Quantification of the TMS-EEG response in epilepsy
Transcranial Magnetic Stimulation (TMS) is a relatively noninvasive method to stimulate the brain. With TMS the excitability of the brain can be measured, for example by determining the motor threshold: the lowest intensity of a magnetic pulse which induces a motor evoked potential. In several neurological conditions, the cortical excitability may be changed. Patients suffering from epilepsy, for instance, have an increased cortical excitability.
Recently, combined TMS-EEG has become technically available. TMS induces a cortical response that can be measured with the EEG, resulting in a TMS evoked potential, the TEP. The advantage of combining TMS and EEG is that it is a direct measurement of cortical excitability. In addition, the response of other areas than motor or visual cortex can be studied with TMS-EEG. TMS-EEG may prove relevant for various clinical applications.
The aim of this project is to explore different techniques of signal analysis leading to a reliable quantification of the TMS-EEG response and to investigate the differences in TMS-EEG response between healthy volunteers and patients suffering from epilepsy.
This graduation project is part of the PhD project of Esther ter Braack.
Prof. dr. ir. M.J.A.M. van Putten (University of Twente & Medisch Spectrum Twente)
E.M. ter Braack, MSc (University of Twente)