (2002)Cytometry, 47(3), 163-172. Tibbe, A. G. J., de Grooth, B. G., Greve, J., Dolan, G. J., Rao, C. & Terstappen, L. W. M. M.https://doi.org/10.1002/cyto.10060Sensor based on an integrated optical microcavity (2002)Optics letters, 27(7), 512-514. Krioukov, E., Klunder, D. J. W., Driessen, A., Greve, J. & Otto, C.https://doi.org/10.1364/OL.27.000512

2001

Magneto-hydrodynamically (MHD) directed flow in microfluidic networks (2001)In Proceedings of the MicroTAS 2001 Symposium, Monterey, CA, USA (pp. 577-578) (MESA monographs). Kluwer Academic Publishers. Schasfoort, R. B. M. & Lüttge, R.Cell Analysis System Based on Immunomagnetic Cell Selection and Alignment Followed by Immunofluorescent Analysis Using Compact Disk Technologies (2001)Cytometry, 43(1), 31-37. Tibbe, A. G. J., de Grooth, B. G., Greve, J., Liberti, P. A., Dolan, G. J. & Terstappen, L. W. M. M.https://doi.org/10.1002/1097-0320(20010101)43:1<31::AID-CYTO1016>3.0.CO;2-FNew approaches for fabrication of microfluidic capillary electrophoresis devices with on-chip conductivity detection (2001)Electrophoresis, 22(2), 235-241. Guijt, R. M., Baltussen, E., van der Steen, G., Schasfoort, R. B. M., Schlautmann, S., Billiet, H. A. H., Frank, J., van Dedem, G. W. K. & van den Berg, A.https://doi.org/10.1002/1522-2683(200101)22:2<235::AID-ELPS235>3.0.CO;2-OPowder-blasting technology as an alternative tool for microfabrication of capillary electrophoresis chips with integrated conductivity sensors (2001)Journal of micromechanics and microengineering, 11(4), 386-389. Schlautmann, S., Wensink, H., Elwenspoek, M. C., Schasfoort, R. B. M. & van den Berg, A.https://doi.org/10.1088/0960-1317/11/4/318Trends in miniaturized total analysis systems for point-of-care testing in clinical chemistry (2001)Lab on a chip, 1(1), 83-95. Tudos, A. J., Besselink, G. A. J. & Schasfoort, R. B. M.https://doi.org/10.1039/b106958fVibrational bands of luminescent zinc(II)-octaethyl-porphyrin using a polarization-sensitive 'microcopic' multiplex CARS technique (2001)Journal of raman spectroscopy, 32(6-7), 495-501. Otto, C., Voroshilov, A., Kruglik, S. & Greve, J.https://doi.org/10.1002/jrs.737

2000

Powder-blasting technology as a poerful tool for micro-fabrication of CE-chips with integrated conductivity sensors (2000)In Proceedings of MicroMechanics Europe (MME) 2000 Conference (pp. -). Schlautmann, S., Wensink, H., Schasfoort, R. B. M., Elwenspoek, M. C. & van den Berg, A.Miniaturized capillary electrophoresis system with integrated conductivity detector (2000)In Micro Total Analysis Systems 2000 (pp. 391-394). Kluwer Academic Publishers. Schasfoort, R. B. M., Guijt-van duijn, R., Schlautmann, S., Frank, H., Billiet, H. A. H., van Dedem, G. W. K. & van den Berg, A.An ISFET-based anion sensor for the potentiometric detection of organic acids in liquid chromatography (2000)Sensors and Actuators B: Chemical, 67(3), 194-299. Poels, I., Schasfoort, R. B. M., Picioreanu, S., Frank, J., van Dedem, G. W. K., van den Berg, A. & Nagels, L. J.https://doi.org/10.1016/S0925-4005(00)00531-1CARS and Raman spectroscopy of function-related conformational changes of chymotrypsin (2000)Journal of raman spectroscopy, 31(8-9), 731-737. Brandt, N. N., Chikishev, A. Y., Chikishev, A. Y., Greve, J., Koroteev, N. I., Otto, C., Sakodinskaya, I. K. & Sakodynskaya, I. K.https://doi.org/10.1002/1097-4555(200008/09)31:8/9<731::AID-JRS609>3.0.CO;2-0High-Finesse Integrated Optical Microcavities for Use in Spectroscopy (2000)In Proceedings 2000 IEEE/LEOS Symposium Benelux Chapter (pp. 111-114). Delft University of Technology. Krioukov, E., Klunder, D. J. W., Driessen, A., Greve, J. & Otto, C.http://www.leosbenelux.org/symp00/s00p111.pdfIntracellular Reactions in Single Human Granulocytes upon Phorbol Myristate Acetate Activation using Confocal Raman Microspectroscopy (2000)Biophysical journal, 78(78), 2606-2613. Sijtsema, N. M., Tibbe, A. G. J., Segers-Nolten, G. M. J., Verhoeven, A. J., Weening, R. S., Greve, J. & Otto, C.https://doi.org/10.1016/S0006-3495(00)76805-6Technologies and devices for micro chemical systems (2000)MST news, 2000(4), 10-13. Gardeniers, H., Schasfoort, R. & van den Berg, A.

1999

Increased separation efficiency via controlled aggregation of magnetic nanoparticles (1999)[Patent › Patent]. Immunivest Corp. Liberti, P. A., Rao, G. C. & Terstappen, L. W. M. M.µTransparent Insulating Channels as Components for Miniaturized Chemical Separation Devices (1999)In Transducers '99: proceedings of the Tenth International Conference on Solid-State Sensors and Actuators (pp. 872-875). Schasfoort, R. B. M., Hendrikse, J. & van den Berg, A.Methods for enhancing binding interactions between members of specific binding pairs (1999)[Patent › Patent]. Rao, C., Terstappen, L. W. M. M. & Liberti, P. A.Characterization of the Asp94 and Glu242 mutants in myeloperoxidase, the residue linking the heme group via ester bonds (1999)The FEBS Journal, 264(1), 211-217. Kooter, I. M., Moguilevsky, N., Bollen, A., Sijtsema, N. M., Otto, C., Dekker, H. L. & Wever, R.https://doi.org/10.1046/j.1432-1327.1999.00606.xField-effect flow control for microfabricated fluidic networks (1999)Science, 286(5441), 942-945. Schasfoort, R. B. M., Schlautmann, S., Hendrikse, J. & van den Berg, A.https://doi.org/10.1126/science.286.5441.942Localization Study of Co-Phthalocyanines in Cells by Raman Micro(spectro)scopy (1999)Journal of raman spectroscopy, 30(3), 205-208. Arzhantsev, S. Y., Arzhantsev, S. Y., Chikishev, A. Y., Chikishev, A. Y., Koroteev, N. I., Greve, J., Otto, C. & Sijtsema, N. M.http://www3.interscience.wiley.com/journal/60500864/abstractMechanism of Exciplex Formation Between Cu-Porphyrin and Calf-thymus DNA as Revealed by Saturation Resonance Raman Spectroscopy (1999)Journal of raman spectroscopy, 30(8), 677-684. Shvedko, A. G., Kruglik, S. G., Ermolenkov, V. V., Turpin, P. Y., Greve, J. & Otto, C.https://doi.org/10.1002/(sici)1097-4555(199908)30:8<677::aid-jrs440>3.0.co;2-9

1998

Apparatus and methods for magnetic separation (1998)[Patent › Patent]. Terstappen, L. W. M. M., Doyle, G. V., Liberti, P. A. & Dolan, G. J.Methods and reagents for the rapid and efficient isolation of circulating cancer cells (1998)[Patent › Patent]. Terstappen, L. W. M. M., Rao, C., Uhr, J. W., Racila, E. V. & Liberti, P. A.A narrow-bandwidth optical parametric oscillator (1998)Optics communications, 154(1-3), 83-86. Tukker, T. W., Otto, C. & Greve, J.https://doi.org/10.1016/S0030-4018(98)00315-0Chromatin Structure in Bands and Interbands of Polytene Chromosomes Imaged by Atomic Force Microscopy (1998)Journal of structural biology, 121(1), 2-8. de Grauw, C. J., Avogadro, A., van den Heuvel, D. J., van der Werf, K. O., Otto, C., Kraan, Y., van Hulst, N. F. & Greve, J.https://doi.org/10.1006/jsbi.1997.3929Resonance Raman Microspectroscopy of Myeloperoxidase and Cytochrome b558 in Human Neutrophilic Granulocytes (1998)Biophysical journal, 74(6), 3250-3255. Sijtsema, N. M., Otto, C., Segers-Nolten, G. M. J., Verhoeven, A. J. & Greve, J.https://doi.org/10.1016/S0006-3495(98)78031-2

1997

Apparatus and methods for capture and analysis of particulate entities (1997)[Patent › Patent]. Terstappen, L. W. M. M. & Rao, G. C.Applications of Micro-Raman Imaging in Biomedical Research (1997)Journal of raman spectroscopy, 28(28), 143-150. Otto, C., de Grauw, C. J., Duindam, J. J., Sijtsema, N. M. & Greve, J.https://doi.org/10.1002/(SICI)1097-4555(199702)28:2/3<143::AID-JRS70>3.0.CO;2-9Axial Resolution of Confocal Raman Microscopes: Gaussian Beam Theory and Practice (1997)Journal of microscopy, 188(3), 273-279. de Grauw, C. J., Sijtsema, N. M., Otto, C. & Greve, J.https://doi.org/10.1046/j.1365-2818.1997.2620818.xIntermolecular interaction of photoexcited Cu(/TMpy-P4) with water studied by transient resonance Raman and picosecond absorption spectroscopies (1997)Chemical physics letters, 270(3-4), 293-298. Kruglik, S. G., Ermolenkov, V. V., Shvedko, A. G., Orlovich, V. A., Galievsky, V. A., Chirvony, V. S., Otto, C. & Turpin, P.-Y.https://doi.org/10.1016/S0009-2614(97)00362-XSubpicosecond Dynamics in Nucleotides Measured by Spontaneous Raman Spectroscopy (1997)Biopolymers, 41(41), 751-763. Terpstra, P. A., Terpstra, P. A., Otto, C. & Greve, J.https://doi.org/10.1002/(SICI)1097-0282(199706)41:7<751::AID-BIP4>3.0.CO;2-O

1996

Method to select and transfect cell subpopulations (1996)[Patent › Patent]. Immunivest Corp. Terstappen, L. W. M. M.Raman microscopy of phthalocyanines in cells (1996)Proceedings of SPIE - the international society for optical engineering, 2802, 211-215. Arzhantsev, S. Y., Chikishev, A. Y., Greve, J., Otto, C., Ruzmetov, D. A. & Sijtsema, N. M.https://doi.org/10.1117/12.242168Magnetic separation apparatus and methods (1996)[Patent › Patent]. Terstappen, L. W. M. M. & Dolan, G.Magnetic separation apparatus and methods employing an internal magnetic capture gradient and an external transport force (1996)[Patent › Patent]. Immunivest Corp. Dolan, G. J. & Terstappen, L. W. M. M.Methods for biological substance analysis employing internal magnetic gradients separation and an externally-applied transport force (1996)[Patent › Patent]. Immunivest Corp. Terstappen, L. W. M. M. & Liberti, P. A.Quantitative cell analysis methods employing magnetic separation (1996)[Patent › Patent]. Immunivest Corp. Terstappen, L. W. M. M. & Liberti, P. A.Niet-lineaire vibratie spectroscopiën van biomoleculaire systemen (1996)Van A tot Q, 1996(10), 43-51. Otto, C., Tukker, T., Voroshilov, A., Kanger, H. & Greve, J.Polarization-Sensitive CARS of the Amide I Band of Pure and Liganded Chymotrypsin (1996)Journal of raman spectroscopy, 27(27), 893-896. Chikishev, A. Y., Chikishev, A. Y., Koroteev, N. I., Otto, C. & Greve, J.https://doi.org/10.1002/(SICI)1097-4555(199612)27:12<893::AID-JRS48>3.0.CO;2-YStimulated Raman Gain Scattering in Planar Dielectric Waveguides (1996)Optics letters, 21(21), 671-673. Kanger, J. S., Tukker, T. W., Otto, C. & Greve, J.https://doi.org/10.1364/OL.21.000671Towards Molecular Resolution (1996)Progress in biophysics & molecular biology, 65(1), 1-. Greve, J., de Grooth, B. G., van Hulst, N. F., Kooyman, R. P. H., Otto, C. & Schins, J. M.

1995

Phage antibodies (1995)[Patent › Patent]. Becton Dickinson and Co.. Terstappen, L. W. M. M. & Logtenberg, T.Polarization-Sensitive Resonance CSRS of Deoxy- and Oxyhaemoglobin (1995)Journal of raman spectroscopy, 26, 443-450. Voroshilov, A., Lucassen, G. W., Otto, C. & Greve, J.https://doi.org/10.1002/jrs.1250260608Raman Depolarization Ratios in RNA and DNA are Sensitive for Sugar-Base Coupling (1995)Biospectroscopy, 1995(1), 255-263. Terpstra, P. A., Terpstra, P. A., Otto, C., Segers-Nolten, G. M. J., Kanger, J. S. & Greve, J.https://doi.org/10.1002/bspy.350010404Stimulated Raman gain scattering in thin planar dielectric waveguides (1995)Optics letters, 20(20), 2231-2233. Kanger, J. S., Otto, C. & Greve, J.https://doi.org/10.1364/OL.20.002231The ISFET based heparin sensor with a monolayer of protamine as affinity ligand (1995)Biosensors & bioelectronics, 10(3-4), 269-282. van Kerkhof, J. C., van Kerkhof, J. C., Bergveld, P. & Schasfoort, R. B. M.https://doi.org/10.1016/0956-5663(95)96846-Q

1994

Polarisation-sensitive coherent anti-Stokes and spontaneous Raman spectroscopy of calix[4]arene films (1994)In Proceedings Conference on Lasers and Electro-Optics Europe (CLEO'94) (pp. 252-253). Vardanyan, A. G., Vardanyan, A. G., van Hulst, N. F., Kanger, J. S., Otto, C. & Greve, J.Spontaneous Raman and CARS of Novel Organic Molecule Calix[4]arene (1994)In Proceedings: XIVth International Conference on Raman Spectroscopy (ICORS'94) (pp. 448-449). Vardanyan, A. G., Vardanyan, A. G., van Hulst, N. F., Kanger, J. S., Otto, C. & Greve, J.Combined Elastic and Raman Light Scattering of Human Eye Lenses (1994)Experimental eye research, 59(4), 393-400. Yaroslavsky, I. V., Yaroslavsky, A. N., Otto, C., Puppels, G. J., Vrensen, G. F. J. M., Duindam, J. J. & Greve, J.https://doi.org/10.1006/exer.1994.1123Effect of axial ligands on the spectroelectrochemical properties of zinc phthalocyanine films: In situ Raman and electroreflection spectra (1994)Journal of electroanalytical chemistry, 379(1-2), 89-101. Palys, B. J., van den Ham, D. M. W. & Otto, C.https://doi.org/10.1016/0022-0728(94)87127-2Nucleic acid detection with surface plasmon resonance using cationic latex (1994)Biosensors & bioelectronics, 9(7), 509-514. de Vries, E. F. A., Schasfoort, R. B. M., van der Plas, J. & Greve, J.https://doi.org/10.1016/0956-5663(94)90013-2Relation between Local Acoustic Parameters and Protein Distribution in Human and Porcine Eye Lenses (1994)Experimental eye research, 59(5), 617-627. de Korte, C. L., van der Steen, A. F. W., Thijssen, J. M., Duindam, J. J., Otto, C. & Puppels, G. J.https://doi.org/10.1006/exer.1994.1147

1993

Method to distinguish hematopoietic progenitor cells (1993)[Patent › Patent]. Becton Dickinson and Co.. Olweus, J., Lund-Johansen, F. & Terstappen, L. W. M. M.Automatic lineage assignment of acute leukemias by flow cytometry (1993)[Patent › Patent]. Becton Dickinson and Co.. Verwer, B. J. H. & Terstappen, L. W. M. M.Development of an ISFET based heparin sensor using the ion-step measuring method (1993)Biosensors & bioelectronics, 8(9/10), 463-472. van Kerkhof, J. C., van Kerkhof, J. C., Bergveld, P. & Schasfoort, R. B. M.https://doi.org/10.1016/0956-5663(93)80031-JLocal variations in protein structure in the human eye lens: a Raman microspectroscopic study (1993)BBA - Protein Structure and Molecular Enzymology, 1164(3), 236-242. Smeets, M. H., Vrensen, G. F. J. M., Otto, C., Puppels, G. J. & Greve, J.https://doi.org/10.1016/0167-4838(93)90254-OResonance Polarization and Phase-Mismatched CARS of Pheophytin b Excited in the Qy Band (1993)Journal of raman spectroscopy, 24(6), 383-396. de Boeij, W. P., Lucassen, G. W., Lucassen, G., Otto, C. & Greve, J.https://doi.org/10.1002/jrs.1250240608Temperature dependence of Raman vibrational bandwidths in poly(rA) and rAMP (1993)Biophysical journal, 48(2), 113-122. Terpstra, P. A., Terpstra, P. A., Otto, C. & Greve, J.https://doi.org/10.1016/0301-4622(93)85003-Z

1992

Apparatus for indirect fluorescent assay of blood samples (1992)[Patent › Patent]. Becton Dickinson and Co.. Levine, R. A., Wardlaw, S. C., Terstappen, L. W. M. M., Mercolino, T. J. & Recktenwald, D. J.Assay of blood or other biologic samples for target analytes (1992)[Patent › Patent]. Becton Dickinson and Co.. Levine, R. A., Wardlaw, S. C., Terstappen, L. W. M. M., Manion, K. L., Rodriguez, R. R., Malick, A. P., Dhanesar, S., Lovell, S. J. & Ozinskas, A. J.Indirect fluorescent assay of blood samples (1992)[Patent › Patent]. Becton Dickinson and Co.. Levine, R. A., Wardlaw, S. C., Terstappen, L. W. M. M., Mercolino, T. J. & Recktemwald, D. J.Multidimensional cell differential analysis (1992)[Patent › Patent]. Becton Dickinson and Co.. Terstappen, L. W. M. M. & Chen, C. H.Ageing and changes in protein conformation in the human lens: a Raman microspectroscopic study (1992)Experimental eye research, 54(5), 759-767. Siebinga, I., Vrensen, G. F. J. M., Otto, K., Puppels, G. J., de Mul, F. F. M. & Greve, J.https://doi.org/10.1016/0014-4835(92)90031-M

1991

Method for the classification and monitoring of leukemias (1991)[Patent › Patent]. Becton Dickinson and Co.. Terstappen, L. W. M. M.Affinity-binding separation and release of one or more selected subset of biological entities from a mixed population thereof (1991)[Patent › Patent]. Immunivest Corp. Terstappen, L. W. M. M., Rao, G. C., Gohel, D., Feeley, B., Gross, S., Church, E. & Liberti, P. A.Description and Performance of a Highly Sensitive Confocal Raman Microspectrometer (1991)Journal of raman spectroscopy, 22(4), 217-225. Puppels, G. J., Colier, W., Olminkhof, J. H. F., Otto, C., de Mul, F. F. M. & Greve, J.https://doi.org/10.1002/jrs.1250220405Laser Irradiation and Raman Spectroscopy of Single Living Cells and Chromosomes: Sample Degradation Occurs with 514.5 nm but not with 660 nm Laser Light (1991)Experimental cell research, 195(2), 361-367. Puppels, G. J., Olminkhof, J. H. F., Segers-Nolten, G. M. J., Otto, C., de Mul, F. F. M. & Greve, J.https://doi.org/10.1016/0014-4827(91)90385-8Surface-Enhanced Raman Scattering of the Complexes of Silver with Adenine and dAMP (1991)Journal of raman spectroscopy, 22(12), 791-796. Otto, C., Hoeben, F. P., Hoeben, F. P. & Greve, J.https://doi.org/10.1002/jrs.1250221211The ion-step induced response of membrane-coated ISFETs: theoretical description and experimental verification (1991)Biosensors & bioelectronics, 6(6), 477-489. Schasfoort, R. B. M., Bergveld, P., Kooyman, R. P. H. & Greve, J.https://doi.org/10.1016/0956-5663(91)85045-X

1990

Method for data transformation (1990)[Patent › Patent]. Terstappen, L. W. M. M., Mickaels, R., Dost, R. & Loken, M.Phenotypic characterization of the hematopoietic stem cell (1990)[Patent › Patent]. Becton Dickinson and Co.. Terstappen, L. W. M. M., Loken, M. R., Huang, S., Olweus, J. & Lund-Johansen, F.T lymphocyte precursor (1990)[Patent › Patent]. Becton Dickinson and Co.. Terstappen, L. W. M. M. & Picker, L.A new approach to immunoFET operation (1990)Biosensors & bioelectronics, 5(2), 103-124. Schasfoort, R. B. M., Kooyman, R. P. H., Bergveld, P. & Greve, J.https://doi.org/10.1016/0956-5663(90)80002-UCompetitive immunological detection of progesterone by means of the ion-step induced response of an immunoFET (1990)Sensors and Actuators B: Chemical, 1(1-6), 368-372. Schasfoort, R. B. M., Keldermans, C. E. J. M., Kooyman, R. P. H., Bergveld, P. & Greve, J.https://doi.org/10.1016/0925-4005(90)80232-OIdentification and Characterization of Plasma Cells in Normal Human Bone Marrow by High-Resolution Flow Cytometry (1990)Blood, 76(9), 1739-1747. Terstappen, L. W. M. M., Johnsen, S., Segers-Nolten, G. M. J. & Loken, M. R.Possibilities and limitations of direct detection of protein changes by means of an immunological field-effect transistor (1990)Analytica chimica acta, 238, 323-329. Schasfoort, R. B. M., Bergveld, P., Kooyman, R. P. H. & Greve, J.https://doi.org/10.1016/S0003-2670(00)80554-1The MCGA (Multiple Cubic Gradient Approximation) Method for the Analysis of Raman Spectra (1990)Journal of raman spectroscopy, 21(11), 725-736. de Mul, F. F. M., ten Have, H. B. G., Otto, C. & Greve, J.https://doi.org/10.1002/jrs.1250211105

1989

Influence of an immunological precipitate on D.C. and A.C. behaviour of an isfet (1989)Sensors and actuators, 18(2), 119-129. Schasfoort, R. B. M., Streekstra, G. J., Bergveld, P., Kooyman, R. P. H. & Greve, J.https://doi.org/10.1016/0250-6874(89)87012-XModulation of the ISFET response by an immunological reaction (1989)Sensors and actuators, 17(3-4), 531-535. Schasfoort, R. B. M., Bergveld, P., Bomer, J. G., Kooyman, R. P. H. & Greve, J.https://doi.org/10.1016/0250-6874(89)80041-1

1988

Method for analysis of cellular components of a fluid (1988)[Patent › Patent]. Becton Dickinson and Co.. Loken, M. R. & Terstappen, L. W. M. M.Method for discriminating between intact and damaged cells in a sample (1988)[Patent › Patent]. Becton Dickinson and Co.. Terstappen, L. W. M. M., Loken, M. R. & Shah, V. O.Flow cytometric characterization of white blood cells of healthy donors and patients with lymphocytic diseases (1988)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Terstappen, L. W. M. M.https://doi.org/10.3990/1.9789090021973Abnormal distribution of CD8 subpopulation in B-chronic lymphocytic leukemia identified by flow cytometry (1988)Leukemia Research, 12(7), 551-557. Terstappen, L. W. M. M., de Grooth, B. G., van Berkel, W. & ten Napel, C. H. H.https://doi.org/10.1016/0145-2126(88)90084-7Application of orthogonal light scattering for routine screening of lymphocyte samples (1988)Cytometry, 9(3), 220-225. Terstappen, L. W. M. M., de Grooth, B. G., van Berkel, W., ten Napel, C. H. H. & Greve, J.https://doi.org/10.1002/cyto.990090306Calculation of the Raman line broadening on carbonation in synthetic hydroxyapatite (1988)Journal of raman spectroscopy, 19(1), 13-21. de Mul, F. F. M., Otto, C., Greve, J., Arends, J. & ten Bosch, J. J.https://doi.org/10.1002/jrs.1250190104Four-Parameter white blood cell differential counting based on light scattering measurements (1988)Cytometry, 9(1), 39-43. Terstappen, L. W. M. M., de Grooth, B. G., Visscher, K., van Kouterik, F. A. & Greve, J.https://doi.org/10.1002/cyto.990090107The effects of splenic irradiation on lymphocyte subpopulations in chronic B-lymphocytic leukemia (1988)European Journal of Haematology, 41(5), 496-505. Terstappen, L. W. M. M., de Grooth, B. G., van Berkel, W., ten Napel, C. H. H., van Reijn, M. & Greve, J.https://doi.org/10.1111/j.1600-0609.1988.tb00233.x

1987

A Raman spectroscopic study of the interaction between nucleotides and the DNA binding protein gp32 of bacteriophage T4 (1987)Biopolymers, 26(10), 1667-1689. Otto, C., de Mul, F. F. M. & Greve, J.https://doi.org/10.1002/bip.360261003Light-scattering polarization measurements as a new parameter in flow cytometry (1987)Cytometry, 8(6), 539-544. de Grooth, B. G., Terstappen, L. W. M. M., Puppels, G. J. & Greve, J.https://doi.org/10.1002/cyto.990080602

1986

Particle discriminator and method (1986)[Patent › Patent]. Sequoia Turner. de Grooth, B. G., Greve, J. & Terstappen, L. W. M. M.https://patents.google.com/patent/US5017497A/enDiscrimination of human cytotoxic lymphocytes from regulatory and B-lymphocytes by orthogonal light scattering (1986)Journal of immunological methods, 95(2), 211-216. Terstappen, L. W. M. M., de Grooth, B. G., ten Napel, C. H. H., van Berkel, W. & Greve, J.https://doi.org/10.1016/0022-1759(86)90408-4Physical discrimination between human T-lymphocyte subpopulations by means of light scattering, revealing two populations of T8-positive cells (1986)Cytometry, 7(2), 178-183. Terstappen, L. W. M. M., de Grooth, B. G., Nolten, G. M. J., ten Napel, C. H. H., van Berkel, W. & Greve, J.https://doi.org/10.1002/cyto.990070209Surface-enhanced Raman spectroscopy of DNA bases (1986)Journal of raman spectroscopy, 17(3), 289-298. Otto, C., van den Tweel, T. J. J., de Mul, F. F. M. & Greve, J.https://doi.org/10.1002/jrs.1250170311

1985

Flow cytometric determination of circulating immune complexes with the indirect granulocyte phagocytosis test (1985)Cytometry, 6(4), 316-320. Terstappen, L. W. M. M., de Grooth, B. G., Nolten, G. M. J., ten Napel, C. H. H., van Berkel, W. & Greve, J.https://doi.org/10.1002/cyto.990060407Raman microspectroscopy of LiDNA fibres in ethanol and tert-butanol (1985)Journal of raman spectroscopy, 16(6), 373-376. Mud, J., Otto, C., de Mul, F. F. M. & Greve, J.https://doi.org/10.1002/jrs.1250160605

1984

Micro-Raman spectroscopy of chromosomes (1984)Journal of raman spectroscopy, 15(4), 268-272. de Mul, F. F. M., van Welle, A. G. M., Otto, C. & Greve, J.https://doi.org/10.1002/jrs.1250150412Two small-volume electrochemical cells for the measurement of surface enhanced Raman scattering (1984)Measurement science and technology, 17, 624-626. Otto, C., van Welie, A., de Jong, E., de Mul, F. F. M., Mud, J. & Greve, J.https://doi.org/10.1088/0022-3735/17/7/019
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