Srirang Manohar, Prof. Dr.


Telephone: +31 53 489 3164

Srirang Manohar is Adjunct Hoogleraar, Biomedical Photonic Imaging. He has pioneered research into photoacoustic imaging of breast cancer. He also investigates the feasibility of the method in imaging inflammation in joints in rheumatoid arthritis. Prof. Manohar’s research spans technology development to early clinical assessment. The intended applications of the technologies span the range of ex vivo tissue imaging, minimally invasive imaging to non-invasive. He has also done investigations into synthesis and characterization of gold nanoparticles, and in vitro and in vivo application of these and iron oxide nanoparticles in the context of providing contrast for photoacoustics.

Prof. Manohar is the coordinator of the H2020 project, PAMMOTH running from 2017-2021. He is member of the Organizing Committee for the conference “Photons plus Ultrasound: Imaging and Sensing held annually under auspices of SPIE (Photonics West, San Francisco, USA). He is also member of the Program Committee for the conference Opto-Acoustic Methods & Applications, European Conferences on Biomedical Optics (ECBO), Munich, Germany.


Biomedical imaging specifically photoacoustic imaging for non-invasive and minimally-invasive detection, diagnosis and therapy monitoring of various pathologies including breast cancer and rheumatoid arthritis;

Molecular medicine spanning the trajectory from synthesis, characterization, minimizing cytotoxicity to preclinical applications of antibody conjugated gold nanoparticles for photoacoustic imaging and photothermal therapies.


Bachelor (Biomedical Technology BMT)
In the new Education model of Project Oriented Learning in the 1st year:
1) Geometrical Optics (4 EC)
2) Tissue Optics (3 EC)

Master (Biomedical Engineering BME Master)
3) Advanced Medical Imaging and Therapy Systems (5 EC) 
4) Biomedical Optics (5 EC): (with W. Steenbergen, I. M. Vellekoop & N. Bosschaart) Specific part on Photoacoustic Imaging


  • One granted patent
  • One patent application


Total journal publications = 58; Book chapters = 4;
Average impact factor: 4.04.
Highest 3 impact factors: 12.94, 12.033, 10.742.

Selected publications

[1] Heijblom, M., Piras, D., Brinkhuis, M., Van Hespen, J. C. G., Van den Engh, F. M., Van der Schaaf, M., Klaase, J. M., Van Leeuwen, T. G., Steenbergen, W. & Manohar, S. (2015). Photoacoustic image patterns of breast carcinoma and comparisons with Magnetic Resonance Imaging and vascular stained histopathology. Sci. Rep. Nature 5, Article number 11778
[2] Heijblom, M., Steenbergen, W., & Manohar, S. (2015). Clinical Photoacoustic Breast Imaging: The Twente experience. Pulse, IEEE, 6(3), 42-46.
[3] Van Es, P., Biswas, S. K., Moens, H. J., Steenbergen, W., & Manohar, S. (2014) Initial results of finger imaging using Photoacoustic Computed Tomography, Journal of Biomedical Optics 19, 60501.
[4] Lajoinie, G., Gelderblom, E., Chlon, C., Böhmer, M., Steenbergen, W., De Jong, N., Manohar, S., & Versluis, M. (2014) Ultrafast vaporization dynamics of laser-activated polymeric microcapsules Nature Communications 5, Article number: 3671.
[5] Heijblom, M., Piras, D., Xia, W., Van Hespen, J. C. G., Klaase, J. M., van den Engh, F. M., Steenbergen, W., Leeuwen, A. G. J. M & Manohar, S. (2012). Visualizing breast cancer using the Twente photoacoustic mammoscope: What do we learn from twelve new patient measurements?. Optics Express, 20(11), 11582-11597.
[6] Manohar, S., Vaartjes, S. E., Van Hespen, J. C. G., Klaase, J. M., Van den Engh, F. M., Steenbergen W. & Van Leeuwen T. G. (2007) Initial results of in vivo non-invasive detection of cancer in the human breast using near-infrared photoacoustic imaging Opt. Express 15, 12277.
[7] Rayavarapu, R., Petersen, W., Ungureanu, C., Post, J., Van Leeuwen, T. G. & Manohar, S. (2007) Synthesis and bioconjugation of gold nanoparticles as potential molecular probes for light-based imaging techniques. Intl. J. Biomed. Imag. 2007, 29817.
[8] Rayavarapu, R., Hartsuiker, L., Chin, P, Janssen, H., Van Leeuwen, F. W. B. , Otto, C., Manohar, S. & Van Leeuwen, T. G. (2010) In vitro toxicity studies of polymer-coated gold nanorods. Nanotechnol. 2010, 21, 145101.
[9] Ungureanu, C., Kroes, R., Peteresen, W., Groothuis, T. A. M., Ungureanu, F., Janssen, H., Van Leeuwen, F. W. B., Kooyman, R. P. H., Manohar, S. & Van Leeuwen (2011) Light Interactions with Gold Nanorods and Cells: Implications for Photothermal Nanotherapeutics Nanolett. 11, 1187.
[10] Manohar, S., Willemink. G. H., Van der Heijden, F., Slump, C. H. & Van Leeuwen T. G. (2007) Concomitant speed-of-sound imaging in photoacoustic imaging Appl. Phys. Lett. 91, 131911.


[1] Pioneers in Health Care Voucher 2014 – Medisch Spectrum Twente, ZGT (Ziekenhuisgroep Twente) and the University of Twente joint innovation fund.
[2] Decentrale Onderwijsprijs 2015, 2014 and 2010 (Best Teacher elected by students) in the Biomedical Technology (BMT) Education stream.
[3] TNW (Science & Technology) Education Award 2012 for excellence in education in the Biomedical Technology (BMT) Education stream.
[4] VENI - Vernieuwingsimpuls Grant 2004 - NWO Innovational Research Incentives Scheme.

Prizes won by PhD students/students

[5] Michelle Heijblom (MSc) - 1st prize in the Best Student Oral Presentation competition of the European Conferences on Biomedical Optics (ECBO) Munich, (May 2013).
[6] Rogier Wildeboer (BSc) – Dutch National award for Best Bachelor research 2012.
[7] Michelle Heijblom (MSc) - 2nd prize in the Best Paper competition of the conference ‘Photons plus Ultrasound: Imaging and Sensing’ Photonics West – BIOS event in San Francisco, USA 2012.
[8] Jithin Jose (MSc) - Best Poster Award in the ‘Photoacoustic Imaging and Spectroscopy’ session at the Biomedical Optics (BIOMED) Topical Meeting in Miami, USA 2010.