Weerd, van - Supported Lipid Bilayers for the Generation of Dynamic Cell-Material Interfaces

Jasper van Weerd, Marcel Karperien en Pascal Jonkheijm

Advanced Healthcare Materials - 2015

Abstract

Supported lipid bilayers (SLB) offer unique possibilities for studying cellular
membranes and have been used as a synthetic architecture to interact with
cells. Here, the state-of-the-art in SLB-based technology is presented. The
fabrication, analysis, characteristics and modification of SLBs are described
in great detail. Numerous strategies to form SLBs on different substrates,
and the means to patteren them, are described. The use of SLBs as model
membranes for the study of membrane organization and membrane
processes in vitro is highlighted. In addition, the use of SLBs as a substratum
for cell analysis is presented, with discrimination between cell–cell and
cell–extracellular matrix (ECM) mimicry. The study is concluded with a
discussion of the potential for in vivo applications of SLBs.