Alina Dima - MIA

A Foundational Model for Biomedical Shapes



Organization:

Funded by:

 and


PostDoc:


Supervisors:

chair MIA:

Collaboration:

UT personel:

Hospitals:

  • Dennis Janssen (ORL, RadboudUMC),

Industry Partners:

  • Stryker 

Description:

Geometric representations of anatomical structures, specifically meshes and point clouds, are being actively researched in medical imaging for the development of neural surrogates, statistical shape modeling, brain parcellation, or biomarker detection. In the medical domain, where high-quality labeled data is notoriously difficult to acquire, these representations are highly sought after because they provide a compact, geometric alternative to high-dimensional voxel data, effectively reducing noise in data-scarce environments.

 In recent years, foundational models have revolutionized representation learning in the language and vision domains by leveraging large-scale datasets to achieve superior generalization, reaching widespread commercial use. These models offer a robust solution for downstream applications with limited training data. This project aims to bridge these fields by developing a foundational model specifically tailored to organ geometries. By training a shape encoder on a large set of shapes, we aim to provide a versatile framework for medical applications currently constrained by data sparsity and the complexities of anatomical variation.  

Output:


2025

Parametric shape models for vessels learned from segmentations via differentiable voxelization (2025)[Working paper › Preprint]. ArXiv.org. Dima, A. F., Shit, S., Qiu, H., Holland, R., Mueller, T. T., Musio, F., Yang, K., Menze, B., Braren, R., Makowski, M. & Rueckert, D.https://doi.org/10.48550/arXiv.2507.02576Automated Thoracolumbar Stump Rib Detection and Analysis in a Large CT Cohort (2025)[Working paper › Preprint]. ArXiv.org. Möller, H., Schön, H., Dima, A., Keinert-Weth, B., Graf, R., Atad, M., Paetzold, J., Jungmann, F., Braren, R., Kofler, F., Menze, B., Rueckert, D. & Kirschke, J. S.https://doi.org/10.48550/arXiv.2505.05004

2023

3D Arterial Segmentation via Single 2D Projections and Depth Supervision in Contrast-Enhanced CT Images (2023)[Working paper › Preprint]. ArXiv.org. Dima, A. F., Zimmer, V. A., Menten, M. J., Li, H. B., Graf, M., Lemke, T., Raffler, P., Graf, R., Kirschke, J. S., Braren, R. & Rueckert, D.https://doi.org/10.48550/arXiv.2309.08481

2022

Physiology-based simulation of the retinal vasculature enables annotation-free segmentation of OCT angiographs (2022)[Working paper › Preprint]. ArXiv.org. Menten, M. J., Paetzold, J. C., Dima, A., Menze, B. H., Knier, B. & Rueckert, D.https://doi.org/10.48550/arXiv.2207.11102

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