Leferink - Engineered Micro-Objects as Scaffolding Elements in Cellular Building Blocks for Bottom-Up Tissue Engineering Approaches

A. Leferink, D. Schipper, E. Arts, E. Vrij, N. Rivron, M. Karperien, K. Mittmann, C. van Blitterswijk, L. Moroni, and R. Truckenmüller

Advanced Materials 2014

Abstract

A material-based bottom-up approach is proposed towards an assembly of cells and engineered micro-objects at the macroscale. We show how shape, size and wettability of engineered micro-objects play an important role in the behavior of cells on these objects. This approach can, among other applications, be used as a tool to engineer complex 3D tissues of clinically relevant size.