Jan Holsheimer 1941-2021

Dr. J. HolsheimerFull name: Dr. J. Holsheimer - ✝ 21-02-2021
Function: Associate professor



Primary research interests: the theoretical, experimental and clinical aspects of electrical stimulation of the central and peripheral nervous system. These studies are focused on the design of electrodes, which - together with the appropriate stimulation parameters – should enable the stimulation of specific neuronal pathways, as characterized by their positions and fiber diameters. The main clinical applications are Spinal Cord Stimulation and Motor Cortex Stimulation in the management of chronic pain, and Peripheral Nerve Stimulation in the restoration of motor functions in central motor disorders (stroke, spinal cord injury). In these studies computer models are used for the design of the stimulating electrodes.

This research belongs to the research theme "Electrical Neurostimulation" of the BSS group.

Publications: J. Holsheimer

Education: Courses in


Jan Holsheimer was born in Enschede, The Netherlands. He received the M.Sc. degree in biology and biophysics from the University of Groningen, The Netherlands in 1965 and the Ph.D. degree in biomedical engineering from the University of Twente, The Netherlands, in 1982. In 1965 he joined the Biomedical Engineering Division in the Department of Electrical Engineering at the University of Twente.

He was first engaged in the recording and analysis of tremor-related deep brain activity during stereotactic interventions in Parkinson patients. His next research field was the measurement, analysis and computer modeling of field potentials related to theta rhythm and epileptiform activity in the hippocampus of the rat and guinea pig.

Since 1986 his research interests are focused on the theoretical, experimental and clinical aspects of the electrical stimulation of the central and peripheral nervous system, in particular computer modeling of Spinal Cord Stimulation for the relief of chronic pain. This approach has recently been extended to Motor Cortex Stimulation in chronic pain.

From 1994 until 2000 he was a board member of the International Neuromodulation Society (INS). Since 1998 he is an editorial board member of Neuromodulation. In 2002 he was one of the founders of the Benelux Chapter of the INS and since 2003 he is the secretary of the Benelux Neuromodulation Society.