FORMER STUDENTS
Stijn Geraats
Technical Medicine, Medical Sensing & Stimulation, University of Twente
Biomedical Engineering, Physiological Signals & Systems, University of Twente
Contact: https://www.linkedin.com/in/stijn-geraats-b51b05220/
Duration: May 2024 - October 2025
Assignment
Currently, it is not yet possible to continuously obtain values such as compliance or pressure generated by the diaphragm in ventilated patients without invasive monitoring modalities. These values could provide better insights to physicians about the condition of the lungs and how patients can be ventilated more effectively. By utilizing the non-invasive electrical signal of the diaphragm and auxiliary respiratory muscles, these values may potentially be derived. During this thesis, I will focus on obtaining such parameters non-invasively and continuously to give the clinician a better idea about the ventilated patients using computational physiological models.
Collaborating partner
Medisch Spectrum Twente – Intensive Care Unit
Committee
Prof. Dr. D.W. Donker (Chair)
A.D. Cornet, MD PhD (Medical supervisor)
R.S.P. Warnaar, MSc. (Technical-medical supervisor)
Dr. E. Mos-Oppersma (Technical supervisor)
R.G.K.M. Aarts, PhD (Technical supervisor/ external member)
E.M. Walter, MSc. (Process supervisor)
Arno Fennema
Technical Medicine, Medical Sensing and Stimulation
Duration: September 2024 to July 2025
Assignment
Venoarterial extracorporeal membrane oxygenation (VA ECMO) is a life-saving technique used provide mechanical circulatory support in patients with severe cardiogenic shock. However, monitoring their recovery during VA ECMO remains difficult due to profound alterations in hemodynamics. This makes weaning from VA ECMO complex and challenging. In my thesis I aim to evaluate the potential of pulse pressure as a marker for cardiac recovery. I investigate its association with successful weaning through a data analysis and explore its physiological behavior using computational modeling.
Collaborating partner
University Medical Centre Utrecht – Intensive Care Unit
Committee
Prof. Dr. D.W. Donker (Chair & Medical supervisor)
Dr. L.M. van Loon (Technical & Technical-Medicine supervisor)
E. Walter MSc (Process supervisor)
Kim van der Tak, BSc
Technical Medicine, Medical Imaging & Intervention, University of Twente
Contact: https://www.linkedin.com/in/kim-van-der-tak/
Duration: July 2024 – June 2025
Assignment
Managing hemodynamically unstable patients in intensive care involves complex challenges, as it requires balancing fluctuating blood pressure and impaired tissue perfusion. Despite available guidelines, physicians often resort to treatments like fluid administration, vasopressor therapy, and inotropes without strong justification. This study aims to develop a personalized approach for hemodynamically unstable intensive care patients by analysing treatment effects to create a decision support algorithm that optimizes patient care.
Collaborating partner
University Medical Centre Utrecht – Intensive Care Unit
Committee
Prof. Dr. D.W. Donker (Chair & Medical supervisor)
Dr. L.M. van Loon (Technical & Medical supervisor)
Drs. N.S. Cramer Bornemann (Process supervisor)
Kimmia Azampanah, BSc
Technical Medicine, Medical Sensing & Stimulation, University of Twente
Contact: https://www.linkedin.com/in/kimmia-azampanah-7114ba15a/
October 2023 – August 2024
Assignment
To optimizing daily management of patients that receive venoarterial extracorporeal membrane oxygenation (VA ECMO) therapy in the Intensive Care, it is vital to assess the cardiac function of the patient. Due to complex patient-device interactions, it is challenging to estimate ventricular recovery or deterioration. This research aims to develop a method to continuously monitor left ventricular function by using a digital twin.
Collaborating partner
University Medical Centre Utrecht – Intensive Care Unit
Committee
Prof. Dr. D.W. Donker (Chair)
J.A.J.M. Hermens, MSc. (Medical supervisor)
Dr. L. Fresiello (Technical supervisor)
M.P. Mulder, MSc. (Technical-Medical supervisor)
E.M. Walter, MSc. (Process supervisor)
Emese van Dalen, BSc
Biomedical Engineering, Physiological Signals & Systems, University of Twente
Contact: emesevandalen@hotmail.com / https://www.linkedin.com/in/emese-van-dalen/
September 2023 - April 2024
Assignment
Hypotension is a common complication during or shortly after the anaesthesia induction, referred to as post-induction hypotension. My research aims to predict post-induction hypotension based on patient and surgery characteristics and medication and physiological data using Machine Learning models. The ultimate goal is to utilize the predictive model as a decision support tool for the anaesthesiologist, improving patient safety.
Collaborating partner
Medisch Spectrum Twente Enschede - Anesthesiology
Committee
Prof. Dr. D.W. Donker (Chair)
Dr. J.W. Potters (Daily (medical) supervisor UT)
M.P. Mulder, MSc (Daily (technical) supervisor UT)
Dr. M. Poel (External supervisor UT)
Drs. R.M. Krol (Process supervisor)
Mirjam Markusse, BSc
Technical Medicine, Medical Sensing & Stimulation, University of Twente
Contact: m.markusse@student.utwente.nl
August 2022 - September 2023
Assignment
Though hypotension is common during surgery, its treatment is of more reactive than preventive in nature. My research focuses on advanced signal analysis and machine learning methods to predict hypotension, and guide haemodynamic management in the operating room.
Collaborating partner
Medisch Spectrum Twente Enschede - Anesthesiology
Committee
Prof. Dr. D.W. Donker (Chair)
Dr. J.W. Potters (Medical supervisor)
Dr. L. Fresiello (Technological supervisor UT)
M.P. Mulder, MSc (Technological supervisor UT)
Drs. R.M. Krol (Process supervisor)
Maaike Wösten, BSc
Technical Medicine, Medical Sensing & Stimulation, University of Twente
Applied Mathematics, Systems, Analysis and Computational Sciences
Contact: http://www.linkedin.com/in/maaike-wösten-152b6a153
September 2022 - October 2023
Assignment
To improve the clinical management of patients supported with VA-ECMO, it is important to continuously monitor the condition of the heart. The heart and the VA-ECMO circuit both contribute to the patient’s hemodynamics. This complicates monitoring the condition of the heart accurately. Therefore, in this research, we aim to describe the contribution of the native heart using cardiovascular models and clinical data.
Collaborating partner
University Medical Centre Utrecht, Intensive Care Centrum
Research Group: Mathematics of Systems Theory, University of Twente
Committee
Prof. Dr. H. Zwart (Chair)
Prof. Dr. D.W. Donker (Medical supervisor)
Dr. L. Fresiello (Technological supervisor UT)
Dr. Lisette M. Vernooij (Additional supervisor)
Drs. R.M. Krol (Process supervisor)
Wibrich Boskma, BSc
Technical Medicine, Medical Sensing & Stimulation, University of Twente
Applied Mathematics, Systems, Analysis and Computational Sciences
Contact: www.linkedin.com/in/wibrich-boskma
October 2022 – October 2023
Assignment
This research aims to develop and validate a bedside stand-alone device to measure functional residual capacity in mechanical ventilated children as a tool to assess their pulmonary status and the effect of ventilator settings. With the results, a decision support model can be designed to improve ventilation settings, lung recruitment and clinical practice in the paediatric intensive care unit.
Collaborating partner
University Medical Centre Groningen – Paediatric Intensive Care Unit
Committee
Prof. Dr. D.W. Donker (Chair)
Dr. M.C.J. Kneyber, MD PhD FCCM (Medical supervisor)
Drs. R.G.T. Blokpoel (Medical supervisor)
A.A. Koopman, MSc. (Technical medicinal supervisor)
Dr. E. Mos-Oppersma (Technical supervisor UT)
Drs. J. de Witte (Process supervisor)
Marit Bot, BSc
Technical Medicine, Medical Sensing & Stimulation, University of Twente
Contact: https://www.linkedin.com/in/marit-bot-745b74222/
Jan 2023 – Dec 2023
Assignment
Discovering underlying markers in the identification of sepsis. Using waveforms measured at the Emergency Department as input for an unsupervised deep learning model, I aim to uncover clusters of sepsis patients and relate the findings.
Collaborating partner
University Medical Centre Groningen – Emergency Room
Committee
Prof. Dr. D. W. Donker (Chair)
Prof. Dr. J.C. ter Maaten (Medical Supervisor)
M.P. Mulder, MSc (Technological supervisor UT)
Drs. J. de Witte (Process supervisor)
Gerwin Numan, BSc
Biomedical Engineering, Medical Device Design, University of Groningen
Contact : g.k.numan@utwente.nl or g.k.numan@student.rug.nl
February 2023 - July 2023
Assignment
The goal is to develop a 3D anatomical model of the aorta which can be attached to the in silico- in vitro blood circulation simulator. By creating a compliant aorto, which can be attached to the simulator, investigations on Extracorporeal Membrane Oxygenation (ECMO) therapy can be performed. When the pump of the ECMO is inserted into the aorta, the setup can be altered to mimic patient specific conditions, investigate patient-device interactions, measure the region of collision, flow pattern and flow development during ECMO treatment.
Committee
dr. ir. L. Fresiello (Daily Supervisor UT)
dr. ir. R. Fluit (First Examiner, University of Groningen)
Prof. Dr. D. W. Donker (Second Examiner, University of Twente
Anna Schoonhoven, BSc
Technical Medicine, Medical Sensing & Stimulation, University of Twente
Contact: https://www.linkedin.com/in/anna-schoonhoven-50692b160/
January 2022 - December 2022
Assignment
Accurate identification of sepsis and prediction of patients at risk is essential to improve treatment. In this research, I try to predict sepsis within 48 hours among patients with early sepsis in the Emergency Room, based on several features from waveforms derived from EMG and PPG wearables with machine-learning methods.
Collaborating partner
University Medical Centre Groningen - Emergency Room
Committee
Prof. Dr. Ir. H.J. Hermens (Chair)
Prof. Dr. J.C. ter Maaten (Medical supervisor)
Prof. Dr. D.W. Donker (Technological supervisor UT)
M.P. Mulder, MSc (Technological supervisor UT)
dr. M. Groenier (Process supervisor)