High-resolution NMR of nanoliter sample volumes using microcoil detectors
High-resolution liquid- and solid-state nuclear magnetic resonance
of nanoliter sample volumes using microcoil detectors
The development of microfluidic chips with integrated microelectronic components for Nuclear Magnetic Resonance excitation and detection is reviewed in a paper in the Journal of Chemical Physics, by our colleagues of Radboud University Nijmegen. The challenges in the design of probes based on e.g. microcoils are to get the highest possible sensitivity while maintaining high resolution and keeping the versatility to apply all known NMR techniques. This means that the coils have to be optimized for a given sample geometry, circuit losses should be avoided, susceptibility broadening due to probe materials has to be minimized, and finally the B1-fields generated by the rf coils should be homogeneous over the sample volume. This contribution compares three designs that have been miniaturized for NMR detection: solenoid coils, flat helical coils, and the novel stripline and microslot designs. So far most emphasis in microcoil research was in liquid-state NMR. This contribution gives an overview of the state of the art of microcoil solid-state NMR by reviewing literature data and showing the latest results in the development of static and micro magic angle spinning (microMAS) solenoid-based probeheads. Besides their mass sensitivity, microcoils can also generate tremendously high rf fields which are very useful in various solid-state NMR experiments. The benefits of the stripline geometry for studying thin films are shown. This geometry also proves to be a superior solution for microfluidic NMR implementations in terms of sensitivity and resolution.
A.P.M. Kentgens, J. Bart, P.J.M. van Bentum, A. Brinkmann, E.R.H. van Eck, J.G.E. Gardeniers, J.W.G. Janssen, P. Knijn, S. Vasa and M. Verkuijlen
High-resolution liquid- and solid-state nuclear magnetic resonance of nanoliter sample volumes using microcoil detectors
J. Chem. Phys. 128 (2008) 052202-1 - 052202-17.
The full paper can be found at: http://link.aip.org/link/?JCPSA6/128/052202/1