Nanoparticle enhanced fluorescence for tumor-margin detection
Surgical removal remains one of the most used and most effective techniques to treat cancer. The outcome of the treatment is however tightly linked to the effectiveness by which the surgeon removes the tumor. In order to better visualize tumor-margins to the surgeon during operation we use gold-nanoparticles that are bio-conjugated. The nanoparticles are labeled with antibodies and a fluorescent molecule to enhance tumor visibility. Once the tumor-margins are visualized, the gold-particles can be used for laser-induced hyperthermia to kill the remaining tumor cells.
This project will be implementing new technology on fluorescence enhancement by plasmonic (gold) nanoparticles available commercially or developed in-house. Using this effect, the visibility of the particles would be much higher compared to current techniques.
The first round of experiments will be done on cell culture, which will then be extrapolated to mouse tumor models. Collaboration with the Netherlands Cancer Institute-Antoni van Leeuwenhoek ziekenhuis (NKI-AVL) in Amsterdam for providing tumor samples and specialized ‘know-how’ is already in place.
This assignment involves biochemical work, cell culture, and molecular imaging. Clinical experience can be gained at the NKI-AVL.
If you are interested in this Master assigment, you can contact:
Room: ZH 153 (Zuidhorst)
Phone: 053 489 3161
Prof. Theo Ruers
NKI-AVL (dept. of Surgery)