Dr.ir. K.M. (Kirsten) Pondman - 2014

  
  
  
  
PhD Candidate – obtained PhD degree (Cum Laude) September 2014

Room:

Phone: +31 53 489 1116

 

General information

Kirsten Pondman (1987) obtained a BSc and MSc in biomedical engineering at the University of Twente. During an internship at Oxford University, department of pharmacology, with Professor R.B. Sim, she became interested in nanomedicine, especially targeted drug delivery and interactions with the immune system. After a masters assignment within the NIM-group, which focussed on magnetic drug delivery, she got an opportunity to pursue a Phd-degree within the NIM-group in collaboration with Professor R.B. Sim at Oxford University and dr. U. Kishore at Brunel University, Londen.

Research interests

The main focus in Kirstens PhD was the application of nanoparticles in medicine; she worked both at developing particles that could be used for magnetic drug delivery and on interactions of various nanoparticles with different components of the (innate) immune system. Furthermore she developed ways to either suppress or stimulate the immune system using nanoparticles. She set up collaborations with Prof. Jos van Putten at the university of Utrecht and Prof. Thorben Moos at the university of Aalborg, where she got a chance to work on the magnetic transport of nanoparticles through the blood brain barrier.

Publications

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K.M. Pondman, A.G. Tsolaki, B. Paudyal, M.H. Shamji, A. Switzer, A. Pathan, S.M. Abozaid, B. Ten Haken, G. Stenbeck, R.B. Sim, U. Kishore, “Complement deposition on nanoparticles can modulate immune responses by macrophage, B and T cells, Journal of Biomedical Nanotechnology, in press

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K.M. Pondman, Nathan D. Bunt, A.W. Maijenburg, R. van Wezel, U. Kishore, L. Abelmann, J.E. ten Elshof, B. ten Haken. “Magnetic drug delivery with FePd nanowires.” Journal of Magnetism and Magnetic Materials, in press

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B. Matt, K.M. Pondman, S.J. Asshoff, B. ten Haken, B. Fleury, N. Katsonis. "Soft Magnets from the Self-Organization of Magnetic Nanoparticles in Chiral Liquid Crystals", Angewandte, 2014, in press.

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K.M. Pondman, M. Sobik, A. Nayak, A.G. Tsolaki, A. Jäkel, E. Flahaut, S. Hampel, B. ten Haken, RB Sim, U Kishore. “Complement activation by carbon nanotubes and its influence on phagocytosis and cytokine response by macrophages”, Nanomedicine: Nanotechnology, Biology and Medicine, 2014, 10: p. 1287-1299.

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K.M. Pondman, A.W. Maijenburg, F.B. Celikkol, A.A. Pathan, U. Kishore, B. ten Haken and J.E. ten Elshof, "Au coated Ni nanowires with tuneable dimensions for biomedical applications", Journal of Materials Chemistry B, 2013, 1: p. 6129-6136

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L.B. Thomsen, T. Linemann, K.M. Pondman, J. Lichota, K.S. Kim, R.J. Pieters, G.M Visser, T. Moos, "Uptake and transport of superparamagnetic iron oxide nanoparticles through human brain capillary endothelial cells", ACS Chemical Neuroscience, 2013, 4(10), pp 1352–1360

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M. Sobik, K.M. Pondman, B. Erné, B. Kuipers, B. ten Haken, H. Rogalla, "Magnetic nanoparticles for diagnosis and medical therapy", in: R. Klingeler, R.B. Sim (Eds.), Carbon nanotubes for biomedical applications, Springer, Heidelberg, 2011

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M.J. Rybak-Smith, K.M. Pondman, E. Flahaut, C. Salvador-Morales, R.B. Sim, "Recognition of carbon nanotubes by the human innate immune system, in: R. Klingeler, R.B. Sim (Eds.), Carbon nanotubes for biomedical applications, Springer, Heidelberg, 2011

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K.M. Pondman, J.J. Fütterer, B. ten Haken, L.J. Schultze Kool, J.A. Witjes, T. Hambrock, K.J. Macura, J.O. Barentsz, "MR-Guided Biopsy of the Prostate: An Overview of Techniques and a Systematic Review", European Urology, 2008, 54(3): p. 517-27