Vagus nerve stimulation (VNS) is a form of neurostimulation, first introduced in 1988 for treating patients suffering from refractory epilepsy, and has shown to be an effective treatment in numerous patients. However, not for all epilepsy patients VNS is as effective and sometimes side-effects of the stimulation limit the amplitude that can be applied. Besides the seizure reducing effects, VNS can also have influence on the larynx, the heart and the respiratory system.
The mechanisms of action of VNS and the origin(s) of its side-effects are largely unknown. During my master project I will try both to identify cause(s) of side-effects and obtain insight in the mechanisms of action of VNS.
Ir. C.C. de Vos (Medisch Spectrum Twente and University of Twente)
Prof. dr. J.A.M. van der Palen (Medisch Spectrum Twente and University of Twente)
Prof. dr. ir. M.J.A.M van Putten (Medisch Spectrum Twente and University of Twente)
Dr. ir. F.H.C. de Jongh (Medisch Spectrum Twente)
M.J. Driesse (Medisch Spectrum Twente)