Biomedical membranes and (bio) artificial organs

The vision of the cluster is to perform excellent research and education in the field of biomedical membranes and (bio) artificial organs.

The current research activities are focused on three main areas:

·

(Bio) artificial Organs

Main focus is the development of (bio) bioartificial kidney and pancreas devices.

·

Tissue Engineering

Main focus is the understanding of biomaterial–cell interactions and the development of membrane based scaffolds for tissue engineering.

·

Bioseparations - Biotechnology

Efforts are focused on developing membrane concepts for bioseparations and membrane chromatography.

Towards the next generation of dialysis: mixed matrix membranes

(PhD student: Denys Pavlenko)

We develop a prototype device for removal of toxins from blood. In our concept, adsorptive particles are incorporated into a highly porous membrane combining filtration and adsorption in one step. The project is part of the EU Marie Curie Innovative training network (ITN) entitled “BIOART” (2012-2016).

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Mixed matrix membranes: preclinical testing

(PhD student: Denys Pavlenko,

Technical assistant: Lydia Bolhuis – Versteeg)

A very important next step towards application of the MMM in the clinic is its preclinical testing in vivo. We plan to produce the first preclinical in vivo data using a goat chronic kidney disease model. This multidisciplinary project is performed in collaboration with the Department of Nephrology and Hypertension at UMC Utrecht. The project is funded by a MIRA voucher.

Development of nanoporous materials for blood purification

(PhD student: Ilaria Geremia)

The objective of the project is the development of nanoporous polymeric materials for blood purification including sorbents of urea and protein bound toxins, and their integration in mixed matrix membranes. The project is part of the EU Marie Curie Innovative training network (ITN) entitled “TheLink” (2014-2018).

Development of bioartificial kidney device

(PhD student: Natalia Chevtchik)

The project aims to develop a bioactive hollow fiber membrane that regulates long-lived monolayer integrity and cell viability under uremic conditions. To develop a bioactive surface extracellular matrix factors are incorporated using grafting of bioactive peptides on the surface and the application of bioactive coatings. The project is part of the EU Marie Curie Innovative training network (ITN) entitled “BIOART” (2012-2016).

bioartificial pancreas device

Novel islet encapsulation strategy for optimal mass transfer and immune protection

(PhD student: Kasia Skrzypek)

We create bioartificial pancreas device based on the combination of membrane technology and microfabrication. The device consists of a high number of encapsulated islets with tailored spatial distribution, optimal mass transfer (nutrients, oxygen, cell metabolites, insulin), close contact with the surrounding vasculature, and an immune-privileged niche. The project is funded by the Juvenile Diabetes Research foundation, JDRF (2013-2016).

high throughput screening

High throughput screening of biologically active surface nano-topographies

(PhD student: Frits Hulshof)

The project aims to establish a high throughput-screening device for biologically active surface topographies on biomaterials. We manufacture a micro-array comprising thousands of different nano-topographies which are screened for the proliferation and functional performance of cells. The project is funded by the NanoNext NL program (2011-2015).

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New methods for blood detoxification - KidneyPort

(PhD student: Odyl de Beek)

We develop hollow fiber and modules based on new hydrogel biomaterials, known as SlipSkinTM. Doping of the biomaterial with an anticoagulant agent or with a platelet inhibitor is also investigated to further improve blood compatibility. The project is funded by the Life Science and Health Impulse program (2014-2018).

Purification and separation of therapeutic agents in complex mixtures

(PhD student: Bade Kavurt)

The project developd a purification method based on the field-flow fractionation (FFF) technique (which uses a membrane to retain the proteins but passes the carrier solution - usually an aqueous buffer solution) under mild conditions and continuous operation. The project is of the STW program entitled “SmartSep” (2011-2015).

For more information contact:

Prof. Dr. Dimitrios Stamatialis

d.stamatialis@utwente.nl

ZH 242, Tel: +31 (0)53 4894675 or +31 (0)53 4892968