Tel: +31 53 4893671
Room: Zuidhorst 243
SCIENTIFIC EDUCATION AND PROFESSIONAL EXPERIENCE
2001 – present
Assistant Professor, Department of Polymer Chemistry and Biomaterials, as from 01-01-2010 Biomaterials Science and Technology, University of Twente.
Senior Researcher, Department of Polymer Chemistry and Biomaterials, UT.
Post-doc, Endothelialization of artificial surfaces, Department of Biomedical Materials Technology, UT.
PhD Thesis, Protein adsorption and platelet deposition on biomaterials: in vitro studies concerning biocompatibility. Department of Materials Technology, UT.
Effects of fluid shear on endothelial cell signal transduction. Tissue engineering of small-diameter blood vessels and nerve guides. Angiogenesis of tissue-engineered constructs. Effects of fluid shear on (mesenchymal) stem cell differentiation. Induced pluripotent stem cells for tissue engineering. Microfluidics and organs-on-chip.
CELL-MATERIAL INTERACTIONS AND TISSUE ENGINEERING
The vision of the cluster is to perform excellent research and education in the field of cell-material interactions and tissue engineering. The current research activities are focused on three main areas:
The main focus of this area is to understand and improve the adhesion and proliferation of endothelial cells on natural and artificial surfaces.
Efforts are directed at the preparation of small-diameter vascular grafts and nerve guides.
The aim of this area is to prepare a lung-on-a-chip for the development of novel strategies to regenerate damaged lung tissue.
(Technician: Lydia Bolhuis)
After removal of atherosclerotic plaque from an artery by endarterectomy, the luminal surface of the vessel should be re-endothelialized as soon as possible. Together with partners we are developing a less-invasive technique to remove the plaque and to subsequently cover the arterial wall with patient-own endothelial cells.
TISSUE ENGINEERING OF SMALL-DIAMETER ARTERIAL GRAFTS AND NERVE GUIDES
(PhD student: Zhengchao Guo)
In view of its biocompatibility, mechanical properties and degradation behavior, poly(trimethylene carbonate) (PTMC) is a very suitable polymer for the preparation of tissue engineering scaffolds. The aim of this project is to prepare PTMC scaffolds for vascular tissue engineering and nerve regeneration by photopolymerization (e.g. stereolithography).
DEVELOPMENT OF A LUNG-ON-A-CHIP
(PhD student: Thijs Pasman)
In this project, lung alveolar epithelial cells and microvascular endothelial cells will be cultured on curved, flexible and elastic PTMC membranes in a chip. This lung-on-a-chip will subsequently be used to develop novel strategies for lung regeneration as well as the engineering of bioartificial lung tissue.
Bachelor and Master assignments are possible in all three areas.
- Reviewer for scientific journals: a.o. Biomaterials, Journal of Biomedical Materials Research, Acta Biomaterialia, Frontiers in Neuroengineering, Tissue Engineering, Journal Controlled Release, Stem Cell Research and Therapy.
- Safety officer.
- Project leader genetically modified organisms (GMO).