Ciska Heida: Central Motor Control

How does human neural circuitry control posture and voluntary movements? Insight into the central mechanisms of human motor control and motor disorders such as Parkinson’s disease forms the basis for development of advanced therapies. Deep Brain Stimulation within the anterior-dorsal subthalamic nucleus (STN) or globus pallidus internus (GPi), which are both part of the Basal Ganglia, can be used to improve the suppression of symptoms for Parkinson’s disease (PD) patients. However, the mechanism(s) of DBS is(/are) still unclear and side-effects may occur. It is not known which neuronal elements are stimulated and/or blocked during DBS treatment, nor is it known whether the stimulation has effects locally or if it acts on the entire circuit. Furthermore, there is limited knowledge of the connections within this network as well as the interconnectivity within the nuclei of this network.

Computational of (part of) the brain networks involved in motor control aid in determining the function of the Basal Ganglia and the effects of stimulation on network behaviour. In addition, experimental research including movement tests performed by PD patients and in-vitro studies using brain slices provide information regarding the symptoms, and clinical effects of DBS as well as more fundamental electrophysiological data.


Peter Veltink

Frauke Luft

Kees van Dijk


Ciska Heida: Central Motor Control

Deep Brain Stimulation in Parkinson's Disease - Towards an intelligent form of neural modulation

The “Deep Brain Stimulation in Parkinson's Disease - Towards an intelligent form of neural modulation” project (also known as the iDBS project) is funded by TWIN, a Dutch initiative to support research on neural modulation. The collaborating partners within the project are University of Twente (UT) and the Academic medical Center in Amsterdam (AMC). ... read more

NeuroSIPE: The movement diagnostic system

A diagnostic system will be developed to capture abnormal brain activations in movement disorders patients, combining functional MRI, measures of muscle activity, video tracking devices and ... read more

BrainGain: Modulation of abnormal brain activity by neurostimulation

The stimulated nucleus is part of an extensive network involving many brain structures and consisting of several closed loops. Stimulation directly affects neuronal elements within the vicinity of the stimulus site, but ... read more

BrainGain: Targeting the brain with DBS in Parkinson’s disease

Finding optimal DBS settings is complicated by uncertainties regarding optimum targets leading to therapeutic benefits as well as the low thresholds for side effects. ... read more