Translational insights into MASH: From mechanisms to medicine
Marit ten Hove is a PhD student in the department Medical Cell Biophysics. (Co)Promotors are prof.dr. R. Bansal; prof.dr. P.C.J.J. Passier and prof.dr. A. Kocer from the faculty Science & Technology, University of Twente.
Metabolic dysfunction-associated steatohepatitis (MASH) is an increasingly prevalent global health issue, characterized by hepatic steatosis, inflammation, and fibrosis. MASH can progress to end-stage liver diseases, including cirrhosis, end-stage liver failure, and hepatocellular carcinoma, if not treated. Its multifaceted pathology, driven by dysregulated lipid metabolism, chronic inflammation, and fibrotic remodeling, presents significant therapeutic challenges, necessitating the development of targeted interventions that address the disease’s complexity. This thesis explores innovative and translational therapeutic strategies by dissecting key pathways driving MASH progression, by contributing to the understanding of the molecular and cellular mechanisms driving MASH progression and exploring the therapeutic potential of novel treatments by targeting steatosis, inflammation, and/or fibrosis.
