MESA+ University of Twente
The BIOS Lab-on-a-chip group

Crosslinking polymer microparticles in non-equilibrium with light: redox-active designer hydrogels for low-cost lab-on-paper diagnostics

The aim of this project is the construction of a biosensor on paper, using microparticles of a redox-active polymer, polyferrocenylsilane (PFS). PFS changes colour upon oxidation/reduction, giving a direct qualitative readout of the signal. A quantitative signal can be obtained by measuring the number of oxidations/reductions electrochemically.

The polymer particles will be produced using microfluidics, which enables us to capture non-equilibrium liquid shapes into solid particles. Two approaches are being investigated, namely droplet based particle formation and flow lithography. In the first approach, droplets of polymer solution will be made in a microfluidic device. These droplets can then be crosslinked into spherical (or distorted spherical) particles. Flow lithography is the direct writing of shapes into a flowing polymer solution, enabling the design production of non-spherical particles. For the flow lithography, an adapted Blue Ray player will be used as light source for the crosslinking.

Source picture optical pickup:

Contact Information

Laura Hendriks

Mathieu Odijk


Kaihuan Zhang (MTP,

Mark Hempenius (MTP,

Julius Vancso (MTP,