See Research

Previous Publications

T. Ma, M. Walko, M. Lepoitevin, J. M. Janot, E. Balanzat, A Kocer, S. Balme “Combining light-gated and pH-responsive nanopore based on PEG-spiropyran functionalization” Advanced Materials Interfaces, 5: 1701051, 1-9 (2018)

D. Calle, D. Yilmaz, S. Cerdan, A. Kocer “Drug delivery from engineered organisms and nanocarriers as monitored by multimodal imaging technologies” AIMS Bioengineering 4(2): 198- 222 (2017)


M. N. Melo, C. Arnarez, H. Sikkema, N. Kumar, M. Walko, H. J. C. Berendsen, A. Kocer, S. J.
Marrink and H. I. Ingólfsson “High-throughput simulations reveal membrane-mediated effects of alcohols on MscL gating” J. Am. Chem. Soc. 139: 2664-2671(2017)                                                                                                                                                                                                                                                                                                                                                                                                                      

A. Dimitrova, M. Walko, M. Hashemi Shabestari, P. Kumar, M. Huber, and A. Kocer  “In situ, Reversible Gating of a Mechanosensitive Ion Channel through Protein-Lipid Interactions” Frontiers in Physiology, 7: Article 409 (2016) 

A. Kocer Mechanisms of mechanosensing - Mechanosensitive channels, function and re-engineering” Current Opinion in Chemical Biology 29: 120-127 (2015) (invited)

D. Yilmaz, A. Dimitrova, M. Walko, A. Kocer “Study of Light-induced MscL Gating by EPR Spectroscopy” European Biophysics Journal 44(7): 557-565 (2015)

A. Konijnenberg, J B Gonzalez, L Bannwarth, D Yilmaz, A Kocer, C Venien-Bryan, N Zitzmann, F Sobott “Top-down mass spectrometry of intact membrane protein complexes reveals oligomeric state and sequence information in a single experiment” Protein Science 24: 1292 - 1300 (Invited) (2015)

J Pacheco-Torres, N Mukherjee, M Walko, P López-Larrubia, P Ballesteros, S Cerdan, A Kocer “Image Guided Drug Release From pH-sensitive Ion Channel-functionalized Stealth Liposomes into an in vivo Glioblastoma Model” Nanomedicine: Nanotechnology, Biology, and Medicine 11: 1345-1354 (2015)

A. Konijnenberg#, D Yilmaz#, H. I. Ingólfsson, A  Dimitrova, S J Marrink, Z. Lid, C. Vénien-Bryand, F. Sobott, A. Kocer “Global structural changes of an ion channel during its gating are followed by ion mobility mass spectrometry” Proc Natl Acad Sci USA 111: 17170-17175 (2014) (#: equal contribution)

 H. I. Ingólfsson*, P. Thakur, K.  Herold, E.  Hobart, N.  Ramsey, X. Periole, D. de Jong, M. Zwama, D.  Yilmaz, K.  Hall, T.  Maretzky, H. Hemmings, C. Blobel, S. Marrink, A.  Kocer, J.  Sack, O. Andersen "Phytochemicals perturb membranes and promiscuously alter protein function" ACS Chemical Biology 9: 1788-1798 (2014)

 N Mukherjee, M. D. Jose, J. P. Birkner, M. Walko, H. I. Ingólfsson, A. Dimitrova, C. Arnarez, S. J. Marrink, A. Koçer “The activation mode of mechanosensitive ion channel MscL by lysophosphatidylcholine differs from tension-induced gating” The FASEB Journal 28:4292-4302 (2014)

 M. Urban, Al. Kleefen, N. Mukherjee, B. Windschiegl, P. Seelheim, M. vor der Brüggen, A. Koçer, and R. Tampé “Semi-automated nanopore biochips for multiplexed parallel single transport recordings” Nano Letters 14: 1674-1680 (2014)

 M. D.F. Jose#, M. Barthmes#, J. P. Birkner, A. Brüggemann, C. Wahl-Schott, A. Kocer “Studying mechanosensitive ion channels with automated patch clamp” European Biophysics Journal 43:97-104 (2014)

 E.Halzǎ,T. Hedegaard Bro, B. Bilenberg, and A. Kocer  “Well-Defined Microapertures for Ion Channel Biosensors” Anal. Chem.85: 811−815 (2013) 

 J. T. Mika, J. P. Birkner, B. Poolman, A. Koçer “On the role of individual subunits in MscL gating: “All for one, one for all?” FASEB J 27: 882-892, (2013) 

 W. Szymanski§, D. Yilmaz§, A. Kocer*, B.L. Feringa* “Bright ion channels and lipid bilayers”. Accounts of Chemical Research 46(12):2910-23, (2013) (*Both corresponding authors are invited to generate this article.) (§: equal first authorship)

 M. Persson, M. Gullberg, C. Tolf, A. M. Lindberg, A. Månsson, and A. Kocer “Transportation of nanoscale cargoes by Myosin propelled actin filaments.” PLoS ONE 8 (2):  p. e55931 (2013) 

 L. Tauk, T. Thami, L. Ferez, A. Koçer, J.M. Janot, P.Déjardin “Phosphatidylcholine background surfaces for biosensors” Colloids and Surfaces B: Biointerfaces 101 (1): 189-195 (2013) 

 J. P. Birkner, B. Poolman, A. Koçer “Hydrophobic gating of Mechanosensitive channel of large conductance evidenced by single-subunit resolution” Proc Natl Acad Sci USA 109 (32): 12944-12949 (2012) 

 A.Kocer, Lara Tauk,Philippe Dejardin “Nanopore sensors: from hybrid to abiotic systems” Biosensors and Bioelectronics 38(1): 1-10 (2012) 

 I. Kusters, N. Mukherjee, M. R. de Jong, S. Tans, A. Koçer, A.Driessen “Taming Membranes: Functional Immobilization of Biological Membranes in Hydrogels” PLoS ONE 6(5):e20435. (2011) 

 C. E. Price, A. Koçer, S. Kol, J. P. van der Berg, A. J.M. Driessen* “In vitro synthesis and oligomerization of the mechanosensitive channel of large conductance, MscL, into a functional ion channel” FEBS Letters 585(1), 249-254 (2011)

 A. D. Cirac, G. Moiset, J. T. Mika, A. Koçer, P. Salvador, B.Poolman, S. J. Marrink*, D. Sengupta* “The Molecular Basis for Antimicrobial Activity of Pore-Forming Cyclic Peptides” Biophysical Journal 100(10) pp. 2422 – 2431 (2011). 

 A.Dudia, A. Koçer, V. Subramaniam, H. Kanger. “Biofunctionalized lipid-polymer hybrid nanocontainers with controlled permeability” Nano Letters 8 (4): 1105-1110, (2008)

 A. Koçer.” A Remote Controlled Valve in Liposomes for Triggered Liposomal Release” J Liposome Research 17 (3): 219 – 225, (2007) (Invited).

 A. Koçer, M. Walko, B. L. Feringa. “Synthesis and Utilization of reversible and irreversible light-activated nanovalves derived from the channel protein MscL” Nature Protocols 2(6): 1426- 1437, (2007) 

 A. Koçer, M. Walko, E. Bulten, E. Halza, B. L. Feringa, W. Meijberg. “Rationally Designed Chemical Modulators Convert a Bacterial Channel Protein into a pH-Sensory Valve” Angew. Chem. Int. Ed. 45: 3126-3130, (2006)

 A. Koçer, M. Walko, W. Meijberg, B. L. Feringa. “A Light-Actuated Nanovalve Derived from a Channel Protein.” Science309: 755-759, (2005)