Dr.ir. M. (Martijn) Visscher - 2014

PhD Candidate – obtained PhD degree August 2014
Phone: +31 53 489 1116

GENERAL INFORMATION

Martijn Visscher was born in Apeldoorn (1983) and obtained his BSc degree in Biomedical Engineering from the University of Twente in 2005. At the same university, he received his MSc degree in 2008 with a study on the cortical processing of electrocutaneous stimuli, using EEG and source localization algorithms. In the same year, he started with a PhD program in the Neuro-Imaging group (at that time Low Temperatures group) at the MIRA Institute for Biomedical Engineering and Technical Medicine, focussing on clinical detection of magnetic nanoparticles in tissue samples. This research was performed in close collaboration with Medisch Spectrum Twente and the Technical Medicine Department as well as various research chairs in the MIRA and MESA+ institutes at the University of Twente. In the meantime, he contributed to several granted research proposals and practical courses for the educational program of Biomedical Engineering and Technical Medicine. He obtained his PhD in 2014.

RESEARCH INTERESTS

The main research interest of Martijn is magnetic detection of magnetic nanoparticles for clinical applications. During his PhD a patented detection technique, called DiffMag, was developed for specific detection of magnetic nanoparticles in the human body or smaller tissue samples. The development of a smart and clinically useful system for (surgical) interventions is the main goal of his present research. The development of the detection technology is accompanied by investigating magnetic tracers for optimal technical and clinical performance. Other fields of interest include the application of magnetic nanoparticles for imaging and (targeted) diagnostic and therapeutic applications

PUBLICATIONS

PhD - Thesis

Detection of magnetic nanoparticles for clinical interventions
M. Visscher
August 2014

Peer-reviewed journal papers

• Selective detection of magnetic nanoparticles in biomedical applications using differential magnetometry 
  M. Visscher, S. Waanders, H.J.G. Krooshoop, B. ten Haken,
  Journal of Magnetism and Magnetic Materials, Vol.365, pp. 31-39, 2014,
• Quantitative analysis of superparamagnetic contrast agent in sentinel lymph nodes using ex vivo vibrating sample magnetometry 
  M. Visscher, J. J. Pouw, J. van Baarlen, J. M. Klaase, B. ten Haken, 
  IEEE Transactions on Biomedical Engineering, Vol. 60, pp. 2594-2602, 2013.
• Magnetic properties and paleointensities as function of depth in a Hawaiian lava flow
  Lennart de Groot, Mark Dekkers, Martijn Visscher, Geertje ter Maat (collaboration with UU)
  G³ – Geochemistry Geophysics Geosystems Vol. 15(4), pp. 1096–1112, 2014, doi:10.1002/2013GC005094
• Intra-operative ex vivo photoacoustic nodal staging in a rat model using a clinical superparamagnetic iron oxide nanoparticle dispersion
• Diederik J. Grootendorst, Raluca M. Fratila, Martijn Visscher, Bennie Ten Haken, Richard J. A. Wezel, Sven Rottenberg, Wiendelt Steenbergen, Srirang Manohar and Theo J. M. Ruers
• Journal of Biophotonics, vol. 6, Issue 6-7, pp. 493–504, June 2013
• Evaluation of superparamagnetic iron oxide nanoparticles (Endorem®) as a photoacoustic contrast agent for intra-operative nodal staging
• Diederik J. Grootendorst, Jithin Jose, Raluca M. Fratila, Martijn Visscher, Aldrik H. Velders, Bennie Ten Haken, Ton G. Van Leeuwen, Wiendelt Steenbergen, Srirang Manohar and Theo J. M. Ruers
• Contrast Media & Molecular Imaging vol. 8 (1), pp. 83, January/February 2013

Patent

• Method and apparatus for measuring an amount of superparamagnetic material in an object
  S. Waanders, M. Visscher, T.O.B. Oderkerk, H.J.G. Krooshoop, B. ten Haken
  EU-patent 12194029.0 – 2216, November 23 2012

Conference contributions

• Depth limitations for In-vivo Magnetic Nanoparticle detection with a Handheld Device
  M. Visscher, S. Waanders, J.J. Pouw, B. ten Haken
  Conference proceedings of the 10th International Conference on the Scientific and Clinical Applications of Magnetic Carriers, Dresden, Germany, June 10-14 2014 (supplement of the Journal of Magnetism and Magnetic Materials, Not issued yet)
• Analyzing Magnetic Nanoparticle Content In Biological Samples: AC-Susceptometry Using Offset Fields
  M. Visscher, S. Waanders, B. ten Haken
  3rd International Workshop on Magnetic Particle Imaging, Berkeley, California USA, March 23-24 2013
• Finding the sentinel lymph node with a handheld differential magnetometer
  S. Waanders, M. Visscher, T.O.B Oderkerk, B. ten Haken 
  3rd International Workshop on Magnetic Particle Imaging, Berkeley, California USA, March 23-24 2013
• Photoacoustic intra-operative nodal staging using clinically approved superparamagnetic iron oxide nanoparticles 
  D.J. Grootendorst, R.M.Fratila, M. Visscher, B. Ten Haken, R. Van Wezel, W. Steenbergen, S. Manohar, T.J.M. Ruers
  Progress in Biomedical Optics and Imaging - Proceedings of SPIE , 8581 , art. no. 858102, 2013
• Ex vivo quantification of magnetic nanoparticles in clinical samples at room temperature with high specificity and improved stability
  M. Visscher, S. Waanders, J.J. Pouw, H.J.G. Krooshoop, B. ten Haken
• 9th International Conference on the Scientific and Clinical Applications of Magnetic Carriers Minneapolis, MN, USA, May 22-26, 2012
• A magnetometer cooled with liquid nitrogen for the characterization and quantification of magnetic nanoparticles in biological samples at room temperature
  Martijn Visscher, Matthias Holling, Joost Pouw, Bennie ten Haken
  2nd International Workshop on Magnetic Particle Imaging, Lübeck, Germany, March 15-16 2012
• A Magnetometer for Biological Samples Using Frequency Mixing Detection
  Martijn Visscher, Matthias Holling, Joost Pouw, Bennie ten Haken, Horst Rogalla
  20th Soft Magnetic Materials Conference – 2011, Kos Island, Greece, 18-22 September 2011
• Superparamagnetic Iron Oxides as Contrast Agent for Magnetic Detection of Sentinel Lymph Nodes in Colorectal Cancer
  M. Visscher, J.J. Pouw, B. ten Haken, J.M. Klaase, J. van Baarlen, H. Rogalla 
  3^rd Dutch Biomedical Engineering Conference 2011, Egmond aan Zee, The Netherlands, 20-21 January 2011
• Magnetic Particles and Sensing Methods for Medical Applications
  M. Visscher, M. Sobik, B. ten Haken, J.J. Pouw, J.M. Klaase, J.J. Galindo Millan, A.H. Velders, H. Rogalla
  11th European Symposium on Controlled Drug Delivery, Egmond aan Zee, The Netherlands, 7-9 April 2010
• Sentinel Lymph Node Detection Using Superparamagnetic Iron Oxides
  M. Visscher, B. ten Haken, J.J. Pouw, J.M. Klaase, Q.A. Pankhurst, A.H. Velders, H. Rogalla 
  1st Event MIRA Institute for Biomedical Engineering and Technical Medicine, Hengelo, The Netherlands, 1-2 April 2010
• Magnetic Detection of the Sentinel Lymph Node in Ex Vivo Tissue with Colorectal Cancer
  B. ten Haken, M. Visscher, J.J. Pouw, J.M. Klaase, Q.A. Pankhurst, A.H. Velders, H. Rogalla
  17th International Conference on Biomagnetism BIOMAG 2010, Dúbrovnik, Croatia, 28 March-1 April 2010
• Magnetic Sensing Methods and Materials for Medical Applications
  Bennie ten Haken, Martijn Visscher, Martin Sobik, Aldrik H. Velders
  International Workshop on Magnetic Particle Imaging, Lübeck, Germany, March 18-19 2010
• Magnetic Detection of the Sentinel Lymph Node
  M. Visscher, B. ten Haken, A.H. Velders, J.J. Pouw, J.M. Klaase, H. Rogalla
  IEEE-EMBS Benelux Chapter Symposium, Enschede, The Netherlands, November 9-10, 2009