Antibody ISFET biosensing

Ion-Sensitive Field-Effect Transistor (ISFET) is a variation of the standard Metal-Oxide-Semiconductor Field-Effect Transistor (MOSFET), where the metal gate is replaced by an ion-sensitive membrane, electrolyte solution, and a reference electrode. This modification allows the ISFET to directly translate the activity of specific ions in a solution into an electrical signal, making it a great tool for measuring ion concentrations in a variety of settings, from medical diagnostics to water quality analysis. In our group we are developing an ISFET sensor that is going to be used for screening affinities of biomolecules to different coatings we place on the top of the transistor. 

In this Bachelor/Master assignment your task will be to perform sensing of the biomolecules in the solution using our in-house made ISFETs. You will learn : handling microfluidics, basics of surface chemistry, in-depth knowledge of the ISFET operation and biosensing.