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2025
Blood-perfused Vessels-on-Chips stimulated with patient plasma recapitulate endothelial activation and microthrombosis in COVID-19 (2025)Lab on a chip, 25(7), 1787-1800. Weener, H. J., van Haaps, T. F., van Helden, R. W. J., Albers, H. J., Haverkate, R., Middelkamp, H. H. T., Ridderikhof, M. L., van Mens, T. E., van den Berg, A., Mummery, C. L., Orlova, V. V., Middeldorp, S., van Es, N. & van der Meer, A. D.https://doi.org/10.1039/d4lc00848kUnlocking cellular secrets: Innovations driving research in liver disease & cancer (2025)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Booijink, R. S.https://doi.org/10.3990/1.9789036564823Organoids-on-a-chip: microfluidic technology enables culture of organoids with enhanced tissue function and potential for disease modeling (2025)Frontiers in bioengineering and biotechnology, 13. Article 1515340. Papamichail, L., Koch, L. S., Veerman, D., Broersen, K. & van der Meer, A. D.https://doi.org/10.3389/fbioe.2025.1515340Silica-coated magnetic nanobeads in a flow enrichment target capture Halbach (FETCH) magnetic separation system for circulating tumor cell enrichment (2025)FEBS letters, 599(5), 724-738. Liu, P., He, S., Mentink, A., Hart, P., Wu, Y., Terstappen, L. W. M. M., Jonkheijm, P. & Stevens, M.https://doi.org/10.1002/1873-3468.15094Cardiac differentiation roadmap for analysis of plasticity and balanced lineage commitment (2025)Stem cell reports, 20(3). Article 102422. Snabel, R. R., Cofiño-Fabrés, C., Baltissen, M., Schwach, V., Passier, R. & Veenstra, G. J. C.https://doi.org/10.1016/j.stemcr.2025.102422FORCETRACKER: A versatile tool for standardized assessment of tissue contractile properties in 3D Heart-on-Chip platforms (2025)PLoS ONE, 20(2 February). Article e0314985. Rivera-Arbeláez, J. M., Dostanić, M., Windt, L. M., Stein, J. M., Cofiño-Fabres, C., Boonen, T., Wiendels, M., Van Den Berg, A., Segerink, L. I., Mummery, C. L., Sarro, P. M., Van Meer, B. J., Ribeiro, M. C., Mastrangeli, M. & Passier, R.https://doi.org/10.1371/journal.pone.0314985Retina-on-chip: engineering functional in vitro models of the human retina using organ-on-chip technology (2025)Lab on a chip, 25(5), 996-1014. Gensheimer, T., Veerman, D., van Oosten, E. M., Segerink, L., Garanto, A. & van der Meer, A. D.https://doi.org/10.1039/d4lc00823e
2024
Integrated Silicon-On-Insulator Based Mesh Membrane for Continuous Monitoring in Organs-on-a-chip (2024)In 2024 IEEE SENSORS. IEEE. Zakharova - Kolezhuk, M., Condor, M., Shaikh, S., Delahanty, A., Braeken, D., van der Meer, A. & Segerink, L.https://doi.org/10.1109/SENSORS60989.2024.10784460Novel strategies to assess cytokine release mediated by chimeric antigen receptor T cells based on the adverse outcome pathway concept (2024)Journal of Immunotoxicology, 21(suppl. 1), S13-S28. Alb, M., Reiche, K., Rade, M., Sewald, K., Loskill, P., Cipriano, M., Maulana, T. I., van der Meer, A. D., Weener, H. J., Clerbaux, L. A., Fogal, B., Patel, N., Adkins, K., Lund, E., Perkins, E., Cooper, C., van den Brulle, J., Morgan, H., Rubic-Schneider, T., … Hudecek, M.https://doi.org/10.1080/1547691X.2024.2345158Biopurification using non-growing microorganisms to improve plant protein ingredients (2024)npj Science of Food, 8(1). Article 48. Nugroho, A. D. W., van Schalkwijk, S., Cebeci, S., Jacobs, S., Wesselink, W., Staring, G., Goerdayal, S., Prodan, A., Stijnman, A., Teuling, E., Broersen, K. & Bachmann, H.https://doi.org/10.1038/s41538-024-00290-xInhibition of intrahepatic monocyte recruitment by Cenicriviroc and extracellular matrix degradation by MMP1 synergistically attenuate liver inflammation and fibrogenesis in vivo (2024)Scientific reports, 14(1). Article 16897. Geervliet, E., Karkdijk, E. & Bansal, R.https://doi.org/10.1038/s41598-024-67926-6Upscaling Osteoclast Generation by Enhancing Macrophage Aggregation Using Hollow Microgels (2024)Small, 20(46). Article 2403272. Husch, J. F. A., Araújo-Gomes, N., Willemen, N. G. A., Cofiño-Fabrés, C., van Creij, N., Passier, R., Leijten, J. & van den Beucken, J. J. J. P.https://doi.org/10.1002/smll.202403272The Effects Of In Vitro Exercise Of Engineered Heart Tissues On Cardiac Injury And Function: 721 (2024)Medicine and science in sports and exercise, 56(10S), 247-247. Luiken, T. T. J., Cofiño-Fabres, C., Rivera-Arbeláez, J. M., Snippert, D., Denessen, E. J. S., Mingels, A. M. A., Thijssen, D. H. J., Passier, R. C. J. J. & Eijsvogels, T. M. H.https://doi.org/10.1249/01.mss.0001054648.81137.2fThe Gut-Brain Axis on Chip to unravel Inter-Tissue Interactions (2024)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Koch, L. S.https://doi.org/10.3990/1.9789036563253Data of manuscript Blood-perfused Vessels-on-Chips stimulated with patient plasma recapitulate endothelial activation and microthrombosis in COVID-19 (2024)[Dataset Types › Dataset]. 4TU.Centre for Research Data. Weener, H., van Haaps, T., van Helden, R., Albers, H., Haverkate, R., Middelkamp, H., Ridderikhof, M., van Mens, T., van den Berg, A. & Mummery, C.https://doi.org/10.4121/5bb846d8-ed30-4e2e-bfe3-4fb607cbe8edMultimodal Mapping of Electrical and Mechanical Latency of Human-Induced Pluripotent Stem Cell-Derived Cardiomyocyte Layers (2024)ACS nano, 18(35), 24060-24075. Zhang, X., Burattini, M., Duru, J., Chala, N., Wyssen, N., Cofino Fabres, C., Rivera Arbelaez, J. M., Passier, R., Poulikakos, D., Ferrari, A., Tringides, C., Vörös, J., Battista Luciani, G., Miragoli, M. & Zambelli, T.https://doi.org/10.1021/acsnano.4c03896Engineered SPIONs functionalized with endothelin a receptor antagonist ameliorate liver fibrosis by inhibiting hepatic stellate cell activation (2024)Bioactive Materials, 39, 406-426. ten Hove, M., Smyris, A., Booijink, R., Wachsmuth, L., Hansen, U., Alic, L., Faber, C., Hӧltke, C. & Bansal, R.https://doi.org/10.1016/j.bioactmat.2024.05.034Standardizing designed and emergent quantitative features in microphysiological systems (2024)Nature Biomedical Engineering, 8, 941-962. Nahon, D., Moerkens, R., Aydogmus, H., Lendemeijer, B., Martínez-Silgado, A., Stein, J., Dostanić, M., Frimat, J.-P., Gontan, C., de Graaf, M. N. S., Hu, M., Kasi, D., Koch, L. S., Le, K., Lim, S., Middelkamp, H. H. T., Mooiweer, J., Montreux-Ragot, P., Niggl, E., … Mummery, C. L.https://doi.org/10.1038/s41551-024-01236-0Global Literature Analysis of Organoid and Organ-on-Chip Research (2024)Advanced healthcare materials, 13(21). Article 2301067. Shoji, J. y., Davis, R. P., Mummery, C. L. & Krauss, S.https://doi.org/10.1002/adhm.202301067The Translational Organ-on-Chip Platform Starter Kit: An ISO-compliant, Reconfigurable Platform for Plug-and-Play Organ-on-Chip Research (2024)[Contribution to conference › Abstract] 28th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2024. Loessberg-Zahl, J. T., Paul, A., Safai, E., Vollertsen, A. R., Lozeman, J. J. A., Segerink, L., Odijk, M. & van der Meer, A.A Survey of AI Utilisation in High-Throughput Screening Systems Using Stem Cell Models (2024)In Proceedings of the 3rd International Conference on Innovations in Computing Research (ICR’24) (pp. 595-604) (Lecture Notes in Networks and Systems; Vol. 1058 LNNS). Springer. Cao, L., Schwach, V. & Verbeek, F.https://doi.org/10.1007/978-3-031-65522-7_51Micro-Engineered Heart Tissues On-Chip with Heterotypic Cell Composition Display Self-Organization and Improved Cardiac Function (2024)Advanced healthcare materials, 13(18). Article 2303664. Cofiño-Fabres, C., Boonen, T., Rivera-Arbeláez, J. M., Rijpkema, M., Blauw, L., Rensen, P. C. N., Schwach, V., Ribeiro, M. C. & Passier, R.https://doi.org/10.1002/adhm.202303664Photoannealing of Microtissues Creates High-Density Capillary Network Containing Living Matter in a Volumetric-Independent Manner (2024)Advanced materials, 36(28). Article 2308949. Schot, M., Becker, M., Paggi, C. A., Gomes, F., Koch, T., Gensheimer, T., Johnbosco, C., Nogueira, L. P., van der Meer, A., Carlson, A., Haugen, H. & Leijten, J.https://doi.org/10.1002/adma.202308949Photoannealing of Microtissues Creates High-Density Capillary Network Containing Living Matter in a Volumetric-Independent Manner (Adv. Mater. 28/2024) (2024)Advanced materials, 36(28). Article 2470219. Schot, M., Becker, M., Paggi, C. A., Gomes, F., Koch, T., Gensheimer, T., Johnbosco, C., Nogueira, L. P., van der Meer, A., Carlson, A., Haugen, H. & Leijten, J.https://doi.org/10.1002/adma.202470219Implications of innate immune sexual dimorphism for MASLD pathogenesis and treatment (2024)Trends in pharmacological sciences, 45(7), 614-627. Booijink, R., Ramachandran, P. & Bansal, R.https://doi.org/10.1016/j.tips.2024.05.004Effects of allopurinol and febuxostat on uric acid transport and transporter expression in human umbilical vein endothelial cells (2024)PLoS ONE, 19(6). Article e0305906. van der Pol, K. H., Koenderink, J., van den Heuvel, J. J. M. W., van den Broek, P., Peters, J., van Bunningen, I. D. W., Pertijs, J., Russel, F. G. M., Koldenhof, J., Morshuis, W. J., van Drongelen, J., Schirris, T. J. J., van der Meer, A. & Rongen, G. A.https://doi.org/10.1371/journal.pone.0305906Innovative models for cardiotoxicity assessment in human pluripotent stem cell-derived cardiomyocytes that enable clinically relevant treatment regimen (2024)Cardiovascular Research, 120(Supplement_1). Article cvae088.068. Schwach, V., Cofino-Fabres, C., Slaats, R. H., Rivera Arbelaez, J., Ten Den, S. A., Ribeiro, M. C. & Passier, R.https://doi.org/10.1093/cvr/cvae088.068Guiding organs-on-chips towards applications: a balancing act between integration of advanced technologies and standardization (2024)Frontiers in Lab on a Chip Technologies, 3. Meneses, J., Pereira Dos Santos Conceição, F., van der Meer, A., de Wit, S. & Moreira Teixeira Leijten, L. S.https://doi.org/10.3389/frlct.2024.1376964Supplementary data to "High-Resolution Raman Imaging of >300 Patient-Derived Cells from Nine Different Leukemia Subtypes: A Global Clustering Approach" (2024)[Dataset Types › Dataset]. Zenodo. Vanna, R., Masella, A., Manuela, B., Lenferink, A., Morasso, C., Cerullo, G., Polli, D., Bregonzio, M. & Otto, C.https://doi.org/10.5281/zenodo.11195903Identification of functional and diverse circulating cancer‐associated fibroblasts in metastatic castration‐naïve prostate cancer patients (2024)Molecular oncology (E-pub ahead of print/First online). Booijink, R., Terstappen, L. W. M. M., Dathathri, E., Isebia, K., Kraan, J., Martens, J. & Bansal, R.https://doi.org/10.1002/1878-0261.13653Gradient Method to Determine the Avidity of Cell Binding (2024)Research in medical & engineering sciences, 11(1), 1157-1159. Schasfoort, R. B. M., van de Vosse, D. & van Weperen, J.https://doi.org/10.31031/RMES.2024.11.000752A safety screening platform for individualized cardiotoxicity assessment (2024)iScience, 27(3). Article 109139. Schwach, V., Slaats, R. H., Cofiño-Fabres, C., ten Den, S. A., Rivera-Arbeláez, J. M., Dannenberg, M., van Boheemen, C., Ribeiro, M., van der Zanden, S. Y., Nollet, E. E., van der Velden, J., Neefjes, J., Cao, L. & Passier, R.https://doi.org/10.1016/j.isci.2024.109139Electrochemical Sensing with Spatially Patterned Pt Octahedra Electrodes (2024)Advanced Materials Technologies, 9(5). Article 2300878. Jonker, D., Eyovge, C., Berenschot, E., Di Palma, V., Wasserberg, D., Michel-Souzy, S., Jonkheijm, P., Krol, S., Gardeniers, H., Creatore, M., Tas, N. & Susarrey-Arce, A.https://doi.org/10.1002/admt.202300878Embedded macrophages induce intravascular coagulation in 3D blood vessel-on-chip (2024)Biomedical microdevices, 26(1). Article 2. Middelkamp, H. H. T., Weener, H. J., Gensheimer, T., Vermeul, K., Heus, L. E. d., Albers, H. J., Berg, A. v. d. & Meer, A. D. v. d.https://doi.org/10.1007/s10544-023-00684-wA magnetic microneedle to isolate single immunomagnetically labeled cells (2024)Lab on a chip, 24(3), 460-466. Stevens, M., Harder, P. & Terstappen, L. W. M. M.https://doi.org/10.1039/d3lc00920cLoss of Pulmonary Endothelial Cells in Emphysema Impairs Support of Human Alveolar Epithelial Cell Growth (2024)American Journal of Respiratory Cell and Molecular Biology, 70(2), 149-152. Ravi, A., Jia, L., Wu, X., van der Meer, A. D., Gosens, R., Stolk, J., van der Does, A. M., Koning, F., Hiemstra, P. S. & Khedoe, P. P. J. S.https://doi.org/10.1165/rcmb.2023-0084LERetraction: Interferon gamma peptidomimetic targeted to interstitial myofibroblasts attenuates renal fibrosis after unilateral ureteral obstruction in mice (2024)Oncotarget, 15, 35. Poosti, F., Bansal, R., Yazdani, S., Prakash, J., Beljaars, L., van den Born, J., de Borst, M. H., van Goor, H., Hillebrands, J. L. & Poelstra, K.https://doi.org/10.18632/oncotarget.28532Considering future qualification for regulatory science in the early development of microphysiological systems: a case study of microthrombosis in a Vessel-on-Chip (2024)Frontiers in Toxicology, 6. Article 1513002. Weener, H. J., Middelkamp, H. H. T. & Van der Meer, A. D.https://doi.org/10.3389/ftox.2024.1513002Inertial Ballistic Microfluidics as a Platform for Biomedical and Chemical Engineering Applications (2024)In 28th International Conference on Miniaturized Systems for Chemistry and Life Sciences - Micro-Total Analysis Systems (µTAS 2024). van der Ven, D. L., Cuartas Velez, C. A., Bansal, R., Bosschaart, N. & Fernández Rivas , D.
2023
Cardiac PET Imaging of ATP Binding Cassette (ABC) Transporters: Opportunities and Challenges (2023)Pharmaceuticals, 16(12). Article 1715. Liu, W., Mossel, P., Schwach, V., Slart, R. H. J. A. & Luurtsema, G.https://doi.org/10.3390/ph16121715Flow-based immunomagnetic enrichment of circulating tumor cells from diagnostic leukapheresis product (2023)Molecular oncology (E-pub ahead of print/First online). Stevens, M., Mentink, A., Coumans, F. A. W., Dathathri, E., Isebia, K. T., Kraan, J., de Wit, R., Martens, J. W. M. & Terstappen, L. W. M. M.https://doi.org/10.1002/1878-0261.13565Heart and kidney organoids maintain organ-specific function in a microfluidic system (2023)Materials Today Bio, 23. Article 100818. Gabbin, B., Meraviglia, V., Angenent, M. L., Ward-van Oostwaard, D., Sol, W., Mummery, C. L., Rabelink, T. J., van Meer, B. J., van den Berg, C. W. & Bellin, M.https://doi.org/10.1016/j.mtbio.2023.100818Mass production of lumenogenic human embryoid bodies and functional cardiospheres using in-air-generated microcapsules (2023)Nature communications, 14. Article 6685. van Loo, S. R., ten Den, S. A., Araújo-Gomes, N., de Jong, V., Snabel, R., Schot, M. R., Rivera Arbelaez, J. M., Veenstra, G. J., Passier, R., Kamperman, T. & Leijten, J.https://doi.org/10.1038/s41467-023-42297-0The TNFR1 antagonist Atrosimab reduces neuronal loss, glial activation and memory deficits in an acute mouse model of neurodegeneration (2023)Scientific reports, 13(1). Article 10622. Ortí-Casañ, N., Boerema, A. S., Köpke, K., Ebskamp, A., Keijser, J., Zhang, Y., Chen, T., Dolga, A. M., Broersen, K., Fischer, R., Pfizenmaier, K., Kontermann, R. E. & Eisel, U. L. M.https://doi.org/10.1038/s41598-023-36846-2Tracking the dynamics of thrombus formation in a blood vessel-on-chip with visible-light optical coherence tomography (2023)Biomedical optics express, 14(11), 5642-5655. Cuartas Velez, C. A., Middelkamp, H. H. T., van den Berg, A., van der Meer, A. & Bosschaart, N.https://doi.org/10.1364/BOE.5004343D Porous Microfluidic Architectures for Heart-on-Chip (2023)[Contribution to conference › Poster] 27th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2023. Paul, A., van Dorp, T., Leferink, A. M., Vollertsen, A. R., van der Meer, A. & Odijk, M.Cell Patterning Technology on Polymethyl Methacrylate through Controlled Physicochemical and Biochemical Functionalization (2023)Biosensors, 13(10). Article 904. Azuaje-Hualde, E., Komen, J., Alonso-Cabrera, J. A., van den Berg, A., de Pancorbo, M. M., van der Meer, A. D., Benito-Lopez, F. & Basabe-Desmonts, L.https://doi.org/10.3390/bios13100904Towards Improved Human In Vitro Models for Cardiac Arrhythmia: Disease Mechanisms, Treatment, and Models of Atrial Fibrillation (2023)Biomedicines, 11(9). Article 2355. Cofiño-Fabres, C., Passier, R. & Schwach, V.https://doi.org/10.3390/biomedicines11092355Advancements in molecular and bioengineering techniques for driving maturation of human pluripotent stem cell-derived cardiac three-dimensional models (2023)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Cofino Fabres, C.https://doi.org/10.3990/1.9789036558228Applying ISO Standards to Organ-on-Chip Designs (2023)[Dataset Types › Dataset]. 4TU.Centre for Research Data. Safai, E.https://doi.org/10.4121/871d6c3a-cf1a-44f9-865a-6da842bd2f27The effect of embedded macrophages on intravascular coagulation in 3D vessels-on-chips (2023)In Abstracts of the 2nd Microphysiological Systems World Summit, Berlin, 2023. Middelkamp, H. H. T., Weener, H. J., Gensheimer, T., Vermeul, K., de Heus, L. E., Albers, H. J., van den Berg, A. & van der Meer, A.Maturing differentiated human pluripotent stem cells in vitro: methods and challenges (2023)Development (Cambridge), 150(11). Article dev201103. Ottaviani, D., ter Huurne, M., Elliott, D. A., Bellin, M. & Mummery, C. L.https://doi.org/10.1242/dev.201103Robust Tissue Fabrication for Long-Term Culture of iPSC-Derived Brain Organoids for Aging Research (2023)Journal of visualized experiments, 2023(195). Article e64586. Koch, L. S., Buentello, D. C. & Broersen, K.https://doi.org/10.3791/64586Metabolic Cardiomyopathies and Cardiac Defects in Inherited Disorders of Carbohydrate Metabolism: A Systematic Review (2023)International journal of molecular sciences, 24(10). Article 8632. Conte, F., Sam, J.-E., Lefeber, D. J. & Passier, R.https://doi.org/10.3390/ijms24108632Automated assessment of human engineered heart tissues using deep learning and template matching for segmentation and tracking (2023)Bioengineering and Translational Medicine, 8(3). Article e10513. Rivera-Arbeláez, J. M., Keekstra, D., Cofiño-Fabres, C., Boonen, T., Dostanic, M., ten Den, S. A., Vermeul, K., Mastrangeli, M., van den Berg, A., Segerink, L. I., Ribeiro, M. C., Strisciuglio, N. & Passier, R.https://doi.org/10.1002/btm2.10513Methacrylated human recombinant collagen peptide as a hydrogel for manipulating and monitoring stiffness-related cardiac cell behavior (2023)iScience, 26(4). Article 106423. Mostert, D., Jorba, I., Groenen, B. G. W., Passier, R., Goumans, M. J. T. H., van Boxtel, H. A., Kurniawan, N. A., Bouten, C. V. C. & Klouda, L.https://doi.org/10.1016/j.isci.2023.106423Nanoparticle Printing for Microfluidic Applications:: Bipolar Electrochemistry and Localized Raman Sensing Spots (2023)Micromachines, 14(2). Article 453. Broccoli, A., Vollertsen, A. R., Roels, P., van Vugt, A., van den Berg, A. & Odijk, M.https://doi.org/10.3390/mi14020453Automated Sarcomere Structure Analysis for Studying Cardiotoxicity in Human Pluripotent Stem Cell-Derived Cardiomyocytes (2023)Microscopy and microanalysis, 29(1), 254-264. Cao, L., Schoenmaker, L., Ten Den, S. A., Passier, R., Schwach, V. & Verbeek, F. J.https://doi.org/10.1093/micmic/ozac016Generation of AAVS1 and CLYBL STRAIGHT-IN v2 acceptor human iPSC lines for integrating DNA payloads (2023)Stem cell research, 66. Article 102991. Blanch-Asensio, A., van der Vaart, B., Vinagre, M., Groen, E., Arendzen, C., Freund, C., Geijsen, N., Mummery, C. L. & Davis, R. P.https://doi.org/10.1016/j.scr.2022.102991Following the dots: Versatile and modular approach for engineering and analyzing three-dimensional cardiac tissues (2023)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Rivera Arbeláez, J. M.https://doi.org/10.3990/1.9789036555272Multiplexed fluidic circuit board for controlled perfusion of 3D blood vessels-on-a-chip (2023)Lab on a chip, 23(1), 168-181. de Graaf, M. N. S., Vivas, A., Kasi, D. G., van den Hil, F. E., van den Berg, A., van der Meer, A. D., Mummery, C. L. & Orlova, V. V.https://doi.org/10.1039/d2lc00686cEmbedded 3D printing of dilute particle suspensions into dense complex tissue fibers using shear thinning xanthan baths (2023)Biofabrication, 15(1). Article 015014. Trikalitis, V. D., Kroese, N. J. J., Kaya, M., Cofino Fabres, C., ten Den, S. A., S.M. Khalil, I., Misra, S., Koopman, B. F. J. M., Passier, R., Schwach, V. & Rouwkema, J.https://doi.org/10.1088/1758-5090/aca124Segmentation of NKX2.5 Signal in Human Pluripotent Stem Cell-Derived Cardiomyocytes (2023)In Data Science and Artificial Intelligence - 1st International Conference, DSAI 2023, Proceedings (pp. 170-184) (Communications in Computer and Information Science; Vol. 1942 CCIS). Springer. Jongsma, S., Schwach, V., Den, S. A. T., Passier, R., Verbeek, F. J. & Cao, L.https://doi.org/10.1007/978-981-99-7969-1_13
2022
Human pluripotent stem cell-derived cardiomyocytes align under cyclic strain when guided by cardiac fibroblasts (2022)APL Bioengineering, 6(4). Article 046108. Mostert, D., Groenen, B., Klouda, L., Passier, R., Goumans, M. J., Kurniawan, N. A. & Bouten, C. V. C.https://doi.org/10.1063/5.0108914Microfluidic and microengineered systems for automated cardiac organ-on-a-chip tissue culture (2022)[Thesis › PhD Thesis - Research UT, graduation UT]. University of Twente. Vivas, A.https://doi.org/10.3990/1.9789036554930Effect of continuous electrical stimulation on engineered 3D cardiac tissues using hPSCs in a versatile platform (2022)[Contribution to conference › Abstract] NanoBioTech-Montreux Conference 2022. Rivera Arbelaez, J. M., Kutucu, C., Snippert, D., Dannenberg, M., Cofino Fabres, C., van den Berg, A., Ribeiro, M., Passier, R. & Segerink, L.Alzheimer’s Disease: Treatment Strategies and Their Limitations (2022)International journal of molecular sciences, 23(22). Article 13954. Passeri, E., Elkhoury, K., Morsink, M., Broersen, K., Linder, M., Tamayol, A., Malaplate, C., Yen, F. T. & Arab-Tehrany, E.https://doi.org/10.3390/ijms232213954Animal models and animal-free innovations for cardiovascular research: current status and routes to be explored. Consensus document of the ESC Working Group on Myocardial Function and the ESC Working Group on Cellular Biology of the Heart (2022)Cardiovascular Research, 118(15), 3016-3051. van der Velden, J., Asselbergs, F. W., Bakkers, J., Batkai, S., Bertrand, L., Bezzina, C. R., Bot, I., Brundel, B. J. J. M., Carrier, L., Chamuleau, S., Ciccarelli, M., Dawson, D., Davidson, S. M., Dendorfer, A., Duncker, D. J., Eschenhagen, T., Fabritz, L., Falcão-Pires, I., Ferdinandy, P., … Thum, T.https://doi.org/10.1093/cvr/cvab370STRAIGHT-IN enables high-throughput targeting of large DNA payloads in human pluripotent stem cells (2022)Cell Reports Methods, 2(10). Article 100300. Blanch-Asensio, A., Grandela, C., Brandão, K. 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Patterning Biological Gels for 3D Cell Culture inside Microfluidic Devices by Local Surface Modification through Laminar Flow Patterning (2020)Micromachines, 11(12). Article 1112. Loessberg-Zahl, J. T., Beumer, J., van den Berg, A., Eijkel, J. C. T. & van der Meer, A. D.https://doi.org/10.3390/mi11121112Organ-on-a-chip: The next generation platform for risk assessment of radiobiology (2020)RSC advances, 10(65), 39521-39530. Quan, Y., Sun, M., Tan, Z., Eijkel, J. C. T., Van Den Berg, A., Van Der Meer, A. & Xie, Y.https://doi.org/10.1039/d0ra05173jNew approach methodologies (NAMs) for human-relevant biokinetics predictions: Meeting the paradigm shift in toxicology towards an animal-free chemical risk assessment (2020)Alternatives to Animal Experimentation, 37(4), 607-622. Punt, A., Bouwmeester, H., Blaauboer, B. J., Coecke, S., Hakkert, B., Hendriks, D. F. G., Jennings, P., Kramer, N. I., Neuhoff, S., Masereeuw, R., Paini, A., Peijnenburg, A. A. C. M., Rooseboom, M., Shuler, M. L., Sorrell, I., Spee, B., Strikwold, M., Van der Meer, A. D., Van der Zande, M., … Heringa, M. B.https://doi.org/10.14573/altex.2003242A Miniaturized EHT Platform for Accurate Measurements of Tissue Contractile Properties (2020)Journal of microelectromechanical systems, 29(5), 881-887. Article 9152964. Dostanić, M., Windt, L. M., Stein, J. M., Van Meer, B. J., Bellin, M., Orlova, V., Mastrangeli, M., Mummery, C. L. & Sarro, P. M.https://doi.org/10.1109/JMEMS.2020.3011196A modular microfluidic parallel dispensing system (2020)[Contribution to conference › Abstract] 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2020. de Boer, D., Vollertsen, A. R., van den Berg, A., van der Meer, A. & Odijk, M.Membranes for modelling cardiac tissue stiffness in vitro based on poly(Trimethylene carbonate) and poly(ethylene glycol) polymers (2020)Membranes, 10(10), 1-12. Article 274. Allijn, I., Ribeiro, M., Poot, A., Passier, R. & Stamatialis, D.https://doi.org/10.3390/membranes10100274Metabolic environment in vivo as a blueprint for differentiation and maturation of human stem cell-derived cardiomyocytes (2020)Biochimica et biophysica acta. Molecular basis of disease, 1866(10). Article 165881. Slaats, R. H., Schwach, V. & Passier, R.https://doi.org/10.1016/j.bbadis.2020.165881Controlled pharmacokinetic anti-cancer drug concentration profiles lead to growth inhibition of colorectal cancer cells in a microfluidic device (2020)Lab on a chip, 20(17), 3167-3178. Komen, J., Westerbeek, E. Y., Kolkman, R. W., Roesthuis, J., Lievens, C., van den Berg, A. & van der Meer, A. D.https://doi.org/10.1039/d0lc00419gMultiplexed blood-brain barrier organ-on-chip (2020)Lab on a chip, 20(17), 3132-3143. Zakharova, M., Palma do Carmo, M. A., van der Helm, M. W., Le-The, H., de Graaf, M. N. S., Orlova, V., van den Berg, A., van der Meer, A. D., Broersen, K. & Segerink, L. I.https://doi.org/10.1039/d0lc00399aMilk processing affects structure, bioavailability and immunogenicity of β-lactoglobulin (2020)Foods, 9(7). Article 874. Broersen, K.https://doi.org/10.3390/foods9070874Blinded, Multicenter Evaluation of Drug-induced Changes in Contractility Using Human-induced Pluripotent Stem Cell-derived Cardiomyocytes (2020)Toxicological Sciences, 176(1), 103-123. Saleem, U., Meer, B. J. V., Katili, P. A., Yusof, N. A. N. M., Mannhardt, I., Krotenberg Garcia, A., Tertoolen, L., Korte, T. D., Vlaming, M. L. H., McGlynn, K., Nebel, J., Bahinski, A., Harris, K., Rossman, E., Xu, X., Burton, F. L., Smith, G. L., Clements, P., Mummery, C. L., … Denning, C.https://doi.org/10.1093/toxsci/kfaa058Determining the antioxidant properties of various beverages using staircase voltammetry (2020)Heliyon, 6(6). Article e04210. Schilder, W. H., Tanumihardja, E., Leferink, A. M., van den Berg, A. & Olthuis, W.https://doi.org/10.1016/j.heliyon.2020.e04210Human-iPSC-Derived Cardiac Stromal Cells Enhance Maturation in 3D Cardiac Microtissues and Reveal Non-cardiomyocyte Contributions to Heart Disease (2020)Cell stem cell, 26(6), 862-879.e11. Giacomelli, E., Meraviglia, V., Campostrini, G., Cochrane, A., Cao, X., van Helden, R. W. J., Krotenberg Garcia, A., Mircea, M., Kostidis, S., Davis, R. P., van Meer, B. J., Jost, C. R., Koster, A. J., Mei, H., Míguez, D. G., Mulder, A. A., Ledesma-Terrón, M., Pompilio, G., Sala, L., … Mummery, C. L.https://doi.org/10.1016/j.stem.2020.05.004In vitro microfluidic disease model to study whole blood-endothelial interactions and blood clot dynamics in real-time (2020)Journal of visualized experiments, 159. Article e61068. Manz, X. D., Albers, H. J., Symersky, P., Aman, J., van der Meer, A. D., Bogaard, H. J. & Szulcek, R.https://doi.org/10.3791/61068Automated image analysis system for studying cardiotoxicity in human pluripotent stem cell-Derived cardiomyocytes (2020)BMC bioinformatics, 21(1). Article 187. Cao, L., Der Meer, A. D. V., Verbeek, F. J. & Passier, R.https://doi.org/10.1186/s12859-020-3466-1Human Pluripotent Stem Cell-Derived Cardiomyocytes for Assessment of Anticancer Drug-Induced Cardiotoxicity (2020)Frontiers in Cardiovascular Medicine, 7, 1-12. Article 50. Schwach, V., Slaats, R. H. & Passier, R.https://doi.org/10.3389/fcvm.2020.00050A cardiomyocyte show of force: A fluorescent alpha-actinin reporter line sheds light on human cardiomyocyte contractility versus substrate stiffness (2020)Journal of molecular and cellular cardiology, 141, 54-64. Ribeiro, M. C., Slaats, R. H., Schwach, V., Rivera Arbelaez, J. M., Tertoolen, L. G. J., van Meer, B. J., Molenaar, R., Mummery, C. L., Claessens, M. M. A. E. & Passier, R.https://doi.org/10.1016/j.yjmcc.2020.03.008Expandable human cardiovascular progenitors from stem cells for regenerating mouse heart after myocardial infarction (2020)Cardiovascular Research, 116(3), 545-553. Schwach, V., Gomes Fernandes, M., Maas, S., Gerhardt, S., Tsonaka, R., Van Der Weerd, L., Passier, R., Mummery, C. L., Birket, M. J. & Salvatori, D. C. F.https://doi.org/10.1093/cvr/cvz181Generation and Functional Characterization of Monocytes and Macrophages Derived from Human Induced Pluripotent Stem Cells (2020)Current Protocols in Stem Cell Biology, 52(1). Article e108. Cao, X., van den Hil, F. E., Mummery, C. L. & Orlova, V. V.https://doi.org/10.1002/cpsc.108Development of double porous poly (ε-caprolactone)/chitosan polymer as tissue engineering scaffold (2020)Materials Science and Engineering C: Materials for Biological Applications, 107. Article 110257. Das, P., Remigy, J. C., Lahitte, J. F., van der Meer, A. D., Garmy-Susini, B., Coetsier, C., Desclaux, S. & Bacchin, P.https://doi.org/10.1016/j.msec.2019.110257Detection of amyloid aggregation in living systems (2020)In Protein Homeostasis Diseases: Mechanisms and Novel Therapies (pp. 127-152). Elsevier. Broersen, K.https://doi.org/10.1016/B978-0-12-819132-3.00007-5E-learning on the lab with lab education software: Deeper learning & more efficiency? (2020)In Varietas delectat... Complexity is the new normality: SEFI 47th Annual Conference Proceedings (pp. 1261-1270). Societe Europeenne pour la Formation des Ingenieurs (SEFI). Vreman-de Olde, G. C., Rouwenhorst, C., Alers, J. C. & van der Veen, J. T.Highly parallelized human embryonic stem cell differentiation in nanoliter chambers (2020)In MicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 861-862). The Chemical and Biological Microsystems Society. Vollertsen, A. R., ten Den, S. A., Schwach, V., van den Berg, A., Passier, R., van der Meer, A. D. & Odijk, M.Modular operation of microfluidic chips for highly parallelized cell culture and liquid dosing via a fluidic circuit board (2020)Microsystems & nanoengineering, 6(1). Article 107. Vollertsen, A. R., de Boer, D., Dekker, S., Wesselink, B. A. M., Haverkate, R., Rho, H. S., Boom, R. J., Skolimowski, M., Blom, M., Passier, R., van den Berg, A., van der Meer, A. D. & Odijk, M.https://doi.org/10.1038/s41378-020-00216-zUsing 3D-printing to fabricate a microfluidic vascular model to mimic arterial thrombosis (2020)In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017 (pp. 1070-1071). The Chemical and Biological Microsystems Society. Albers, H. J., Linssen, J. E. A., Costa, P. F., Middelkamp, H. H. T., van der Hout, L., Malda, J., Passier, R., van den Berg, A. & van der Meer, A. D.
2019
Molecular Mechanisms and Genetics of Oxidative Stress in Alzheimer's Disease (2019)Journal of Alzheimer's Disease, 72(4), 981-1017. Cioffi, F., Adam, R. H. I. & Broersen, K.https://doi.org/10.3233/JAD-190863Tunable microstructured membranes in organs-on-chips to monitor transendothelial hydraulic resistance (2019)Tissue engineering. Part A, 25(23-24), 1635-1645. Das, P., van der Meer, A. D., Vivas, A., Arik, Y. B., Remigy, J. C., Lahitte, J. F., Lammertink, R. G. H. & Bacchin, P.https://doi.org/10.1089/ten.tea.2019.0021Automated analysis of platelet aggregation on cultured endothelium in a microfluidic chip perfused with human whole blood (2019)Micromachines, 10(11). Article 781. Albers, H. J., Passier, R., van den Berg, A. & van der Meer, A. D.https://doi.org/10.3390/mi10110781Diffusion from steady-state profile (DSSP) for low cost, low concentration measurement of diffusion (2019)In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences: uTAS 2019 (pp. 1530-1531). The Chemical and Biological Microsystems Society. Loessberg-Zahl, J. T., Gillrie, M., Kamm, R. D., van den Berg, A., van der Meer, A. & Eijkel, J. C. T.A microfluidic device for testing static and dynamic, in vivo like, drug concentration effects on cancer cells (2019)In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences. Komen, J., Westerbeek, E. Y., van der Meer, A. & van den Berg, A.Standardized, modular microfluidic building blocks for automated cell culturing systems (2019)In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 86-87). The Chemical and Biological Microsystems Society. Vollertsen, A., Bossink, E., de Boer, D., Spalink, J., Passier, R., van den Berg, A., Segerink, L., van der Meer, A. & Odijk, M.Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V (2019)Protein engineering design and selection, 32(10), 443-457. Claes, F., Rudyak, S., Laird, A. S., Louros, N., Beerten, J., Debulpaep, M., Michiels, E., van der Kant, R., Van Durme, J., De Baets, G., Houben, B., Ramakers, M., Yuan, K., Gwee, S. S. L., Hernandez, S., Broersen, K., Oliveberg, M., Moahamed, B., Kirstein, J., … Schymkowitz, J.https://doi.org/10.1093/protein/gzaa008Organs-on-Chips: a new paradigm for safety assessment of drug-induced thrombosis (2019)Current Opinion in Toxicology, 17, 1-8. Ng, P., Belgur, C., Barthakur, S., van der Meer, A. D., Hamilton, G. A. & Barrile, R.https://doi.org/10.1016/j.cotox.2019.08.004Hybrid polyester-hydrogel electrospun scaffolds for tissue engineering applications (2019)Frontiers in bioengineering and biotechnology, 7(SEP). Article 231. de Pinho, A. R. G., Odila, I., Leferink, A., van Blitterswijk, C., Camarero-Espinosa, S. & Moroni, L.https://doi.org/10.3389/fbioe.2019.00231Simultaneous measurement of excitation-contraction coupling parameters identifies mechanisms underlying contractile responses of hiPSC-derived cardiomyocytes (2019)Nature communications, 10(1). Article 4325. van Meer, B. J., Krotenberg, A., Sala, L., Davis, R. P., Eschenhagen, T., Denning, C., Tertoolen, L. G. J. & Mummery, C. L.https://doi.org/10.1038/s41467-019-12354-8A platform for assessing pro- and anti-arrhythmic effects of drugs based on isogenic human iPSC-derived cardiomyocytes (2019)Acta physiologica, 227(S718), 159-160. Article e13366. Campostrini, G., Sala, L., Ward-van Oostwaard, D., van Meer, B. J., Tertoolen, L. G. J., Bartulos-Encinas, O., Braam, S. R., IJzerman, A. P., Mummery, C. L. & Bellin, M.https://doi.org/10.1111/apha.13366Native cardiac environment and its impact on engineering cardiac tissue (2019)Biomaterials Science, 7(9), 3566-3580. Schwach, V. & Passier, R.https://doi.org/10.1039/c8bm01348aShape-defined solid micro-objects from poly(D,L-lactic acid) as cell-supportive counterparts in bottom-up tissue engineering (2019)Materials Today Bio, 4. Article 100025. Leferink, A. M., Tibbe, M. P., Bossink, E. G. B. M., de Heus, L. E., van Vossen, H., van den Berg, A., Moroni, L. & Truckenmüller, R. K.https://doi.org/10.1016/j.mtbio.2019.100025Scalable microphysiological system to model three-dimensional blood vessels (2019)APL Bioengineering, 3(2). Article 026105. de Graf, M. N. S., Cochrane, A., van den Hil, F. E., Buijsman, W., van der Meer, A., van den Berg, A., Mummery, C. L. & Orlova, V. V.https://doi.org/10.1063/1.5090986Apolipoprotein E associated with reconstituted high-density lipoprotein-like particles is protected from aggregation (2019)FEBS letters, 593(11), 1144-1153. Hubin, E., Verghese, P. B., van Nuland, N. & Broersen, K.https://doi.org/10.1002/1873-3468.13428Advanced in vitro models of vascular biology: Human induced pluripotent stem cells and organ-on-chip technology (2019)Advanced drug delivery reviews, 140, 68-77. Cochrane, A., Albers, H. J., Passier, R., Mummery, C. L., van den Berg, A., Orlova, V. V. & van der Meer, A.https://doi.org/10.1016/j.addr.2018.06.007Non-invasive sensing of transepithelial barrier function and tissue differentiation in organs-on-chips using impedance spectroscopy (2019)Lab on a chip, 19(3), 452-463. van der Helm, M. W., Henry, O. Y. F., Bein, A., Hamkins-Indik, T., Cronce, M. J., Leineweber, W. D., Odijk, M., van der Meer, A. D., Eijkel, J. C. T., Ingber, D. E., van den Berg, A. & Segerink, L. I.https://doi.org/10.1039/c8lc00129dFlow focusing through gels as a tool to generate 3D concentration profiles in hydrogel-filled microfluidic chips (2019)Lab on a chip, 19(2), 206-213. Loessberg-Zahl, J., Van der Meer, A. D., Van Den Berg, A. & Eijkel, J. C. T.https://doi.org/10.1039/C8LC01140KPersonalised organs-on-chips: functional testing for precision medicine (2019)Lab on a chip, 19(2), 198-205. Van Den Berg, A., Mummery, C. L., Passier, R. & Van der Meer, A. D.https://doi.org/10.1039/c8lc00827bAsessing barrier properties using impedance spectroscopy in a semi-circular, blood-brain barrier on-chip (2019)In Microtas 2019. Avgidis, F., Tibbe, M. P., Leferink, A. M. & Segerink, L.Assessing barrier properties using impedance spectroscopy in a semi-circular, blood-brain barrier on-chip (2019)In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 (pp. 422-423) (23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019). The Chemical and Biological Microsystems Society. Avgidis, F., Tibbe, M., Leferink, A. & Segerink, L.Multiplexed organ-on-chip device for increased throughput analysis of the tissue barrier function (2019)In 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2019 (pp. 432-433). The Chemical and Biological Microsystems Society. Zakharova, M., van der Helm, M., do Carmo, M. P., Le-The, H., Tibbe, M., van der Meer, A., Broersen, K., Eijkel, J. & Segerink, L.Multiplexed organ-on-chip device for increased throughput analysis of the tissue barrier function (2019)[Contribution to conference › Poster] 23rd International Conference on Miniaturized Systems for Chemistry and Life Sciences, µTAS 2019. Zakharova, M., van der Helm, M., Palma Do Carmo, M., Le The, H., Tibbe, M., van der Meer, A., Broersen, K., Eijkel, J. & Segerink, L.
2018
The Next Chapter for Stem Cell Reports (2018)Stem cell reports, 11(6), 1303-1304. Mummery, C.https://doi.org/10.1016/j.stemcr.2018.10.021Organ-on-Chip Recapitulates Thrombosis Induced by an anti-CD154 Monoclonal Antibody: Translational Potential of Advanced Microengineered Systems (2018)Clinical pharmacology & therapeutics, 104(6), 1240-1248. Barrile, R., van der Meer, A. D., Park, H., Fraser, J. P., Simic, D., Teng, F., Conegliano, D., Nguyen, J., Jain, A., Zhou, M., Karalis, K., Ingber, D. E., Hamilton, G. A. & Otieno, M. A.https://doi.org/10.1002/cpt.1054Flow Through Gels as a Tool to Generate 3D Concentration Profiles in Hydrogel-Filled Devices (2018)In MicroTAS 2018: The 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 2239-2241). The Chemical and Biological Microsystems Society. Loessberg-Zahl, J., van der Meer, A. D., van den Berg, A. & Eijkel, J. C. T.Human induced pluripotent stem cell-derived endothelial cells in thrombosis-on-a-chip devices (2018)In MicroTas 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 2392-2393). The Chemical and Biological Microsystems Society. Albers, H. J., da Silva Simão, J. P., Middelkamp, H. H. T., Mummery, C. L., Passier, R., van den Berg, A., Orlova, V. V. & van der Meer, A. D.Standardized, Modular Parallelization Platform for Microfluidic Large-Scale Integration Cell Culturing Chips (2018)In MicroTAS 2018: 22nd International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 2199-2201). The Chemical and Biological Microsystems Society. Vollertsen, A. R., Dekker, S., Wesselink, B. A. M., Haverkate, R., Bomer, J. G., Rho, H. S., Boom, R. J., Skolimowski, M., Blom, M., van der Meer, A., Passier, R., van den Berg, A. & Odijk, M.Microfluidic assay for the assessment of leukocyte adhesion to human induced pluripotent stem cell-derived endothelial cells (HiPSC-ECs) (2018)Journal of visualized experiments, 2018(141). Article e58678. Halaidych, O. V., van den Hil, F., Mummery, C. L. & Orlova, V. V.https://doi.org/10.3791/58678Quantification of Muscle Contraction In Vitro and In Vivo Using MUSCLEMOTION Software: From Stem Cell-Derived Cardiomyocytes to Zebrafish and Human Hearts (2018)Current Protocols in Human Genetics, 99(1). Article e67. van Meer, B. J., Sala, L., Tertoolen, L. G. J., Smith, G. L., Burton, F. L. & Mummery, C. L.https://doi.org/10.1002/cphg.67Differentiation and validation of human iPSC-derived atrial cardiomyocytes (2018)Journal of Pharmacological and Toxicological Methods, 93, 168-168. Article 176. Sutton, K., El Haou, S., Williams, S., Devalla, H., Stoelzle-Feix, S., Juhasz, K., Doerr, L., Beckler, M., Haarmann, C., George, M., Passier, R., Fertig, N. & Rogers, M.https://doi.org/10.1016/j.vascn.2018.01.544Microfabricated tuneable and transferable porous PDMS membranes for Organs-on-Chips (2018)Scientific reports, 8(1). Article 13524. Quirós-Solano, W. F., Gaio, N., Stassen, O. M. J. A., Arik, Y. B., Silvestri, C., Van Engeland, N. C. A., van der Meer, A., Passier, R., Sahlgren, C. M., Bouten, C. V. C., van den Berg, A., Dekker, R. & Sarro, P. M.https://doi.org/10.1038/s41598-018-31912-6Evolution of the Proximal Sealing Rings of the Anaconda Stent-Graft After Endovascular Aneurysm Repair (2018)Journal of Endovascular Therapy, 25(4), 480-491. Koenrades, M. A., Klein, A., Leferink, A. M., Slump, C. H. & Geelkerken, R. H.https://doi.org/10.1177/1526602818773085Advanced Good Cell Culture Practice for Human Primary, Stem Cell-Derived and Organoid Models as well as Microphysiological Systems (2018)Alternatives to Animal Experimentation, 35(3), 353-378. Pamies, D., Bal-Price, A., Chesne, C., Coecke, S., Dinnyes, A., Eskes, C., Grillari, R., Gstraunthaler, G., Hartung, T., Jennings, P., Leist, M., Martin, U., Passier, R., Schwamborn, J. C., Stacey, G. N., Ellinger-Ziegelbauer, H. & Daneshian, M.https://doi.org/10.14573/altex.1710081Barriers-on-chips: Measurement of barrier function of tissues in organs-on-chips (2018)Biomicrofluidics, 12(4). Article 042218. Arık, Y. B., van der Helm, M. W., Odijk, M., Segerink, L. I., Passier, R., van den Berg, A. & van der Meer, A. D.https://doi.org/10.1063/1.5023041Reaktive Sauerstoffspezies und Gefäßdegeneration (2018)Zeitschrift fur Herz-, Thorax- und Gefasschirurgie, 32(3), 242-247. Minol, J. P., Reinsch, I., Luik, M., Leferink, A., Barth, M., Assmann, A., Lichtenberg, A. & Akhyari, P.https://doi.org/10.1007/s00398-018-0227-9Large-scale fabrication of free-standing and sub-μm PDMS through-hole membranes (2018)Nanoscale, 10(16), 7711-7718. Le-The, H., Tibbe, M., Loessberg-Zahl, J., Palma Do Carmo, M., van der Helm, M., Bomer, J., Van Den Berg, A., Leferink, A., Segerink, L. & Eijkel, J.https://doi.org/10.1039/c7nr09658eA novel method to transfer porous PDMS membranes for high throughput Organ-on-Chip and Lab-on-Chip assembly (2018)In 2018 IEEE Micro Electro Mechanical Systems, MEMS 2018 (pp. 318-321) (Proceedings of the IEEE International Conference on Micro Electro Mechanical Systems (MEMS); Vol. 2018-January). IEEE. Quiros-Solano, W. F., Gaio, N., Silvestri, C., Arik, Y. B., Stassen, O. M. J. A., Van Der Meer, A. D., Bouten, C. V. C., Van Den Berg, A., Dekker, R. & Sarro, P. M.https://doi.org/10.1109/MEMSYS.2018.8346550Cardiac differentiation of pluripotent stem cells and implications for modeling the heart in health and disease (2018)Science Translational Medicine, 10(435). Article eaah5457. Devalla, H. D. & Passier, R.https://doi.org/10.1126/scitranslmed.aah5457Interpretation of field potentials measured on a multi electrode array in pharmacological toxicity screening on primary and human pluripotent stem cell-derived cardiomyocytes (2018)Biochemical and biophysical research communications, 497(4), 1135-1141. Tertoolen, L. G. J., Braam, S. R., van Meer, B. J., Passier, R. & Mummery, C. L.https://doi.org/10.1016/j.bbrc.2017.01.151Musclemotion: A versatile open software tool to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo (2018)Circulation research, 122(3), e5-e16. Sala, L., Van Meer, B. J., Tertoolen, L. G. J., Bakkers, J., Bellin, M., Davis, R. P., Denning, C., Dieben, M. A. E., Eschenhagen, T., Giacomelli, E., Grandela, C., Hansen, A., Holman, E. R., Jongbloed, M. R. M., Kamel, S. M., Koopman, C. D., Lachaud, Q., Mannhardt, I., Mol, M. P. H., … Mummery, C. L.https://doi.org/10.1161/CIRCRESAHA.117.312067Primary Human Lung Alveolus-on-a-chip Model of Intravascular Thrombosis for Assessment of Therapeutics (2018)Clinical pharmacology & therapeutics, 103(2), 332-340. Jain, A., Barrile, R., van der Meer, A. D., Mammoto, A., Mammoto, T., De Ceunynck, K., Aisiku, O., Otieno, M. A., Louden, C. S., Hamilton, G. A., Flaumenhaft, R. & Ingber, D. E.https://doi.org/10.1002/cpt.742Membranes for Organs-on-Chips (2018)In Biomedical Membranes and (Bio)Artificial Organs (pp. 295-321). World Scientific. Tibbe, M. P., van der Meer, A. D., van den Berg, A., Stamatialis, D. & Segerink, L.https://doi.org/10.1142/9789813223974_0011Micro-structured membrane as a 3D biodegradable scaffold: development, characterization and cell-matrix interaction (2018)[Thesis › PhD Thesis - Research external, graduation UT]. Université Fédérale Toulouse Midi-Pyrénées. Das, P.https://doi.org/10.3990/1.159058878Porous sbum-micrometer PDMS membranes as cell culture substrates in a microfludiic chip (2018)[Contribution to conference › Poster] 9th International Conference on Microtechnologies in Medicine and Biology, MMB 2018. Tibbe, M. P., Le The, H., Leferink, A. M., Eijkel, J. C. T. & Segerink, L. I.Transwell integrated porous sub-micrometer PDMS membranes as alternative cell culture platform (2018)[Contribution to conference › Poster] EMBS Micro and Nantechnology in Medicine Conference, MNMC 2018. Tibbe, M., Le The, H., Eijkel, J., van den Berg, A., Leferink, A. & Segerink, L.
2017
A COUP-TFII Human Embryonic Stem Cell Reporter Line to Identify and Select Atrial Cardiomyocytes (2017)Stem cell reports, 9(6), 1765-1779. Schwach, V., Verkerk, A. O., Mol, M., Monshouwer-Kloots, J. J., Devalla, H. D., Orlova, V. V., Anastassiadis, K., Mummery, C. L., Davis, R. P. & Passier, R.https://doi.org/10.1016/j.stemcr.2017.10.024Human Pluripotent Stem Cell Differentiation into Functional Epicardial Progenitor Cells (2017)Stem cell reports, 9(6), 1754-1764. Guadix, J. A., Orlova, V. V., Giacomelli, E., Bellin, M., Ribeiro, M. C., Mummery, C. L., Pérez-Pomares, J. M. & Passier, R.https://doi.org/10.1016/j.stemcr.2017.10.023Compartmentalized 3D Tissue Culture Arrays under Controlled Microfluidic Delivery (2017)Scientific reports, 7. Article 3381. Gümüscü, B., Albers, H. J., van den Berg, A., Eijkel, J. C. T. & van der Meer, A. D.https://doi.org/10.1038/s41598-017-01944-5Integrating cardiomyocytes from human pluripotent stem cells in safety pharmacology: has the time come? (2017)British journal of pharmacology, 174(21), 3749-3765. Sala, L., Bellin, M. & Mummery, C. L.https://doi.org/10.1111/bph.13577Electrical simulations and experimental results of 4-electrode AC transepithelial electrical resistance measurements in gut-on-a-chip (2017)In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1114-1115) (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS); Vol. 2017). The Chemical and Biological Microsystems Society. van der Helm, M., Henry, O., Hamkins-Indik, T., Cronce, M., Leineweber, W., Odijk, M., van der Meer, A., Eijkel, J., Ingber, D. E., van den Berg, A. & Segerink, L.A gut-on-a-chip study: Enabling on-demand manipulation of the outer cell microenvironment in a multicompartmental 3D culture array (2017)In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1013) (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS); Vol. 2017). The Chemical and Biological Microsystems Society. Gümüscü, B., Albers, H. J., van den Berg, A., Eijkel, J. & van der Meer, A. D.Chipholder-integrated 3d-printed pneumatic logic controllers for microfluidic chips (2017)In The 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 645) (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS(; Vol. 2017). The Chemical and Biological Microsystems Society. Loessberg-Zahl, J., Vollenbroek, J., van der Meer, A., Eijkel, J. & van den Berg, A.Configurable gel geometry via flow patterning for angiogenisis assays (2017)In 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences (pp. 1074-) (International Conference on Miniaturized Systems for Chemistry and Life Sciences (μTAS); Vol. 2017). The Chemical and Biological Microsystems Society. Loessberg-Zahl, J., Makkinga, D., van der Meer, A., Eijkel, J. & van den Berg, A.Organs-on-chips for vascular function (2017)Toxicology Letters, 280(1), S29. van der Meer, A.https://doi.org/10.1016/j.toxlet.2017.07.069Human heart disease: lessons from human pluripotent stem cell-derived cardiomyocytes (2017)Cellular and Molecular Life Sciences, 74(20), 3711-3739. Giacomelli, E., Mummery, C. L. & Bellin, M.https://doi.org/10.1007/s00018-017-2546-5Electrophysiological analysis of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) using multi-electrode arrays (MEAs) (2017)Journal of visualized experiments, 2017(123). Article e55587. Sala, L., Ward-van Oostwaard, D., Tertoolen, L. G. J., Mummery, C. L. & Bellin, M.https://doi.org/10.3791/55587A multiplexed organ-on-chip device with individually addressable channels (2017)[Contribution to conference › Poster] 2nd International Organ-on-Chip Symposium, IOOCS17, 2017. Palma Do Carmo, M., van der Helm, M. W., van der Meer, A., van den Berg, A., Eijkel, J. C. T. & Segerink, L.Shear-sensitive nanocapsule drug release for site-specific inhibition of occlusive thrombus formation (2017)Journal of thrombosis and haemostasis, 15(5), 972-982. Molloy, C. P., Yao, Y., Kammoun, H., Bonnard, T., Hoefer, T., Alt, K., Tovar-Lopez, F., Rosengarten, G., Ramsland, P. A., van der Meer, A. D., van den Berg, A., Murphy, A. J., Hagemeyer, C. E., Peter, K. & Westein, E.https://doi.org/10.1111/jth.13666Three-dimensional cardiac microtissues composed of cardiomyocytes and endothelial cells co-differentiated from human pluripotent stem cells (2017)Development (Cambridge), 144(6), 1008-1017. Giacomelli, E., Bellin, M., Sala, L., Van Meer, B. J., Tertoolen, L. G. J., Orlova, V. V. & Mummery, C. L.https://doi.org/10.1242/dev.143438Modelling and drug screening for cardiovascular disease (2017)Acta physiologica, 219(S711), 7-7. Article SO2-2. Passier, R.https://doi.org/10.1111/apha.12866Fabrication and validation of an organ-on-chip system with integrated electrodes to directly quantify transendothelial electrical resistance (2017)Journal of visualized experiments, 127. Article e56334. van der Helm, M. W., Odijk, M., Frimat, J.-P., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I.https://doi.org/10.3791/56334Human Ventricular Stem Cell Cardiomyocytes: Validating In Vitro Assays and Screening Platforms for Pro-arrhythmia Risk Prediction (2017)Journal of Pharmacological and Toxicological Methods, 88(2), 241-241. Article 0237. Rogers, M., Ridley, J., El-Haou, S., Williams, S., Webdale, L., Sutton, K., Stoelzle-Feix, S., Thomas, U., Fertig, N., Zwetsloot, T., Devalla, H. D. & Passier, R.https://doi.org/10.1016/j.vascn.2017.09.238InPulse CrackIT Challenge: Development of An In Vitro Platform Using Physiologically Mature Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes to Screen for Drug-Induced Effects on Cardiac Contractility (2017)Journal of Pharmacological and Toxicological Methods, 88(2), 238-238. Article 0227. Harris, K., Rossman, E., Xu, X., Clements, P., Mannhardt, I., Hansen, A., Saleem, U., Eschenhagen, T., Hortigon, M., Rodriguez, V. Z., Smith, G., van Meer, B., Tertoolen, L., Mummery, C., Catarino Ribeiro, M., Passier, R., de Korte, T., Vlaming, M., Braam, S., … Denning, C.https://doi.org/10.1016/j.vascn.2017.09.228Mimicking arterial thrombosis in a 3D-printed microfluidic in vitro vascular model based on computed tomography angiography data (2017)Lab on a chip, 17(16), 2785-2792. Costa, P. F., Albers, H. J., Linssen, J. E. A., Middelkamp, H. H. T., van der Hout, L., Passier, R., Van Den Berg, A., Malda, J. & van der Meer, A. D.https://doi.org/10.1039/c7lc00202eSmall molecule absorption by PDMS in the context of drug response bioassays (2017)Biochemical and biophysical research communications, 482(2), 323-328. van Meer, B. J., de Vries, H., Firth, K. S. A., van Weerd, J., Tertoolen, L. G. J., Karperien, H. B. J., Jonkheijm, P., Denning, C., IJzerman, A. P. & Mummery, C. L.https://doi.org/10.1016/j.bbrc.2016.11.062Versatile open software to quantify cardiomyocyte and cardiac muscle contraction in vitro and in vivo (2017)[Working paper › Working paper]. bioRxiv. Sala, L., Van Meer, B. J., Tertoolen, L. G. J., Bakkers, J., Bellin, M., Davis, R. P., Denning, C., Dieben, M. A. E., Eschenhagen, T., Giacomelli, E., Grandela, C., Hansen, A., Holman, E. R., Jongbloed, M. R. M., Kamel, S. M., Koopman, C. D., Lachaud, Q., Mannhardt, I., Mol, M. P. H., … Burton, F. L.https://doi.org/10.1101/160754
2016
TECRL, a new life-threatening inherited arrhythmia gene associated with overlapping clinical features of both LQTS and CPVT (2016)EMBO molecular medicine, 8(12), 1390-1408. Devalla, H. D., Gélinas, R., Aburawi, E. H., Beqqali, A., Goyette, P., Freund, C., Chaix, M. A., Tadros, R., Jiang, H., Le Béchec, A., Monshouwer-Kloots, J. J., Zwetsloot, T., Kosmidis, G., Latour, F., Alikashani, A., Hoekstra, M., Schlaepfer, J., Mummery, C. L., Stevenson, B., … Passier, R.https://doi.org/10.15252/emmm.201505719Fluorescent Reporters in Human Pluripotent Stem Cells: Contributions to Cardiac Differentiation and Their Applications in Cardiac Disease and Toxicity (2016)Stem cells, 34(1), 13-26. den Hartogh, S. C. & Passier, P. C. J. J.https://doi.org/10.1002/stem.2196Challenges of immaturity and proliferation in using hPSC-derived cardiomyocytes as disease models (2016)Human Gene Therapy, 27(11), A11-A11. Article INV38. Mummery, C., Birket, M., van Meer, B., Ribeiro, M., Passier, R., Bellin, M., Orlova, V., Davis, G. R., Freund, C., Kosmidis, G. & Tertoolen, L.https://doi.org/10.1089/hum.2016.29035.abstractsGeneration and purification of human stem cell-derived cardiomyocytes (2016)Differentiation, 91(4-5), 126-138. Schwach, V. & Passier, R.https://doi.org/10.1016/j.diff.2016.01.001Go with the flow: humane stamcellen in vasculair onderzoek (2016)[Book/Report › Inaugural speech]. University of Twente. Mummery, C. L.Waar het hart vol van is (2016)[Book/Report › Inaugural speech]. University of Twente. Passier, P. C. J. J.Complex Tissue and Disease Modeling using hiPSCs (2016)Cell stem cell, 18(3), 309-321. Passier, R., Orlova, V. V. & Mummery, C.https://doi.org/10.1016/j.stem.2016.02.011Organs-on-Chips in Drug Development: The Importance of Involving Stakeholders in Early Health Technology Assessment (2016)Applied in vitro toxicology, 2(2), 74-81. Middelkamp, H. H. T., van der Meer, A. D., Hummel, J. M., Stamatialis, D., Mummery, C. L., Passier, P. C. J. J. & IJzerman, M. J.https://doi.org/10.1089/aivt.2015.0029Ultra-thin nanochannel-based liquid TEM cell for EELS analysis and high resolution imaging (2016)In 2016 IEEE 29th International Conference on Micro Electro Mechanical Systems (MEMS) (pp. 804-807). IEEE. Arik, Y. B., Matsui, R., Sarajlic, E., Takayama, Y., Boom, B. A., Berenschot, J. W., le Gac, S., Tas, N. R. & Fujita, H.https://doi.org/10.1109/MEMSYS.2016.7421751A comprehensive gene expression analysis at sequential stages of in vitro cardiac differentiation from isolated MESP1-expressing-mesoderm progenitors (2016)Scientific reports, 6. Article 19386. den Hartogh, S. C., Wolstencroft, K., Mummery, C. L. & Passier, R.https://doi.org/10.1038/srep19386Assessment of whole blood thrombosis in a microfluidic device lined by fixed human endothelium (2016)Biomedical microdevices, 18(73), 73-. Article 73. Jain, A., van der Meer, A. D., Papa, A.-L., Barrile, R., Lai, A., Schlechter, B. L., Otieno, M. A., Louden, C. S., Hamilton, G. A., Michelson, A. D., Frelinger, A. L. & Ingber, D. E.https://doi.org/10.1007/s10544-016-0095-6Direct quantification of transendothelial electrical resistance in organs-on-chips (2016)Biosensors & bioelectronics, 85, 924-929. van der Helm, M. W., Odijk, M., Frimat, J.-P., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I.https://doi.org/10.1016/j.bios.2016.06.014Distinct Contributions of Astrocytes and Pericytes to Neuroinflammation Identified in a 3D Human Blood-Brain Barrier on a Chip (2016)PLoS ONE, 11(3), -. Article e0150360. Herland, A., van der Meer, A. D., Fitzgerald, E. A., Park, T.-E., Sleeboom, J. J. F. & Ingber, D. E.https://doi.org/10.1371/journal.pone.0150360Microfluidic organ-on-chip technology for blood-brain barrier research (2016)Tissue barriers, 4(1), e1142493-. Article e1142493. van der Helm, M. W., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I.https://doi.org/10.1080/21688370.2016.1142493Stamcellen. Wetenschap, werkelijkheid en fictie (2016)[Book/Report › Book]. Stichting Bio-Wetenschappen en Maatschappij. Karperien, H. B. J. & Mummery, C. L.http://www.biomaatschappij.nl/product/stamcellen-2/Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes (2016)European heart journal, 38(4), 292–301. Chen, Z., Xian, W., Bellin, M., Dorn, T., Tian, Q., Goedel, A., Dreizehnter, L., Schneider, C. M., Ward-van Oostwaard, D., Ng, J. K. M., Hinkel, R., Pane, L. S., Mummery, C. L., Lipp, P., Moretti, A., Laugwitz, K.-L. & Sinnecker, D.https://doi.org/10.1093/eurheartj/ehw189
2015
Studying the blood-brain barrier on a microfluidic chip (2015)[Contribution to conference › Abstract] In Vitro Toxicology Society Annual Meeting. van der Helm, M. W., Broersen, K., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I.https://doi.org/10.1089/aivt.2015.29000.abstractsAltered calcium handling and increased contraction force in human embryonic stem cell derived cardiomyocytes following short term dexamethasone exposure (2015)Biochemical and biophysical research communications, 467(4), 998-1005. Kosmidis, G., Bellin, M., Ribeiro, M. C., van Meer, B., Ward-van Oostwaard, D., Passier, R., Tertoolen, L. G. J., Mummery, C. L. & Casini, S.https://doi.org/10.1016/j.bbrc.2015.10.026Studying the blood-brain barrier on a microfluidic chip for drug development, pathology and toxicology (2015)[Contribution to conference › Poster] Annual meeting of In Vitro Toxicological Society. van der Helm, M. W., Broersen, K., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I.Transcribed enhancers lead waves of coordinated transcription in transitioning mammalian cells (2015)Science, 347(6225), 1010-1014. Arner, E., Daub, C. O., Vitting-Seerup, K., Andersson, R., Lilje, B., Drabløs, F., Lennartsson, A., Rönnerblad, M., Hrydziuszko, O., Vitezic, M., Freeman, T. C., Alhendi, A. M. N., Arner, P., Axton, R., Baillie, J. K., Beckhouse, A., Bodega, B., Briggs, J., Brombacher, F., … Passier, R.https://doi.org/10.1126/science.1259418Studying the blood-brain barrier on a microfluidic chip (2015)[Contribution to conference › Paper] In Vitro Toxicology Society Annual Meeting. McKim, J. M., van der Helm, M. W., Broersen, K., van der Meer, A. D., Eijkel, J. C. T., van den Berg, A. & Segerink, L. I.https://doi.org/10.1089/aivt.2015.29000.abstracts