Dr. Ling Wu

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Personal information

I graduated from the Sichuan University (Chendu, China) in 2005, with a degree of B. Sc. I was then enrolled to a 5-year PhD program in College of Stomatology at the same university. In March 2008, I aborted my study in China and joined the research group leading by Dr. Marcel Karperien in the department of Tissue Regeneration as a PhD student.

Research summary

Autologous chondrocyte transplantation (ACT) is the golden standard for treatment of large-size cartilage defects. ACT requires, however, at least two operative procedures which take several weeks. We recently developed a simple method that can circumvent the necessity for chondrocyte expansion by cell culture. In this single step procedure, chondrocytes are isolated, mixed with mesenchymal stem cells, loaded on a scaffold and directly re-implanted into the patient. The amount of cartilage produced in this procedure equals or is even more than that formed by a pure chondrocyte population or a pure mesenchymal stem cells population. The improved chondrocyte formation may be explained by cross-talk between the chondrocytes and the stem cells with an as yet unknown mechanism. What I am going to do is to uncover the cellular interaction in the co-culture system. So, my research project can be described as: Elucidation of the mechanism of action of chondro-induction in co-cultures of chondrocytes and mesenchymal stem cells.

Publications of interest

Ling Wu defended his thesis titled “Mesenchymal Stem cells as trophic mediators in cartilage regeneration” on 12 September 2012

Contact details

E-mail: l.wu@utwente.nl