Master assignment - Well-defined polymer nanoparticles for drug delivery

BACKGROUND

Owing to the development of controlled radical polymerization techniques over the past decade, very well defined polymers can nowadays be prepared. A very wide variety of functional vinyl monomers is readily (commercially) available. While excellent control is achieved over molecular weight and polydispersity. Functional polymers are also widely applied in the preparation of nanoparticles. Recently, single polymer chains are being wrapped into a particle. The advantage of this is that size and polydispersity of the polymer directly translate to that of the particle, moreover, the size of these particles (5-20 nm) is not easily achieved via other methods.

AIM OF THE PROJECT

Linear water-compatible and water-soluble polymers will be prepared via controlled radical polymerization techniques. The resulting polymers will be functionalized with a reactive group, which will serve as a crosslinker during the wrapping of the polymer chain. We will study these particles, as well as their functionalization with a fluorescent dye.

APPROACH

Poly(2-hydroxyethylmethacrylate) polymers of different lengths will be prepared. These polymers will be characterized in detail by NMR spectroscopy and size exclusion chromatography. The polymers will then be functionalized with acrylate moieties, with which thiols easily react. Bifunctional thiols will be used to crosslink the polymers. The final nanoparticles will be analyzed in detail as well.

CONTACT INFORMATION

 

DR. JOS PAULUSSE

 

 

DEPARTMENT OF BIOMEDICAL CHEMISTRY

 

Email:

Phone:

Room:

J.M.J.Paulusse@utwente.nl

053 - 489 3306

ZH 245