MESA+ University of Twente
NanoMedicine

NanoMedicine

Jasper van Weerd, Shrikrishnan Sankaran, Oliver Roling, Sertan Sukas, Sven Krabbenborg, Jurriaan Huskens, Séverine Le Gac, Bart-Jan Ravoo, Marcel Karperien, Pascal Jonkheijm, A microfluidic device with continuous ligand gradients in supported lipid bilayers to probe effects of ligand surface density and solution shear stress on pathogen adhesion, Adv. Mat. Interf., accepted.

Guillaume Lajoinie, Ine de Cock, Constantin C. Coussios, Ine Lentacker, Séverine Le Gac, Eleanor Stride, Michel Versluis, In vitro methods to study bubble-cell interactions: fundamentals and therapeutic applications, Biomicrofluidics, 2016, 10, 011501.

Sarah Aβhoff, Sertan Sukas, Tadatsugu Yamaguchi, Catharina A. Hommersom, Séverine Le Gac, Nathalie Katsonis, Superstructures of chiral nematic microspheres as all-optical switchable distributors of light, Sci. Rep., 2015, 5, 14183.

Hedwig M. Braakhuis, Samantha K. Kloet, Sanja Kezic, Frieke Kuper, Margriet V.D.Z. Park, Susann Bellmann, Meike van der Zande, Séverine Le Gac, Petra Krystek, Ruud J.B. Peters, Ivonne M.C.M. Rietjens, Hans Bouwmeester, Progress and future of in vitro models to study translocation of nanoparticles, Archiv. Toxicol., 2015, 89, 1469-1495.

Dorit C. Kieslinger*, Zhenxia Hao*, Carlijn G. Vergouw, Elizabeth H. Kostelijk, Cornelis B. Lambalk, Séverine Le Gac, In vitro development of donated frozen thawed human embryos in a prototype static microfluidic device: a randomized controlled trial, Fertil. Steril., 2015, 103, 680-686.

Ravi Sinha, Séverine Le Gac, Nico Verdonschot, Albert van den Berg, Bart Koopman, Jeroen Rouwkema, A medium throughput device to study the effects of combinations of surface strains and fluid-flow shear stresses on cells, Lab Chip, 2015, 15, 429-435.

Class-Willem Visser*, Marise V. Gielen*, Zhenxia Hao, Séverine Le Gac, Detlef Lohse, Chao Sun, Quantifying cell adhesion through impingement of a controlled microjet, Biophys. J., 2015, 108, 23-31. Highlighted in the Biophys. J. Newsletter. Click here for a movie.

Björn Harink, Séverine Le Gac, David Barata, Clemens van Blitterswijk, Pamela Habibovic, Microfluidic platform with four orthogonal and overlapping gradients for soluble compound screening for use in regenerative medicine research, Electrophoresis, 2015, 36, 475-484..

Johan Bomer, Alexander Prokofyev, Albert van den Berg, Séverine Le Gac, Wafer-scale fabrication of glass-FEP-glass microfluidic devices for lipid bilayer experimentation, Lab Chip, 2014, 14, 4461-4464.

Yoonsun Yang, Joost Swennenhuis, Hoon Suk-Rho, Séverine Le Gac, Leon Terstappen, Parallel Single Cancer Cell Whole Genome Amplification Using Button-Valve Assisted Mixing In Nanoliter Chambers, PLOS ONE, 2014, 9, e107958.

Adithya Sridhar, Albert van den Berg, Séverine Le Gac, Non-invasive monitoring of osteogenic differentiation on microtissue arrays under physiological conditions using scanning electrochemical microscopy, Electroanalysis, 2014, 26, 1881–1885.

Sertan Sukas, Erik Schreuder, Björn de Wagenaar, Joost Swennenhuis, Albert van den Berg, Leon Terstappen, Séverine Le Gac, Novel side electrode configuration integrated in fused silica microsystems for synchronous optical and electrical spectroscopy, Lab Chip, 2014, 14, 1821-1825.

Björn Harink, Séverine Le Gac, David Barata, Clemens van Blitterswijk, Pamela Habibovic, Microtiter plate-sized standalone chip holder for microenvironmental physiological control in gas-impermeable microfluidic devices, Lab Chip, 2014, 7, 1816-1820.

Adithya Sridhar, Hans L. de Boer, Albert van den Berg, Séverine Le Gac, Microstamped Petri dishes for scanning electrochemical microscopy analysis of arrays of microtissues, PLOS ONE, 2014, 9, e93618.

Sandra A. Henkemeyer, Caroline Schwarzer, Michele Boiani, Jens Ehmcke, Séverine Le Gac, Stefan Schlatt, Verena Nordhoff, Effects of embryo culture media do not persist after implantation: a histological study in mice, Hum. Reprod., 2014, 29, 220-233.

Telma C. Esteves, Fleur van Rossem, Verena Nordhoff, Stefan Schlatt, Michele Boiani, Séverine Le Gac, Microfluidic system supports single mouse embryo culture leading to full-term development, RSC Adv., 2013, 3, 26451-26458.

Björn Harink, Séverine Le Gac, Roman Truckenmüller, Clemens van Blitterswijk, Pamela Habibovic, Regeneration-on-a-chip? The perspectives on use of microfluidics in regenerative medicine, Lab Chip, 2013, 13, 3512–3528.

Verena Stimberg, Johan G. Bomer, Iris van Uitert, Albert van den Berg, Séverine Le Gac, High-yield, reproducible and quasi-automated bilayer formation in a microfluidic format, Small, 2013, 9, 1076-1085, (cover article)

Caroline Schwarzer, Telma C. Esteves, Marcos J. Arauzo-Bravo, Séverine Le Gac, Verena Nordhoff, Stefan Schlatt, Michele Boiani; ART culture conditions change the probability of mouse embryo gestation through defined cellular and molecular responses, Human Reproduction, 2012, 27, 2627-2640, (cover article).

Nicolas C. Rivron, Erik J. Vrij, Jeroen Rouwkema, Séverine Le Gac, Albert van den Berg, Roman Truckenmüller, Clemens A. van Blitterswijk, Tissue deformation spatially modulates VEGF signaling and angiogenesis. PNAS, 2012, 109, 18, 6881-6891.

Floris van den Brink, Elmar Gool, Jean-Philippe Frimat, Johan Bomer, Albert van den Berg, Séverine Le Gac, Parallel single cell analysis (PaSCAl) microfluidic platform, Electrophoresis, 2011, 32, 3094–3100, (cover article).

Iris van Uitert, Séverine Le Gac, Albert van den Berg, Determination of the electroporation onset of bilayer lipid membranes as a novel approach to establish ternary phase diagrams: example of the l-a-PC/SM/cholesterol system, Soft Matter, 2010, 6, 4420-4429.

Rerngchai Arayanarakool, Séverine Le Gac, Albert van den Berg, Low temperature, simple and fast integration technique of microfluidic chips using a UV-curable adhesive, Lab on a Chip, 2010, 10, 2115-2121.

Séverine Le Gac, Albert van den Berg, Single cells as experimentation units in lab-on-a-chip devices (invited opinion article), Trends in Biotechnology, 2010, 28, 55.

Iris van Uitert, Séverine Le Gac, Albert van den Berg, Towards a better understanding of the mechanism of (electro)pore formation using planar membrane models, Biophysica Biochimica Acta membranes, 2010, 1798, 21-31.

Erwin Nijhuis, Séverine Le Gac, Andre A. Poot, Jan Feijen, Istvan Vermes, Bax-mediated mitochondrial membrane permeabilization after heat treatment is caspase-2 dependent, International Journal of Hyperthermia, 2008, 24, 357.

Rory Dijkink, Séverine Le Gac, Erwin Nijhuis, Albert van den Berg, Istvan Vermes, Claus-Dieter Ohl, Laser-induced cavitation bubbles for drug deliver into biological cells, Physics in Medicine and Biology, 2008, 53, 375.

Séverine Le Gac, Ed Zwaan, Albert van den Berg, Claus-Dieter Ohl, Sonoporation of suspension cells with single cavitation bubbles in a microfluidic environment, Lab on a Chip, 2007, 7, 1666.

Ed Zwaan, Séverine Le Gac, Kinko Tsuji, Claus-Dieter Ohl, Controlled cavitation in microfluidic systems, Physics Review Letters, 2007, 98, 254501.

Floor Wolbers, Paul ter Braak, Séverine Le Gac, Regina Luttge, Helene Andersson, Istvan Vermes, Albert van den Berg, Viability study of HL60 cells in contact with commonly used microchip materials, Electrophoresis, 2006, 27, 5073-5080.

Séverine Le Gac, Istvan Vermes, Albert van den Berg, Quantum dots-based probes conjugated to Annexin V for photostable apoptosis detection and imaging, NanoLetters, 2006, 6, 1863-1869.

Séverine Le Gac, Steve Arscott, Christian Rolando, An open design microfabricated nib-like nanoelectrospray emitter tip on a conducting silicon substrate for the application of the ionization voltage, J. Am. Soc. Mass Spectrom., 2006, 17, 75-80 (cover article).

Julien Carlier, Steve Arscott, Vincent Thomy, Jean-Christophe Camart, Cécile Cren-Olivé, Séverine Le Gac, Integrated microfabricated systems including a purification module and an on-chip nano electrospray ionization interface for biological analysis, J. Chrom. A, 2005, 1071, 213-222.

Steve Arscott, Séverine Le Gac, Christian Druon, Pierre Tabourier, Christian Rolando, Polysilicon nanoelectrospray emitter tips for mass spectrometry, Sens. and Act. B, 2005, 106, 241-249.

Martin Brinkmann, Steve Arscott, Séverine Le Gac, Christian Druon, Pierre Tabourier, Christian Rolando, Ralf Blossey, Microfluidic design rules for capillary-slot based electrospray sources, Appl. Phys. Lett., 2004, 85, 2140-2142.

Séverine Le Gac, Julien Carlier, Cécile Cren-Olivé, Jean-Christophe Camart, Christian Rolando, Monoliths for microfluidics devices in proteomics, J. Chrom. B, 2004, 808, 3-14.

Steve Arscott, Séverine Le Gac, Christian Druon, Pierre Tabourier, Christian Rolando, A micromachined 2D nanoelectrospray emitter, Electronic letters, 2003, 39, 1702-1703.

Steve Arscott, Séverine Le Gac, Christian Druon, Pierre Tabourier, Christian Rolando, A Micro-nib nanoelectrospray source for mass spectrometry, Sens. and Act. B, 2004, 98, 140-147.

Séverine Le Gac, Steve Arscott, Cécile Cren-Olivé, Christian Rolando, A novel nib-like design for microfabricated nanospray tips, J. Am. Soc. Mass Spectrom., 2004, 15, 409-412.

Steve Arscott, Séverine Le Gac, Christian Druon, Pierre Tabourier, Christian Rolando, A planar on-chip micro-nib interface for NanoESI-MS microfluidic applications, J. Micromech. Microeng., 2004, 14, 310-316.

Séverine Le Gac, Steve Arscott, Christian Rolando, Two-dimensional microfabricated sources for nanoelectrospray, J. Mass Spectrom., 2003, 38, 1259-1264.

Séverine Le Gac, Steve Arscott, Christian Rolando, A planar microfabricated nanoelectrospray tip based on a capillary slot, Electrophoresis, 2003, 24, 3640-3647.

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National (refereed) journals

Mohammed Kajjout, Christian Rolando, Séverine Le Gac, Microfluidics reactors and selectivity for organic chemistry applications, La Houille Blanche-Revue internationale de l’eau, 2006, 2, 83-86.

Julien Carlier, Steve Arscott, François Caron, Jean-Christophe Fourrier, Vincent Thomy, Jean-Christophe Camart, Christian Druon, Pierre Tabourier, Kasia Chuda, Xavier Coqueret, Séverine Le Gac, Christian Rolando, Microfluidique intégrée pour le couplage d’un microcanal à une interface nanoESI : application à la protéomique, La Houille Blanche-Revue internationale de l’eau, 2006, 3, 60-64.

Séverine Le Gac, Steve Arscott, Christian Rolando, Novel microfabricated nanoESI sources for proteomics applications, La Houille Blanche-Revue internationale de l’eau, 2006, 5, 45-50.

Séverine Le Gac, Christian Rolando, Christian Druon, Pierre Tabourier, Microfluidic system for proteomics analysis by ESI-MS, La Houille Blanche-Revue internationale de l’eau, 2003, 3, 60-64.

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Books, or contributions to books

S. Le Gac, A. van den Berg, Single Cell Electroporation in “Single Cell Analysis” edited by Sara Lindström and Helene Andersson-Svahn, Springer's Methods in Molecular Biology (MiMB), 2012, ISBN 978-1-61779-566-4.

S. Le Gac, A. van den Berg, Capturing and lysing cells on a microchip in “Unraveling single cell genomics Micro and nanotools!”, edited by N. Bontoux, L. Dauphinot and M.-C. Potier, RSC Publisher, 2010, ISBN 978-1-84755-911-1.

S. Le Gac, Analysis of proteins at the single cell level in “Unraveling single cell genomics Micro and nanotools!”, edited by N. Bontoux, L. Dauphinot and M.-C. Potier, RSC Publisher, 2010, ISBN 978-1-84755-911-1.

S. Le Gac, S. Arscott, C. Rolando, Microfabricated Nanoelectrospray Emitter Tips based on a Microfluidic Capillary Slot in “Miniaturization and Mass Spectrometry”, edited by S. Le Gac and A. van den Berg), RSC Publisher.

“Miniaturization and Mass Spectrometry”, edited by S. Le Gac and A. van den Berg, 2009. RSC Publisher.

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Patents

Chihiro Uematsu, Muneo Maeshima, Yasunori Shoji, Séverine Le Gac, J. G. E. Gardeniers, A blood cell removal device and a bacteriological examination device, JP 2013217879.

Muneo Maeshima, Yasunori Shoji, Chihiro Uematsu, Takuya Matsui, J. G. E. Gardeniers, Séverine Le Gac, Akira Miyake, A Sample Processing Unit, JP 2013221780.

Séverine Le Gac, Telma C. Esteves, Albert van den Berg, Microfluidic device with integrated sensors for cultivation of cells, 2011, WP 2013/004644.

Nicolas C Rivron, Erik J. Vrij, Roman Trückemüller, Jeroen Rouwkema, Séverine Le Gac, Clemens .A. van Blitterswijk, Self-assembling tissue modules, 2009, WO/2009/154466.

Steve Arscott, Séverine Le Gac, Christian Rolando, Christian Druon, Sources d’électronébulisation planaires sur le modèle d’une plume de calligraphie et leur fabrication, 2006, WO2005046881

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Wide-audience articles

Séverine Le Gac, Steve Arscott, Christian Rolando, Nouvelles sources de nano-ESI microfabriquées dédiées à la protéomique, Spectra Analyse, 34, 2005, 20-25.

Séverine Le Gac, Christian Rolando, Protéomique et microfluidique: le consortium BioChipLab, Biofutur, Novembre 2004 (Special issue Nanobio(techno)logy).

Séverine Le Gac, Christian Rolando, Microsystèmes d’analyse biologique, Chimix (Sigma-Aldrich), 9, 2003, 2-3.

Séverine Le Gac, Christian Rolando, Les microsystèmes en chimie, L’actualité chimique, February 2002, 21-31 (review).