THE EFFECT OF EXOGENOUS HUMAN α-SYNUCLEIN ON NEURONAL NETWORK FUNCTIONALITY
The formation of protein aggregates called Lewy Bodies (LB) and Lewy Neurites (LN) is the pathological hallmark of Parkinson’s disease and other synucleinopathies. The main component of these protein aggregates is α-synuclein (αS). In synucleinopathies, elevated levels of αS found in the cerebrospinal fluid are associated with the disease onset. Little is known about the mechanisms by which increased levels of αS and the appearance of αS inclusions contribute to development of synucleinopathies. Here we study the effect of exogenously added αS on in vitro cultured neuronal networks.
Wednesday 18 November 2015, 16:30 - 17:30 h
Building Carré - room CR 3.718