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2025
Enhancing organoid technology with carbon-based nanomaterial biosensors: Advancements, challenges, and future directions (2025)Advanced drug delivery reviews, 222. Article 115592. Rezaei, Z., Wang, N., Yang, Y., Govindaraj, K., Velasco, J. J., Martinez Blanco, A. D., Bae, N. H., Lee, H. Y. & Shin, S. R.https://doi.org/10.1016/j.addr.2025.115592Hierarchical engineering of modular tissues (2025)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Johnbosco, C.https://doi.org/10.3990/1.9789036567060Effect of fluid flow-induced shear stress on the behavior of synovial fibroblasts in a bioinspired synovium-on-chip model (2025)Journal of Cartilage & Joint Preservation, 5(2). Article 100233. Piluso, S., Li, Y., Texeira, L. M., Padmanaban, P., Rouwkema, J., Leijten, J., van Weeren, R., Karperien, M. & Malda, J.https://doi.org/10.1016/j.jcjp.2025.100233Sex-stratified osteochondral organ-on-chip model reveals sex-specific responses to inflammatory stimulation (2025)Materials Today Bio, 32. Article 101728. Pereira Dos Santos Conceição, F., Meneses, J., Lebre, F., Becker, M., Araújo-Gomes, N., Vos, R., Ribeiro, A. R., Alfaro-Moreno, E., Leijten, J. & Moreira Teixeira, L.https://doi.org/10.1016/j.mtbio.2025.101728Molecular profiling of oxygen's impact on chondrocytes: Insights from mass spectrometry imaging (2025)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Bakker, B.https://doi.org/10.3990/1.9789036565783Genetic Engineering of VHH Antibody Fragments for Efficient Site-Specific Conjugation to Polysaccharides (2025)Bioconjugate chemistry (E-pub ahead of print/First online). Zhong, L., Morshuis, L. C. M., Koerselman, M., Memelink, A., Kolecka, A., Heukers, R., Verrips, T., Karperien, M. & Zoetebier, B.https://doi.org/10.1021/acs.bioconjchem.5c00167Bioxolography Using Diphenyliodonium Chloride and N-Vinylpyrrolidone Enables Rapid High-Resolution Volumetric 3D Printing of Spatially Encoded Living Matter (2025)Advanced materials (E-pub ahead of print/First online). Wolfel, A., Johnbosco, C., Anspach, A., Meteling, M., Olijve, J., König, N. F. & Leijten, J.https://doi.org/10.1002/adma.202501052Covalent On-Cell Conjugation of Biomaterials Through Oxidative Phenolic Coupling Regulates Stem Cell Fate via Intracellular Biophysical Programming (2025)Advanced functional materials, 35(17). Article 2418963. Johnbosco, C., Becker, M., Willemen, N., Meteling, M., Govindaraj, K., Kamperman, T. & Leijten, J.https://doi.org/10.1002/adfm.202418963The Modified Canine Groove Model of Osteoarthritis † (2025)Biomedicines, 13(4). Article 913. van der Weiden, G. S., Meij, B. P., van de Belt, A., Custers, R. J. H., Both, S. K., Karperien, M. & Mastbergen, S. C.https://doi.org/10.3390/biomedicines13040913ATPS-enabled single-step printing of chemically and mechanically on-demand tunable perfusable channels in ejectable constructs (2025)Biofabrication, 17(2). Article 025027. Becker, M., Gomes, F., Porsul, I. & Leijten, J.https://doi.org/10.1088/1758-5090/adbcdcDesign, molecular characterization and therapeutic investigation of a novel CCR8 peptide antagonist that attenuates acute liver injury by inhibiting infiltration and activation of macrophages (2025)Acta Pharmaceutica Sinica B, 15(4), 2114-2133. Geervliet, E., Arora, S., Donohue, D., de Albuquerque Pinheiro, C. A., Terstappen, L. W. M. M., Schasfoort, R., Paez, J., Kumar, R. & Bansal, R.https://doi.org/10.1016/j.apsb.2025.02.018Hydrogel-Based Bioinks for Coaxial and Triaxial Bioprinting: A Review of Material Properties, Printing Techniques, and Applications (2025)Polymers, 17(7). Article 917. Banigo, A. T., Nauta, L., Zoetebier, B. & Karperien, M.https://doi.org/10.3390/polym17070917Engineering synthetic erythrocytes for blood substitution (2025)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Fernandes Gomes, F. L.https://doi.org/10.3990/1.9789036565226OPSALC: On-Particle Solvent-Assisted Lipid Coating to Create Erythrocyte Membrane-like Coatings with Improved Hemocompatibility (2025)ACS applied materials & interfaces, 17(12), 18179-18193. Fernandes Gomes, F. L., Wasserberg, D., Edelbroek, R., van Weerd, J., Jonkheijm, P. & Leijten, J.https://doi.org/10.1021/acsami.5c02103High-Throughput Single-Cell Analysis of Local Nascent Protein Deposition in 3D Microenvironments via Extracellular Protein Identification Cytometry (EPIC) (2025)Advanced materials, 37(6). Article 2415981. Meteling, M., Johnbosco, C., Wolfel, A., Conceição, F., Govindaraj, K., Teixeira, L. M. & Leijten, J.https://doi.org/10.1002/adma.202415981Synergistic effect of Hypoxic Conditioning and Cell-Tethering Colloidal Gels enhanced Productivity of MSC Paracrine Factors and Accelerated Vessel Regeneration (2025)Advanced materials, 37(3). Article 2408488. Lee, M. C., Lee, J. S., Kim, S., Jamaiyar, A., Wu, W., Gonzalez, M. L., Durán, T. C. A., Madrigal-Salazar, A. D., Bassous, N., Carvalho, V., Choi, C., Kim, D. S., Seo, J. W., Rodrigues, N., Teixeira, S. F. C. F., Alkhateeb, A. F., Soto, J. A. L., Hussain, M. A., Leijten, J., … Shin, S. R.https://doi.org/10.1002/adma.202408488Production of Hydrophobic Microparticles at Safe-To-Inject Sizes for Intravascular Administration (2025)Pharmaceutics, 17(1). Article 64. Gomes, F. L., Conceição, F., Teixeira, L. M., Leijten, J. & Jonkheijm, P.https://doi.org/10.3390/pharmaceutics17010064
2024
Development of a Microphysiological Cartilage-on-Chip Platform for Dynamic Biomechanical Stimulation of Three-Dimensional Encapsulated Chondrocytes in Agarose Hydrogels (2024)Current Protocols, 4(12). Article e70079. Peitso, V., Sarmadian, Z., Henriques, J., Lauwers, E., Paggi, C. A. & Mobasheri, A.https://doi.org/10.1002/cpz1.70079Dissecting SOX9 dynamics reveals its differential regulation in osteoarthritis (2024)Journal of cellular physiology, 239(12). Article e31443. Govindaraj, K., Kannan, S., Coutinho de Almeida, R., Jansen Klomp, L., Karperien, M., Meulenbelt, I. & Post, J. N.https://doi.org/10.1002/jcp.31443Synthesis and Engineering of Hyaluronic Acid-Gelatin Hydrogels with Improved Cellular Attachment and Growth (2024)Polymers, 16(23). Article 3410. Banigo, A. T., Konings, I. B. M., Nauta, L., Zoetebier, B. & Karperien, M.https://doi.org/10.3390/polym16233410Upscaling Osteoclast Generation by Enhancing Macrophage Aggregation Using Hollow Microgels (2024)Small, 20(46). Article 2403272. Husch, J. F. A., Araújo-Gomes, N., Willemen, N. G. A., Cofiño-Fabrés, C., van Creij, N., Passier, R., Leijten, J. & van den Beucken, J. J. J. P.https://doi.org/10.1002/smll.202403272Microfluidic Generation of Thin-Shelled Polyethylene Glycol-Tyramine Microgels for Non-Invasive Delivery of Immunoprotected β-Cells (2024)Advanced healthcare materials, 13(25). Article 2301552. Araújo-Gomes, N., Zoetebier-Liszka, B., van Loo, B., Becker, M., Nijhuis, S., Smink, A. M., de Haan, B. J., de Vos, P., Karperien, M. & Leijten, J.https://doi.org/10.1002/adhm.202301552Hyaluronic acid and dextran hydrogels for tissue engineering applications (2024)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Banigo, A. T.https://doi.org/10.3990/1.9789036562218Coaxial Bioprinting of Enzymatically Crosslinkable Hyaluronic Acid-Tyramine Bioinks for Tissue Regeneration (2024)Polymers, 16(17). Article 2470. Banigo, A. T., Nauta, L., Zoetebier, B. & Karperien, M.https://doi.org/10.3390/polym16172470Dextran-tryamine hydrogel maintains position and integrity under simulated loading in a human cadaver knee model (2024)Osteoarthritis and Cartilage Open, 6(3). Article 100492. van der Weiden, G. S., Mastbergen, S. C., Both, S. K., Karperien, M., Lafeber, F. P., van Egmond, N. & Custers, R. J. H.https://doi.org/10.1016/j.ocarto.2024.100492Bioactive Hydrogels Based on Tyramine and Maleimide Functionalized Dextran for Tissue Engineering Applications (2024)Gels, 10(9). Article 566. Zhong, L., Banigo, A. T., Zoetebier, B. & Karperien, M.https://doi.org/10.3390/gels10090566Injectable Self-Oxygenating Cardio-Protective and Tissue Adhesive Silk-Based Hydrogel for Alleviating Ischemia After Mi Injury (2024)Small, 20(32). Article 2312261. Hassan, S., Rezaei, Z., Luna, E., Yilmaz-Aykut, D., Lee, M. C., Perea, A. M., Jamaiyar, A., Bassous, N., Hirano, M., Tourk, F. M., Choi, C., Becker, M., Yazdi, I., Fan, K., Avila-Ramirez, A. E., Ge, D., Abdi, R., Fisch, S., Leijten, J., … Shin, S. R.https://doi.org/10.1002/smll.202312261Photoannealing of Microtissues Creates High-Density Capillary Network Containing Living Matter in a Volumetric-Independent Manner (2024)Advanced materials, 36(28). Article 2308949. Schot, M., Becker, M., Paggi, C. A., Gomes, F., Koch, T., Gensheimer, T., Johnbosco, C., Nogueira, L. P., van der Meer, A., Carlson, A., Haugen, H. & Leijten, J.https://doi.org/10.1002/adma.202308949Photoannealing of Microtissues Creates High-Density Capillary Network Containing Living Matter in a Volumetric-Independent Manner (Adv. Mater. 28/2024) (2024)Advanced materials, 36(28). Article 2470219. Schot, M., Becker, M., Paggi, C. A., Gomes, F., Koch, T., Gensheimer, T., Johnbosco, C., Nogueira, L. P., van der Meer, A., Carlson, A., Haugen, H. & Leijten, J.https://doi.org/10.1002/adma.202470219Engineering Synthetic Erythrocytes as Next-Generation Blood Substitutes (2024)Advanced functional materials, 34(28). Article 2315879. Gomes, F. L., Jeong, S. H., Shin, S. R., Leijten, J. & Jonkheijm, P.https://doi.org/10.1002/adfm.202315879Bioinspired crosslinking reactions occurring under physiological conditions for the synthesis of hydrogels for cell culture (2024)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Jin, M.https://doi.org/10.3990/1.9789036561051An introduction to injectable hydrogels (2024)Journal of materials chemistry. B: materials for biology and medicine, 12(23), 5571-5572. Paez, J. I. & Lim, K. S.https://doi.org/10.1039/d4tb90085eTowards single-cell bioprinting: micropatterning tools for organ-on-chip development (2024)Trends in biotechnology, 42(6), 739-759. Bosmans, C., Ginés Rodriguez, N., Karperien, M., Malda, J., Moreira Teixeira, L., Levato, R. & Leijten, J.https://doi.org/10.1016/j.tibtech.2023.11.014An oxygenating colloidal bioink for the engineering of biomimetic tissue constructs (2024)Bio-Design and Manufacturing, 7(3), 240-261. Jeong, S. H., Hiemstra, J., Blokzijl, P. V., Damian-Ferrara, R., dos Santos, D. M., da Fonseca, J. H. L., Kang, M. H., Kim, J., Yilmaz-Aykut, D., Cham-Pérez, M. L. L., Leijten, J. & Shin, S. R.https://doi.org/10.1007/s42242-024-00281-7Osmolarity-Induced Altered Intracellular Molecular Crowding Drives Osteoarthritis Pathology (2024)Advanced science, 11(11). Article 2306722. Govindaraj, K., Meteling, M., van Rooij, J., Becker, M., van Wijnen, A. J., van den Beucken, J. J. J. P., Ramos, Y. F. M., van Meurs, J., Post, J. N. & Leijten, J.https://doi.org/10.1002/advs.202306722Scalable production of 3D microtissues using novel microfluidic technologies (2024)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. van Loo, S. R.https://doi.org/10.3990/1.9789464960372Gelatin-tyramine addition and low hydrogel density improves cell attachment, migration, and metabolic activity in vitro and tissue response in vivo in enzymatically crosslinkable dextran-hyaluronic acid hydrogels (2024)International journal of biological macromolecules, 259. Article 128843. Hendriks, J., Zoetebier, B., Larrea, C. S., Le, N. X. T., Saris, D. B. F. & Karperien, M.https://doi.org/10.1016/j.ijbiomac.2023.128843Enzyme Responsive Delivery of Engineered Antibody Fragments (2024)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Zhong, L.https://doi.org/10.3990/1.9789036559706
2023
Mass production of lumenogenic human embryoid bodies and functional cardiospheres using in-air-generated microcapsules (2023)Nature communications, 14. Article 6685. van Loo, S. R., ten Den, S. A., Araújo-Gomes, N., de Jong, V., Snabel, R., Schot, M. R., Rivera Arbelaez, J. M., Veenstra, G. J., Passier, R., Kamperman, T. & Leijten, J.https://doi.org/10.1038/s41467-023-42297-0Development of a Synovium-on-Chip Model with a Porous Membrane to Study Inflammatory Arthritis (2023)[Contribution to conference › Poster] NanoBioTech Montreux 2023. Spoelstra, L. R., Araújo-Gomes, N., Zakharova - Kolezhuk, M., Welting, T. J. M., Karperien, M., Segerink, L. & Le Gac, S.Single-Step Biofabrication of In Situ Spheroid-Forming Compartmentalized Hydrogel for Clinical-Sized Cartilage Tissue Formation (2023)Advanced healthcare materials, 12(27). Article 2300095. van Loo, B., Schot, M., Gurian, M., Kamperman, T. & Leijten, J.https://doi.org/10.1002/adhm.202300095The use of peptides, aptamers, and variable domains of heavy chain only antibodies in tissue engineering and regenerative medicine (2023)Acta biomaterialia, 170, 1-14. Koerselman, M., Morshuis, L. C. M. & Karperien, M.https://doi.org/10.1016/j.actbio.2023.07.045Bioluminescence imaging on-chip platforms for non-invasive high-content bioimaging (2023)Biosensors & bioelectronics, 237. Article 115510. Araújo-Gomes, N., Zambito, G., Johnbosco, C., Calejo, I., Leijten, J., Löwik, C., Karperien, M., Mezzanotte, L. & Teixeira, L. M.https://doi.org/10.1016/j.bios.2023.115510Microencapsulated stem cells reduce cartilage damage in a material dependent manner following minimally invasive intra-articular injection in an OA rat model (2023)Materials Today Bio, 22. Article 100791. Johnbosco, C., Karbaat, L., Korthagen, N. M., Warmink, K., Koerselman, M., Coeleveld, K., Becker, M., van Loo, B., Zoetebier, B., Both, S., Weinans, H., Karperien, M. & Leijten, J.https://doi.org/10.1016/j.mtbio.2023.100791Self-oxygenation of engineered living tissues orchestrates osteogenic commitment of mesenchymal stem cells (2023)Biomaterials, 300. Article 122179. Hassan, S., Wang, T., Shi, K., Huang, Y., Urbina Lopez, M. E., Gan, K., Chen, M., Willemen, N., Kalam, H., Luna-Ceron, E., Cecen, B., Elbait, G. D., Li, J., Garcia-Rivera, L. E., Gurian, M., Banday, M. M., Yang, K., Lee, M. C., Zhuang, W., … Ryon Shin, S.https://doi.org/10.1016/j.biomaterials.2023.122179Choice of Protein, Not Its Amyloid-Fold, Determines the Success of Amyloid-Based Scaffolds for Cartilage Tissue Regeneration (2023)ACS Omega, 8(27), 24198-24209. Dalen, M. C. E. v., Karperien, M., Claessens, M. M. A. E. & Post, J. N.https://doi.org/10.1021/acsomega.3c00151Effect of Autologous Conditioned Plasma Injections in Patients With Knee Osteoarthritis (2023)Orthopaedic Journal of Sports Medicine, 11(7). Korpershoek, J. V., Vonk, L. A., Filardo, G., Kester, E. C., van Egmond, N., Saris, D. B. F. & Custers, R. J. H.https://doi.org/10.1177/23259671231184848A Modular Platform for Cytocompatible Hydrogels with Tailored Mechanical Properties Based on Monolithic Matrices and Particulate Building Blocks (2023)Biomacromolecules, 24(6), 2755–2765. Andrée, L., Bertsch, P., Wang, R., Becker, M., Leijten, J., Fischer, P., Yang, F. & Leeuwenburgh, S. C. G.https://doi.org/10.1021/acs.biomac.3c00177Altered intracellular molecular crowding plays a key role in osteoarthritis pathology (2023)[Contribution to conference › Poster] 47th FEBS Congress 2023. Govindaraj, K., Meteling, M. A. W. & Leijten, J.Steering Stem Cell Fate within 3D Living Composite Tissues Using Stimuli-Responsive Cell-Adhesive Micromaterials (2023)Advanced science, 10(10). Article 2205487. Kamperman, T., Willemen, N. G. A., Kelder, C., Koerselman, M., Becker, M., Lins, L., Johnbosco, C., Karperien, M. & Leijten, J.https://doi.org/10.1002/advs.202205487Spatial control of self-organizing vascular networks with programmable aptamer-tethered growth factor photopatterning (2023)Materials Today Bio, 19. Article 100551. Rana, D., Padmanaban, P., Becker, M., Stein, F., Leijten, J., Koopman, B. & Rouwkema, J.https://doi.org/10.1016/j.mtbio.2023.100551Mapping RUNX2 transcriptional dynamics during multi-lineage differentiation of human mesenchymal stem cells (2023)[Working paper › Preprint]. bioRxiv. Govindaraj, K., Kannan, S., Karperien, M. & Post, J. N.https://doi.org/10.1101/2023.03.30.534618High-Throughput Fabrication of Size-Controlled Pickering Emulsions, Colloidosomes, and Air-Coated Particles via Clog-Free Jetting of Suspensions (2023)Advanced materials, 35(13). Article 2208894. Jiang, J., Poortinga, A. T., Liao, Y., Kamperman, T., Venner, C. H. & Visser, C. W.https://doi.org/10.1002/adma.202208894Aqueous Two-Phase Enabled Low Viscosity 3D (LoV3D) Bioprinting of Living Matter (2023)Advanced science, 10(8). Article 2204609. Becker, M., Gurian, M., Schot, M. & Leijten, J.https://doi.org/10.1002/advs.202204609Programmable bio-ionic liquid functionalized hydrogels for in situ 3D bioprinting of electronics at the tissue interface (2023)Materials Today Advances, 17. Article 100352. Krishnadoss, V., Kanjilal, B., Masoumi, A., Banerjee, A., Dehzangi, I., Pezhouman, A., Ardehali, R., Martins-Green, M., Leijten, J. & Noshadi, I.https://doi.org/10.1016/j.mtadv.2023.100352Aggregation and Gelation Behavior of Stereocomplexed Four-Arm PLA-PEG Copolymers Containing Neutral or Cationic Linkers (2023)International journal of molecular sciences, 24(4). Article 3327. Signori, F., Wennink, J. W. H., Bronco, S., Feijen, J., Karperien, M., Bizzarri, R. & Dijkstra, P. J.https://doi.org/10.3390/ijms24043327Chitosan and carboxymethyl cellulose-based 3D multifunctional bioactive hydrogels loaded with nano-curcumin for synergistic diabetic wound repair (2023)International journal of biological macromolecules, 227, 1203-1220. Shah, S. A., Sohail, M., Karperien, M., Johnbosco, C., Mahmood, A. & Kousar, M.https://doi.org/10.1016/j.ijbiomac.2022.11.307Enzymatic co-crosslinking of star-shaped poly(ethylene glycol) tyramine and hyaluronic acid tyramine conjugates provides elastic biocompatible and biodegradable hydrogels (2023)Bioactive Materials, 20, 53-63. Wang, R., Huang, X., Zoetebier, B., Dijkstra, P. J. & Karperien, M.https://doi.org/10.1016/j.bioactmat.2022.05.020Gelation Kinetics and Mechanical Properties of Thiol-Tetrazole Methylsulfone Hydrogels Designed for Cell Encapsulation (2023)Macromolecular bioscience, 23(2). Article 2200419. de Miguel-Jiménez, A., Ebeling, B., Paez, J. I., Fink-Straube, C., Pearson, S. & del Campo, A.https://doi.org/10.1002/mabi.202200419Improving Interfacial Adhesion of Hydrogel Matrices to PDMS-based Microfluidic Platforms (2023)[Contribution to conference › Poster] 32nd NBTE Annual Meeting 2023. Na, Y., Devamoglu, U., Le Gac, S. & Paez, J.Improving Interfacial Adhesion of Hydrogel Matrices to PDMS-based Microfluidic Platforms (2023)[Contribution to conference › Poster] 27th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2023. Na, Y., Devamoglu, U., Le Gac, S. & Paez, J.Improving interfacial adhesion of hydrogel matrices to PDMS-based microfluidic platforms (2023)[Contribution to conference › Poster] TechMed Research Day 2023. Na, Y., Devamoglu, U., Le Gac, S. & Paez, J.Improving Interfacial Adhesion of Hydrogel Matrices to PDMS-based Microfluidic Platforms (2023)[Contribution to conference › Poster] NanoBioTech Montreux 2023. Na, Y., Devamoglu, U., Le Gac, S. & Paez, J.Scalable fabrication, compartmentalization and applications of living microtissues (2023)Bioactive Materials, 19, 392-405. Schot, M., Araújo-Gomes, N., van Loo, B., Kamperman, T. & Leijten, J.https://doi.org/10.1016/j.bioactmat.2022.04.005
2022
Kinetic characterization of SPR-based biomarker assays enables quality control, calibration free measurements and robust optimization for clinical application (2022)Analytical biochemistry, 658. Article 114918. Hendriks, J., Schasfoort, R. B. M., Huskens, J., Saris, D. B. F. & Karperien, M.https://doi.org/10.1016/j.ab.2022.114918Use of Allogeneic Mesenchymal Signaling Cells (MSCs) to Augment Cartilage Repair (2022)Operative Techniques in Sports Medicine, 30(4). Article 150962. Saris, T. F. F., de Windt, T. S., Custers, R. J. H. & Saris, D. B. F.https://doi.org/10.1016/j.otsm.2022.150962Tunable and Compartmentalized Multimaterial Bioprinting for Complex Living Tissue Constructs (2022)ACS applied materials & interfaces, 14(46), 51602-51618. Hassan, S., Gomez-Reyes, E., Enciso-Martinez, E., Shi, K., Campos, J. G., Soria, O. Y. P., Luna-Cerón, E., Lee, M. C., Garcia-Reyes, I., Steakelum, J., Jeelani, H., García-Rivera, L. E., Cho, M., Cortes, S. S., Kamperman, T., Wang, H., Leijten, J., Fiondella, L. & Shin, S. R.https://doi.org/10.1021/acsami.2c12585Scalable Production of Size-Controlled Cholangiocyte and Cholangiocarcinoma Organoids within Liver Extracellular Matrix-Containing Microcapsules (2022)Cells, 11(22). Article 3657. van Tienderen, G. S., Willemse, J., van Loo, B., van Hengel, E. V. A., de Jonge, J., van der Laan, L. J. W., Leijten, J. & Verstegen, M. M. A.https://doi.org/10.3390/cells11223657Small antibodies with a big opportunity: The variable domain of the heavy chain only antibody and its potential as disease modifying osteoarthritic drug (2022)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Koerselman, M.https://doi.org/10.3990/1.9789036554404Hybrid extracellular vesicles-liposome incorporated advanced bioink to deliver microRNA (2022)Biofabrication, 14(4). Article 045008. Elkhoury, K., Chen, M., Koçak, P., Enciso-Martínez, E., Bassous, N. J., Lee, M. C., Byambaa, B., Rezaei, Z., Li, Y., Ubina López, M. E., Gurian, M., Sobahi, N., Hussain, M. A., Sanchez-Gonzalez, L., Leijten, J., Hassan, S., Arab-Tehrany, E., Ward, J. E. & Ryon Shin, S.https://doi.org/10.1088/1758-5090/ac8621Injectable Cell-Laden Polysaccharide Hydrogels: In Vivo Evaluation of Cartilage Regeneration (2022)Polymers, 14(20). Article 4292. Fu, Y., Both, S. K., Plass, J. R. M., Dijkstra, P. J., Zoetebier, B. & Karperien, M.https://doi.org/10.3390/polym14204292Current strategies for ligand bioconjugation to poly(acrylamide) gels for 2D cell culture: Balancing chemo-selectivity, biofunctionality, and user-friendliness (2022)Frontiers in Chemistry, 10. Article 1012443. Wolfel, A., Jin, M. & Paez, J. I.https://doi.org/10.3389/fchem.2022.1012443Embedded 3D Printing in Self-Healing Annealable Composites for Precise Patterning of Functionally Mature Human Neural Constructs (2022)Advanced science, 9(25). Article 2201392. Kajtez, J., Wesseler, M. F., Birtele, M., Khorasgani, F. R., Rylander Ottosson, D., Heiskanen, A., Kamperman, T., Leijten, J., Martínez-Serrano, A., Larsen, N. B., Angelini, T. E., Parmar, M., Lind, J. U. & Emnéus, J.https://doi.org/10.1002/advs.202201392Redox-triggerable firefly luciferin-bioinspired hydrogels as injectable and cell-encapsulating matrices (2022)Polymer chemistry, 13(35), 5116-5126. Jin, M., Gläser, A. & Paez, J. I.https://doi.org/10.1039/d2py00481jEnzyme-Mediated Alleviation of Peroxide Toxicity in Self-Oxygenating Biomaterials (2022)Advanced healthcare materials, 11(13). Article 2102697. Willemen, N. G. A., Hassan, S., Gurian, M., Jasso-Salazar, M. F., Fan, K., Wang, H., Becker, M., Allijn, I. E., Bal-Öztürk, A., Leijten, J. & Ryon Shin, S.https://doi.org/10.1002/adhm.202102697Simulating differentiation from iPS cells to chondrocytes (2022)[Contribution to conference › Poster] Bioinformatics & Systems Biology Conference, BioSB 2022. 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2013
Introducing small cationic groups into 4-armed PLLAePEG copolymers leads to preferred micellization over thermo-reversible gelation (2013)Polymer, 54(26), 6894-6901. Wennink, J. W. H., Signori, F., Karperien, M., Bronco, S., Feijen, J. & Dijkstra, P. J.https://doi.org/10.1016/j.polymer.2013.11.007Maintenance of multi-potential differentiation capacity of human mesenchymal stem cells on polymeric rapid prototyped 3D scaffolds (2013)[Contribution to conference › Poster] Till & McCulloch meetings. Leferink, A. M., Karperien, H. B. J., van Blitterswijk, C. & Moroni, L.Label-Free Detection of Insulin and Glucagon within Human Islets of Langerhans Using Raman Spectroscopy (2013)PLoS ONE, 8(10), e78148-e78148. Hilderink, J., Otto, C., Slump, C. H., Lenferink, A. T. M., Engelse, M. A., van Blitterswijk, C., de Koning, E. J. P., Karperien, H. B. J. & van Apeldoorn, A. 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2011
HYDROGELS BASED ON POLYMERS OF DEXTRAN TYRAMINE AND TYRAMINE CONJUGATES OF NATURAL POLYMERS (2011)[Patent › Patent]. Karperien, H. B. J., Jin, R., Moreira Teixeira, L., Feijen,, J. & Dijkstra, P. J.Differential bone-forming capacity of osteogenic cells from either embryonic stem cells or bone marrow-derived mesenchymal stem cells (2011)Journal of tissue engineering and regenerative medicine, 5(3), 180-190. Both, S. K., van Apeldoorn, A. A., Jukes, J. M., Englund, M. C. O., Hyllner, J., van Blitterswijk, C. & de Boer, J.https://doi.org/10.1002/term.303Expression of aromatase and estrogen receptor alpha in chondrosarcoma, but no beneficial effect of inhibiting estrogen signaling both in vitro and in vivo (2011)Clinical sarcoma research, 1. Article 5. Meijer, D., Gelderblom, H., Karperien, M., Cleton-Jansen, A.-M., Hogendoorn, P. C. W. & Bovée, J. V. M. G.https://doi.org/10.1186/2045-3329-1-5Genome-wide association identifies three new susceptibility loci for Paget's disease of bone (2011)Nature genetics, 43(7), 685-689. Albagha, O. M. E., Wani, S. E., Visconti, M. R., Alonso, N., Goodman, K., Brandi, M. L., Cundy, T., Chung, P. Y. J., Dargie, R., Devogelaer, J.-P., Falchetti, A., Fraser, W. D., Gennari, L., Gianfrancesco, F., Hooper, M. J., van Hul, W., Isaia, G., Nicholson, G. C., Nuti, R., … Karperien, H. B. J.https://doi.org/10.1038/ng.845
2010
Dextran-tyramine Hydrogels for Cartilage Repair: Enhanced Chondrogenicity by Engraftment with Hyaluronic Acid and Heparin (2010)[Contribution to conference › Abstract] TERMIS-EU Chapter Meeting 2010. Moreira Teixeira, L., Jin, R., Dijkstra, P. T. S., van Blitterswijk, C., Feijen, J. & Karperien, H. B. J.https://www.termis.org/docs/eu10_abstracts/TERMIS2010_0371.pdfMateriomics: Dealing with complexity in tissue engineering (2010)European cells & materials, 20(SUPPL. 1). van Blitterswijk, C. A., Stamatialis, D., Unadkat, H., Papenburg, B., Rouwkema, J., Truckenmuller, R., van Apeldoorn, A., Wessling, M. & de Boer, J.
2009
Scaffold for diabetes treatment (2009)[Patent › Patent] (Submitted). van Apeldoorn, A. A., van Blitterswijk, C., Engelse, M. A., de Koning, E. J. P. & Karperien, H. B. J.
2007
Cell-based and molecular imaging tools for validating new therapies in the treatment of bone metabolic disorders and metastases (2007)Current opinion in molecular therapeutics, 8(6), 477-479. Kaijzel, E. L., Karperien, M., van der Horst, G., van der Pluijm, G., Löwik, C. W. G. M. & Chan, A.
2003
Imaging molecular interactions in cells by dynamic and static fluorescence anisotropy (rFLIM and emFRET) (2003)Biochemical Society transactions, 31(5), 1020-1027. Lidke, D. S., Nagy, P., Barisas, B. G., Heintzmann, R., Post, J. N., Lidke, K. A., Clayton, A. H. A., Arndt-jovin, D. J. & Jovin, T. M.https://doi.org/10.1042/bst0311020
2001
Nuclear localization signals in the Xenopus FGF embryonic early response 1 protein (2001)FEBS letters, 502(1-2), 41-45. Post, J. N., Gillespie, L. L. & Paterno, G. D.https://doi.org/10.1016/S0014-5793(01)02653-9