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Developmental BioEngineering (DBE)
Developmental BioEngineering (DBE)
UTFacultiesTNWResearchDept BETDBEResearchPost LabPrevious Projects

Previous Projects

PREVIOUS PROJECTS AND LAB MEMBERS:

  1. Smart leads for (preventing) OA: deciphering the network that regulates chondrocyte cell fate. ReumaNederland project 17-2-402, PhD student: Sakshi Kannan Khurana.
  2. Protein mobility determines transcriptional activity, ReumaNederland project 13-3-404, PhD student: Kannan Govindaraj. 
  3. Lipid metabolism determines cell communication, ReumaNederland project number 13-2-402, PhD student: Brenda Bakker.
  4. Signaling antagonists determine cell fate, Reumafonds project 11-1-408, PhD student: Leilei Zhong.
  5. Cell communication of chondrocytes with executable modeling and phosphorylation events with peptide arrays, PhD student: Jetse Scholma; Post-Doc Stefano Schivo, PhD ANIMO web page http://fmt.cs.utwente.nl/tools/animo/
  6. Natural peptides in amyloid structures as instructive carriers, PhD student: Maurice van Dalen. Joint project with NBP group of Mireille Claessens, (https://www.utwente.nl/tnw/nbp/ )

Publications

http://www.ncbi.nlm.nih.gov/pubmed/?term=Post%20JN%5BAuthor%5D&cauthor=true&cauthor_uid=25205812

Key output

  1. Schivo S, Scholma J, van der Vet PE, Karperien M, Post JN, van de Pol J, Langerak R. (2016) Modelling with ANIMO: between fuzzy logic and differential equations. BMC Systems Biology; doi.org/10.1186/s12918-016-0286-z
  2. Schivo S, Khurana S, Govindaraj K, Scholma J, Kerkhofs J, Zhong L, Huang X, van de Pol J, Langerak R, van Wijnen AJ, Geris L, Karperien M, Post JN. (2020) ECHO, the executable CHOndrocyte: A computational model to study articular chondrocytes in health and disease. Cell Signal; 68:109471, doi.org/10.1016/j.cellsig.2019.109471
  3. Khurana S, Schivo S, Plass JRM, Mersinis N, Scholma J, Kerkhofs J, Zhong L, van de Pol J, Langerak R, Geris L, Karperien M, Post JN. (2021) An ECHO of Cartilage: In Silico Prediction of Combinatorial Treatments to Switch Between Transient and Permanent Cartilage Phenotypes With Ex Vivo Validation. Frontiers in Bioeng Biotechnol. 2021; 9:732917. doi.org/10.3389/fbioe.2021.732917
  4. Lidke DS, Nagy P, Heintzmann R, Arndt-Jovin DJ, Post JN, Grecco HE, Jares-Erijman EA, Jovin TM. (2004) Quantum dot ligands provide new insights into erbB/HER receptor-mediated signal transduction. Nature Biotechnology.;22(2):198-203. doi.org/10.1038/nbt929
  5. Leijten, Georgi, Moreira Teixeira, van Blitterswijk, Post, Karperien. (2014) Metabolic programming of mesenchymal stromal cells by oxygen tension directs chondrogenic cell fate. PNAS. (38):13954-9. doi.org/10.1073/pnas.1410977111
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