3D blood vessels-on-chips to model vascular malformations (VESCEL)
The research in the EU advanced grant-supported VESCEL project aims at cultivating blood vessels on a chip, made from 'reprogrammed' human stem cells. The blood vessels will then be used to develop disease models to improve research into the occurrence of thrombosis and brain diseases such as Alzheimer's and MS.
The research in this PhD project combines top-down micromachining methods such as 3D printing with bottom-up methods such as vascular sprouting controlled by signaling factors transported through hydrogels. Aim is to obtain maximal control of the vascular layout.