MESA+ University of Twente
MESA+ NanoLab

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Analysis

In addition to the optical and electron microscopy facilities with various imaging modes to investigate a sample in microspace (1 m = 10-6 m) and nanospace (1 nm = 10-9 m), MAC-Twente offers a variety of chemical analysis techniques to explore the surface and internal structure of a specimen. Most of the techniques are commonly used to study inorganic materials but some of these can be used on specimens of organic nature too. The chemical analysis techniques offered by MAC-Twente will, e.g., give the elemental composition and in some cases also the chemistry of shallow surfaces of the sample and its bulk. Knowledge of the chemical constitution of the surface is required in areas such as adhesion, catalysis, photonics and chemical modification. Analyses can be done on scales from nanometres to micrometres in the normal direction, and from nanometres to millimetres in the lateral direction. Concentrations can be determined down to 0.1 atomic % . The MAC-Twente analysis facilities are completed by technologies for characterisation of samples in liquid.

Scanning X-ray photoelectron spectroscopy (XPS)

exploring the top atomic layers

XPS, for microscopic elemental mapping of nm thick layers, powders. Composition and chemistry by measuring spectra and chemical shifts .

Energy dispersive X-ray analysis (EDX)

compositional bulk analysis in SEM and TEM

In combination with SEM and TEM. Local analysis and elemental distribution (SEM) with spatial resolution from (sub)mm (SEM) to a few nm (TEM).

Electron Energy Loss Spectroscopy (EELS)

compositiional analysis and chemistry in TEM

Only in TEM. EELS can provide info about, e.g., composition and chemistry, and absolute thickness of a thin electron transparent TEM specimen.

Cathodoluminescence (CL)

probing optical and electronic properties in SEM, then correlate with composition and chemistry

CL in an SEM or scanning TEM (STEM) is a tool to characterise the optical and electronic properties of materials, then correlate them with morphology, microstructure, composition, and chemistry at the micron and sub-nm scale.

Matrix-Assisted Laser Desorption Ionization (MALDI) and ElectroSpray Ionization mass spectrometry (ESI)

analysis of bio– and large organic molecules

A soft ionization technique used in mass spectrometry, allowing the analysis of biomolecules and large organic molecules, which tend to be fragile and fragment when ionized by more conventional ionization methods.

Nanoparticle Tracking Analysis (NTA)

measurement of nanoparticle size and concentration; Visualization and analysis of Brownian motion tracks to determine particle size and concentration

Microscale Thermophoresis (MST)

measurement of binding constants in (bio)molecular interactions; Fast analysis of intermolecular interactions (KD’s) using microliter sample volumes

Circular Dichroism (CD) spectroscopy

measurement of chirality and protein secondary structure

Analysis

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>>>>In addition to the optical and electron microscopy facilities with various imaging modes to investigate a sample in microspace (1

m
>
m = 10>-6 m) and nanospace (1 nm = 10-9 m), MAC-Twente offers a  variety of chemical analysis techniques to explore the surface and internal structure of a specimen. Most of the techniques are commonly used to study inorganic materials but some of these can be used on specimens of organic nature too. The chemical analysis techniques offered by MAC-Twente will, e.g., give the elemental composition and in some cases also the chemistry of  shallow surfaces of the sample and its bulk. Knowledge of the chemical constitution of the surface is required in areas such as adhesion, catalysis, photonics and chemical modification. Analyses can be done on scales from nanometres to micrometres in the normal direction, and from nanometres to millimetres in the lateral direction. Concentrations can be determined down to 0.1 atomic % .
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Scanning X-ray photoelectron spectroscopy (XPS)

XPS, for microscopic elemental mapping of nm thick layers, powders. Composition and chemistry by measuring spectra and chemical shifts .

 

Energy dispersive X-ray analysis (EDX)

>In combination with SEM and TEM. Local analysis and elemental distribution (SEM) with spatial resolution from (sub)mm (SEM) to a few nm (TEM).

 

Electron Energy Loss Spectroscopy (EELS)

Only in TEM. EELS can provide info about, e.g., composition and chemistry, and absolute thickness of a thin electron transparent TEM specimen.

 

Matrix-Assisted Laser Desorption Ionization (MALDI) mass spectrometry

A soft ionization technique used in mass spectrometry, allowing the analysis of biomolecules and large organic molecules, which tend to be fragile and fragment when ionized by more conventional ionization methods.

 

Cathodoluminescence (CL)

CL in an SEM or scanning TEM (STEM) is a tool to characterise the optical and electronic properties of materials, then correlate them with morphology, microstructure, composition, and chemistry at the micron and sub-nm scale. Available at MAC-Twente in the high resolution SEM.

 

 

(TMP….ED is used to study the crystal structure of solids, either in a TEM, or in an SEM known as electron backscatter diffraction. Electron Backscatter Diffraction (EBSD) EBSD is a  characterisation technique to study any crystalline or polycrystalline material. The technique involves understanding the structure, crystal orientation and phase of materials in the SEM..)

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