QUANTITATIVE ANALYSIS OF EEG REACTIVITY IN COMATOSE PATIENTS
Abstract
EEG reactivity has been reported as a predictor of outcome in comatose patients with post-anoxic encephalopathy. However, visual analysis of EEG reactivity has a high inter-rater variability and is time consuming. Therefore, analysis of EEG reactivity may benefit from a quantitative approach enabling automatic interpretation.
We performed a prospective cohort study in comatose ICU patients in two Dutch ICUs. Reactivity to auditory, visual and sensory stimuli was tested following a strict protocol. Visual analysis was regarded as the gold standard. Reactivity was defined as a change in amplitude or frequency in the EEG after stimulation, excluding muscle activity. Stimulus responses were scored by three independent experts (JH, MvP, MT-C), responses on which two experts agreed were used. Data was separated in an independent training and validation set. Spectral characteristics of the EEG before and after each stimulus were compared. These were determined by both parametric and non-parametric methods.
Wednesday 16 December 2015, 16:30 - 17:30 h
Building Carré - room CR 3.718