In patients with severe stable chronic obstructive pulmonary disease (COPD), chronic nocturnal noninvasive ventilation (NIV) has been shown to result in physiological and clinical benefits. However, while achieving optimal ventilatory efficacy is challenging in this group, there is an imperative need to move care from hospital to home. First, we aim to greatly improve chronic NIV treatment by using more precise, synchronized and continuous monitoring of mechanics, patient-ventilator synchrony and gas exchange. Second, the developed system will be designed for sufficient stability and reliability to be used at home without the extensive aid of caregivers.

Therefore, in the present study, we aim to develop an integrated monitoring system that allows for automatic detection of events, easy interpretation, and eventually a set-up for a closed loop feedback system improving chronic NIV in severe COPD patients.

Research group:

Dr. E. Mos-Oppersma, Project leader
Cardiovascular and Respiratory Physiology group, University of Twente

Dr. M. L. Duiverman, Co-project leader
Department of Pulmonary Diseases/Home Mechanical Ventilation, University Medical Center Groningen

Collaboration partners:
- Löwenstein Medical Technology, Germany
- Sencure, the Netherlands
- Vivisol Nederland BV, the Netherlands