dirk_dekker

-Short Biography

In 2001 Dirk Roelof started his study Biomedical Engineering in Enschede. I finished my bachelor with a thesis on ‘Microfluidics for erythrocytes’, I continued my study Biomedical Engineering with the master materials and tissue engineering. After completing my internship at the University medical center Groningen (UMCG) studying a capillary based DGGE system I started my master project in the NanoBioPhysics group. During my master assignment I studied suprafibrillar α-synuclein aggregates.

-Contact Information -

D R Dekker (MSc)

Nanobiophysics

University of Twente

Institute for Nanotechnology MESA+

Zuidhorst ZH153

Drienerlolaan 5

7522 NB  Enschede, the Netherlands

PO-box 217

7500AE Enschede, the Netherlands

P +31-(0)53-489-3163


d.r.dekker@utwente.nl

-Own Research in NBP-

TOPIC: Supra-fibrillar α- Synuclein aggregates

During my masters assignment I started my research on suprafibrillar α-synuclein aggregates. α-Synuclein is a small neuronal protein (140 amino-acids) involved in Parkinson’s disease. The pathological hallmark of the disease are intracellular aggregates called Lewy bodies. The main component of Lewy bodies are amyloid fibrils made of α-synuclein. In my research I look at the conditions (salt concentration, temperature, pH) needed for the formation of supra-fibrillar α-synuclein aggregates. Besides the conditions needed for the formation of supra-fibrillar aggregates I am also interested in interaction partners (proteins, small molecules, lipids) for α-synuclein that might influence the formation, kinetics or morphology of supra-fibrillar aggregates. Another research interest is to study conditions needed to break down the supra-fibrillar α-synuclein aggregates.

Figure1-3

Phase contrast image of supra-fibrillar α-synuclein aggregates (scalebar 20 µm)

Studentprojects

De ziekte van Parkinson, alpha-synculeine en groene thee (BSc project)