In 2001 Dirk Roelof started his study Biomedical Engineering in Enschede. I finished my bachelor with a thesis on ‘Microfluidics for erythrocytes’, I continued my study Biomedical Engineering with the master materials and tissue engineering. After completing my internship at the University medical center Groningen (UMCG) studying a capillary based DGGE system I started my master project in the NanoBioPhysics group. During my master assignment I studied suprafibrillar α-synuclein aggregates.
-Contact Information -
D R Dekker (MSc)
University of Twente
Institute for Nanotechnology MESA+
7522 NB Enschede, the Netherlands
7500AE Enschede, the Netherlands
-Own Research in NBP-
TOPIC: Supra-fibrillar α- Synuclein aggregates
During my masters assignment I started my research on suprafibrillar α-synuclein aggregates. α-Synuclein is a small neuronal protein (140 amino-acids) involved in Parkinson’s disease. The pathological hallmark of the disease are intracellular aggregates called Lewy bodies. The main component of Lewy bodies are amyloid fibrils made of α-synuclein. In my research I look at the conditions (salt concentration, temperature, pH) needed for the formation of supra-fibrillar α-synuclein aggregates. Besides the conditions needed for the formation of supra-fibrillar aggregates I am also interested in interaction partners (proteins, small molecules, lipids) for α-synuclein that might influence the formation, kinetics or morphology of supra-fibrillar aggregates. Another research interest is to study conditions needed to break down the supra-fibrillar α-synuclein aggregates.
Phase contrast image of supra-fibrillar α-synuclein aggregates (scalebar 20 µm)