Antonella Facchinetti


Name: Antonella Facchinetti
Date of birth: 15 June 1957
Place of birth: Verona (Italy)
Academic position: Technician - DOSS University of Padova
Bachelor’s degree: Biological Science at the University of Padova (1986)

Professional positions:

Technician at the Oncology Section of the DOSS-University of Padova (since 1991).

Scientific activity:

21 publications in peer-reviewed journals; 2 publications in Italian; 1 book chapters; h-index 81.

Research interests:

  1. Immunological tolerance and mechanisms of T cell clonal deletion.
  2. Autoreactive T cell repertoire; MHC and non-MHC genes involved in resistance to experimental autoimmune encephalomyelitis.
  3. Immunological follow up of patients with multiple sclerosis during drug treatment.
  4. CD8 T lymphocyte repertoire involved in tumor antigen recognition; immunological memory.
  5. Predictive value and biologic significance of Circulating Tumor Cells (CTC) in solid tumors.



  1. Dabbeni-Sala, F., Vàzquez.Laslop, N., Facchinetti, A., Devars, S. and Dreyfus, G. Modulation of mitochondrial F0F1 catalysis by boundary and bulk phase phospholipids. Biochem Biophys Res Commun 1989. 158: 1013-1020.
  2. Finotti P, Facchinetti A, Palatini P. Mechanism of Na+/K(+)-ATPase activation by trypsin and kallikrein. Biochim Biophys Acta. 1990. 1039:123-129.
  3. Biasi, G., Mazzocchi, M., Facchinetti, A., Panozzo, M., Zanovello, P., Collavo, D. and Chieco-Bianchi, L. Induction of Moloney murine sarcoma virus tolerance in adult mice by anti-CD4 monoclonal antibody treatment. Cancer Res (Suppl). 1990. 50:5703S-5706S
  4. Biasi, G., Facchinetti, A., Panozzo, M., Zanovello, P., Chieco-Bianchi, L. and Collavo, D., Moloney murine leukemia virus tolerance in anti-CD4 monoclonal antibody-treated adult mice. J Immunol 1991. 147: 2284-2289.
  5. Facchinetti, A., Tessarollo, L., Mazzocchi, M., Kingston, R., Collavo, D. and Biasi, G., An improved method for the detection of DNA fragmentation. J Immunol Methods 1991. 136: 125-131.
  6. Collavo, D., Zanovello, P., Rosato, A., Bronte, V., Facchinetti, A., Biasi, G., La risposta immunologica verso antigeni tumorali specifici. In: Scuola Superiore di Oncologia e Scienze Biomediche 1991 p.15-20.
  7. Biasi, G., Facchinetti, A., Panozzo, M. and Pertile, P., Apoptosis of mature T lymphocytes. Ann N Y Acad Sci 1992. 663: 481-482.
  8. Facchinetti, A., Panozzo, M., Pertile, P., Tessarollo, L. and Biasi, G., In vivo and in vitro death of mature T cells induced by separate signals to CD4 and alpha beta TCR. Immunobiology 1992. 185: 380-389.
  9. Biasi, G., Panozzo, M., Pertile, P., Mezzalira, S. and Facchinetti, A., Mechanism underlying superantigen-induced clonal deletion of mature T lymphocytes. Int Immunol 1994. 6: 983-989.
  10. Gallo, P., Sivieri, S., Facchinetti, A., Biasi, G., and Tavolato, B., Nuove prospettive terapeutiche per la sclerosi multipla. In: Neurologia 1996. XIII Corso di Aggiornamento della Società Italiana di Neurologia. M. Carreras, A. Federico, C. Fieschi, E. Paolino (Ed.), Ed. Pisani. p. 262-266.
  11. Biasi, G., Facchinetti, A., Mezzalira, S., Tavolato, B., and Gallo, P. Mechanisms of peripheral T-cell tolerance induction by non-depleting anti-CD4 mAb treatment. In: Frontiers in multiple sclerosis: clinical research and therapy. Abramsky O., Ovadia H. Ed. Martin Dunitz Ltd Publ., 1997 p.279-286.
  12. Biasi, G., Facchinetti, A., Monastra, G., Mezzalira, S., Sivieri, S., Tavolato, B. and Gallo, P., Protection from experimental autoimmune encephalomyelitis (EAE): non-depleting anti-CD4 mAb treatment induces peripheral T-cell tolerance to MBP in PL/J mice. J Neuroimmunol 1997. 73: 117-123.
  13. B iasi, G., Facchinetti, A., Mezzalira, S. and MacDonald, H. R., Selective lysis of activated cells in oncorna virus infection. Scand J Immunol 1997. 45: 366-370.
  14. Ferrarini, A. M., Sivieri, S., Buttarello, M., Facchinetti, A., Perini, P. and Gallo, P., Time-course analysis of CD25 and HLA-DR expression on lymphocytes in interferon-beta 1b-treated multiple sclerosis patients. Mult Scler 1998. 4: 174-177.
  15. Perini, P., Tiberio, M., Sivieri, S., Facchinetti, A., Biasi, G. and Gallo, P., Interleukin-1 receptor antagonist, soluble tumor necrosis factor-alpha receptor type I and II, and soluble E-selectin serum levels in multiple sclerosis patients receiving weekly intramuscular injections of interferon-beta1a. Eur Cytokine Netw 2000. 11: 81-86.
  16. Perini, P., Wadhwa, M., Buttarello, M., Meager, A., Facchinetti, A., Thorpe, R., Biasi, G. and Gallo, P., Effect of IFNbeta and anti-IFNbeta antibodies on NK cells in multiple sclerosis patients. J Neuroimmunol 2000. 105: 91-95.
  17. Perini, P., Facchinetti, A., Bulian, P., Massaro, A. R., Pascalis, D. D., Bertolotto, A., Biasi, G. and Gallo, P., Interferon-beta (INF-beta) antibodies in interferon-beta1a- and interferon-beta1b-treated multiple sclerosis patients. Prevalence, kinetics, cross-reactivity, and factors enhancing interferon-beta immunogenicity in vivo. Eur Cytokine Netw 2001. 12: 56-61.
  18. Facchinetti, A., Gallo, P., Perini, P., Mezzalira, S., Ronchese, F. and Biasi, G., The MBP-reactive repertoire is shaped by recognition of minor histocompatibility antigens. J Neuroimmunol 2004. 148: 154-161.
  19. Facchinetti, A., Dalla Santa, S., Mezzalira, S., Rosato, A. and Biasi, G., A large number of T lymphocytes recognize Moloney-murine leukemia virus-induced antigens, but a few mediate long-lasting tumor immunosurveillance. J Immunol 2005. 174: 5398-5406.
  20. Biasi, G., Facchinetti, A., Cappellari , R., Rossi, E. and Zanovello, P. Immune response to Moloney-murine leukemia virus-induced antigens in bone marrow. Immunol Lett. 2011. 138:79-85
  21. Rossi E, Facchinetti A, Zamarchi R: Customizing CellSearch platform, Cytometry Part A 2013, 83A:595-598