Patents 2016

Simple and affordable method for immunophenotyping using a microfluidic chip sample preparation with image cytometry

Inventors: Markus Beck, Leon Terstappen
United States Patent: 9442106 B2
Filed: Sep 13, 2016

Patents 2015

Circulating tumor cell assay
Inventors: Antonio Gualberto, Maria Luisa Paccagnella, Carrie L. Melvin, Madeline I. Repollet, David Chianese, Mark Carle Connely, Leon Terstappen
United States Patent: 8940493 B2
Filed: Jan 27, 2015

System for the detection and enumeration of suspect target cells in a mixed cell population
Inventors: John A. Verrant, Arjan Tibbe, Brad Foulk, Joost Swennenhuis, Leon Terstappen, Mark Carle Connely, Michael T. Kagan
United States Patent: 9127302 B2
Filed: Sep 8, 2015

Patents 2013

Imaging of immunomagnetically enriched rare cells

Inventors: Tycho Scholtens, Frederik Schreuder, Jan Greve, Arjan Tibbe, Leon Terstappen
United States Patent: 8569077 B2
Filed: Oct 29, 2013

Patents 2012

Methods and algorithms for cell enumeration in a low-cost cytometer
Inventors: Droog, E. Gohel, D. Tibbe, AGJ. Greve, J. Terstappen, Leon WMM, 
United States Patent: 8128890 B2
Filed: Mar 6, 2012

Method and apparatus for imaging target components in a biological sample using permanent magnets
Inventors: Arjan GJ Tibbe, Leon WMM Terstappen
United States Patent No: 8110101 B2
Filed: February 7, 2012

Patents 2011

Methods and algorithms for cell enumeration in a low-cost cytometer
Inventors: Droog, E. Tibbe, A. Greve, J. Gohel, D. Terstappen, L.
United States Patent: 7943397
Filed: May 17, 2011

A Method For Assessing Disease States By Profile Analysis of Isolated Circulating Endothelial Cells
Inventors: Mark Connelly, Gerald V. Doyle, Galla Chandra Rao, Leon Terstappen.
United States Patent: 7901950.
Filed: March 8, 2011

Analysis of Circulating Tumor Cells, Fragments, and Debris
Inventors: Galla Chandra Rao, Christopher Larson, Madeline Repollet, Herman Rutner, Leon WMM Terstappen, Shawn Mark O’Hara, Steven Gross.
United States Patent: 7863012 B2
Filed: January 4, 2011

Patents 2010

Method and apparatus for imaging target components in a biological sample using permanent magnets
Inventors: Arjan GJ Tibbe, Leon WMM Terstappen 
United States Patent No: 7828968 B2
Filed: November 9, 2010

Method and algorithms for cell enumeration in low-cost cytometer
Inventors: Coumans FAW, Greve J, Modica F, Greve J, Modica F, Terstappen LWMM, Tibbe A,Verrant J 
United States Patent No: 7764821 B2
Filed: July 27, 2010

Method and apparatus for imaging target components in a biological sample using permanent magnets
Inventors: Arjan GJ Tibbe, Leon WMM Terstappen
United States Patent No: 7828968 B2
Filed: November 9, 2010

Magnetic separation apparatus and methods
Inventors: Tycho M Scholtens, Leon WMM Terstappen, Arjan GJ Tibbe. United States Patent No: 7666308 B2
Filed: February 23, 2010

Patents 2008

Methods and reagents for rapid and efficient isolation of circulating tumor cells

Inventors: Leon WMM Terstappen, Galla Chandra Rao, Jonathan W. Uhr, Emillian V. Racilla, Paul A Liberti
United States Patent No: 7332288 B2
Filed: February 18, 2008

Patents 2007

Devices and methods to image objects

Inventors: Arjan Tibbe,Jan Greve, Leon WMM Terstappen, Bart De Grooth 
United States Patent No: 7282180 B2
Filed: October 16, 2007

Patents 2006

Apparatus and methods for magnetic separation 

Inventors: Leon Terstappen, Gerald V Doyle, Paul A Liberti, Gerald J Dolan
United States Patent No: 7056657 B2
Filed: June 6, 2006

Patents 2005

Magnetic separation apparatus and methods
Inventors: Leon WMM Terstappen, GJ Dolan 
United States Patent No: 6890426 B2
Filed: May 10, 2005

Phage antibodies 
Inventors: Leon WMM Terstappen, Ton Logtenberg 
United States Patent No: 6858384 B2
Filed: February 22, 2005

Patents 2004

Magnetic separation apparatus and methods 

Inventors: Leon WMM Terstappen, GJ Dolan 
United States Patent No: 6790366 B2
September 14, 2004

Patents 2003

Increased separation efficiency via controlled aggregation of magnetic nanoparticles
Inventors: Leon WMM Terstappen, Galla Chandra Rao, Paul A Liberti
United States Patent No: 6623982 B1
Filed: April 22, 2003

Methods for enhancing binding interactions between members of specific binding pairs
Inventors: Leon WMM Terstappen, Galla Chandra Rao, Paul A Liberti
United States Patent No: 6551843 B1
Filed: September 23, 2003

Increased separation efficiency via controlled aggregation of magnetic nanoparticles
Inventors: Leon WMM Terstappen, Galla Chandra Rao, Paul A Liberti
United States Patent No: 6620627 B1
Filed: September 16, 2003

Apparatus and methods for capture and analysis of particulate entities
Inventors: Leon WMM Terstappen, Galla Chandra Rao, Paul A Liberti
United States Patent No: 6623983 B1
Filed: September 23, 2003

Methods and reagents for the rapid and efficient isolation of circulating cancer cells
Inventors: Leon WMM Terstappen, Galla Chandra Rao, Jonathan W. Uhr, Emillian V. Racilla, Paul A Liberti
United States Patent No: 6645731 B2
Filed: November, 2003

Magnetic separation apparatus and methods
Inventors: Leon WMM Terstappen, GJ Dolan
United States Patent No: 6660159 B1
Filed: December 9, 2003

Method to distinguish hematopoietic progenitor cells
Inventors: Johanna Olweus, Fridtjof Lund-Johansen, Leon WMM Terstappen United States Patent No: 6555324 B1
Filed: April 29, 2003

Patents 2002

Apparatus and methods for magnetic separation
Inventors: LWMM Terstappen Gerald V. Doyle, Paul A. Libert, Gerald J. Dolan
United States Patent No: 6361749
Filed: March 26, 2002

Methods and reagents for the rapid and efficient isolation of circulating cancer cells
Inventors: LWMM Terstappen, Galla Chandra Rao, Jonathan W. Uhr, Emillian V. Racilla, Paul A Liberti
United States Patent No: 6365362
Filed: April 2, 2002

Patents 2001

Method to select and transfect cell subpopulations
Inventor: Leon WMM Terstappen
United States Patent No: 6228624 B1
Filed: May 8, 2001

Phage antibodies
Inventors: Leon WMM Terstappen, Ton Logtenberg
United States Patent No: 6265150 B1
Filed: July 24, 2001

Multidimensional cell differential analysis
Inventors: Leon WMM Terstappen, Chia-Huei Chen
United States Patent No: 6287791 B1
Filed: Sept 11, 2001

Patents 2000

Methods for biological substance analysis employing internal magnetic gradients separation and an externally-applied transport force
Inventors: Terstappen, Leon W. M. M.; Liberti, Paul A
United States Patent No: 6013188
Filed: January 11, 2000

Magnetic devices and sample chambers for examination and manipulation of cells
Inventors: GJ Dolan, Leon WMM Terstappen
United States Patent No: 6136182
Filed: October 24, 2000

Patents 1999

Magnetic Separation Apparatus and Methods Employing an Internal Magnetic Capture Gradient and an External Transport Force
Inventors: GJ Dolan, Leon WMM Terstappen
United States Patent No: 5985153
Filed: November 16, 1999

Quantitative cell analysis methods employing magnetic separation
Inventors: Terstappen, Leon W. M. M.; Liberti, Paul A.
United States Patent No: 5993665
Filed: November 30, 1999

Patents 1998

Assay of blood or other biologic samples for target analytes
Inventors: RA Levine, SC Wardlaw, LWMM Terstappen
United States Patent No: 5776710
Filed: July 7, 1998

Assay of blood or other biological samples for target analytes
Inventors: RA Levine, SC Wardlaw, LWMM Terstappen
United States Patent No: 5834217
Filed: November 10, 1998

Phenotypic characterization of the hematopoietic stem cell
Inventors: LWMM Terstappen
United States Patent No: 5840580
Filed: November 24, 1998

Patents 1997

T Lymphocyte precursor
Inventors: LWMM Terstappen, Louis J Picker
United States Patent No: 5622853
Filed: 1997

Automatic lineage assignment of acute leukemias by flow cytometry
Inventors: LWMM Terstappen, Ben JH Verwer
United States Patent No: 5605805
Filed: 1997

Affinity-binding separation and release of one or more selected subset of biological entities from a mixed population thereof
Inventors: LWMM Terstappen, CC Rao, DL Gohel, B Feeley, Gross S, Church E, Liberti P
United States Patent No: 5646001
Filed: July 8, 1997

Patents 1996

New population of human progenitor stem cells - lack CD38 but express CD34 and are used in bone marrow transplantation and gene therapy
Inventors: M Loken, LWMM Terstappen
European Patent No: 455482
Filed: 1996

T Lymphocyte precursor
Inventors: LWMM Terstappen, Louis J Picker
United States Patent No: 5583033
Filed: 1996

Patents 1995

Indirect fluorescent assay of blood samples

Inventors: RA Levine, SC Wardlaw, LWMM Terstappen, TJ Mercolino, Recktenwald DJ
United States Patent No: 5460979
Filed: Oct. 24, 1995

Patents 1994

Apparatus for indirect fluorescent assay of blood samples

Inventors: RA Levine, SC Wardlaw, LWMM Terstappen, TJ Mercolino, Recktenwald DJ 
United States Patent No: 5342790
European Patent Application No: 595641
Filed: Aug. 30, 1994

Patents 1993

Method for the classification and monitoring of leukemias
Inventor: LWMM Terstappen
United States Patent No: 5234816
Filed: Aug. 10, 1993

Method for data transformation
Inventors: RA Mickaels, RK Dost, LWMM Terstappen, MR Loken
United States Patent No: 5224058
European Patent Application No: 455392
Filed: June 29, 1993

Patents 1991

Method for discriminating between intact and damaged cells in a sample
Inventors: LWMM Terstappen, MR Loken
United States Patent No: 5057413
European Patent No: 347039
Filed: October 15, 1991

Particle discriminator and method
Inventors: BG de Grooth, J Greve, LWMM Terstappen
United States Patent No: 5017497
DE 3712862 C2 960711
Filed: May 21,1991

Method for analysis of cellular components of a fluid
Inventors: LWMM Terstappen, MR Loken
United States Patent No: 5047321
European Patent No: 347210
Filed: September 10, 1991