Leijten - Regulators of Articular Cartilage Homeostasis - 2012

Leijten J.C.H.

University of Twente 2012 - dissertation

Abstract

Prevention of hypertrophic differentiation is essential for successful cartilage repair
strategies. Although this process is essential for longitudinal growth, it also is part of
degenerative cartilage diseases such as osteoarthritis. Moreover, it limits the use of
cell types prone to this process for articular cartilage repair; cartilage that becomes
hypertrophic can be transformed into endochondral bone. Therefore, fundamental
knowledge on hypertrophic differentiation might prove crucial for cartilage repair
strategies.